MPD: JaxKOMP-EAP genotype: Hmg20a<sup>em1(IMPC)J</sup>/Mmjax -/+

JaxKOMP-EAP effect sizes: Hmg20a^em1(IMPC)J/Mmjax -/+ Gene Hmg20a

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-0.18768	2.7033	-0.33307	0.984	0.949
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-2.1250	2.4046	-0.45994	0.826	0.442
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-0.21694	3.5616	-0.22849	0.988	0.955
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	0.90612	8.2445	0.011963	0.975	0.919
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	6.3750	4.0976	0.97868	0.609	0.218
body composition	body length	0.024269	0.050012	0.55539	0.826	0.630
body composition	body weight (at time of DXA)	-0.75680	0.74531	-0.46138	0.536	0.316
body composition	bone area, whole body scan, head excluded	-0.30010	0.17903	-0.96524	0.324	0.101
body composition	bone mineral content of whole body scan, head excluded	-0.015732	0.013059	-0.71269	0.519	0.236
body composition	bone mineral content to body weight ratio	-0.0010138	0.00049184	-1.0707	0.195	0.0460
body composition	bone mineral density of whole body scan, head excluded	-0.00040691	0.00055888	-0.41976	0.735	0.471
body composition	fat tissue mass of whole body scan, head excluded	0.60921	0.42716	0.88968	0.396	0.162
body composition	fat tissue mass to body weight ratio	0.010908	0.012828	0.55887	0.632	0.400
body composition	lean tissue mass of whole body scan, head excluded	-0.18277	0.43461	-0.55568	0.870	0.676
body composition	lean tissue mass to body weight ratio	-0.020412	0.011163	-1.1099	0.263	0.0751
body composition	percent fat, whole body scan, head excluded	1.8117	1.2410	0.88968	0.369	0.152
body composition	ratio of soft-tissue attenuation coefficients	-0.0020453	0.0013811	-0.90865	0.360	0.147
body composition	tissue area	0.73063	0.31119	1.9775	0.162	0.0240
body composition	total tissue mass, whole body scan, head excluded	0.42383	0.50057	0.66594	0.649	0.402
clinical blood chemistry	alanine transaminase (plasma ALT)	14.544	8.4378	0.96253	0.444	0.0982
clinical blood chemistry	albumin (plasma Alb)	-0.28692	0.29151	-0.35980	0.643	0.336
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.9544	3.5709	0.17734	0.536	0.280
clinical blood chemistry	aspartate transaminase (plasma AST)	4.1076	8.4445	0.20415	0.858	0.631
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.15100	0.19353	-0.48378	0.803	0.443
clinical blood chemistry	blood urea nitrogen (BUN)	1.1847	0.99113	0.43860	0.509	0.245
clinical blood chemistry	calcium (plasma Ca)	0.054573	0.080511	0.73603	0.713	0.505
clinical blood chemistry	creatinine (plasma)	0.040444	0.024352	1.1284	0.316	0.111
clinical blood chemistry	glucose (plasma GLU, no fast)	8.6635	10.795	0.63162	0.636	0.431
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.1875	1.7027	-0.78984	0.514	0.212
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0037866	0.0087196	-0.38432	0.885	0.668
clinical blood chemistry	phosphorus (plasma phosphate)	0.46892	0.29601	0.65803	0.370	0.127
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0062500	0.010791	-0.48698	0.814	0.568
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-2.5833	2.8648	-0.68839	0.679	0.377
clinical blood chemistry	total protein (plasma TP)	-0.83333	0.57203	-0.71446	0.439	0.159
clinical blood chemistry	triglyceride (plasma TG, no fast)	35.414	8.9713	1.7190	0.0261	0.000641
EKG	duration of PQ interval	-1.4328	0.85074	-1.2788	0.675	0.109
EKG	duration of PR interval	-2.2164	0.91292	-1.8728	0.469	0.0253
EKG	duration of QRS interval	0.059798	0.75655	0.030229	0.991	0.938
EKG	duration of QT interval	0.0014935	2.2794	0.15782	0.999	0.999
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.3306	2.1880	1.4133	0.925	0.550
EKG	duration of RR interval	-0.99836	2.0234	-0.25876	0.871	0.627
EKG	duration of ST interval	-1.4853	1.4295	-1.2131	0.765	0.312
EKG	heart rate coefficient of variation (signal intensity)	-0.77593	1.6376	-0.52718	0.927	0.641
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-3.6830	11.607	-0.33884	0.961	0.754
EKG	heart rate, beats per min	6.5082	15.599	0.12028	0.876	0.681
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.13433	0.18373	-1.1837	0.784	0.474
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.49372	0.26070	-2.4873	0.364	0.0744
EKG	number of signals	-11.214	7.8930	-1.7869	0.698	0.172
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-2.8176	9.4850	-0.45016	0.973	0.770
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-0.23179	4.4778	-0.030229	0.995	0.959
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.49344	4.2866	-0.12932	0.986	0.910
EKG	root mean square of successive differences of neighboring RR intervals	-0.18249	2.6944	0.014105	0.989	0.947
glucose tolerance test	amount glucose injected	-2.2927	4.4419	-0.31954	0.867	0.610
glucose tolerance test	plasma glucose, 0min	-5.2125	3.3278	-0.73341	0.304	0.128
glucose tolerance test	plasma glucose, 15min	2.1795	23.487	0.16131	0.973	0.927
glucose tolerance test	plasma glucose, 30min	-19.848	21.685	-0.49750	0.683	0.367
glucose tolerance test	plasma glucose, 60min	-3.8068	12.794	-0.013728	0.913	0.768
glucose tolerance test	plasma glucose, 120min	-10.868	9.2037	-0.87375	0.558	0.247
grip strength	body weight (at time of grip strength test)	-0.93030	0.53920	-0.62610	0.237	0.0992
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-7.3140	8.5808	-0.28709	0.612	0.404
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.29885	0.39897	-0.23151	0.662	0.463
grip strength	forelimb and hindlimb grip strength by trial, trial1	6.4442	8.8098	0.67540	0.736	0.473
grip strength	forelimb and hindlimb grip strength by trial, trial2	-21.825	9.7357	-1.1247	0.169	0.0359
grip strength	forelimb and hindlimb grip strength by trial, trial3	-6.8209	14.869	-0.23599	0.834	0.651
grip strength	forelimb grip strength (mean of trials), average	-1.8972	5.9678	0.010166	0.889	0.754
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.093088	0.25432	0.48612	0.877	0.718
grip strength	forelimb grip strength by trial, trial1	-16.302	8.2287	-1.4925	0.309	0.0608
grip strength	forelimb grip strength by trial, trial2	0.82119	7.0609	0.30074	0.963	0.909
grip strength	forelimb grip strength by trial, trial3	10.510	6.4454	1.3384	0.395	0.118
heart weight	heart weight, normalized to body weight	-0.13089	0.11589	-0.95278	0.491	0.271
heart weight	heart weight, weight	-5.3338	3.1824	-1.0772	0.283	0.109
hematology	basophil differential (percent of total WBC)	0.064150	0.037644	0.93363	0.510	0.102
hematology	calculated hemoglobin (cHGB)	0.45721	0.23239	1.1181	0.264	0.0613
hematology	eosinophil differential (percent of total WBC)	-0.14583	0.24587	-0.32782	0.854	0.559
hematology	hematocrit (HCT)	1.0808	0.58304	0.89299	0.321	0.0772
hematology	hemoglobin concentration distribution width (HDW)	-0.0016636	0.028846	-0.027816	0.973	0.955
hematology	large unstained cells (percent of total WBC)	0.046604	0.097520	0.31887	0.854	0.637
hematology	lymphocyte differential (percent of total WBC)	3.8061	1.4142	1.2316	0.108	0.0130
hematology	mean corpuscular hemoglobin (CHr)	-0.058501	0.078237	-0.45717	0.696	0.463
hematology	mean platelet volume (MPV)	0.19783	0.10594	0.96196	0.217	0.0752
hematology	mean RBC corpuscular hemoglobin (MCH)	0.045077	0.084208	0.15125	0.830	0.598
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.35120	0.42534	0.73687	0.746	0.418
hematology	mean RBC corpuscular volume (MCV)	-0.23477	0.51415	-0.43423	0.814	0.652
hematology	measured hemoglobin (mHGB)	0.54425	0.26640	1.1803	0.270	0.0527
hematology	monocyte differential (percent of total WBC)	-0.45148	0.18256	-1.0297	0.231	0.0216
hematology	neutrophil differential (percent of total WBC)	-2.9624	1.0535	-1.1590	0.0913	0.0102
hematology	platelet count (PLT; units per volume x 10³)	-67.917	28.499	-0.82961	0.237	0.0258
hematology	RBC corpuscular distribution width (RDW)	-0.47411	0.20819	-1.5865	0.178	0.0324
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.30072	0.39848	0.73246	0.700	0.458
hematology	red blood cell count (RBC; per volume x 10⁶)	0.33565	0.17598	1.1268	0.286	0.0690
hematology	reticulocyte count (Retic; units per volume x 10⁹)	27.637	20.422	1.1777	0.591	0.189
hematology	reticulocyte differential (percent of total RBC)	0.16848	0.21110	0.86749	0.752	0.433
hematology	white blood cell count (WBC; units per volume x 10³)	0.64191	0.49475	0.61311	0.411	0.208
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.34981	0.85746	0.39762	0.915	0.685
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.12313	0.41879	0.35055	0.953	0.770
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.89599	0.57141	-1.4087	0.661	0.123
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.31157	1.1536	0.38668	0.936	0.788
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.70709	0.39285	-1.0650	0.570	0.0780
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.35129	0.33194	0.93472	0.855	0.295
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.0027413	0.32008	-0.0059159	1.00	0.993
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.63386	0.49085	-0.92905	0.735	0.203
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.24347	0.38978	0.52867	0.895	0.535
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.18709	0.22952	0.54116	0.870	0.419
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.031029	0.35680	0.087947	0.987	0.931
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.063433	0.44641	0.20899	0.971	0.888
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.41185	0.78355	0.48759	0.874	0.602
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.66554	0.79956	-0.98007	0.798	0.409
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.50198	0.45255	-0.71638	0.727	0.273
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.40683	1.0750	-0.33688	0.927	0.707
holeboard	total number of hole pokes, 20 min test	-2.4440	5.6215	-0.24534	0.835	0.666
light / dark	fecal boli count, 20 min test	1.7427	0.61448	1.7839	0.185	0.00658
light / dark	latency to enter dark zone, 20 min test	-12.665	31.289	-0.34902	0.908	0.687
light / dark	number of transitions between light and dark zones, 20 min test	-1.6108	7.7561	-0.036512	0.932	0.836
light / dark	percentage of total time in dark zone, 20 min test	-2.2906	3.1808	-0.28503	0.773	0.475
light / dark	percentage of total time in light zone, 20 min test	2.2906	3.1808	0.28081	0.771	0.475
light / dark	time mobile in dark zone, 20 min test	8.5678	9.8138	0.43667	0.677	0.387
light / dark	time mobile in light zone, 20 min test	13.480	10.275	0.56074	0.448	0.196
light / dark	time spent in dark zone, 20 min test	-12.753	37.445	0.032454	0.920	0.735
light / dark	time spent in light zone, 20 min test	12.753	37.445	-0.032454	0.920	0.735
open field	average speed in center of arena, 20 min test	0.24834	0.42318	0.36580	0.818	0.560
open field	average speed in periphery of arena, 20 min test	0.37992	0.12070	0.91345	0.0246	0.00280
open field	distance traveled habituation ratio, 20 min test	-1.7095	7.0813	-0.096144	0.924	0.810
open field	distance traveled in center of arena, 20 min test	-5.4747	60.693	-0.41214	0.962	0.928
open field	distance traveled in periphery of arena, 20 min test	410.87	143.64	1.0958	0.0505	0.00620
open field	distance traveled slope, 20 min test	-1.3106	6.9389	-0.058436	0.958	0.851
open field	distance traveled, 20 min test, 1st 5min	93.231	62.702	0.42239	0.357	0.143
open field	distance traveled, 20 min test, 2nd 5min	111.63	41.885	0.71335	0.0681	0.0104
open field	distance traveled, 20 min test, 3rd 5min	120.55	42.102	0.84239	0.0484	0.00615
open field	distance traveled, 20 min test, 4th 5min	79.887	46.969	0.42239	0.278	0.0953
open field	number of clockwise revolution episodes, 20 min test	1.7267	0.98775	0.58839	0.381	0.0867
open field	number of counter-clockwise revolution episodes, 20 min test	2.2747	1.0288	0.75376	0.193	0.0317
open field	number of fecal boli, 20 min test	1.0364	0.91970	1.0188	0.603	0.267
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.0912	1.6344	0.64196	0.255	0.0645
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.91884	1.9300	-0.12045	0.822	0.636
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	1.6604	1.9893	0.085358	0.675	0.408
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.99254	2.1436	-0.14212	0.820	0.645
open field	percentage of total time in center of arena, 20 min test	-0.22814	2.0792	-0.25723	0.974	0.913
open field	percentage of total time in center of arena, slope, 20 min test	-2.0277	0.93838	-0.92987	0.408	0.0357
open field	percentage of total time in center, habituation ratio, 20 min test	-2.1239	1.0081	-0.94655	0.418	0.0404
open field	percentage of total time in corners of arena, 20 min test	-1.4451	3.0923	0.028870	0.851	0.642
open field	percentage of total time in corners, habituation ratio, 20 min test	0.33179	1.6645	-0.12451	0.969	0.843
open field	percentage of total time in corners, slope, 20 min test	0.73036	1.6710	0.063817	0.931	0.664
open field	permanence time in center of arena, 20 min test	-2.7134	24.952	-0.25446	0.973	0.914
open field	permanence time in corners of arena, 20 min test	-17.348	37.105	0.028870	0.852	0.642
open field	permanence time in periphery of arena, 20 min test	2.7474	24.953	0.25446	0.973	0.913
open field	total distance traveled, 20 min test	405.27	158.39	0.64900	0.0694	0.0136
open field	total number of rears, 20 min test	6.6950	6.1070	0.13128	0.534	0.278
open field	whole arena average speed, 20 min test	0.33792	0.13206	0.64900	0.0694	0.0136
open field	whole arena resting time, 20 min test	-37.680	14.841	-0.49398	0.0699	0.0143
open field	whole arena time spent mobile, 20 min test	37.647	14.831	0.74488	0.0711	0.0144
open field	whole arena time spent vertical, 20 min test	0.68829	6.1864	-0.062471	0.965	0.912
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.3139	1.7526	0.73157	0.737	0.462
startle / PPI	average baseline movement during background noise	0.093791	1.3613	0.16254	0.995	0.945
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.057292	0.054686	-0.63671	0.657	0.301
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.050763	0.051797	-0.58178	0.675	0.333
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-1.2399	5.6366	-0.098941	0.986	0.827
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-4.4974	6.0282	-0.47628	0.758	0.460
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-5.8599	6.6374	-0.65744	0.682	0.383
startle / PPI	average startle response to full pulse (120 dB)	-63.588	51.230	-0.90904	0.455	0.222
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-64.740	53.529	-0.96556	0.474	0.234
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-46.458	47.743	-0.73053	0.553	0.336
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-31.849	43.118	-0.56290	0.659	0.465
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.62807	1.3726	-0.42203	0.933	0.650
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-2.4959	1.9549	-1.5564	0.724	0.209
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-2.4949	2.3292	-1.4055	0.705	0.291
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.020918	0.059813	-0.14695	0.946	0.728
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.058492	0.066033	-0.56031	0.695	0.381
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.075908	0.076642	-0.75411	0.593	0.328
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-63.682	50.929	-0.91541	0.450	0.219
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-64.080	53.727	-0.94784	0.477	0.240
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-43.396	47.693	-0.66616	0.576	0.368
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-28.030	43.241	-0.46532	0.705	0.521
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.036717	0.065360	-0.28765	0.928	0.577
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.064352	0.071495	-0.56571	0.688	0.374
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.067291	0.077280	-0.68332	0.646	0.389
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-199.37	175.06	-0.78849	0.504	0.262
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-203.44	185.68	-0.85124	0.519	0.280
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-126.94	169.32	-0.50473	0.652	0.458
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-79.218	152.19	-0.31256	0.758	0.606
startle / PPI	maximum baseline movement during background noise	-0.92113	3.2289	-0.19244	0.960	0.777
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-2.9550	6.2790	-0.25132	0.942	0.641
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-5.0373	6.7103	-0.51590	0.763	0.457
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-5.7964	6.9710	-0.65570	0.688	0.411
startle / PPI	maximum startle response to full pulse (120 dB)	-200.30	175.75	-0.79041	0.504	0.261
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-206.14	185.15	-0.86135	0.514	0.272
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-137.87	169.24	-0.56454	0.629	0.420
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-87.404	151.89	-0.37651	0.733	0.568
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-2.4924	2.8055	-0.68730	0.791	0.380
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-9.3479	4.6045	-2.2477	0.506	0.0494
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-3.9120	5.2452	-1.0042	0.799	0.460

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

Download Plot

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	9.0 %	0.359
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	4.0 %	0.428
eye morphology	cornea vascularization	females	12.0 %	0.189
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	6.0 %	0.234
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	11.0 %	0.220
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	5.0 %	0.292
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	28.0 %	0.0174
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	11.0 %	0.0718
eye morphology	narrow eye opening	females	12.0 %	0.171
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	6.0 %	0.144
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	12.0 %	0.0619
eye morphology	optic disc	both	6.0 %	0.0690
eye morphology	persistence of hyaloid vascular system	females	6.0 %	0.690
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	3.0 %	0.790
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	7.0 %	0.750
eye morphology	retina	both	7.0 %	0.888
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.00
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.00
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.00
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.00
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.00
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.00
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.00
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.00
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.00
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.00
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.00
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	24.0 %	0.0320
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	9.0 %	0.0663
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.0
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.00
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.00
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.00
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.00
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.00
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.00
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.00
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.00
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.00
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.00
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	16.0 %	0.310
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	3.0 %	0.530
SHIRPA	lower lip morphology	females	0.0 %	1.00
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.00
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.00
SHIRPA	snout size	males	1.0 %	1.00
SHIRPA	snout size	both	0.0 %	1.00
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.0
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.00
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.00
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.00
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.00
SHIRPA	tremor	males	0.0 %	1.00
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.00
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.0
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Hmg20a^em1(IMPC)J/Mmjax -/+ with genotype: