MPD: JaxKOMP-EAP genotype: Sdr42e1<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Sdr42e1^em1(IMPC)J/Mmjax -/- Gene Sdr42e1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-5.6652	2.9553	-1.6176	0.428	0.0759
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-10.137	4.2616	-1.7050	0.362	0.0322
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-6.2751	3.5584	-1.4097	0.444	0.0996
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	2.7083	3.0464	0.33181	0.741	0.388
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	2.7083	3.7984	0.39713	0.783	0.487
body composition	body length	-0.037648	0.050603	-0.23778	0.735	0.461
body composition	body weight (at time of DXA)	-2.5980	0.74378	-1.4701	0.0116	0.00116
body composition	bone area, whole body scan, head excluded	-0.072099	0.17352	-0.11768	0.852	0.680
body composition	bone mineral content of whole body scan, head excluded	0.0025093	0.011894	0.29075	0.931	0.834
body composition	bone mineral content to body weight ratio	0.00015225	0.00049827	0.35549	0.894	0.762
body composition	bone mineral density of whole body scan, head excluded	0.00069582	0.00061512	0.79391	0.564	0.265
body composition	fat tissue mass of whole body scan, head excluded	-0.51620	0.41204	-0.99392	0.460	0.218
body composition	fat tissue mass to body weight ratio	-0.014852	0.014162	-0.64395	0.543	0.301
body composition	lean tissue mass of whole body scan, head excluded	0.79321	0.32677	1.3152	0.152	0.0198
body composition	lean tissue mass to body weight ratio	0.043744	0.010187	1.9974	0.00641	0.000105
body composition	percent fat, whole body scan, head excluded	-1.8299	1.3321	-0.87357	0.407	0.177
body composition	ratio of soft-tissue attenuation coefficients	0.0022838	0.0014810	0.99923	0.336	0.131
body composition	tissue area	-0.27179	0.27057	-0.72601	0.626	0.321
body composition	total tissue mass, whole body scan, head excluded	0.26930	0.26680	0.37153	0.572	0.319
clinical blood chemistry	alanine transaminase (plasma ALT)	-6.2739	5.3541	-0.58338	0.628	0.258
clinical blood chemistry	albumin (plasma Alb)	-0.99709	0.63940	-1.2307	0.449	0.138
clinical blood chemistry	alkaline phosphatase (plasma ALP)	5.0685	4.5917	0.41472	0.544	0.286
clinical blood chemistry	aspartate transaminase (plasma AST)	-57.861	25.028	-2.0130	0.247	0.0344
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.69680	0.40689	-1.8562	0.480	0.105
clinical blood chemistry	blood urea nitrogen (BUN)	0.78294	1.5781	0.27501	0.814	0.626
clinical blood chemistry	calcium (plasma Ca)	-0.13080	0.078029	-0.59237	0.307	0.113
clinical blood chemistry	creatinine (plasma)	0.029034	0.015845	0.81115	0.276	0.0868
clinical blood chemistry	glucose (plasma GLU, no fast)	-8.9007	13.584	-0.055016	0.712	0.521
clinical blood chemistry	HDL cholesterol (plasma HDL)	-6.6554	2.7697	-1.6100	0.186	0.0287
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.015813	0.011997	-0.99390	0.540	0.205
clinical blood chemistry	phosphorus (plasma phosphate)	-0.20418	0.34885	-0.39247	0.793	0.567
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.00083126	0.012227	-0.053963	0.984	0.947
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-6.7489	3.8207	-1.2571	0.343	0.0964
clinical blood chemistry	total protein (plasma TP)	-1.7875	0.61640	-1.3374	0.0984	0.00996
clinical blood chemistry	triglyceride (plasma TG, no fast)	-9.5441	7.6151	-0.30812	0.517	0.227
EKG	duration of PQ interval	0.69802	0.84525	0.88193	0.886	0.414
EKG	duration of PR interval	0.89809	0.95433	1.0845	0.877	0.352
EKG	duration of QRS interval	0.28493	0.34437	0.67196	0.901	0.413
EKG	duration of QT interval	-0.69500	0.95885	-0.50645	0.890	0.473
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.56125	1.0088	-0.53181	0.933	0.581
EKG	duration of RR interval	-1.4932	1.1069	-0.51333	0.600	0.185
EKG	duration of ST interval	-0.99875	0.90142	-0.74980	0.754	0.274
EKG	heart rate coefficient of variation (signal intensity)	-0.62688	1.2441	-0.41897	0.927	0.617
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-4.3233	9.0846	-0.43885	0.931	0.637
EKG	heart rate, beats per min	14.641	9.1354	0.63637	0.496	0.117
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.13942	0.089687	0.93936	0.474	0.128
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.20838	0.11294	1.1363	0.362	0.0723
EKG	number of signals	13.549	3.9575	1.9477	0.149	0.00144
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.93312	3.2614	-0.12238	0.973	0.776
EKG	QT dispersion, measured as inter-lead variability of QT intervals	7.8629	4.2852	1.8728	0.858	0.0740
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	8.5106	5.0242	1.7392	0.835	0.0981
EKG	root mean square of successive differences of neighboring RR intervals	-0.46617	2.5679	-0.13542	0.965	0.857
glucose tolerance test	amount glucose injected	-1.2603	1.5723	-0.015813	0.764	0.433
glucose tolerance test	plasma glucose, 0min	-0.36506	4.8488	-0.28095	0.974	0.941
glucose tolerance test	plasma glucose, 15min	-27.050	22.052	-0.62949	0.567	0.234
glucose tolerance test	plasma glucose, 30min	-73.476	20.406	-1.9954	0.0419	0.00191
glucose tolerance test	plasma glucose, 60min	7.3366	14.918	0.43023	0.857	0.628
glucose tolerance test	plasma glucose, 120min	1.1875	10.675	-0.052188	0.961	0.913
grip strength	body weight (at time of grip strength test)	-1.9576	0.56047	-1.4298	0.00935	0.00116
grip strength	forelimb and hindlimb grip strength (mean of trials), average	6.9046	6.0275	0.75223	0.467	0.259
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.45029	0.27145	0.85871	0.267	0.105
grip strength	forelimb and hindlimb grip strength by trial, trial1	13.038	9.7022	1.1220	0.464	0.187
grip strength	forelimb and hindlimb grip strength by trial, trial2	-3.6617	6.7622	-0.0058091	0.797	0.591
grip strength	forelimb and hindlimb grip strength by trial, trial3	6.7602	8.4469	0.65547	0.687	0.428
grip strength	forelimb grip strength (mean of trials), average	-1.3978	5.2900	0.081417	0.914	0.793
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.15219	0.22791	0.63579	0.754	0.508
grip strength	forelimb grip strength by trial, trial1	-3.1236	5.8358	-0.10038	0.829	0.595
grip strength	forelimb grip strength by trial, trial2	0.88648	5.4679	0.31139	0.951	0.872
grip strength	forelimb grip strength by trial, trial3	-2.3210	5.8425	0.017428	0.878	0.693
heart weight	heart weight, normalized to body weight	0.34315	0.087185	0.70665	0.0100	0.000660
heart weight	heart weight, weight	9.3171	2.7143	0.85908	0.0255	0.00238
hematology	basophil differential (percent of total WBC)	0.15049	0.039235	1.7140	0.0967	0.00132
hematology	calculated hemoglobin (cHGB)	-0.67500	0.22402	-1.8345	0.0903	0.00783
hematology	eosinophil differential (percent of total WBC)	-0.32318	0.20423	-0.78378	0.526	0.133
hematology	hematocrit (HCT)	-1.2152	0.68178	-1.4077	0.349	0.0926
hematology	hemoglobin concentration distribution width (HDW)	0.026571	0.025563	0.71543	0.618	0.314
hematology	large unstained cells (percent of total WBC)	-0.046520	0.087198	-0.30246	0.838	0.601
hematology	lymphocyte differential (percent of total WBC)	-1.7333	1.4886	-0.79351	0.516	0.260
hematology	mean corpuscular hemoglobin (CHr)	-0.14790	0.066609	-1.1601	0.159	0.0412
hematology	mean platelet volume (MPV)	0.23313	0.091161	1.0971	0.0915	0.0204
hematology	mean RBC corpuscular hemoglobin (MCH)	0.10196	0.33007	0.37157	0.898	0.761
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.15245	0.72430	-0.34796	0.946	0.836
hematology	mean RBC corpuscular volume (MCV)	0.19133	0.30131	0.36757	0.740	0.534
hematology	measured hemoglobin (mHGB)	-0.44902	0.37935	-1.1093	0.565	0.253
hematology	monocyte differential (percent of total WBC)	0.030392	0.15150	0.31110	0.940	0.843
hematology	neutrophil differential (percent of total WBC)	1.6946	1.3500	0.86285	0.475	0.226
hematology	platelet count (PLT; units per volume x 10³)	26.277	48.434	0.40142	0.840	0.594
hematology	RBC corpuscular distribution width (RDW)	0.40648	0.23799	1.2507	0.335	0.107
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.47113	0.24125	-1.2467	0.235	0.0686
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.38466	0.17445	-1.6375	0.215	0.0415
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-32.986	20.084	-1.2494	0.487	0.119
hematology	reticulocyte differential (percent of total RBC)	-0.18770	0.25732	-0.60966	0.774	0.476
hematology	white blood cell count (WBC; units per volume x 10³)	-0.56054	0.61945	-0.22606	0.585	0.379
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.23160	0.72837	-0.17732	0.939	0.752
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.28613	0.48938	-0.33087	0.887	0.562
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.45155	0.46560	-0.68566	0.801	0.338
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.36786	0.73466	-0.27257	0.891	0.619
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.84863	0.77192	-1.2796	0.767	0.278
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.023390	0.27438	0.12175	0.994	0.932
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.16609	0.43698	0.45934	0.971	0.706
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.33819	0.57774	-0.44373	0.902	0.562
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.76544	0.34847	-1.2238	0.398	0.0341
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.10333	0.23597	0.34500	0.946	0.664
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.062636	0.48321	0.19204	0.979	0.898
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.53106	0.42596	-0.79263	0.665	0.220
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.22278	0.75049	-0.13876	0.937	0.768
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.10285	0.52868	-0.089521	0.969	0.847
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.24310	0.46178	0.43505	0.888	0.601
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.53873	0.95706	0.51052	0.878	0.577
holeboard	total number of hole pokes, 20 min test	-3.1669	4.9688	-0.33332	0.755	0.528
light / dark	fecal boli count, 20 min test	-0.59583	0.87376	-0.62934	0.825	0.499
light / dark	latency to enter dark zone, 20 min test	-30.700	57.593	-0.67874	0.872	0.597
light / dark	number of transitions between light and dark zones, 20 min test	4.9292	6.3028	0.54499	0.717	0.439
light / dark	percentage of total time in dark zone, 20 min test	-1.6481	5.0981	-0.17119	0.915	0.748
light / dark	percentage of total time in light zone, 20 min test	1.6481	5.0981	0.16707	0.917	0.748
light / dark	time mobile in dark zone, 20 min test	28.171	11.642	1.2645	0.139	0.0200
light / dark	time mobile in light zone, 20 min test	16.431	9.7813	0.70971	0.309	0.101
light / dark	time spent in dark zone, 20 min test	-18.124	60.925	-0.062233	0.929	0.768
light / dark	time spent in light zone, 20 min test	18.124	60.925	0.062233	0.929	0.768
open field	average speed in center of arena, 20 min test	0.33025	0.33672	0.50768	0.665	0.332
open field	average speed in periphery of arena, 20 min test	0.34636	0.13448	0.79361	0.0703	0.0138
open field	distance traveled habituation ratio, 20 min test	-4.9450	6.6422	-0.38453	0.736	0.461
open field	distance traveled in center of arena, 20 min test	162.29	87.678	0.66399	0.242	0.0716
open field	distance traveled in periphery of arena, 20 min test	362.69	131.41	0.93194	0.0625	0.00860
open field	distance traveled slope, 20 min test	-7.3989	6.2848	-0.63580	0.576	0.246
open field	distance traveled, 20 min test, 1st 5min	159.52	56.696	0.88727	0.0537	0.00749
open field	distance traveled, 20 min test, 2nd 5min	173.10	48.437	1.2837	0.0129	0.000937
open field	distance traveled, 20 min test, 3rd 5min	65.108	55.663	0.28090	0.494	0.249
open field	distance traveled, 20 min test, 4th 5min	120.69	47.156	0.84047	0.0871	0.0143
open field	number of clockwise revolution episodes, 20 min test	2.6835	1.1008	1.0524	0.159	0.0192
open field	number of counter-clockwise revolution episodes, 20 min test	2.7667	1.1136	1.0251	0.148	0.0172
open field	number of fecal boli, 20 min test	-1.4233	0.93553	-0.90509	0.441	0.136
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.1708	1.7100	0.39561	0.476	0.211
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.1553	2.7950	-0.074583	0.844	0.681
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.4111	2.9451	0.27113	0.681	0.418
open field	number of rears in 5 min bins, 20 min test, 4th 5min	3.5875	2.8685	0.44600	0.487	0.218
open field	percentage of total time in center of arena, 20 min test	3.8445	2.3750	0.68082	0.406	0.113
open field	percentage of total time in center of arena, slope, 20 min test	2.4832	1.3505	1.5072	0.488	0.0732
open field	percentage of total time in center, habituation ratio, 20 min test	2.4401	1.3916	1.4549	0.529	0.0870
open field	percentage of total time in corners of arena, 20 min test	-5.8454	3.4358	-0.81027	0.379	0.0965
open field	percentage of total time in corners, habituation ratio, 20 min test	-2.7261	1.9032	-1.5371	0.641	0.160
open field	percentage of total time in corners, slope, 20 min test	-2.7126	1.7745	-1.6064	0.629	0.134
open field	permanence time in center of arena, 20 min test	46.140	28.498	0.68421	0.406	0.113
open field	permanence time in corners of arena, 20 min test	-70.130	41.225	-0.80841	0.379	0.0965
open field	permanence time in periphery of arena, 20 min test	-46.125	28.494	-0.68421	0.406	0.113
open field	total distance traveled, 20 min test	471.47	178.89	0.81401	0.0624	0.0119
open field	total number of rears, 20 min test	9.3868	9.2183	0.30472	0.569	0.315
open field	whole arena average speed, 20 min test	0.39185	0.14934	0.81401	0.0642	0.0122
open field	whole arena resting time, 20 min test	-55.775	20.820	-0.92368	0.0559	0.0107
open field	whole arena time spent mobile, 20 min test	55.548	20.811	1.1282	0.0591	0.0109
open field	whole arena time spent vertical, 20 min test	1.7106	8.6716	0.026184	0.936	0.845
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-3.8396	1.3241	-1.4174	0.0870	0.00598
startle / PPI	average baseline movement during background noise	0.63417	1.8534	0.49204	0.950	0.734
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.063194	0.058126	0.49045	0.641	0.284
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.043326	0.056246	0.34699	0.766	0.446
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-3.7928	8.4949	-0.36300	0.949	0.658
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	4.5710	5.3679	0.40068	0.724	0.400
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	6.8794	5.1579	0.62134	0.480	0.191
startle / PPI	average startle response to full pulse (120 dB)	32.678	50.016	0.84722	0.745	0.518
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	70.406	44.061	1.3006	0.317	0.119
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	26.549	35.905	0.75267	0.662	0.465
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	11.000	33.839	0.46220	0.857	0.747
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.34725	1.0584	-0.21246	0.960	0.745
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.3947	1.0946	-0.94565	0.724	0.211
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.9068	1.9768	0.67493	0.740	0.341
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.038519	0.093088	-0.30668	0.932	0.682
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.050488	0.060150	0.33807	0.710	0.407
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.11704	0.064172	0.72463	0.258	0.0767
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	31.841	50.562	0.83923	0.756	0.533
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	71.068	44.219	1.2973	0.313	0.117
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	28.051	36.338	0.78087	0.644	0.445
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	8.1805	34.653	0.42050	0.902	0.815
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.0011027	0.098207	0.023121	0.998	0.991
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.079911	0.063753	0.54934	0.562	0.218
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.13701	0.064999	0.80348	0.193	0.0423
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	94.137	178.26	0.71597	0.806	0.601
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	213.04	157.06	1.1630	0.407	0.184
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	55.695	131.68	0.50314	0.808	0.675
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-11.734	124.94	0.12432	0.957	0.926
startle / PPI	maximum baseline movement during background noise	1.4843	5.2109	0.53359	0.960	0.777
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.14749	9.1609	0.023121	1.00	0.987
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.6416	5.9929	0.61625	0.582	0.211
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	10.948	5.7596	0.87977	0.275	0.0656
startle / PPI	maximum startle response to full pulse (120 dB)	96.068	177.39	0.73053	0.800	0.592
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	211.77	156.81	1.1548	0.409	0.186
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	53.278	130.54	0.49362	0.814	0.686
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-5.0610	123.51	0.16680	0.980	0.968
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.96808	2.4260	-0.20101	0.935	0.692
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-3.3412	2.5490	-0.92611	0.706	0.198
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	4.0238	4.4113	0.54006	0.734	0.368

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	34.0 %	0.00124
eye morphology	cornea	males	23.0 %	0.00665
eye morphology	cornea	both	29.0 %	0.0000368
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	12.0 %	0.0696
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	6.0 %	0.0885
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	22.0 %	0.00360
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	10.0 %	0.0141
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	11.0 %	0.316
eye morphology	lens opacity	males	24.0 %	0.0186
eye morphology	lens opacity	both	17.0 %	0.0208
eye morphology	narrow eye opening	females	12.0 %	0.0786
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	6.0 %	0.0890
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	6.0 %	0.690
eye morphology	persistence of hyaloid vascular system	males	11.0 %	0.333
eye morphology	persistence of hyaloid vascular system	both	8.0 %	0.504
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	12.0 %	0.139
eye morphology	retinal blood vessels pattern	males	12.0 %	0.0346
eye morphology	retinal blood vessels pattern	both	12.0 %	0.00909
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	7.0 %	0.687
eye morphology	retinal pigmentation	both	7.0 %	0.889
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	25.0 %	0.000157
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	12.0 %	0.000625
SHIRPA	coat hair distribution head	females	12.0 %	0.0629
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	6.0 %	0.104
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	12.0 %	0.0235
SHIRPA	startle response	both	6.0 %	0.0349
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	12.0 %	0.0740
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	5.0 %	0.202
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Sdr42e1^em1(IMPC)J/Mmjax -/- with genotype: