MPD: JaxKOMP-EAP genotype: Sap18<sup>em1(IMPC)J</sup>/Mmjax +/-

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
body composition	body length	0.0041293	0.062684	0.26187	0.989	0.948
body composition	body weight (at time of DXA)	-1.4321	0.71373	-0.90640	0.190	0.0610
body composition	bone area, whole body scan, head excluded	0.36520	0.17133	1.7106	0.210	0.0479
body composition	bone mineral content of whole body scan, head excluded	0.021912	0.015379	1.3866	0.440	0.172
body composition	bone mineral content to body weight ratio	0.00096802	0.00062252	1.4120	0.380	0.139
body composition	bone mineral density of whole body scan, head excluded	-0.0000038620	0.00093792	0.018442	1.00	0.997
body composition	fat tissue mass of whole body scan, head excluded	-1.1219	0.48924	-1.9145	0.172	0.0357
body composition	fat tissue mass to body weight ratio	-0.036913	0.015629	-1.6763	0.138	0.0312
body composition	lean tissue mass of whole body scan, head excluded	0.81885	0.49931	1.3551	0.404	0.121
body composition	lean tissue mass to body weight ratio	0.032242	0.014655	1.5785	0.193	0.0428
body composition	percent fat, whole body scan, head excluded	-3.6200	1.5253	-1.6990	0.143	0.0305
body composition	ratio of soft-tissue attenuation coefficients	0.0039507	0.0016915	1.7096	0.147	0.0329
body composition	tissue area	-0.39588	0.21297	-1.0846	0.317	0.0815
body composition	total tissue mass, whole body scan, head excluded	-0.30301	0.31447	-0.97618	0.601	0.350
clinical blood chemistry	alanine transaminase (plasma ALT)	1.2781	7.8840	0.11859	0.964	0.886
clinical blood chemistry	albumin (plasma Alb)	-1.3057	0.48624	-1.6280	0.417	0.115
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-0.80405	2.6392	-0.66077	0.903	0.789
clinical blood chemistry	aspartate transaminase (plasma AST)	7.4465	15.210	0.36524	0.883	0.673
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.11097	0.16392	0.38242	0.854	0.568
clinical blood chemistry	blood urea nitrogen (BUN)	-1.5093	1.6867	-0.64818	0.712	0.465
clinical blood chemistry	calcium (plasma Ca)	0.032733	0.094199	0.55881	0.873	0.761
clinical blood chemistry	creatinine (plasma)	-0.024227	0.026021	-0.43746	0.682	0.450
clinical blood chemistry	glucose (plasma GLU, no fast)	3.0997	25.189	0.41044	0.950	0.913
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.4133	3.3042	-0.66077	0.890	0.711
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.00044529	0.022324	-0.13636	0.999	0.986
clinical blood chemistry	phosphorus (plasma phosphate)	1.2441	0.24624	1.6904	0.192	0.0370
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0086793	0.023037	0.55362	0.908	0.743
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-1.4771	4.8693	-0.49188	0.919	0.790
clinical blood chemistry	total protein (plasma TP)	-1.6884	0.83617	-1.2738	0.466	0.181
clinical blood chemistry	triglyceride (plasma TG, no fast)	12.254	9.3664	0.87135	0.611	0.321
EKG	duration of PQ interval	0.45250	1.4156	0.62472	0.939	0.752
EKG	duration of PR interval	0.53988	1.4170	0.62963	0.938	0.706
EKG	duration of QRS interval	0.38261	0.30516	0.94935	0.885	0.221
EKG	duration of QT interval	1.1288	1.3490	1.2258	0.858	0.410
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.0457	1.1691	1.1103	0.878	0.379
EKG	duration of RR interval	-1.3326	2.5141	-0.42337	0.854	0.601
EKG	duration of ST interval	0.11921	1.1927	0.31758	0.975	0.921
EKG	heart rate coefficient of variation (signal intensity)	-0.43443	1.1898	-0.26710	0.951	0.718
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-2.1481	7.6016	-0.14763	0.965	0.780
EKG	heart rate, beats per min	10.758	19.418	0.40287	0.833	0.584
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.076848	0.11339	-0.75992	0.799	0.504
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.13247	0.14961	-0.82904	0.705	0.384
EKG	number of signals	0.78793	7.6243	0.14152	0.984	0.918
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-5.6263	8.4946	-1.0151	0.867	0.514
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-4.3179	3.6849	-1.2216	0.881	0.252
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-5.1690	3.7416	-1.3114	0.856	0.179
EKG	root mean square of successive differences of neighboring RR intervals	-0.76538	2.3972	-0.27547	0.947	0.752
glucose tolerance test	amount glucose injected	-9.0375	4.2480	-1.8035	0.322	0.0493
glucose tolerance test	plasma glucose, 0min	10.959	3.3867	0.88588	0.0346	0.00486
glucose tolerance test	plasma glucose, 15min	-27.130	22.591	-0.63285	0.577	0.246
glucose tolerance test	plasma glucose, 30min	-19.127	17.520	-0.46207	0.628	0.291
glucose tolerance test	plasma glucose, 60min	3.3652	13.819	0.28095	0.926	0.811
glucose tolerance test	plasma glucose, 120min	4.5242	6.2758	0.17523	0.743	0.481
grip strength	body weight (at time of grip strength test)	0.25491	0.73509	0.45956	0.845	0.734
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-23.976	10.404	-1.4373	0.130	0.0370
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.1585	0.44983	-1.4496	0.0964	0.0220
grip strength	forelimb and hindlimb grip strength by trial, trial1	-19.636	14.591	-1.0588	0.484	0.200
grip strength	forelimb and hindlimb grip strength by trial, trial2	-37.545	11.678	-2.1111	0.0597	0.00623
grip strength	forelimb and hindlimb grip strength by trial, trial3	-14.383	11.970	-0.72363	0.517	0.251
grip strength	forelimb grip strength (mean of trials), average	-13.339	5.7521	-1.3105	0.169	0.0360
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.54132	0.28395	-1.1058	0.276	0.0789
grip strength	forelimb grip strength by trial, trial1	-19.709	9.3242	-1.8226	0.290	0.0530
grip strength	forelimb grip strength by trial, trial2	-11.218	8.3208	-0.96897	0.528	0.199
grip strength	forelimb grip strength by trial, trial3	-9.0909	8.0834	-0.73120	0.596	0.280
heart weight	heart weight, normalized to body weight	-0.031290	0.60561	-0.57709	0.979	0.963
heart weight	heart weight, weight	-3.7254	15.290	-0.87680	0.906	0.830
hematology	basophil differential (percent of total WBC)	0.10282	0.076656	1.3318	0.725	0.312
hematology	calculated hemoglobin (cHGB)	0.13125	0.76691	0.11498	0.952	0.880
hematology	eosinophil differential (percent of total WBC)	-0.21875	0.28655	-0.54952	0.845	0.525
hematology	hematocrit (HCT)	0.13125	0.49525	-0.23729	0.909	0.816
hematology	hemoglobin concentration distribution width (HDW)	0.013125	0.14064	0.34758	0.965	0.934
hematology	large unstained cells (percent of total WBC)	0.050000	0.15412	0.34088	0.908	0.776
hematology	lymphocyte differential (percent of total WBC)	1.8896	1.4000	0.67879	0.561	0.310
hematology	mean corpuscular hemoglobin (CHr)	0.037500	0.45621	0.34182	0.970	0.942
hematology	mean platelet volume (MPV)	0.20000	0.66672	0.97733	0.901	0.793
hematology	mean RBC corpuscular hemoglobin (MCH)	0.093750	0.11007	0.33633	0.783	0.484
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.20625	0.33712	0.47627	0.840	0.603
hematology	mean RBC corpuscular volume (MCV)	-0.068750	0.42018	-0.12470	0.952	0.885
hematology	measured hemoglobin (mHGB)	0.13750	0.19664	0.10343	0.773	0.557
hematology	monocyte differential (percent of total WBC)	-0.3875	0.19797	-0.93448	0.549	0.189
hematology	neutrophil differential (percent of total WBC)	-1.3107	1.2054	-0.60160	0.614	0.390
hematology	platelet count (PLT; units per volume x 10³)	41.062	80.187	0.60488	0.870	0.660
hematology	RBC corpuscular distribution width (RDW)	0.043750	0.40501	0.15896	0.967	0.924
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.1625	1.3373	0.40792	0.960	0.914
hematology	red blood cell count (RBC; per volume x 10⁶)	0.043125	0.21963	-0.16216	0.938	0.862
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-5.6437	28.407	-0.16209	0.961	0.861
hematology	reticulocyte differential (percent of total RBC)	-0.086875	0.24370	-0.14341	0.905	0.756
hematology	white blood cell count (WBC; units per volume x 10³)	0.35000	0.98334	0.42374	0.867	0.756
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.096778	1.4391	-0.034610	0.980	0.947
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.74962	0.69599	1.3732	0.775	0.291
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.064706	0.78988	0.18762	0.978	0.935
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.82941	0.95310	-0.76245	0.795	0.392
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.38824	0.48515	-0.53703	0.846	0.431
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.54118	0.31960	-1.5172	0.688	0.102
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.27059	0.25567	0.70396	0.839	0.299
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.0058824	0.61441	0.13290	0.999	0.992
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.047059	0.41959	0.19204	0.990	0.912
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.42661	0.29975	1.0848	0.746	0.167
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.24118	0.52593	0.62238	0.921	0.650
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.32353	0.53198	0.62347	0.896	0.548
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.57428	0.75912	-0.46868	0.794	0.456
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.0058824	0.70605	0.075980	0.995	0.993
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.23830	0.63366	0.43134	0.911	0.710
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.72353	0.93968	0.65451	0.793	0.448
holeboard	total number of hole pokes, 20 min test	0.85294	5.4097	0.20554	0.945	0.876
light / dark	fecal boli count, 20 min test	-1.1447	0.50612	-1.2615	0.360	0.0323
light / dark	latency to enter dark zone, 20 min test	-31.964	31.425	-0.70450	0.718	0.318
light / dark	number of transitions between light and dark zones, 20 min test	11.782	9.8219	1.1629	0.563	0.241
light / dark	percentage of total time in dark zone, 20 min test	-8.0443	4.5439	-1.3174	0.423	0.0884
light / dark	percentage of total time in light zone, 20 min test	8.0443	4.5439	1.3142	0.421	0.0884
light / dark	time mobile in dark zone, 20 min test	33.854	13.019	1.4709	0.118	0.0149
light / dark	time mobile in light zone, 20 min test	39.198	14.478	1.6591	0.0891	0.0118
light / dark	time spent in dark zone, 20 min test	-62.246	55.058	-0.70797	0.677	0.269
light / dark	time spent in light zone, 20 min test	62.246	55.058	0.70797	0.677	0.269
open field	average speed in center of arena, 20 min test	0.77292	0.41689	1.2023	0.355	0.0756
open field	average speed in periphery of arena, 20 min test	0.33633	0.20190	0.76092	0.274	0.108
open field	distance traveled habituation ratio, 20 min test	1.8668	6.8984	0.18840	0.915	0.789
open field	distance traveled in center of arena, 20 min test	337.12	77.355	1.5241	0.00427	0.000197
open field	distance traveled in periphery of arena, 20 min test	236.60	198.38	0.47887	0.483	0.244
open field	distance traveled slope, 20 min test	0.94615	6.7675	0.16113	0.975	0.890
open field	distance traveled, 20 min test, 1st 5min	144.60	70.459	0.77353	0.192	0.0508
open field	distance traveled, 20 min test, 2nd 5min	156.76	64.646	1.1751	0.115	0.0226
open field	distance traveled, 20 min test, 3rd 5min	115.01	72.119	0.78444	0.325	0.123
open field	distance traveled, 20 min test, 4th 5min	167.56	75.402	1.2566	0.162	0.0355
open field	number of clockwise revolution episodes, 20 min test	2.0481	1.2118	0.76952	0.413	0.103
open field	number of counter-clockwise revolution episodes, 20 min test	1.9380	1.4421	0.60166	0.474	0.191
open field	number of rears in 5 min bins, 20 min test, 1st 5min	9.7519	3.1081	2.1166	0.0541	0.00433
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	11.579	2.4471	2.0357	0.00283	0.0000682
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	14.176	3.4516	2.3198	0.0116	0.000353
open field	number of rears in 5 min bins, 20 min test, 4th 5min	15.789	3.1939	2.4592	0.00303	0.0000390
open field	percentage of total time in center of arena, 20 min test	5.9072	2.2625	1.0788	0.152	0.0148
open field	percentage of total time in center of arena, slope, 20 min test	1.8323	0.91899	1.1181	0.451	0.0568
open field	percentage of total time in center, habituation ratio, 20 min test	1.9683	0.96035	1.1805	0.441	0.0506
open field	percentage of total time in corners of arena, 20 min test	-4.7774	3.3282	-0.59043	0.472	0.164
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.2484	2.0135	-0.87146	0.888	0.541
open field	percentage of total time in corners, slope, 20 min test	-1.1855	1.9997	-0.86754	0.900	0.558
open field	permanence time in center of arena, 20 min test	70.875	27.152	1.0788	0.153	0.0148
open field	permanence time in corners of arena, 20 min test	-57.336	39.936	-0.59043	0.472	0.163
open field	permanence time in periphery of arena, 20 min test	-70.813	27.155	-1.0788	0.153	0.0149
open field	total distance traveled, 20 min test	575.42	249.93	1.0716	0.120	0.0299
open field	total number of rears, 20 min test	51.246	10.285	2.4074	0.00153	0.0000352
open field	whole arena average speed, 20 min test	0.48070	0.20832	1.0740	0.118	0.0296
open field	whole arena resting time, 20 min test	-42.248	24.935	-0.61620	0.259	0.103
open field	whole arena time spent mobile, 20 min test	42.268	24.948	0.86754	0.260	0.103
open field	whole arena time spent vertical, 20 min test	45.101	14.054	2.4074	0.0521	0.00352
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.3449	1.5964	-0.82328	0.477	0.166
startle / PPI	average baseline movement during background noise	-0.73235	0.98426	-0.48730	0.877	0.463
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.021367	0.069471	-0.29349	0.900	0.761
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.027360	0.065917	-0.33362	0.874	0.681
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.37598	8.8262	0.10598	0.995	0.966
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-8.9478	7.9697	-0.91541	0.639	0.271
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	1.8746	7.8093	0.091903	0.928	0.812
startle / PPI	average startle response to full pulse (120 dB)	64.415	60.421	1.3006	0.545	0.296
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	45.420	59.962	1.0230	0.681	0.456
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	104.17	64.301	1.7414	0.303	0.117
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	42.624	52.391	1.1174	0.626	0.423
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.91176	1.6931	-0.60949	0.913	0.595
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-4.3118	1.9101	-2.5035	0.444	0.0323
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-0.22230	2.4987	-0.29788	0.985	0.930
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.0023232	0.089751	0.055373	0.998	0.980
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.10882	0.081408	-0.98969	0.542	0.192
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.023215	0.090980	0.026640	0.916	0.801
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	64.633	60.246	1.2973	0.537	0.293
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	46.214	60.222	1.0206	0.670	0.450
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	108.14	63.904	1.7949	0.280	0.103
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	42.835	52.734	1.1439	0.629	0.424
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.0017686	0.097122	0.014712	0.998	0.986
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.093264	0.089199	-0.80930	0.651	0.305
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.037707	0.090799	0.10111	0.853	0.681
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	216.95	210.12	1.2141	0.558	0.311
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	147.16	216.59	0.92396	0.709	0.503
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	362.31	229.85	1.6809	0.319	0.127
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	141.26	183.52	1.0591	0.645	0.448
startle / PPI	maximum baseline movement during background noise	-1.9441	2.5001	-0.52714	0.845	0.444
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.40947	9.5887	-0.014712	1.00	0.966
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-8.8095	8.6376	-0.85932	0.674	0.317
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	2.6320	8.0392	0.10035	0.895	0.746
startle / PPI	maximum startle response to full pulse (120 dB)	215.93	210.55	1.2229	0.561	0.315
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	146.39	215.71	0.93475	0.712	0.503
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	354.21	230.55	1.6583	0.331	0.137
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	141.66	182.50	1.0640	0.647	0.445
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.4422	3.5654	-0.36151	0.933	0.689
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-9.3696	4.4926	-2.2656	0.496	0.0466
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	0.40234	6.0840	-0.072221	0.991	0.948

body composition

body length

0.0041293

0.062684

0.26187

0.989

0.948

body composition

body weight (at time of DXA)

-1.4321

0.71373

-0.90640

0.190

0.0610

body composition

bone area, whole body scan, head excluded

0.36520

0.17133

1.7106

0.210

0.0479

body composition

bone mineral content of whole body scan, head excluded

0.021912

0.015379

1.3866

0.440

0.172

body composition

bone mineral content to body weight ratio

0.00096802

0.00062252

1.4120

0.380

0.139

body composition

bone mineral density of whole body scan, head excluded

-0.0000038620

0.00093792

0.018442

1.00

0.997

body composition

fat tissue mass of whole body scan, head excluded

-1.1219

0.48924

-1.9145

0.172

0.0357

body composition

fat tissue mass to body weight ratio

-0.036913

0.015629

-1.6763

0.138

0.0312

body composition

lean tissue mass of whole body scan, head excluded

0.81885

0.49931

1.3551

0.404

0.121

body composition

lean tissue mass to body weight ratio

0.032242

0.014655

1.5785

0.193

0.0428

body composition

percent fat, whole body scan, head excluded

-3.6200

1.5253

-1.6990

0.143

0.0305

body composition

ratio of soft-tissue attenuation coefficients

0.0039507

0.0016915

1.7096

0.147

0.0329

body composition

tissue area

-0.39588

0.21297

-1.0846

0.317

0.0815

body composition

total tissue mass, whole body scan, head excluded

-0.30301

0.31447

-0.97618

0.601

0.350

clinical blood chemistry

alanine transaminase (plasma ALT)

1.2781

7.8840

0.11859

0.964

0.886

clinical blood chemistry

albumin (plasma Alb)

-1.3057

0.48624

-1.6280

0.417

0.115

clinical blood chemistry

alkaline phosphatase (plasma ALP)

-0.80405

2.6392

-0.66077

0.903

0.789

clinical blood chemistry

aspartate transaminase (plasma AST)

7.4465

15.210

0.36524

0.883

0.673

clinical blood chemistry

aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)

0.11097

0.16392

0.38242

0.854

0.568

clinical blood chemistry

blood urea nitrogen (BUN)

-1.5093

1.6867

-0.64818

0.712

0.465

clinical blood chemistry

calcium (plasma Ca)

0.032733

0.094199

0.55881

0.873

0.761

clinical blood chemistry

creatinine (plasma)

-0.024227

0.026021

-0.43746

0.682

0.450

clinical blood chemistry

glucose (plasma GLU, no fast)

3.0997

25.189

0.41044

0.950

0.913

clinical blood chemistry

HDL cholesterol (plasma HDL)

-1.4133

3.3042

-0.66077

0.890

0.711

clinical blood chemistry

HDL cholesterol to total cholesterol ratio

0.00044529

0.022324

-0.13636

0.999

0.986

clinical blood chemistry

phosphorus (plasma phosphate)

1.2441

0.24624

1.6904

0.192

0.0370

clinical blood chemistry

total bilirubin (plasma TBIL)

0.0086793

0.023037

0.55362

0.908

0.743

clinical blood chemistry

total cholesterol (plasma CHOL, no fast)

-1.4771

4.8693

-0.49188

0.919

0.790

clinical blood chemistry

total protein (plasma TP)

-1.6884

0.83617

-1.2738

0.466

0.181

clinical blood chemistry

triglyceride (plasma TG, no fast)

12.254

9.3664

0.87135

0.611

0.321

EKG

duration of PQ interval

0.45250

1.4156

0.62472

0.939

0.752

EKG

duration of PR interval

0.53988

1.4170

0.62963

0.938

0.706

EKG

duration of QRS interval

0.38261

0.30516

0.94935

0.885

0.221

EKG

duration of QT interval

1.1288

1.3490

1.2258

0.858

0.410

EKG

duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval

1.0457

1.1691

1.1103

0.878

0.379

EKG

duration of RR interval

-1.3326

2.5141

-0.42337

0.854

0.601

EKG

duration of ST interval

0.11921

1.1927

0.31758

0.975

0.921

EKG

heart rate coefficient of variation (signal intensity)

-0.43443

1.1898

-0.26710

0.951

0.718

EKG

heart rate variability, mean of differences between sequential beats; beats per min

-2.1481

7.6016

-0.14763

0.965

0.780

EKG

heart rate, beats per min

10.758

19.418

0.40287

0.833

0.584

EKG

mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS

-0.076848

0.11339

-0.75992

0.799

0.504

EKG

mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS

-0.13247

0.14961

-0.82904

0.705

0.384

EKG

number of signals

0.78793

7.6243

0.14152

0.984

0.918

EKG

proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms

-5.6263

8.4946

-1.0151

0.867

0.514

EKG

QT dispersion, measured as inter-lead variability of QT intervals

-4.3179

3.6849

-1.2216

0.881

0.252

EKG

QTc dispersion, calculated as rate-corrected QT dispersion

-5.1690

3.7416

-1.3114

0.856

0.179

EKG

root mean square of successive differences of neighboring RR intervals

-0.76538

2.3972

-0.27547

0.947

0.752

glucose tolerance test

amount glucose injected

-9.0375

4.2480

-1.8035

0.322

0.0493

glucose tolerance test

plasma glucose, 0min

10.959

3.3867

0.88588

0.0346

0.00486

glucose tolerance test

plasma glucose, 15min

-27.130

22.591

-0.63285

0.577

0.246

glucose tolerance test

plasma glucose, 30min

-19.127

17.520

-0.46207

0.628

0.291

glucose tolerance test

plasma glucose, 60min

3.3652

13.819

0.28095

0.926

0.811

glucose tolerance test

plasma glucose, 120min

4.5242

6.2758

0.17523

0.743

0.481

grip strength

body weight (at time of grip strength test)

0.25491

0.73509

0.45956

0.845

0.734

grip strength

forelimb and hindlimb grip strength (mean of trials), average

-23.976

10.404

-1.4373

0.130

0.0370

grip strength

forelimb and hindlimb grip strength (mean of trials), average normalized to bw

-1.1585

0.44983

-1.4496

0.0964

0.0220

grip strength

forelimb and hindlimb grip strength by trial, trial1

-19.636

14.591

-1.0588

0.484

0.200

grip strength

forelimb and hindlimb grip strength by trial, trial2

-37.545

11.678

-2.1111

0.0597

0.00623

grip strength

forelimb and hindlimb grip strength by trial, trial3

-14.383

11.970

-0.72363

0.517

0.251

grip strength

forelimb grip strength (mean of trials), average

-13.339

5.7521

-1.3105

0.169

0.0360

grip strength

forelimb grip strength (mean of trials), average normalized to bw

-0.54132

0.28395

-1.1058

0.276

0.0789

grip strength

forelimb grip strength by trial, trial1

-19.709

9.3242

-1.8226

0.290

0.0530

grip strength

forelimb grip strength by trial, trial2

-11.218

8.3208

-0.96897

0.528

0.199

grip strength

forelimb grip strength by trial, trial3

-9.0909

8.0834

-0.73120

0.596

0.280

heart weight

heart weight, normalized to body weight

-0.031290

0.60561

-0.57709

0.979

0.963

heart weight

heart weight, weight

-3.7254

15.290

-0.87680

0.906

0.830

hematology

basophil differential (percent of total WBC)

0.10282

0.076656

1.3318

0.725

0.312

hematology

calculated hemoglobin (cHGB)

0.13125

0.76691

0.11498

0.952

0.880

hematology

eosinophil differential (percent of total WBC)

-0.21875

0.28655

-0.54952

0.845

0.525

hematology

hematocrit (HCT)

0.13125

0.49525

-0.23729

0.909

0.816

hematology

hemoglobin concentration distribution width (HDW)

0.013125

0.14064

0.34758

0.965

0.934

hematology

large unstained cells (percent of total WBC)

0.050000

0.15412

0.34088

0.908

0.776

hematology

lymphocyte differential (percent of total WBC)

1.8896

1.4000

0.67879

0.561

0.310

hematology

mean corpuscular hemoglobin (CHr)

0.037500

0.45621

0.34182

0.970

0.942

hematology

mean platelet volume (MPV)

0.20000

0.66672

0.97733

0.901

0.793

hematology

mean RBC corpuscular hemoglobin (MCH)

0.093750

0.11007

0.33633

0.783

0.484

hematology

mean RBC corpuscular hemoglobin concentration (MCHC)

0.20625

0.33712

0.47627

0.840

0.603

hematology

mean RBC corpuscular volume (MCV)

-0.068750

0.42018

-0.12470

0.952

0.885

hematology

measured hemoglobin (mHGB)

0.13750

0.19664

0.10343

0.773

0.557

hematology

monocyte differential (percent of total WBC)

-0.3875

0.19797

-0.93448

0.549

0.189

hematology

neutrophil differential (percent of total WBC)

-1.3107

1.2054

-0.60160

0.614

0.390

hematology

platelet count (PLT; units per volume x 10³)

41.062

80.187

0.60488

0.870

0.660

hematology

RBC corpuscular distribution width (RDW)

0.043750

0.40501

0.15896

0.967

0.924

hematology

RBC corpuscular hemoglobin concentration mean (CHCM)

0.1625

1.3373

0.40792

0.960

0.914

hematology

red blood cell count (RBC; per volume x 10⁶)

0.043125

0.21963

-0.16216

0.938

0.862

hematology

reticulocyte count (Retic; units per volume x 10⁹)

-5.6437

28.407

-0.16209

0.961

0.861

hematology

reticulocyte differential (percent of total RBC)

-0.086875

0.24370

-0.14341

0.905

0.756

hematology

white blood cell count (WBC; units per volume x 10³)

0.35000

0.98334

0.42374

0.867

0.756

holeboard

number of hole pokes by individual hole number, 20 min test, 1

-0.096778

1.4391

-0.034610

0.980

0.947

holeboard

number of hole pokes by individual hole number, 20 min test, 2

0.74962

0.69599

1.3732

0.775

0.291

holeboard

number of hole pokes by individual hole number, 20 min test, 3

0.064706

0.78988

0.18762

0.978

0.935

holeboard

number of hole pokes by individual hole number, 20 min test, 4

-0.82941

0.95310

-0.76245

0.795

0.392

holeboard

number of hole pokes by individual hole number, 20 min test, 5

-0.38824

0.48515

-0.53703

0.846

0.431

holeboard

number of hole pokes by individual hole number, 20 min test, 6

-0.54118

0.31960

-1.5172

0.688

0.102

holeboard

number of hole pokes by individual hole number, 20 min test, 7

0.27059

0.25567

0.70396

0.839

0.299

holeboard

number of hole pokes by individual hole number, 20 min test, 8

-0.0058824

0.61441

0.13290

0.999

0.992

holeboard

number of hole pokes by individual hole number, 20 min test, 9

0.047059

0.41959

0.19204

0.990

0.912

holeboard

number of hole pokes by individual hole number, 20 min test, 10

0.42661

0.29975

1.0848

0.746

0.167

holeboard

number of hole pokes by individual hole number, 20 min test, 11

0.24118

0.52593

0.62238

0.921

0.650

holeboard

number of hole pokes by individual hole number, 20 min test, 12

0.32353

0.53198

0.62347

0.896

0.548

holeboard

number of hole pokes by individual hole number, 20 min test, 13

-0.57428

0.75912

-0.46868

0.794

0.456

holeboard

number of hole pokes by individual hole number, 20 min test, 14

0.0058824

0.70605

0.075980

0.995

0.993

holeboard

number of hole pokes by individual hole number, 20 min test, 15

0.23830

0.63366

0.43134

0.911

0.710

holeboard

number of hole pokes by individual hole number, 20 min test, 16

0.72353

0.93968

0.65451

0.793

0.448

holeboard

total number of hole pokes, 20 min test

0.85294

5.4097

0.20554

0.945

0.876

light / dark

fecal boli count, 20 min test

-1.1447

0.50612

-1.2615

0.360

0.0323

light / dark

latency to enter dark zone, 20 min test

-31.964

31.425

-0.70450

0.718

0.318

light / dark

number of transitions between light and dark zones, 20 min test

11.782

9.8219

1.1629

0.563

0.241

light / dark

percentage of total time in dark zone, 20 min test

-8.0443

4.5439

-1.3174

0.423

0.0884

light / dark

percentage of total time in light zone, 20 min test

8.0443

4.5439

1.3142

0.421

0.0884

light / dark

time mobile in dark zone, 20 min test

33.854

13.019

1.4709

0.118

0.0149

light / dark

time mobile in light zone, 20 min test

39.198

14.478

1.6591

0.0891

0.0118

light / dark

time spent in dark zone, 20 min test

-62.246

55.058

-0.70797

0.677

0.269

light / dark

time spent in light zone, 20 min test

62.246

55.058

0.70797

0.677

0.269

open field

average speed in center of arena, 20 min test

0.77292

0.41689

1.2023

0.355

0.0756

open field

average speed in periphery of arena, 20 min test

0.33633

0.20190

0.76092

0.274

0.108

open field

distance traveled habituation ratio, 20 min test

1.8668

6.8984

0.18840

0.915

0.789

open field

distance traveled in center of arena, 20 min test

337.12

77.355

1.5241

0.00427

0.000197

open field

distance traveled in periphery of arena, 20 min test

236.60

198.38

0.47887

0.483

0.244

open field

distance traveled slope, 20 min test

0.94615

6.7675

0.16113

0.975

0.890

open field

distance traveled, 20 min test, 1st 5min

144.60

70.459

0.77353

0.192

0.0508

open field

distance traveled, 20 min test, 2nd 5min

156.76

64.646

1.1751

0.115

0.0226

open field

distance traveled, 20 min test, 3rd 5min

115.01

72.119

0.78444

0.325

0.123

open field

distance traveled, 20 min test, 4th 5min

167.56

75.402

1.2566

0.162

0.0355

open field

number of clockwise revolution episodes, 20 min test

2.0481

1.2118

0.76952

0.413

0.103

open field

number of counter-clockwise revolution episodes, 20 min test

1.9380

1.4421

0.60166

0.474

0.191

open field

number of rears in 5 min bins, 20 min test, 1st 5min

9.7519

3.1081

2.1166

0.0541

0.00433

open field

number of rears in 5 min bins, 20 min test, 2nd 5min

11.579

2.4471

2.0357

0.00283

0.0000682

open field

number of rears in 5 min bins, 20 min test, 3rd 5min

14.176

3.4516

2.3198

0.0116

0.000353

open field

number of rears in 5 min bins, 20 min test, 4th 5min

15.789

3.1939

2.4592

0.00303

0.0000390

open field

percentage of total time in center of arena, 20 min test

5.9072

2.2625

1.0788

0.152

0.0148

open field

percentage of total time in center of arena, slope, 20 min test

1.8323

0.91899

1.1181

0.451

0.0568

open field

percentage of total time in center, habituation ratio, 20 min test

1.9683

0.96035

1.1805

0.441

0.0506

open field

percentage of total time in corners of arena, 20 min test

-4.7774

3.3282

-0.59043

0.472

0.164

open field

percentage of total time in corners, habituation ratio, 20 min test

-1.2484

2.0135

-0.87146

0.888

0.541

open field

percentage of total time in corners, slope, 20 min test

-1.1855

1.9997

-0.86754

0.900

0.558

open field

permanence time in center of arena, 20 min test

70.875

27.152

1.0788

0.153

0.0148

open field

permanence time in corners of arena, 20 min test

-57.336

39.936

-0.59043

0.472

0.163

open field

permanence time in periphery of arena, 20 min test

-70.813

27.155

-1.0788

0.153

0.0149

open field

total distance traveled, 20 min test

575.42

249.93

1.0716

0.120

0.0299

open field

total number of rears, 20 min test

51.246

10.285

2.4074

0.00153

0.0000352

open field

whole arena average speed, 20 min test

0.48070

0.20832

1.0740

0.118

0.0296

open field

whole arena resting time, 20 min test

-42.248

24.935

-0.61620

0.259

0.103

open field

whole arena time spent mobile, 20 min test

42.268

24.948

0.86754

0.260

0.103

open field

whole arena time spent vertical, 20 min test

45.101

14.054

2.4074

0.0521

0.00352

SHIRPA

locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)

-2.3449

1.5964

-0.82328

0.477

0.166

startle / PPI

average baseline movement during background noise

-0.73235

0.98426

-0.48730

0.877

0.463

startle / PPI

average of each corrected maximum percent pre-pulse inhibition value

-0.021367

0.069471

-0.29349

0.900

0.761

startle / PPI

average of each corrected percent pre-pulse inhibition value

-0.027360

0.065917

-0.33362

0.874

0.681

startle / PPI

average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

0.37598

8.8262

0.10598

0.995

0.966

startle / PPI

average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

-8.9478

7.9697

-0.91541

0.639

0.271

startle / PPI

average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

1.8746

7.8093

0.091903

0.928

0.812

startle / PPI

average startle response to full pulse (120 dB)

64.415

60.421

1.3006

0.545

0.296

startle / PPI

average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

45.420

59.962

1.0230

0.681

0.456

startle / PPI

average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

104.17

64.301

1.7414

0.303

0.117

startle / PPI

average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

42.624

52.391

1.1174

0.626

0.423

startle / PPI

average startle response to pre-pulse, 74dB sound pressure level

-0.91176

1.6931

-0.60949

0.913

0.595

startle / PPI

average startle response to pre-pulse, 78dB sound pressure level

-4.3118

1.9101

-2.5035

0.444

0.0323

startle / PPI

average startle response to pre-pulse, 82dB sound pressure level

-0.22230

2.4987

-0.29788

0.985

0.930

startle / PPI

corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

0.0023232

0.089751

0.055373

0.998

0.980

startle / PPI

corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

-0.10882

0.081408

-0.98969

0.542

0.192

startle / PPI

corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

0.023215

0.090980

0.026640

0.916

0.801

startle / PPI

corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise

64.633

60.246

1.2973

0.537

0.293

startle / PPI

corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level

46.214

60.222

1.0206

0.670

0.450

startle / PPI

corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level

108.14

63.904

1.7949

0.280

0.103

startle / PPI

corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level

42.835

52.734

1.1439

0.629

0.424

startle / PPI

corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

-0.0017686

0.097122

0.014712

0.998

0.986

startle / PPI

corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

-0.093264

0.089199

-0.80930

0.651

0.305

startle / PPI

corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

0.037707

0.090799

0.10111

0.853

0.681

startle / PPI

corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise

216.95

210.12

1.2141

0.558

0.311

startle / PPI

corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level

147.16

216.59

0.92396

0.709

0.503

startle / PPI

corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level

362.31

229.85

1.6809

0.319

0.127

startle / PPI

corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level

141.26

183.52

1.0591

0.645

0.448

startle / PPI

maximum baseline movement during background noise

-1.9441

2.5001

-0.52714

0.845

0.444

startle / PPI

maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

-0.40947

9.5887

-0.014712

1.00

0.966

startle / PPI

maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

-8.8095

8.6376

-0.85932

0.674

0.317

startle / PPI

maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

2.6320

8.0392

0.10035

0.895

0.746

startle / PPI

maximum startle response to full pulse (120 dB)

215.93

210.55

1.2229

0.561

0.315

startle / PPI

maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

146.39

215.71

0.93475

0.712

0.503

startle / PPI

maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

354.21

230.55

1.6583

0.331

0.137

startle / PPI

maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

141.66

182.50

1.0640

0.647

0.445

startle / PPI

maximum startle response to pre-pulse, 74dB sound pressure level

-1.4422

3.5654

-0.36151

0.933

0.689

startle / PPI

maximum startle response to pre-pulse, 78dB sound pressure level

-9.3696

4.4926

-2.2656

0.496

0.0466

startle / PPI

maximum startle response to pre-pulse, 82dB sound pressure level

0.40234

6.0840

-0.072221

0.991

0.948

There is currently no JaxKOMP-EAP categorical effect size data in MPD for this genotype