MPD: JaxKOMP-EAP genotype: Ndufa9<sup>em1(IMPC)J</sup>/Mmjax +/-

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-0.71580	3.2316	-0.48999	0.957	0.833
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-1.5909	4.7128	-0.32517	0.933	0.747
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	5.0000	4.3519	0.79595	0.648	0.294
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	3.6820	3.5248	0.48175	0.705	0.344
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	5.2273	2.5913	0.80735	0.440	0.0902
body composition	body length	0.029067	0.093174	0.62237	0.899	0.761
body composition	body weight (at time of DXA)	1.6997	1.2247	1.5245	0.400	0.190
body composition	bone area, whole body scan, head excluded	0.0013798	0.23953	0.18398	0.997	0.996
body composition	bone mineral content of whole body scan, head excluded	-0.00088219	0.021711	0.071054	0.994	0.968
body composition	bone mineral content to body weight ratio	-0.00010538	0.00076314	0.012288	0.956	0.892
body composition	bone mineral density of whole body scan, head excluded	-0.00011079	0.0011653	-0.090965	0.977	0.926
body composition	fat tissue mass of whole body scan, head excluded	0.91822	0.72251	1.2897	0.470	0.228
body composition	fat tissue mass to body weight ratio	0.012439	0.021159	0.61071	0.769	0.568
body composition	lean tissue mass of whole body scan, head excluded	-0.071411	0.55085	-0.30074	0.965	0.899
body composition	lean tissue mass to body weight ratio	-0.016813	0.020711	-0.92224	0.669	0.433
body composition	percent fat, whole body scan, head excluded	1.3371	2.0598	0.70392	0.739	0.528
body composition	ratio of soft-tissue attenuation coefficients	-0.0014172	0.0022373	-0.67965	0.746	0.538
body composition	tissue area	-0.26760	0.34024	-0.71010	0.736	0.448
body composition	total tissue mass, whole body scan, head excluded	0.12584	0.25656	0.075160	0.806	0.633
EKG	duration of PQ interval	0.16667	1.5270	0.29435	0.982	0.915
EKG	duration of PR interval	-0.12000	1.5278	-0.026198	0.986	0.939
EKG	duration of QRS interval	-0.76045	0.69698	-2.2304	0.885	0.299
EKG	duration of QT interval	-0.35333	1.5057	-0.16599	0.970	0.819
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.40000	1.5207	-0.36457	0.983	0.797
EKG	duration of RR interval	0.24667	2.6306	0.35812	0.969	0.927
EKG	duration of ST interval	0.28000	1.3658	0.50645	0.961	0.841
EKG	heart rate coefficient of variation (signal intensity)	2.5273	1.6430	1.9216	0.841	0.152
EKG	heart rate variability, mean of differences between sequential beats; beats per min	18.367	11.298	1.9613	0.839	0.132
EKG	heart rate, beats per min	0.76667	21.543	-0.21232	0.987	0.972
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.25233	0.15102	-1.9750	0.467	0.123
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.14042	0.23209	-0.89033	0.816	0.557
EKG	number of signals	4.6667	7.0155	0.89389	0.883	0.520
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	15.352	12.345	2.2780	0.814	0.239
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.0047121	7.1473	0.044344	0.999	0.999
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	0.040165	6.2515	0.0080600	0.999	0.995
EKG	root mean square of successive differences of neighboring RR intervals	2.6693	2.7527	1.3606	0.874	0.355
glucose tolerance test	amount glucose injected	12.511	5.1064	2.4238	0.228	0.0241
glucose tolerance test	plasma glucose, 0min	11.962	4.1893	0.97035	0.0569	0.0101
glucose tolerance test	plasma glucose, 15min	-6.2706	16.022	-0.074196	0.894	0.700
glucose tolerance test	plasma glucose, 30min	-4.2034	23.610	0.0	0.948	0.861
glucose tolerance test	plasma glucose, 60min	-3.7196	19.660	-0.012355	0.935	0.852
glucose tolerance test	plasma glucose, 120min	-1.0218	13.912	-0.18360	0.971	0.942
grip strength	body weight (at time of grip strength test)	0.83101	0.54920	0.97907	0.309	0.144
grip strength	forelimb and hindlimb grip strength (mean of trials), average	10.167	7.3285	0.99009	0.372	0.179
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.32778	0.34471	0.67540	0.558	0.352
grip strength	forelimb and hindlimb grip strength by trial, trial1	1.7667	13.459	0.34819	0.961	0.897
grip strength	forelimb and hindlimb grip strength by trial, trial2	9.4332	10.704	0.83790	0.630	0.388
grip strength	forelimb and hindlimb grip strength by trial, trial3	19.574	11.345	1.4252	0.315	0.0985
grip strength	forelimb grip strength (mean of trials), average	-5.8011	6.2615	-0.46984	0.620	0.365
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.23539	0.23273	-0.37611	0.600	0.323
grip strength	forelimb grip strength by trial, trial1	-5.9964	9.1748	-0.42172	0.802	0.520
grip strength	forelimb grip strength by trial, trial2	3.6833	8.4432	0.64828	0.878	0.667
grip strength	forelimb grip strength by trial, trial3	-15.705	8.6105	-1.3105	0.338	0.0824
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.87013	1.0722	-0.80141	0.799	0.428
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.93425	0.56701	-1.3393	0.662	0.118
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.88312	0.48346	-1.3863	0.602	0.0844
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.3377	1.4110	-1.2496	0.774	0.356
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.20331	0.64822	-0.21518	0.951	0.758
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.10390	0.25416	0.32797	0.948	0.688
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.073907	0.42866	0.19648	0.987	0.865
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-1.1299	0.73578	-1.7307	0.698	0.142
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.83589	0.57767	-1.3348	0.635	0.166
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.38479	0.35966	-1.0787	0.834	0.299
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.045950	0.43254	0.13554	0.985	0.917
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-1.1661	0.58575	-1.7386	0.490	0.0628
holeboard	number of hole pokes by individual hole number, 20 min test, 13	1.0260	1.1678	1.0684	0.750	0.391
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.35065	0.90976	-0.48190	0.913	0.704
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-1.1269	0.72113	-1.7386	0.628	0.137
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.5274	0.85590	-1.3438	0.511	0.0912
holeboard	total number of hole pokes, 20 min test	-9.1429	4.3579	-1.2069	0.251	0.0503
light / dark	fecal boli count, 20 min test	1.25	1.7668	1.3126	0.822	0.494
light / dark	latency to enter dark zone, 20 min test	-63.028	40.911	-1.2766	0.575	0.138
light / dark	number of transitions between light and dark zones, 20 min test	3.7847	6.2750	0.43965	0.796	0.553
light / dark	percentage of total time in dark zone, 20 min test	0.81632	2.6433	0.29490	0.921	0.760
light / dark	percentage of total time in light zone, 20 min test	-0.81632	2.6433	-0.30055	0.922	0.760
light / dark	time mobile in dark zone, 20 min test	15.148	13.054	0.76290	0.560	0.258
light / dark	time mobile in light zone, 20 min test	-2.3000	8.3146	-0.39247	0.899	0.785
light / dark	time spent in dark zone, 20 min test	57.233	38.811	1.0720	0.586	0.155
light / dark	time spent in light zone, 20 min test	-57.233	38.811	-1.0720	0.586	0.155
open field	average speed in center of arena, 20 min test	0.28500	0.38154	0.42680	0.765	0.463
open field	average speed in periphery of arena, 20 min test	0.13684	0.24122	0.049024	0.763	0.576
open field	distance traveled habituation ratio, 20 min test	3.5863	13.488	0.33156	0.918	0.793
open field	distance traveled in center of arena, 20 min test	-63.189	95.899	-0.76631	0.725	0.517
open field	distance traveled in periphery of arena, 20 min test	218.19	233.80	0.40776	0.609	0.361
open field	distance traveled slope, 20 min test	4.3738	12.741	0.41653	0.905	0.735
open field	distance traveled, 20 min test, 1st 5min	14.009	124.07	-0.22406	0.965	0.911
open field	distance traveled, 20 min test, 2nd 5min	75.391	104.05	0.34577	0.700	0.477
open field	distance traveled, 20 min test, 3rd 5min	85.233	78.863	0.51227	0.542	0.292
open field	distance traveled, 20 min test, 4th 5min	31.287	77.469	-0.086706	0.848	0.690
open field	number of clockwise revolution episodes, 20 min test	0.066667	1.8785	-0.36385	0.989	0.972
open field	number of counter-clockwise revolution episodes, 20 min test	0.75775	1.4292	-0.027527	0.797	0.601
open field	number of fecal boli, 20 min test	-1.75	1.9150	-1.1125	0.689	0.380
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.3378	2.9859	0.43811	0.692	0.442
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	5.8773	3.8476	1.1307	0.413	0.141
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	4.7833	3.9237	0.80284	0.508	0.236
open field	number of rears in 5 min bins, 20 min test, 4th 5min	2.6833	4.5096	0.26140	0.768	0.558
open field	percentage of total time in center of arena, 20 min test	-2.0681	2.6207	-0.71335	0.734	0.438
open field	percentage of total time in center of arena, slope, 20 min test	-0.49156	1.3846	-0.16250	0.941	0.726
open field	percentage of total time in center, habituation ratio, 20 min test	-0.060026	1.2445	0.10694	0.986	0.962
open field	percentage of total time in corners of arena, 20 min test	1.7645	5.5530	0.61945	0.900	0.754
open field	percentage of total time in corners, habituation ratio, 20 min test	1.7987	2.6977	0.54002	0.877	0.512
open field	percentage of total time in corners, slope, 20 min test	2.2350	2.6058	0.75020	0.834	0.400
open field	permanence time in center of arena, 20 min test	-24.827	31.452	-0.71335	0.734	0.438
open field	permanence time in corners of arena, 20 min test	21.178	66.639	0.62108	0.901	0.754
open field	permanence time in periphery of arena, 20 min test	24.822	31.457	0.71335	0.734	0.438
open field	total distance traveled, 20 min test	156.85	302.74	-0.018126	0.782	0.610
open field	total number of rears, 20 min test	14.917	12.812	0.66232	0.506	0.257
open field	whole arena average speed, 20 min test	0.13203	0.25220	-0.0087270	0.780	0.606
open field	whole arena resting time, 20 min test	-12.128	30.851	0.19250	0.826	0.698
open field	whole arena time spent mobile, 20 min test	12.189	30.831	0.027527	0.832	0.696
open field	whole arena time spent vertical, 20 min test	13.605	16.239	0.96137	0.701	0.412
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.11667	2.0570	0.14269	0.990	0.955
startle / PPI	average baseline movement during background noise	1.3359	4.9667	0.87360	0.963	0.791
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.21488	0.076821	1.7043	0.170	0.0119
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.37004	0.27660	2.6138	0.549	0.198
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	9.1898	16.270	1.0518	0.925	0.579
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	17.163	9.5085	1.7478	0.423	0.0888
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	24.654	8.0528	2.4438	0.0859	0.00672
startle / PPI	average startle response to full pulse (120 dB)	-146.71	59.790	-1.9387	0.120	0.0246
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-178.69	46.303	-2.3037	0.0136	0.00115
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-173.80	49.351	-2.6595	0.0223	0.00244
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-143.15	46.661	-2.4725	0.0523	0.00697
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-3.9499	1.9819	-2.3240	0.532	0.0626
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-2.1602	2.2889	-1.4285	0.844	0.359
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.5619	3.0009	0.53520	0.895	0.609
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.14601	0.48833	1.4207	0.961	0.769
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.40994	0.34253	2.4434	0.592	0.247
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.34961	0.081576	2.1530	0.0137	0.000445
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-147.79	59.265	-1.9573	0.114	0.0226
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-175.71	46.743	-2.2477	0.0166	0.00144
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-172.45	49.355	-2.5737	0.0232	0.00259
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-145.03	46.475	-2.4438	0.0466	0.00622
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.094441	0.18603	0.83724	0.930	0.618
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.23742	0.10170	1.7162	0.255	0.0313
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.30843	0.096661	1.8539	0.0562	0.00506
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-517.91	203.41	-1.8947	0.102	0.0203
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-621.69	168.77	-2.3037	0.0179	0.00170
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-621.03	169.63	-2.5370	0.0184	0.00179
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-500.66	157.86	-2.3454	0.0428	0.00558
startle / PPI	maximum baseline movement during background noise	4.3539	10.757	1.1602	0.937	0.690
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.2655	16.876	0.57112	0.968	0.759
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	21.286	9.5165	1.9206	0.305	0.0382
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	25.989	7.9653	2.2656	0.0660	0.00432
startle / PPI	maximum startle response to full pulse (120 dB)	-514.16	204.94	-1.8947	0.108	0.0219
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-617.59	167.14	-2.3037	0.0174	0.00166
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-624.97	169.17	-2.5370	0.0173	0.00166
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-496.46	157.12	-2.3454	0.0435	0.00572
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.23960	9.7121	0.18958	0.997	0.981
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-4.1580	5.8152	-1.1200	0.849	0.484
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.9537	7.1198	0.36300	0.886	0.683

There is currently no JaxKOMP-EAP categorical effect size data in MPD for this genotype