MPD: JaxKOMP-EAP genotype: Tbc1d8<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Tbc1d8^em1(IMPC)J/Mmjax -/- Gene Tbc1d8

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.1327	1.4062	0.063429	0.803	0.434
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-3.0170	2.9111	-0.66606	0.748	0.319
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.8079	3.6872	0.21685	0.871	0.632
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	2.5408	2.5137	0.29632	0.694	0.329
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	4.9525	6.5952	0.75225	0.772	0.466
body composition	body length	0.057732	0.034124	0.96123	0.330	0.0985
body composition	body weight (at time of DXA)	2.2133	0.72250	1.8659	0.0282	0.00386
body composition	bone area, whole body scan, head excluded	0.41234	0.11986	1.8579	0.0225	0.00137
body composition	bone mineral content of whole body scan, head excluded	0.029289	0.0083406	1.7795	0.0231	0.00112
body composition	bone mineral content to body weight ratio	0.00076087	0.00040476	1.1952	0.247	0.0674
body composition	bone mineral density of whole body scan, head excluded	0.00098214	0.00053347	1.0825	0.290	0.0730
body composition	fat tissue mass of whole body scan, head excluded	-0.91996	0.34189	-1.6544	0.0871	0.0104
body composition	fat tissue mass to body weight ratio	-0.035447	0.011573	-1.6080	0.0407	0.00391
body composition	lean tissue mass of whole body scan, head excluded	1.1093	0.30855	1.7599	0.0317	0.000880
body composition	lean tissue mass to body weight ratio	0.031420	0.010611	1.5283	0.0574	0.00514
body composition	percent fat, whole body scan, head excluded	-3.4170	1.0887	-1.6080	0.0358	0.00319
body composition	ratio of soft-tissue attenuation coefficients	0.0037814	0.0012096	1.6169	0.0366	0.00329
body composition	tissue area	0.0026302	0.21237	0.21486	0.998	0.990
body composition	total tissue mass, whole body scan, head excluded	0.18737	0.24743	0.21322	0.688	0.453
clinical blood chemistry	alanine transaminase (plasma ALT)	-21.141	14.934	-1.5275	0.541	0.172
clinical blood chemistry	albumin (plasma Alb)	0.39505	0.47658	0.58663	0.715	0.416
clinical blood chemistry	alkaline phosphatase (plasma ALP)	4.2652	4.1046	0.24984	0.562	0.311
clinical blood chemistry	aspartate transaminase (plasma AST)	-19.386	39.290	-0.88610	0.856	0.627
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.18035	0.48776	0.60397	0.917	0.715
clinical blood chemistry	blood urea nitrogen (BUN)	2.2262	1.6148	0.87434	0.431	0.183
clinical blood chemistry	calcium (plasma Ca)	0.073568	0.093523	0.84894	0.667	0.440
clinical blood chemistry	creatinine (plasma)	0.0096046	0.018811	0.32967	0.793	0.616
clinical blood chemistry	glucose (plasma GLU, no fast)	-4.5606	10.593	0.12386	0.815	0.671
clinical blood chemistry	HDL cholesterol (plasma HDL)	-1.1601	3.4221	-0.61218	0.902	0.738
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.014066	0.010594	-0.91532	0.534	0.199
clinical blood chemistry	phosphorus (plasma phosphate)	-0.15658	0.39792	-0.30611	0.860	0.698
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.011810	0.013169	-0.88741	0.720	0.380
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-2.3209	4.9203	-0.63008	0.860	0.642
clinical blood chemistry	total protein (plasma TP)	-0.54956	0.62665	-0.48677	0.646	0.390
clinical blood chemistry	triglyceride (plasma TG, no fast)	4.6494	11.977	0.47512	0.861	0.702
EKG	duration of PQ interval	-1.2858	1.0623	-1.1406	0.786	0.240
EKG	duration of PR interval	-0.79291	1.1339	-0.67702	0.909	0.492
EKG	duration of QRS interval	0.67378	0.36959	1.6622	0.885	0.0841
EKG	duration of QT interval	4.0536	1.7383	2.7250	0.481	0.0303
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	2.7165	1.7047	2.4072	0.702	0.127
EKG	duration of RR interval	-0.14713	1.4209	0.18850	0.968	0.919
EKG	duration of ST interval	2.9894	1.6610	2.5883	0.569	0.0870
EKG	heart rate coefficient of variation (signal intensity)	-1.3569	1.0139	-1.0845	0.841	0.196
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-9.6673	7.1605	-1.1178	0.853	0.192
EKG	heart rate, beats per min	-1.1301	11.616	-0.33166	0.981	0.923
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.038784	0.087036	-0.42704	0.891	0.661
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.10562	0.10164	-0.68912	0.663	0.311
EKG	number of signals	-7.5880	7.2604	-1.3865	0.804	0.308
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-2.5532	2.8871	-0.40115	0.848	0.387
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-3.8242	3.9927	-1.0737	0.913	0.350
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-3.8084	4.1313	-1.0180	0.911	0.368
EKG	root mean square of successive differences of neighboring RR intervals	-2.0669	1.8605	-1.0882	0.843	0.280
glucose tolerance test	amount glucose injected	-3.1802	2.8818	-0.54806	0.655	0.283
glucose tolerance test	plasma glucose, 0min	9.7034	8.8918	0.75880	0.507	0.288
glucose tolerance test	plasma glucose, 15min	-27.622	28.385	-0.65310	0.662	0.342
glucose tolerance test	plasma glucose, 30min	-31.762	19.694	-0.87778	0.438	0.122
glucose tolerance test	plasma glucose, 60min	-13.402	13.862	-0.44382	0.673	0.345
glucose tolerance test	plasma glucose, 120min	-2.5385e-7	8.7042	-0.11971	1.00	1.00
grip strength	body weight (at time of grip strength test)	1.7026	0.45739	1.6585	0.00718	0.000785
grip strength	forelimb and hindlimb grip strength (mean of trials), average	1.1833	5.6788	0.32667	0.913	0.836
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.10723	0.31320	0.040675	0.848	0.734
grip strength	forelimb and hindlimb grip strength by trial, trial1	-7.3125	7.0023	-0.25545	0.610	0.304
grip strength	forelimb and hindlimb grip strength by trial, trial2	3.1875	7.8741	0.43126	0.848	0.688
grip strength	forelimb and hindlimb grip strength by trial, trial3	7.6750	6.3073	0.71423	0.499	0.233
grip strength	forelimb grip strength (mean of trials), average	-4.4725	5.3683	-0.30074	0.666	0.411
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.37708	0.22947	-0.72741	0.332	0.110
grip strength	forelimb grip strength by trial, trial1	-6.2569	5.7247	-0.45368	0.637	0.283
grip strength	forelimb grip strength by trial, trial2	-5.6725	7.3573	-0.40117	0.756	0.447
grip strength	forelimb grip strength by trial, trial3	2.4500	4.6131	0.52074	0.826	0.599
heart weight	heart weight, normalized to body weight	0.39112	0.13132	0.82442	0.0432	0.00620
heart weight	heart weight, weight	10.134	2.9665	0.94220	0.0237	0.00210
hematology	basophil differential (percent of total WBC)	-0.0035714	0.049526	-0.038446	0.992	0.943
hematology	calculated hemoglobin (cHGB)	-0.86540	0.94877	-2.0659	0.644	0.372
hematology	eosinophil differential (percent of total WBC)	-0.17024	0.25218	-0.41428	0.834	0.507
hematology	hematocrit (HCT)	-2.5143	3.1713	-2.0177	0.690	0.437
hematology	hemoglobin concentration distribution width (HDW)	-0.016653	0.023986	-0.44348	0.742	0.495
hematology	large unstained cells (percent of total WBC)	0.015141	0.12015	0.11752	0.951	0.901
hematology	lymphocyte differential (percent of total WBC)	2.0994	1.2757	0.73852	0.344	0.115
hematology	mean corpuscular hemoglobin (CHr)	0.20995	0.054144	1.4512	0.0102	0.000937
hematology	mean platelet volume (MPV)	0.39568	0.13387	1.5087	0.0451	0.00755
hematology	mean RBC corpuscular hemoglobin (MCH)	0.35980	0.096050	1.2694	0.0331	0.00127
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.40711	0.20044	-0.77700	0.322	0.0551
hematology	mean RBC corpuscular volume (MCV)	1.5093	0.33291	2.0849	0.00306	0.000202
hematology	measured hemoglobin (mHGB)	-0.77532	1.0694	-1.4610	0.722	0.476
hematology	monocyte differential (percent of total WBC)	-0.085699	0.16578	-0.072501	0.850	0.611
hematology	neutrophil differential (percent of total WBC)	-1.8300	1.1504	-0.77677	0.349	0.127
hematology	platelet count (PLT; units per volume x 10³)	-92.940	95.695	-1.1045	0.683	0.342
hematology	RBC corpuscular distribution width (RDW)	0.014387	0.082212	0.052788	0.938	0.863
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.44929	0.20840	-1.1813	0.176	0.0428
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.78745	0.69898	-2.2932	0.550	0.273
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-13.807	26.629	-0.51105	0.868	0.610
hematology	reticulocyte differential (percent of total RBC)	0.20655	0.13476	1.0118	0.480	0.140
hematology	white blood cell count (WBC; units per volume x 10³)	-1.4435	0.62957	-0.80669	0.126	0.0328
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.39072	0.53772	0.43073	0.823	0.472
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.16833	0.42996	-0.13290	0.931	0.698
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.78221	0.41418	1.2314	0.596	0.0662
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.95477	0.65590	-0.90083	0.636	0.153
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.45661	0.56388	0.81545	0.841	0.423
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.080562	0.27878	0.26626	0.968	0.774
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.00048982	0.23324	-0.027893	1.00	0.998
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.0020808	0.66765	0.14312	1.00	0.998
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.35543	0.43255	0.74623	0.847	0.416
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.034893	0.34065	-0.0084570	0.983	0.919
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.23004	0.28111	0.59594	0.857	0.418
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.0076687	0.44640	0.094603	0.997	0.986
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.018960	0.68026	0.057384	0.999	0.978
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.25914	0.51890	0.50859	0.875	0.620
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.25055	0.50437	0.45180	0.896	0.622
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.32434	0.93015	-0.26626	0.931	0.729
holeboard	total number of hole pokes, 20 min test	0.30289	4.2579	0.12515	0.972	0.944
light / dark	fecal boli count, 20 min test	-0.56250	0.54826	-0.57823	0.715	0.311
light / dark	latency to enter dark zone, 20 min test	-42.529	64.478	-0.90050	0.840	0.513
light / dark	number of transitions between light and dark zones, 20 min test	7.5958	7.5221	0.78847	0.636	0.319
light / dark	percentage of total time in dark zone, 20 min test	-3.6684	5.1800	-0.53560	0.780	0.483
light / dark	percentage of total time in light zone, 20 min test	3.6684	5.1800	0.53248	0.778	0.483
light / dark	time mobile in dark zone, 20 min test	10.205	13.366	0.50926	0.726	0.450
light / dark	time mobile in light zone, 20 min test	31.227	11.953	1.3271	0.0927	0.0125
light / dark	time spent in dark zone, 20 min test	-32.195	62.838	-0.26958	0.877	0.611
light / dark	time spent in light zone, 20 min test	32.195	62.838	0.26958	0.877	0.611
open field	average speed in center of arena, 20 min test	-0.044542	0.38646	-0.18157	0.972	0.909
open field	average speed in periphery of arena, 20 min test	0.37758	0.10361	0.89526	0.00923	0.000747
open field	distance traveled habituation ratio, 20 min test	1.7392	5.5274	0.17748	0.897	0.755
open field	distance traveled in center of arena, 20 min test	76.942	81.095	0.15434	0.608	0.348
open field	distance traveled in periphery of arena, 20 min test	369.89	97.856	0.96350	0.00859	0.000501
open field	distance traveled slope, 20 min test	2.7891	5.0452	0.32023	0.820	0.583
open field	distance traveled, 20 min test, 1st 5min	114.74	41.447	0.56190	0.0575	0.00842
open field	distance traveled, 20 min test, 2nd 5min	58.912	41.737	0.14348	0.384	0.166
open field	distance traveled, 20 min test, 3rd 5min	119.78	38.008	0.83475	0.0309	0.00303
open field	distance traveled, 20 min test, 4th 5min	159.57	41.360	1.2106	0.00680	0.000396
open field	number of clockwise revolution episodes, 20 min test	1.9864	0.90448	0.75336	0.224	0.0338
open field	number of counter-clockwise revolution episodes, 20 min test	1.4125	0.94485	0.32589	0.407	0.143
open field	number of fecal boli, 20 min test	-1.3833	1.0173	-0.86576	0.509	0.181
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.6939	2.3434	0.25946	0.717	0.474
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.99422	2.2587	-0.10154	0.840	0.662
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.5254	2.8567	0.30050	0.651	0.382
open field	number of rears in 5 min bins, 20 min test, 4th 5min	9.3083	3.3361	1.5919	0.0898	0.00796
open field	percentage of total time in center of arena, 20 min test	1.3756	2.8818	0.11640	0.856	0.636
open field	percentage of total time in center of arena, slope, 20 min test	1.7587	1.2580	1.0909	0.635	0.170
open field	percentage of total time in center, habituation ratio, 20 min test	1.4962	1.2683	0.92368	0.723	0.245
open field	percentage of total time in corners of arena, 20 min test	-2.4096	4.1226	-0.12993	0.807	0.562
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.98093	1.5489	-0.75020	0.884	0.530
open field	percentage of total time in corners, slope, 20 min test	-1.4568	1.5222	-0.96993	0.808	0.344
open field	permanence time in center of arena, 20 min test	16.486	34.582	0.11369	0.857	0.636
open field	permanence time in corners of arena, 20 min test	-28.927	49.472	-0.12993	0.806	0.562
open field	permanence time in periphery of arena, 20 min test	-16.501	34.584	-0.11640	0.857	0.636
open field	total distance traveled, 20 min test	441.77	130.44	0.75913	0.0158	0.00157
open field	total number of rears, 20 min test	10.031	9.5119	0.34435	0.552	0.298
open field	whole arena average speed, 20 min test	0.36653	0.10845	0.75376	0.0159	0.00160
open field	whole arena resting time, 20 min test	-43.644	14.352	-0.64735	0.0287	0.00410
open field	whole arena time spent mobile, 20 min test	43.644	14.348	0.89727	0.0298	0.00409
open field	whole arena time spent vertical, 20 min test	9.2271	9.0923	0.60972	0.622	0.316
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	3.8559	1.4881	1.6988	0.136	0.0145
startle / PPI	average baseline movement during background noise	-0.18172	1.7169	-0.055373	0.995	0.917
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.53345	0.21137	2.2305	0.232	0.0243
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.53737	0.19459	2.7706	0.195	0.0153
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	33.034	15.422	3.0570	0.784	0.0503
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	50.870	17.273	3.2590	0.198	0.0106
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	44.844	12.388	3.2590	0.0615	0.00279
startle / PPI	average startle response to full pulse (120 dB)	44.760	47.846	1.0591	0.612	0.364
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-9.5777	53.908	-0.016114	0.941	0.862
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-65.213	42.524	-1.0253	0.349	0.147
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-76.984	33.914	-1.4093	0.159	0.0395
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	3.6451	1.3941	1.7609	0.459	0.0195
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.88627	2.0717	0.58271	0.948	0.675
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.5691	2.5656	-1.0136	0.857	0.550
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.44803	0.20348	2.8428	0.744	0.0449
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.48793	0.26190	2.6138	0.374	0.0822
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.42358	0.16951	2.4436	0.141	0.0246
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	45.541	47.605	1.0616	0.603	0.354
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-13.533	54.358	-0.10880	0.909	0.807
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-66.799	43.067	-1.0421	0.343	0.143
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-76.284	34.678	-1.3833	0.170	0.0451
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.43758	0.24204	2.2305	0.766	0.0922
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.46150	0.25480	2.3677	0.386	0.0902
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.54431	0.17476	2.3238	0.0712	0.00761
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	126.35	162.01	0.86950	0.678	0.448
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-18.617	202.27	0.084870	0.962	0.928
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-242.69	163.07	-1.0349	0.362	0.159
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-298.52	130.91	-1.4767	0.151	0.0388
startle / PPI	maximum baseline movement during background noise	-1.3840	3.8839	-0.36900	0.945	0.727
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	34.405	19.855	2.9333	0.781	0.105
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	51.860	18.920	3.2590	0.208	0.0159
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	48.891	14.548	3.2590	0.0695	0.00466
startle / PPI	maximum startle response to full pulse (120 dB)	123.72	163.00	0.85326	0.690	0.460
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-7.9996	201.19	0.14411	0.983	0.969
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-238.80	161.34	-1.0159	0.359	0.161
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-298.13	130.14	-1.4851	0.150	0.0380
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	10.269	3.0658	2.0628	0.291	0.00439
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	3.1176	4.5401	0.81165	0.858	0.503
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-2.7531	6.3208	-0.74895	0.880	0.669

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	53.0 %	0.00000878
eye morphology	lens opacity	males	23.0 %	0.0665
eye morphology	lens opacity	both	36.0 %	0.00000318
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	15.0 %	0.202
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	2.0 %	0.721
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	50.0 %	0.00108
eye morphology	retinal pigmentation	males	61.0 %	0.000339
eye morphology	retinal pigmentation	both	56.0 %	0.00000110
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Tbc1d8^em1(IMPC)J/Mmjax -/- with genotype: