MPD: JaxKOMP-EAP genotype: Pxdn<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Pxdn^em1(IMPC)J/Mmjax -/- Gene Pxdn

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.19670	5.9305	-0.22666	0.993	0.974
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.61644	6.1490	-0.11431	0.973	0.922
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-6.2231	6.9837	-1.4020	0.737	0.389
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-8.2485	6.8549	-1.3452	0.639	0.250
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-12.123	5.8814	-1.5514	0.365	0.0599
body composition	body length	0.018454	0.048570	0.46464	0.866	0.706
body composition	body weight (at time of DXA)	-3.3447	0.73143	-1.8000	0.000671	0.0000293
body composition	bone area, whole body scan, head excluded	-0.016247	0.18440	0.10257	0.978	0.930
body composition	bone mineral content of whole body scan, head excluded	0.0049347	0.012213	0.42923	0.856	0.688
body composition	bone mineral content to body weight ratio	0.00014187	0.00049765	0.34678	0.900	0.777
body composition	bone mineral density of whole body scan, head excluded	0.00064389	0.00059118	0.72821	0.580	0.281
body composition	fat tissue mass of whole body scan, head excluded	-0.51039	0.38055	-0.98280	0.424	0.186
body composition	fat tissue mass to body weight ratio	-0.026719	0.013541	-1.1952	0.195	0.0538
body composition	lean tissue mass of whole body scan, head excluded	0.75900	0.36547	1.2711	0.230	0.0428
body composition	lean tissue mass to body weight ratio	0.015954	0.011298	0.79578	0.411	0.164
body composition	percent fat, whole body scan, head excluded	-2.4697	1.2773	-1.1759	0.211	0.0586
body composition	ratio of soft-tissue attenuation coefficients	0.0026329	0.0014238	1.1346	0.237	0.0701
body composition	tissue area	0.070508	0.18750	0.44628	0.894	0.708
body composition	total tissue mass, whole body scan, head excluded	0.29785	0.24159	0.43823	0.463	0.223
EKG	duration of PQ interval	0.55931	0.98417	0.73388	0.924	0.576
EKG	duration of PR interval	0.57926	0.98937	0.68210	0.919	0.565
EKG	duration of QRS interval	0.45489	0.27946	1.1965	0.885	0.120
EKG	duration of QT interval	0.30612	1.0553	0.44329	0.958	0.775
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.76396	1.0686	0.88491	0.920	0.483
EKG	duration of RR interval	-1.3128	1.3147	-0.41238	0.742	0.331
EKG	duration of ST interval	-0.13564	1.0424	0.084730	0.975	0.898
EKG	heart rate coefficient of variation (signal intensity)	1.0944	0.96761	0.97820	0.848	0.272
EKG	heart rate variability, mean of differences between sequential beats; beats per min	8.4053	6.9646	1.0385	0.853	0.242
EKG	heart rate, beats per min	13.375	10.782	0.55449	0.623	0.230
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.048883	0.11521	0.28513	0.894	0.676
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.085492	0.13945	0.39413	0.811	0.547
EKG	number of signals	-9.1839	4.0164	-1.5390	0.452	0.0346
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	1.9321	2.6884	0.43893	0.862	0.481
EKG	QT dispersion, measured as inter-lead variability of QT intervals	6.0572	3.6560	1.5591	0.858	0.114
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	7.0455	4.1812	1.5523	0.836	0.108
EKG	root mean square of successive differences of neighboring RR intervals	4.0994	2.5927	1.7485	0.843	0.131
glucose tolerance test	amount glucose injected	0.98326	2.4907	0.64500	0.904	0.696
glucose tolerance test	plasma glucose, 0min	10.708	6.7690	0.85579	0.298	0.124
glucose tolerance test	plasma glucose, 15min	-69.270	30.694	-1.7322	0.213	0.0312
glucose tolerance test	plasma glucose, 30min	-44.176	23.519	-1.1891	0.322	0.0695
glucose tolerance test	plasma glucose, 60min	-14.297	22.007	-0.48511	0.793	0.521
glucose tolerance test	plasma glucose, 120min	10.477	12.829	0.60788	0.689	0.420
grip strength	body weight (at time of grip strength test)	-2.9514	0.54314	-1.9619	0.0000587	0.00000142
grip strength	forelimb and hindlimb grip strength (mean of trials), average	22.015	7.0423	1.7311	0.0244	0.00290
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	1.1342	0.39999	1.6873	0.0456	0.00650
grip strength	forelimb and hindlimb grip strength by trial, trial1	23.144	10.490	1.6637	0.179	0.0318
grip strength	forelimb and hindlimb grip strength by trial, trial2	15.873	7.2345	1.1959	0.160	0.0326
grip strength	forelimb and hindlimb grip strength by trial, trial3	19.134	9.4041	1.3862	0.212	0.0470
grip strength	forelimb grip strength (mean of trials), average	-0.51809	6.1590	0.19733	0.980	0.933
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.29608	0.25213	1.0092	0.519	0.246
grip strength	forelimb grip strength by trial, trial1	-4.6227	7.9566	-0.28558	0.812	0.564
grip strength	forelimb grip strength by trial, trial2	3.8094	8.0784	0.65907	0.862	0.639
grip strength	forelimb grip strength by trial, trial3	0.14212	8.5737	0.26596	0.993	0.987
heart weight	heart weight, normalized to body weight	0.81284	0.17942	1.7519	0.00243	0.0000774
heart weight	heart weight, weight	14.859	5.8868	1.3850	0.0926	0.0169
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-2.2099	0.82564	-2.0780	0.284	0.00898
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.92340	0.54092	-1.3229	0.612	0.0916
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.49882	0.61473	0.85614	0.846	0.419
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.98464	0.63598	-0.94476	0.600	0.125
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.40442	0.58714	-0.56453	0.870	0.493
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.19794	0.26740	-0.55720	0.898	0.461
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.13579	0.27251	0.36727	0.958	0.620
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.51658	0.51245	0.98509	0.797	0.316
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.0076383	0.46587	0.096428	0.994	0.987
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.49725	0.27587	-1.3896	0.664	0.0751
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.16809	0.32308	-0.42826	0.918	0.604
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.56319	0.48976	-0.85906	0.704	0.254
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.3118	0.65619	-1.2104	0.396	0.0489
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.13765	0.59558	-0.13025	0.956	0.818
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-1.1060	0.48688	-1.7016	0.371	0.0257
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-2.0681	0.86023	-1.8297	0.323	0.0185
holeboard	total number of hole pokes, 20 min test	-7.0902	4.9469	-0.92692	0.432	0.156
light / dark	fecal boli count, 20 min test	-0.63354	0.66167	-0.65929	0.736	0.342
light / dark	latency to enter dark zone, 20 min test	-62.192	41.272	-1.2615	0.574	0.135
light / dark	number of transitions between light and dark zones, 20 min test	33.759	8.9804	2.4299	0.0146	0.000299
light / dark	percentage of total time in dark zone, 20 min test	-17.972	4.0170	-2.4567	0.00447	0.0000217
light / dark	percentage of total time in light zone, 20 min test	17.972	4.0170	2.4567	0.00447	0.0000217
light / dark	time mobile in dark zone, 20 min test	55.665	10.198	2.0775	0.0000368	3.97e-7
light / dark	time mobile in light zone, 20 min test	115.51	14.795	2.9444	4.18e-9	9.03e-12
light / dark	time spent in dark zone, 20 min test	-153.61	47.381	-1.7906	0.0764	0.00165
light / dark	time spent in light zone, 20 min test	153.61	47.381	1.7906	0.0764	0.00165
open field	average speed in center of arena, 20 min test	2.0129	0.38266	2.3400	0.000124	9.32e-7
open field	average speed in periphery of arena, 20 min test	0.75716	0.17218	1.8074	0.000790	0.0000297
open field	distance traveled habituation ratio, 20 min test	-21.934	6.1625	-1.7740	0.0216	0.000591
open field	distance traveled in center of arena, 20 min test	535.90	84.490	2.1043	0.00000129	8.32e-9
open field	distance traveled in periphery of arena, 20 min test	663.66	167.42	1.6955	0.00325	0.000146
open field	distance traveled slope, 20 min test	-18.688	6.0626	-1.5871	0.0505	0.00271
open field	distance traveled, 20 min test, 1st 5min	419.88	76.489	2.1845	0.0000274	3.61e-7
open field	distance traveled, 20 min test, 2nd 5min	294.07	55.163	1.9133	0.0000380	6.93e-7
open field	distance traveled, 20 min test, 3rd 5min	255.54	60.005	1.8213	0.00153	0.0000500
open field	distance traveled, 20 min test, 4th 5min	257.10	57.681	1.8284	0.000760	0.0000236
open field	number of clockwise revolution episodes, 20 min test	4.9971	1.2532	1.8141	0.00567	0.000134
open field	number of counter-clockwise revolution episodes, 20 min test	3.1432	1.4258	1.1968	0.186	0.0300
open field	number of fecal boli, 20 min test	-0.12972	1.0226	0.17675	0.963	0.900
open field	number of rears in 5 min bins, 20 min test, 1st 5min	8.6511	1.9477	1.8966	0.00185	0.0000248
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	11.675	2.6183	2.0465	0.00129	0.0000235
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	6.5764	2.3225	1.1698	0.0624	0.00569
open field	number of rears in 5 min bins, 20 min test, 4th 5min	13.160	3.0840	2.1427	0.00361	0.0000484
open field	percentage of total time in center of arena, 20 min test	3.7886	2.3795	0.66902	0.406	0.115
open field	percentage of total time in center of arena, slope, 20 min test	-1.8174	0.89492	-0.85007	0.433	0.0452
open field	percentage of total time in center, habituation ratio, 20 min test	-1.1404	0.92111	-0.50768	0.695	0.219
open field	percentage of total time in corners of arena, 20 min test	-6.3604	3.4034	-0.89928	0.313	0.0648
open field	percentage of total time in corners, habituation ratio, 20 min test	1.8312	1.5713	0.56347	0.748	0.247
open field	percentage of total time in corners, slope, 20 min test	2.2650	1.5315	0.76271	0.629	0.143
open field	permanence time in center of arena, 20 min test	45.458	28.555	0.67238	0.407	0.115
open field	permanence time in corners of arena, 20 min test	-76.335	40.840	-0.89928	0.313	0.0648
open field	permanence time in periphery of arena, 20 min test	-45.415	28.552	-0.67238	0.407	0.115
open field	total distance traveled, 20 min test	1192.5	221.14	1.9570	0.0000231	5.45e-7
open field	total number of rears, 20 min test	41.428	9.0251	2.0575	0.000799	0.0000141
open field	whole arena average speed, 20 min test	0.99374	0.18420	1.9570	0.0000229	5.39e-7
open field	whole arena resting time, 20 min test	-87.807	22.619	-1.6064	0.00275	0.000196
open field	whole arena time spent mobile, 20 min test	87.656	22.603	1.7549	0.00299	0.000199
open field	whole arena time spent vertical, 20 min test	28.285	9.3782	1.8143	0.0499	0.00332
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.0346	1.5480	0.61864	0.761	0.507
startle / PPI	average baseline movement during background noise	-1.0874	1.3431	-0.75453	0.867	0.421
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.090310	0.058738	0.74340	0.468	0.129
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.12193	0.055832	1.0986	0.260	0.0326
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	9.5983	6.6880	1.0890	0.843	0.156
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	10.551	6.0877	1.0206	0.423	0.0879
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	9.4606	5.6386	0.86135	0.343	0.0983
startle / PPI	average startle response to full pulse (120 dB)	-1.4739	51.181	0.17249	0.990	0.977
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-7.4342	49.736	0.037139	0.948	0.882
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-48.878	46.719	-0.76388	0.519	0.299
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-41.268	41.603	-0.77329	0.553	0.325
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-2.1261	1.5733	-1.4402	0.717	0.181
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.7240	1.4816	-1.1882	0.760	0.249
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.7876	2.2979	0.61794	0.798	0.440
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.099012	0.072129	0.97003	0.830	0.175
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.14982	0.069602	1.1514	0.264	0.0351
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.12527	0.063555	0.78426	0.211	0.0531
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-1.1891	51.111	0.18673	0.993	0.982
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-6.0076	49.723	0.066603	0.958	0.904
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-48.613	46.840	-0.75267	0.519	0.303
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-42.396	41.738	-0.76575	0.529	0.314
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.064008	0.073748	0.59437	0.860	0.389
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.23830	0.090409	1.7348	0.177	0.0106
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.091959	0.066776	0.49947	0.427	0.173
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-15.504	179.63	0.093311	0.974	0.931
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-4.3958	179.00	0.15829	0.992	0.980
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-226.75	168.14	-0.97003	0.392	0.182
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-146.00	150.10	-0.71597	0.546	0.334
startle / PPI	maximum baseline movement during background noise	-1.0569	3.0317	-0.24121	0.946	0.729
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.5338	6.8603	0.79616	0.884	0.276
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	22.183	7.9594	1.9867	0.157	0.00702
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	7.8886	6.2065	0.60612	0.495	0.208
startle / PPI	maximum startle response to full pulse (120 dB)	-15.957	179.59	0.094718	0.972	0.929
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-7.5828	179.30	0.14836	0.983	0.966
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-226.04	168.05	-0.96556	0.394	0.183
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-141.93	150.09	-0.71236	0.565	0.348
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-4.7204	3.9199	-1.2531	0.727	0.233
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-2.6901	3.4794	-0.74710	0.830	0.442
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	5.4755	5.5670	0.75826	0.709	0.329

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	99.0 %	2.80e-14
eye morphology	anterior chamber depth	males	100.0 %	3.31e-16
eye morphology	anterior chamber depth	both	99.0 %	1.63e-28
eye morphology	bulging eye	females	99.0 %	1.79e-14
eye morphology	bulging eye	males	100.0 %	2.69e-16
eye morphology	bulging eye	both	99.0 %	1.50e-29
eye morphology	cornea	females	71.0 %	3.07e-8
eye morphology	cornea	males	98.0 %	3.35e-15
eye morphology	cornea	both	83.0 %	1.54e-21
eye morphology	cornea opacity	females	95.0 %	7.52e-12
eye morphology	cornea opacity	males	99.0 %	3.31e-15
eye morphology	cornea opacity	both	97.0 %	2.75e-26
eye morphology	cornea vascularization	females	97.0 %	7.78e-13
eye morphology	cornea vascularization	males	99.0 %	3.69e-15
eye morphology	cornea vascularization	both	98.0 %	4.14e-27
eye morphology	corneal deposits	females	98.0 %	1.16e-12
eye morphology	corneal deposits	males	99.0 %	5.99e-15
eye morphology	corneal deposits	both	99.0 %	6.28e-27
eye morphology	corneal mineralization	females	98.0 %	1.09e-12
eye morphology	corneal mineralization	males	99.0 %	1.46e-15
eye morphology	corneal mineralization	both	99.0 %	6.20e-27
eye morphology	corneal scleralization	females	97.0 %	1.36e-12
eye morphology	corneal scleralization	males	99.0 %	4.21e-15
eye morphology	corneal scleralization	both	98.0 %	5.71e-27
eye morphology	corneal ulcer	females	99.0 %	5.26e-13
eye morphology	corneal ulcer	males	99.0 %	3.75e-16
eye morphology	corneal ulcer	both	99.0 %	1.90e-27
eye morphology	eye closure	females	99.0 %	4.37e-14
eye morphology	eye closure	males	100.0 %	1.61e-16
eye morphology	eye closure	both	99.0 %	2.27e-29
eye morphology	eye hemorrhage or blood presence	females	98.0 %	5.76e-13
eye morphology	eye hemorrhage or blood presence	males	99.0 %	1.61e-15
eye morphology	eye hemorrhage or blood presence	both	99.0 %	1.96e-27
eye morphology	eyelid morphology	females	42.0 %	0.0000580
eye morphology	eyelid morphology	males	100.0 %	7.78e-17
eye morphology	eyelid morphology	both	71.0 %	3.94e-18
eye morphology	eyes (present, absent)	females	99.0 %	2.15e-17
eye morphology	eyes (present, absent)	males	100.0 %	1.56e-20
eye morphology	eyes (present, absent)	both	100.0 %	4.65e-37
eye morphology	fusion between cornea and lens	females	98.0 %	3.29e-11
eye morphology	fusion between cornea and lens	males	98.0 %	1.57e-12
eye morphology	fusion between cornea and lens	both	98.0 %	5.25e-23
eye morphology	iris pigmentation	females	99.0 %	2.78e-13
eye morphology	iris pigmentation	males	100.0 %	5.08e-15
eye morphology	iris pigmentation	both	99.0 %	9.42e-28
eye morphology	iris transillumination	females	99.0 %	2.65e-14
eye morphology	iris transillumination	males	100.0 %	1.03e-15
eye morphology	iris transillumination	both	99.0 %	2.35e-29
eye morphology	irispupil	females	99.0 %	2.95e-13
eye morphology	irispupil	males	100.0 %	2.26e-15
eye morphology	irispupil	both	99.0 %	2.99e-28
eye morphology	lacrimation	females	97.0 %	6.67e-11
eye morphology	lacrimation	males	85.0 %	2.13e-10
eye morphology	lacrimation	both	90.0 %	8.67e-21
eye morphology	lens opacity	females	98.0 %	1.17e-10
eye morphology	lens opacity	males	98.0 %	3.72e-11
eye morphology	lens opacity	both	98.0 %	6.39e-22
eye morphology	narrow eye opening	females	99.0 %	1.05e-9
eye morphology	narrow eye opening	males	99.0 %	3.32e-16
eye morphology	narrow eye opening	both	99.0 %	1.18e-24
eye morphology	optic disc	females	98.0 %	1.09e-10
eye morphology	optic disc	males	98.0 %	2.70e-11
eye morphology	optic disc	both	98.0 %	7.99e-22
eye morphology	pupil dilation	females	99.0 %	1.37e-13
eye morphology	pupil dilation	males	100.0 %	1.59e-14
eye morphology	pupil dilation	both	99.0 %	7.37e-28
eye morphology	pupil light response	females	99.0 %	2.21e-13
eye morphology	pupil light response	males	100.0 %	6.25e-15
eye morphology	pupil light response	both	99.0 %	4.88e-28
eye morphology	pupil position	females	99.0 %	5.23e-13
eye morphology	pupil position	males	100.0 %	2.34e-15
eye morphology	pupil position	both	99.0 %	5.62e-28
eye morphology	pupil shape	females	99.0 %	4.26e-13
eye morphology	pupil shape	males	100.0 %	6.82e-15
eye morphology	pupil shape	both	99.0 %	4.90e-28
eye morphology	retinal blood vessels	females	98.0 %	2.69e-11
eye morphology	retinal blood vessels	males	98.0 %	5.23e-12
eye morphology	retinal blood vessels	both	98.0 %	9.92e-23
eye morphology	retinal blood vessels pattern	females	98.0 %	1.80e-10
eye morphology	retinal blood vessels pattern	males	98.0 %	2.38e-11
eye morphology	retinal blood vessels pattern	both	98.0 %	1.02e-21
eye morphology	retinal blood vessels structure	females	98.0 %	1.01e-10
eye morphology	retinal blood vessels structure	males	98.0 %	1.30e-11
eye morphology	retinal blood vessels structure	both	98.0 %	4.33e-22
eye morphology	retinal pigmentation	females	98.0 %	2.09e-10
eye morphology	retinal pigmentation	males	98.0 %	2.35e-11
eye morphology	retinal pigmentation	both	98.0 %	5.87e-22
eye morphology	retinal structure	females	98.0 %	1.02e-10
eye morphology	retinal structure	males	98.0 %	1.99e-11
eye morphology	retinal structure	both	98.0 %	7.24e-22
eye morphology	synechia	females	98.0 %	1.58e-11
eye morphology	synechia	males	98.0 %	4.26e-12
eye morphology	synechia	both	98.0 %	2.38e-23
eye morphology	vitreous	females	98.0 %	4.18e-11
eye morphology	vitreous	males	98.0 %	2.62e-12
eye morphology	vitreous	both	98.0 %	5.42e-23
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	25.0 %	0.0235
SHIRPA	coat color abdomen	males	36.0 %	0.0124
SHIRPA	coat color abdomen	both	30.0 %	0.000654
SHIRPA	coat color back	females	43.0 %	3.63e-7
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	25.0 %	0.00000136
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	28.0 %	0.000757
SHIRPA	coat color pattern abdomen	males	39.0 %	0.000516
SHIRPA	coat color pattern abdomen	both	33.0 %	8.76e-7
SHIRPA	coat color pattern back	females	14.0 %	0.0153
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	8.0 %	0.0219
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.00
SHIRPA	coat hair head texture appearance	females	0.0 %	1.0
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.0
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.0
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.00
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.00
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.00
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.00
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.00
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.0
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.00
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.00
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.00
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.0
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.00
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.0
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.00
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.00
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.00
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.00
SHIRPA	limb grasp	females	9.0 %	1.0
SHIRPA	limb grasp	males	6.0 %	1.00
SHIRPA	limb grasp	both	7.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.00
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.00
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.00
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.00
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	14.0 %	0.0153
SHIRPA	snout size	males	19.0 %	0.0275
SHIRPA	snout size	both	16.0 %	0.000922
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	20.0 %	0.0148
SHIRPA	startle response	both	8.0 %	0.0263
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.0
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	19.0 %	0.0408
SHIRPA	transfer arousal	both	8.0 %	0.0819
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.00
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Pxdn^em1(IMPC)J/Mmjax -/- with genotype: