MPD: JaxKOMP-EAP genotype: Mgme1<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Mgme1^em1(IMPC)J/Mmjax -/- Gene Mgme1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.7557	1.4612	0.28622	0.676	0.253
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	0.71336	2.2884	0.16583	0.933	0.761
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.44160	3.5627	-0.068934	0.971	0.903
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-8.4815	4.8823	-1.3700	0.447	0.108
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	2.0760	4.6111	0.28854	0.864	0.661
body composition	body length	0.015556	0.028786	0.41620	0.807	0.591
body composition	body weight (at time of DXA)	0.60402	0.57072	0.58504	0.515	0.294
body composition	bone area, whole body scan, head excluded	-0.27010	0.13137	-0.87758	0.200	0.0443
body composition	bone mineral content of whole body scan, head excluded	-0.018641	0.0095460	-0.85375	0.234	0.0557
body composition	bone mineral content to body weight ratio	-0.00090172	0.00035270	-0.93734	0.0918	0.0132
body composition	bone mineral density of whole body scan, head excluded	-0.00059344	0.00052307	-0.64856	0.562	0.261
body composition	fat tissue mass of whole body scan, head excluded	0.59712	0.32918	0.88160	0.257	0.0749
body composition	fat tissue mass to body weight ratio	0.0095098	0.010847	0.49610	0.616	0.384
body composition	lean tissue mass of whole body scan, head excluded	0.40878	0.32060	0.69694	0.510	0.207
body composition	lean tissue mass to body weight ratio	0.00017616	0.010135	-0.030740	0.993	0.986
body composition	percent fat, whole body scan, head excluded	0.76413	1.0628	0.44877	0.697	0.475
body composition	ratio of soft-tissue attenuation coefficients	-0.00085851	0.0011811	-0.44680	0.695	0.470
body composition	tissue area	0.055456	0.16954	0.38223	0.911	0.745
body composition	total tissue mass, whole body scan, head excluded	0.98254	0.16425	1.6231	0.0000670	1.46e-7
clinical blood chemistry	alanine transaminase (plasma ALT)	-9.2913	5.9457	-0.79372	0.497	0.132
clinical blood chemistry	albumin (plasma Alb)	0.24626	0.47215	0.38578	0.846	0.607
clinical blood chemistry	alkaline phosphatase (plasma ALP)	8.5144	3.3459	0.90341	0.105	0.0185
clinical blood chemistry	aspartate transaminase (plasma AST)	9.8974	20.629	0.44216	0.859	0.636
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.95705	0.47289	2.0942	0.375	0.0553
clinical blood chemistry	blood urea nitrogen (BUN)	-1.3333	1.1305	-0.57221	0.518	0.251
clinical blood chemistry	calcium (plasma Ca)	0.025926	0.067093	0.51123	0.837	0.703
clinical blood chemistry	creatinine (plasma)	-0.023939	0.017883	-0.42849	0.432	0.195
clinical blood chemistry	glucose (plasma GLU, no fast)	1.4072	11.930	0.34145	0.948	0.907
clinical blood chemistry	HDL cholesterol (plasma HDL)	6.2926	3.1585	1.1131	0.262	0.0589
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0063723	0.0079853	0.22172	0.734	0.434
clinical blood chemistry	phosphorus (plasma phosphate)	0.36667	0.19745	0.49471	0.278	0.0768
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0027778	0.0098156	-0.21309	0.919	0.780
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	7.1296	3.9827	0.94682	0.320	0.0872
clinical blood chemistry	total protein (plasma TP)	-0.53654	0.63082	-0.47555	0.653	0.404
clinical blood chemistry	triglyceride (plasma TG, no fast)	0.67749	9.0325	0.25010	0.973	0.941
EKG	duration of PQ interval	2.5584	0.73379	2.2817	0.139	0.00190
EKG	duration of PR interval	2.4459	0.71615	2.1629	0.211	0.00227
EKG	duration of QRS interval	-0.30556	0.43139	-0.95251	0.924	0.485
EKG	duration of QT interval	-1.4514	0.90063	-1.1523	0.640	0.120
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-1.4991	0.90533	-1.4884	0.687	0.111
EKG	duration of RR interval	0.051419	1.1986	0.26084	0.982	0.966
EKG	duration of ST interval	-1.1075	0.84462	-0.82962	0.708	0.202
EKG	heart rate coefficient of variation (signal intensity)	0.49736	1.2094	0.49048	0.948	0.684
EKG	heart rate variability, mean of differences between sequential beats; beats per min	4.2972	8.8598	0.58122	0.931	0.632
EKG	heart rate, beats per min	-0.67950	10.225	-0.29987	0.981	0.948
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.035813	0.089916	0.18763	0.902	0.694
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.093618	0.12675	0.46491	0.765	0.467
EKG	number of signals	15.669	4.9524	2.1041	0.214	0.00406
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.84465	2.9577	-0.10804	0.973	0.778
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-1.6764	4.6669	-0.46339	0.968	0.722
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-2.2739	5.2373	-0.63455	0.952	0.668
EKG	root mean square of successive differences of neighboring RR intervals	0.044044	2.5566	0.13135	0.997	0.986
glucose tolerance test	amount glucose injected	-0.92188	2.4483	0.072250	0.910	0.709
glucose tolerance test	plasma glucose, 0min	32.241	5.3885	2.2060	0.0000913	6.00e-7
glucose tolerance test	plasma glucose, 15min	23.196	17.199	0.77538	0.504	0.185
glucose tolerance test	plasma glucose, 30min	28.457	24.056	0.96159	0.578	0.244
glucose tolerance test	plasma glucose, 60min	40.687	13.773	1.6153	0.0876	0.00543
glucose tolerance test	plasma glucose, 120min	21.221	9.1571	1.2866	0.210	0.0261
grip strength	body weight (at time of grip strength test)	-0.51008	0.47259	-0.26565	0.481	0.287
grip strength	forelimb and hindlimb grip strength (mean of trials), average	12.680	7.2784	1.1782	0.240	0.0896
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.82526	0.32019	1.3824	0.0709	0.0139
grip strength	forelimb and hindlimb grip strength by trial, trial1	6.0831	9.2745	0.65187	0.768	0.516
grip strength	forelimb and hindlimb grip strength by trial, trial2	19.850	9.8230	1.4414	0.206	0.0502
grip strength	forelimb and hindlimb grip strength by trial, trial3	10.764	7.8483	0.93470	0.434	0.178
grip strength	forelimb grip strength (mean of trials), average	2.6655	5.1623	0.63757	0.819	0.609
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.23949	0.23260	0.85871	0.586	0.310
grip strength	forelimb grip strength by trial, trial1	3.7749	6.0464	0.69931	0.803	0.536
grip strength	forelimb grip strength by trial, trial2	-0.79113	6.0195	0.13841	0.959	0.896
grip strength	forelimb grip strength by trial, trial3	3.5679	5.1911	0.63579	0.765	0.496
heart weight	heart weight, normalized to body weight	0.42795	0.13150	0.90901	0.0262	0.00281
heart weight	heart weight, weight	8.6433	3.8360	0.74892	0.141	0.0320
hematology	basophil differential (percent of total WBC)	-0.056048	0.045834	-0.79406	0.676	0.234
hematology	calculated hemoglobin (cHGB)	0.21832	0.18178	0.40166	0.524	0.243
hematology	eosinophil differential (percent of total WBC)	-0.33699	0.19443	-0.82536	0.465	0.0971
hematology	hematocrit (HCT)	0.44957	0.53690	0.12745	0.670	0.411
hematology	hemoglobin concentration distribution width (HDW)	-0.023095	0.022777	-0.65605	0.625	0.322
hematology	large unstained cells (percent of total WBC)	0.063194	0.044571	0.42692	0.519	0.171
hematology	lymphocyte differential (percent of total WBC)	2.7222	1.1721	0.93026	0.164	0.0299
hematology	mean corpuscular hemoglobin (CHr)	0.30589	0.067435	1.8922	0.00284	0.000163
hematology	mean platelet volume (MPV)	0.063854	0.056861	0.24175	0.502	0.274
hematology	mean RBC corpuscular hemoglobin (MCH)	0.23148	0.091900	0.86114	0.180	0.0195
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.12184	0.20869	0.30032	0.826	0.565
hematology	mean RBC corpuscular volume (MCV)	0.52069	0.25388	0.89299	0.176	0.0524
hematology	measured hemoglobin (mHGB)	0.22608	0.18377	0.34664	0.547	0.232
hematology	monocyte differential (percent of total WBC)	-0.024103	0.12208	0.12745	0.940	0.845
hematology	neutrophil differential (percent of total WBC)	-2.3115	1.0345	-0.96017	0.178	0.0359
hematology	platelet count (PLT; units per volume x 10³)	52.307	39.576	0.73852	0.572	0.200
hematology	RBC corpuscular distribution width (RDW)	-0.075799	0.29373	-0.26270	0.897	0.799
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.30722	0.16371	0.74849	0.248	0.0739
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.037998	0.12143	-0.50814	0.889	0.757
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-1.7315	16.176	0.0075543	0.982	0.916
hematology	reticulocyte differential (percent of total RBC)	-0.035370	0.17742	0.077146	0.936	0.844
hematology	white blood cell count (WBC; units per volume x 10³)	-0.0036572	0.49203	0.18835	0.997	0.994
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.27895	0.53814	0.33087	0.879	0.607
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.39523	0.38232	-0.50609	0.782	0.306
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.13759	0.47283	-0.13971	0.948	0.772
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.57959	0.48740	0.64355	0.706	0.240
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.58310	0.45315	0.98509	0.700	0.204
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.24719	0.24864	0.70120	0.858	0.325
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.45154	0.28088	1.1483	0.731	0.114
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.34085	0.45359	-0.45119	0.862	0.456
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.23281	0.38367	0.50167	0.899	0.547
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.11694	0.23144	0.38660	0.938	0.616
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.056340	0.19647	-0.13384	0.959	0.776
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.17767	0.38434	0.41842	0.926	0.646
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.34691	0.53513	-0.25927	0.833	0.520
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.48186	0.37283	0.82776	0.647	0.202
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.036947	0.42078	0.13876	0.976	0.930
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.26474	0.74645	-0.20382	0.931	0.724
holeboard	total number of hole pokes, 20 min test	1.7440	3.1271	0.32263	0.784	0.580
light / dark	fecal boli count, 20 min test	-0.43052	0.67971	-0.44636	0.840	0.529
light / dark	latency to enter dark zone, 20 min test	20.749	51.444	0.29631	0.908	0.688
light / dark	number of transitions between light and dark zones, 20 min test	-10.290	11.245	-0.95242	0.665	0.364
light / dark	percentage of total time in dark zone, 20 min test	4.6134	4.4228	0.93763	0.659	0.301
light / dark	percentage of total time in light zone, 20 min test	-4.6134	4.4228	-0.94605	0.659	0.301
light / dark	time mobile in dark zone, 20 min test	12.980	13.103	0.66013	0.618	0.326
light / dark	time mobile in light zone, 20 min test	-4.9055	11.068	-0.60237	0.828	0.659
light / dark	time spent in dark zone, 20 min test	25.057	52.441	0.57664	0.889	0.635
light / dark	time spent in light zone, 20 min test	-25.057	52.441	-0.57664	0.889	0.635
open field	average speed in center of arena, 20 min test	-0.72195	0.40389	-1.4434	0.363	0.0795
open field	average speed in periphery of arena, 20 min test	0.026452	0.12190	-0.42533	0.911	0.829
open field	distance traveled habituation ratio, 20 min test	0.24766	6.8763	0.055747	0.989	0.971
open field	distance traveled in center of arena, 20 min test	4.8687	74.347	-0.35577	0.972	0.948
open field	distance traveled in periphery of arena, 20 min test	43.395	125.16	-0.26001	0.861	0.730
open field	distance traveled slope, 20 min test	1.3794	6.4249	0.20894	0.949	0.831
open field	distance traveled, 20 min test, 1st 5min	4.4250	58.472	-0.31035	0.975	0.940
open field	distance traveled, 20 min test, 2nd 5min	-1.7090	47.355	-0.51533	0.984	0.971
open field	distance traveled, 20 min test, 3rd 5min	32.947	48.413	-0.065162	0.721	0.499
open field	distance traveled, 20 min test, 4th 5min	6.6528	49.069	-0.38308	0.959	0.893
open field	number of clockwise revolution episodes, 20 min test	-0.33163	1.2846	-0.60605	0.925	0.797
open field	number of counter-clockwise revolution episodes, 20 min test	1.0830	0.93227	0.16250	0.535	0.250
open field	number of fecal boli, 20 min test	-0.86411	0.81237	-0.42326	0.624	0.292
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-1.6982	1.8730	-0.66357	0.628	0.369
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-2.8019	2.4333	-1.0481	0.546	0.255
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-3.2607	2.6115	-1.0622	0.494	0.217
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-3.7685	2.5765	-1.1592	0.410	0.149
open field	percentage of total time in center of arena, 20 min test	-0.29353	2.5232	-0.26557	0.971	0.908
open field	percentage of total time in center of arena, slope, 20 min test	-1.1189	1.2430	-0.48641	0.801	0.372
open field	percentage of total time in center, habituation ratio, 20 min test	-1.1332	1.2202	-0.50311	0.800	0.357
open field	percentage of total time in corners of arena, 20 min test	0.28266	3.9342	0.36436	0.974	0.943
open field	percentage of total time in corners, habituation ratio, 20 min test	0.60737	1.8541	-0.0046991	0.949	0.744
open field	percentage of total time in corners, slope, 20 min test	0.40935	1.8359	-0.090750	0.959	0.824
open field	permanence time in center of arena, 20 min test	-3.5084	30.279	-0.26279	0.971	0.908
open field	permanence time in corners of arena, 20 min test	3.3954	47.208	0.36436	0.974	0.943
open field	permanence time in periphery of arena, 20 min test	3.5143	30.280	0.26279	0.970	0.908
open field	total distance traveled, 20 min test	42.300	162.23	-0.36150	0.898	0.795
open field	total number of rears, 20 min test	-11.230	8.1822	-1.1384	0.411	0.175
open field	whole arena average speed, 20 min test	0.035316	0.13530	-0.36006	0.898	0.795
open field	whole arena resting time, 20 min test	-16.763	17.830	0.059781	0.555	0.351
open field	whole arena time spent mobile, 20 min test	16.725	17.814	0.18703	0.567	0.352
open field	whole arena time spent vertical, 20 min test	-12.610	7.6137	-1.0812	0.363	0.103
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.11701	1.2356	0.14120	0.979	0.925
startle / PPI	average baseline movement during background noise	1.7163	1.1832	1.0616	0.706	0.154
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.023891	0.067979	0.10598	0.887	0.727
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.020486	0.064849	0.12163	0.904	0.753
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.94275	7.1148	0.16254	0.994	0.895
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	1.7031	7.5875	0.13138	0.947	0.823
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.6885	6.2386	0.28911	0.813	0.557
startle / PPI	average startle response to full pulse (120 dB)	-30.241	40.838	-0.39008	0.699	0.463
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-29.713	38.664	-0.41286	0.670	0.446
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-35.097	36.975	-0.51430	0.562	0.347
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-22.836	31.087	-0.36151	0.660	0.466
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.071867	1.2435	0.13704	0.992	0.954
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.9185	1.6951	-1.3038	0.779	0.263
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.7073	1.8032	0.59437	0.744	0.349
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.011769	0.076293	0.15403	0.981	0.878
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.0014602	0.084468	-0.069490	0.997	0.986
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.045670	0.075185	0.20613	0.765	0.546
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-31.690	40.733	-0.41744	0.681	0.440
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-29.532	38.702	-0.40829	0.670	0.449
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-33.003	37.168	-0.48257	0.587	0.379
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-24.108	31.452	-0.37801	0.648	0.447
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.0019204	0.081865	0.055373	0.998	0.981
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.012495	0.085682	-0.011216	0.956	0.885
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.055587	0.076673	0.22191	0.706	0.472
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-120.67	144.94	-0.43432	0.642	0.409
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-102.92	139.04	-0.39613	0.678	0.463
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-122.89	139.85	-0.48257	0.601	0.384
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-94.455	115.84	-0.39917	0.624	0.419
startle / PPI	maximum baseline movement during background noise	2.6309	2.9131	0.80195	0.808	0.371
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.20977	7.7280	0.010509	1.00	0.978
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	2.3486	7.9667	0.12856	0.912	0.769
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	4.9208	6.6876	0.32436	0.738	0.465
startle / PPI	maximum startle response to full pulse (120 dB)	-118.15	145.29	-0.42203	0.650	0.420
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-103.11	138.95	-0.40524	0.674	0.462
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-128.75	139.46	-0.51750	0.583	0.361
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-91.786	114.81	-0.40372	0.631	0.428
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.18404	2.8577	0.063795	0.988	0.949
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-5.1453	3.6912	-1.3582	0.678	0.170
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.7145	4.4282	0.32436	0.835	0.543

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	5.0 %	0.344
eye morphology	cornea opacity	6.0 %	0.249
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	6.0 %	0.0885
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.00
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	9.0 %	1.0
eye morphology	lens opacity	11.0 %	0.0718
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	5.0 %	0.564
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.00
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	13.0 %	1.0
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	7.0 %	0.889
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.00
SHIRPA	coat color back	0.0 %	1.0
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.0
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.0
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.0
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.00
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.00
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.618
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.0
SHIRPA	tail curvature	0.0 %	1.00
SHIRPA	tail elevation	6.0 %	0.180
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	0.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Mgme1^em1(IMPC)J/Mmjax -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.