MPD: JaxKOMP-EAP genotype: Htr3a<sup>em1.1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Htr3a^em1.1(IMPC)J/Mmjax -/- Gene Htr3a

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	3.8825	2.3727	0.87705	0.536	0.126
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.62500	2.1926	-0.12002	0.938	0.780
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	6.1637	2.4738	0.92774	0.241	0.0283
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	3.8750	2.1982	0.51843	0.435	0.101
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	3.6250	3.7693	0.54771	0.696	0.354
body composition	body length	0.042441	0.037344	0.80690	0.569	0.265
body composition	body weight (at time of DXA)	-0.47264	0.66960	-0.27142	0.692	0.486
body composition	bone area, whole body scan, head excluded	0.17604	0.17367	0.94371	0.582	0.319
body composition	bone mineral content of whole body scan, head excluded	0.012873	0.011082	0.88563	0.539	0.255
body composition	bone mineral content to body weight ratio	0.00036710	0.00037332	0.64395	0.604	0.333
body composition	bone mineral density of whole body scan, head excluded	0.00051398	0.00050677	0.61355	0.618	0.319
body composition	fat tissue mass of whole body scan, head excluded	-0.33619	0.33487	-0.63390	0.584	0.323
body composition	fat tissue mass to body weight ratio	-0.015955	0.011231	-0.71446	0.387	0.166
body composition	lean tissue mass of whole body scan, head excluded	0.73736	0.35056	1.2440	0.231	0.0439
body composition	lean tissue mass to body weight ratio	0.015433	0.0089310	0.78087	0.297	0.0943
body composition	percent fat, whole body scan, head excluded	-1.7022	1.0400	-0.79618	0.307	0.112
body composition	ratio of soft-tissue attenuation coefficients	0.0018525	0.0011530	0.77966	0.315	0.119
body composition	tissue area	0.096029	0.24844	0.53573	0.891	0.702
body composition	total tissue mass, whole body scan, head excluded	0.40478	0.30063	0.64059	0.426	0.188
clinical blood chemistry	alanine transaminase (plasma ALT)	1.1275	3.9855	0.092945	0.933	0.780
clinical blood chemistry	albumin (plasma Alb)	-0.94616	0.50087	-1.1950	0.333	0.0728
clinical blood chemistry	alkaline phosphatase (plasma ALP)	6.7719	2.7354	0.66961	0.117	0.0219
clinical blood chemistry	aspartate transaminase (plasma AST)	-2.8457	6.7965	-0.14512	0.888	0.680
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.24663	0.13764	-0.77319	0.456	0.0876
clinical blood chemistry	blood urea nitrogen (BUN)	1.9024	1.0258	0.75261	0.271	0.0777
clinical blood chemistry	calcium (plasma Ca)	0.23432	0.10881	1.7608	0.176	0.0430
clinical blood chemistry	creatinine (plasma)	-0.042127	0.030921	-0.83697	0.423	0.188
clinical blood chemistry	glucose (plasma GLU, no fast)	5.3972	15.374	0.50078	0.848	0.729
clinical blood chemistry	HDL cholesterol (plasma HDL)	-5.1275	2.0645	-1.3345	0.163	0.0215
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.019619	0.0083302	0.96176	0.211	0.0283
clinical blood chemistry	phosphorus (plasma phosphate)	-0.45272	0.27616	-0.77793	0.353	0.117
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.029268	0.0099243	-1.8105	0.102	0.00766
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-9.4760	3.4828	-1.6083	0.113	0.0128
clinical blood chemistry	total protein (plasma TP)	-0.097817	0.80041	-0.13603	0.958	0.904
clinical blood chemistry	triglyceride (plasma TG, no fast)	-0.42277	11.500	0.19291	0.986	0.971
EKG	duration of PQ interval	0.20296	0.69545	0.34098	0.941	0.772
EKG	duration of PR interval	-0.015676	0.71146	0.072603	0.995	0.983
EKG	duration of QRS interval	-0.31270	0.33507	-0.96207	0.885	0.357
EKG	duration of QT interval	-0.75939	0.81641	-0.58122	0.835	0.358
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.66846	0.74846	-0.64940	0.878	0.377
EKG	duration of RR interval	-0.29586	1.8594	0.094846	0.947	0.874
EKG	duration of ST interval	-0.47085	0.71380	-0.25044	0.870	0.513
EKG	heart rate coefficient of variation (signal intensity)	0.44440	1.0374	0.44551	0.940	0.671
EKG	heart rate variability, mean of differences between sequential beats; beats per min	3.9896	7.0522	0.54112	0.931	0.575
EKG	heart rate, beats per min	2.1782	14.748	-0.12637	0.965	0.883
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.0099796	0.087447	-0.049427	0.972	0.910
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.098732	0.11954	0.48750	0.727	0.414
EKG	number of signals	-2.7075	5.2429	-0.60283	0.893	0.609
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	4.3375	6.4644	0.87217	0.866	0.506
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.4731	3.8227	0.46115	0.968	0.702
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-1.2350	4.3840	-0.31123	0.968	0.780
EKG	root mean square of successive differences of neighboring RR intervals	1.0607	1.9363	0.69230	0.918	0.587
glucose tolerance test	amount glucose injected	-5.9002	2.4946	-1.2548	0.222	0.0230
glucose tolerance test	plasma glucose, 0min	5.9915	4.6419	0.38399	0.410	0.204
glucose tolerance test	plasma glucose, 15min	-24.567	14.484	-0.56549	0.365	0.0974
glucose tolerance test	plasma glucose, 30min	-4.7918	15.208	-0.0082365	0.904	0.754
glucose tolerance test	plasma glucose, 60min	0.094458	11.179	0.13217	0.996	0.993
glucose tolerance test	plasma glucose, 120min	9.7717	4.8649	0.55425	0.290	0.0514
grip strength	body weight (at time of grip strength test)	-0.82605	0.57583	-0.54347	0.337	0.163
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-15.253	7.2510	-0.80534	0.151	0.0456
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.57717	0.31222	-0.66088	0.220	0.0759
grip strength	forelimb and hindlimb grip strength by trial, trial1	-20.951	11.515	-1.1329	0.292	0.0808
grip strength	forelimb and hindlimb grip strength by trial, trial2	-23.217	11.340	-1.2230	0.207	0.0509
grip strength	forelimb and hindlimb grip strength by trial, trial3	-4.7632	10.146	-0.10914	0.829	0.643
grip strength	forelimb grip strength (mean of trials), average	-8.5901	4.7102	-0.78937	0.273	0.0797
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.26969	0.22633	-0.45046	0.519	0.244
grip strength	forelimb grip strength by trial, trial1	-11.664	4.7454	-1.0362	0.188	0.0212
grip strength	forelimb grip strength by trial, trial2	-5.2284	8.4037	-0.35902	0.811	0.539
grip strength	forelimb grip strength by trial, trial3	-4.9984	6.0006	-0.30987	0.721	0.413
heart weight	heart weight, normalized to body weight	0.099360	0.092802	-0.087268	0.515	0.293
heart weight	heart weight, weight	0.77627	2.7944	-0.26873	0.880	0.783
hematology	basophil differential (percent of total WBC)	0.084553	0.038717	1.1671	0.362	0.0405
hematology	calculated hemoglobin (cHGB)	0.041140	0.23071	-0.16590	0.947	0.860
hematology	eosinophil differential (percent of total WBC)	-0.085772	0.28517	-0.17942	0.928	0.767
hematology	hematocrit (HCT)	0.19228	0.35636	-0.17168	0.784	0.595
hematology	hemoglobin concentration distribution width (HDW)	-0.055697	0.038485	-1.4114	0.460	0.163
hematology	large unstained cells (percent of total WBC)	-0.054249	0.065938	-0.35195	0.737	0.420
hematology	lymphocyte differential (percent of total WBC)	-0.015854	1.1061	-0.053329	0.992	0.989
hematology	mean corpuscular hemoglobin (CHr)	0.14273	0.085227	1.0923	0.299	0.110
hematology	mean platelet volume (MPV)	0.090755	0.14018	0.42922	0.733	0.524
hematology	mean RBC corpuscular hemoglobin (MCH)	0.12777	0.089585	0.47058	0.512	0.169
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.044634	0.46562	0.11945	0.969	0.925
hematology	mean RBC corpuscular volume (MCV)	0.29345	0.51421	0.54680	0.764	0.574
hematology	measured hemoglobin (mHGB)	0.15918	0.26152	0.15446	0.770	0.549
hematology	monocyte differential (percent of total WBC)	0.41750	0.19630	1.4004	0.318	0.0454
hematology	neutrophil differential (percent of total WBC)	-0.12276	0.80930	-0.036911	0.944	0.881
hematology	platelet count (PLT; units per volume x 10³)	75.932	43.393	1.0320	0.432	0.0947
hematology	RBC corpuscular distribution width (RDW)	-0.27236	0.14950	-1.0233	0.295	0.0828
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.12239	0.41389	-0.36850	0.901	0.771
hematology	red blood cell count (RBC; per volume x 10⁶)	0.11960	0.12873	0.18995	0.632	0.363
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-2.7988	16.431	-0.033657	0.961	0.866
hematology	reticulocyte differential (percent of total RBC)	-0.083699	0.16219	-0.13434	0.842	0.611
hematology	white blood cell count (WBC; units per volume x 10³)	0.20512	0.46775	0.32980	0.812	0.665
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.68409	0.82513	-0.63941	0.793	0.412
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.39526	0.49530	-0.50801	0.833	0.430
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.24267	0.63820	-0.32909	0.937	0.706
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.72328	0.96842	-0.66656	0.829	0.460
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.058305	0.41841	0.019413	0.973	0.890
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.33793	0.28807	0.90892	0.834	0.248
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.43664	0.37474	-1.2342	0.827	0.251
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.21681	0.48669	-0.24638	0.935	0.658
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.20776	0.50324	-0.30888	0.938	0.682
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.41200	0.29973	1.0490	0.746	0.177
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.084994	0.38001	0.25439	0.971	0.824
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.040948	0.45149	0.17977	0.983	0.928
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.28268	0.81882	-0.20038	0.932	0.732
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.26983	0.86604	-0.32441	0.929	0.757
holeboard	number of hole pokes by individual hole number, 20 min test, 15	1.1961	0.58020	1.6668	0.448	0.0461
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.2780	1.0477	-1.1050	0.644	0.230
holeboard	total number of hole pokes, 20 min test	-2.1127	5.8654	-0.18491	0.872	0.721
light / dark	fecal boli count, 20 min test	0.46465	0.85248	0.56629	0.859	0.591
light / dark	latency to enter dark zone, 20 min test	-47.200	35.750	-0.97827	0.624	0.194
light / dark	number of transitions between light and dark zones, 20 min test	15.533	6.3970	1.4474	0.164	0.0199
light / dark	percentage of total time in dark zone, 20 min test	-7.8408	2.8822	-1.2797	0.174	0.00969
light / dark	percentage of total time in light zone, 20 min test	7.8408	2.8822	1.2766	0.174	0.00969
light / dark	time mobile in dark zone, 20 min test	10.565	10.360	0.53404	0.610	0.314
light / dark	time mobile in light zone, 20 min test	25.085	10.664	1.1138	0.136	0.0238
light / dark	time spent in dark zone, 20 min test	-48.493	41.398	-0.51234	0.667	0.249
light / dark	time spent in light zone, 20 min test	48.493	41.398	0.51234	0.667	0.249
open field	average speed in center of arena, 20 min test	0.24389	0.32112	0.35863	0.758	0.452
open field	average speed in periphery of arena, 20 min test	0.055577	0.14341	-0.29770	0.842	0.701
open field	distance traveled habituation ratio, 20 min test	-10.850	9.5165	-0.92163	0.585	0.262
open field	distance traveled in center of arena, 20 min test	110.16	73.886	0.38597	0.375	0.145
open field	distance traveled in periphery of arena, 20 min test	51.333	152.95	-0.22406	0.867	0.739
open field	distance traveled slope, 20 min test	-10.244	8.6871	-0.89526	0.576	0.246
open field	distance traveled, 20 min test, 1st 5min	82.766	79.608	0.32164	0.548	0.305
open field	distance traveled, 20 min test, 2nd 5min	20.410	54.073	-0.26418	0.847	0.708
open field	distance traveled, 20 min test, 3rd 5min	24.269	50.501	-0.15977	0.815	0.634
open field	distance traveled, 20 min test, 4th 5min	-1.1211	48.011	-0.47136	0.990	0.982
open field	number of clockwise revolution episodes, 20 min test	1.8067	1.2183	0.65356	0.487	0.147
open field	number of counter-clockwise revolution episodes, 20 min test	-0.072115	1.2962	-0.47436	0.982	0.956
open field	number of fecal boli, 20 min test	-0.19916	0.90339	0.12298	0.926	0.827
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.4904	1.4250	0.21249	0.567	0.302
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.7500	2.1135	0.35434	0.492	0.201
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	5.6010	2.4480	0.97639	0.160	0.0279
open field	number of rears in 5 min bins, 20 min test, 4th 5min	4.1251	3.0477	0.54937	0.455	0.184
open field	percentage of total time in center of arena, 20 min test	2.0889	2.2651	0.28229	0.675	0.362
open field	percentage of total time in center of arena, slope, 20 min test	-0.35129	1.1369	-0.077276	0.946	0.759
open field	percentage of total time in center, habituation ratio, 20 min test	-0.28364	1.1802	-0.034243	0.953	0.811
open field	percentage of total time in corners of arena, 20 min test	-3.1540	3.5577	-0.25307	0.675	0.381
open field	percentage of total time in corners, habituation ratio, 20 min test	2.5234	1.7256	0.83666	0.637	0.152
open field	percentage of total time in corners, slope, 20 min test	2.4001	1.7000	0.82151	0.646	0.166
open field	permanence time in center of arena, 20 min test	25.073	27.180	0.28229	0.675	0.362
open field	permanence time in corners of arena, 20 min test	-37.862	42.692	-0.25307	0.675	0.381
open field	permanence time in periphery of arena, 20 min test	-25.092	27.186	-0.28229	0.675	0.362
open field	total distance traveled, 20 min test	120.43	181.79	-0.13941	0.709	0.512
open field	total number of rears, 20 min test	13.995	7.4867	0.61945	0.248	0.0695
open field	whole arena average speed, 20 min test	0.098073	0.15149	-0.14483	0.717	0.521
open field	whole arena resting time, 20 min test	-19.940	20.684	-0.034243	0.545	0.341
open field	whole arena time spent mobile, 20 min test	19.959	20.694	0.28649	0.554	0.341
open field	whole arena time spent vertical, 20 min test	8.4687	7.5702	0.54469	0.580	0.270
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	5.5772	1.6869	2.1942	0.0663	0.00276
startle / PPI	average baseline movement during background noise	1.1031	1.5267	0.76013	0.877	0.476
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.047452	0.083531	0.33323	0.813	0.574
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.0075122	0.080137	-0.013326	0.964	0.926
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.56768	9.2919	0.0049040	0.995	0.952
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-7.5365	9.0500	-0.77897	0.732	0.412
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	5.3473	6.5511	0.47628	0.705	0.421
startle / PPI	average startle response to full pulse (120 dB)	-126.42	34.527	-1.7104	0.0120	0.000959
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-129.24	46.576	-1.7609	0.0585	0.00942
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-101.98	38.770	-1.5755	0.0744	0.0133
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-86.058	34.026	-1.5517	0.0884	0.0169
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.24659	2.4538	-0.12291	0.986	0.921
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.64520	2.1483	0.44512	0.960	0.766
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-4.6397	2.5738	-2.1532	0.483	0.0815
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.018479	0.098456	-0.12150	0.971	0.852
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.018135	0.10148	-0.26321	0.969	0.859
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.059974	0.080895	0.31790	0.714	0.464
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-127.52	34.366	-1.6925	0.0108	0.000840
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-130.11	47.515	-1.7478	0.0628	0.0103
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-102.62	39.316	-1.5658	0.0756	0.0140
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-81.588	35.026	-1.4767	0.121	0.0268
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.0087441	0.10148	0.11444	0.994	0.932
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.033411	0.10367	0.14349	0.892	0.749
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.10287	0.082021	0.57561	0.481	0.219
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-466.69	122.62	-1.7226	0.00914	0.000649
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-469.75	161.43	-1.7949	0.0445	0.00675
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-396.72	140.73	-1.6528	0.0533	0.00845
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-320.83	124.71	-1.5755	0.0816	0.0153
startle / PPI	maximum baseline movement during background noise	3.1755	3.6456	0.91968	0.813	0.391
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	1.5782	9.7744	0.20673	0.995	0.873
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-3.7372	9.6663	-0.40524	0.873	0.702
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	9.3969	7.1716	0.74340	0.488	0.200
startle / PPI	maximum startle response to full pulse (120 dB)	-463.54	123.03	-1.7226	0.00976	0.000720
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-467.86	159.47	-1.7879	0.0427	0.00636
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-394.91	139.51	-1.6583	0.0517	0.00821
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-330.70	122.58	-1.6103	0.0683	0.0113
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.8975	4.9304	0.65396	0.940	0.703
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	4.1003	5.6542	0.98814	0.849	0.474
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-10.107	6.2305	-2.0179	0.493	0.115

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	11.0 %	0.275
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	5.0 %	0.435
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	16.0 %	0.155
eye morphology	lens opacity	males	11.0 %	0.156
eye morphology	lens opacity	both	11.0 %	0.0718
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	12.0 %	0.0740
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	5.0 %	0.202
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Htr3a^em1.1(IMPC)J/Mmjax -/- with genotype: