MPD: JaxKOMP-LAP genotype: Cdc42bpb<sup>em1(IMPC)J</sup> -/+

JaxKOMP-LAP effect sizes: Cdc42bpb^em1(IMPC)J -/+ Gene Cdc42bpb

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

Procedure	JaxKOMP-LAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
body composition	body length	-0.060132	0.055201	-0.20857	0.584	0.287
body composition	body weight (at time of DXA)	-2.7283	2.5000	-0.30729	0.450	0.286
body composition	bone area, whole body scan, head excluded	0.13655	0.32776	0.54434	0.833	0.681
body composition	bone mineral content of whole body scan, head excluded	0.013623	0.019974	0.67449	0.730	0.501
body composition	bone mineral content to body weight ratio	0.00075246	0.00053805	1.0513	0.502	0.175
body composition	bone mineral density of whole body scan, head excluded	0.00057279	0.00068041	0.75829	0.659	0.408
body composition	fat tissue mass of whole body scan, head excluded	1.2148	0.59189	0.62118	0.224	0.0512
body composition	fat tissue mass to body weight ratio	0.028014	0.016178	0.72979	0.299	0.0962
body composition	lean tissue mass of whole body scan, head excluded	-0.79921	0.55995	-0.54434	0.451	0.166
body composition	lean tissue mass to body weight ratio	-0.018725	0.013431	-0.75829	0.503	0.176
body composition	percent fat, whole body scan, head excluded	2.3766	1.4922	0.72979	0.376	0.124
body composition	ratio of soft-tissue attenuation coefficients	-0.0026400	0.0016581	-0.75180	0.373	0.124
body composition	tissue area	0.035916	0.38501	0.23998	0.969	0.926
body composition	total tissue mass, whole body scan, head excluded	0.41626	0.62388	0.35293	0.852	0.511
clinical blood chemistry	alanine transaminase (plasma ALT)	686.19	750.13	2.3263	0.770	0.374
clinical blood chemistry	albumin (plasma Alb)	1.2066	1.5382	1.2700	0.732	0.445
clinical blood chemistry	alkaline phosphatase (plasma ALP)	10.650	9.9261	0.82079	0.846	0.299
clinical blood chemistry	aspartate transaminase (plasma AST)	1554.6	1686.9	2.3301	0.735	0.370
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.23094	0.18637	-0.88485	0.680	0.234
clinical blood chemistry	blood urea nitrogen (BUN)	-4.1440	4.1923	-1.1809	0.625	0.338
clinical blood chemistry	calcium (plasma Ca)	0.057659	0.15816	0.15097	0.988	0.720
clinical blood chemistry	creatinine (plasma)	-0.022500	0.022565	-0.36800	0.772	0.334
clinical blood chemistry	glucose (plasma GLU, no fast)	-9.2000	20.345	-0.81366	0.887	0.657
clinical blood chemistry	HDL cholesterol (plasma HDL)	11.668	7.1204	1.2381	0.455	0.122
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0065000	0.035977	-0.23800	0.989	0.859
clinical blood chemistry	phosphorus (plasma phosphate)	-0.090396	0.45638	-0.012409	0.890	0.845
clinical blood chemistry	total bilirubin (plasma TBIL)	3.1260e-12	0.0086177	-0.11419	1.00	1.00
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	19.391	10.943	1.4104	0.358	0.0967
clinical blood chemistry	total protein (plasma TP)	0.26921	2.1279	0.14799	0.977	0.901
clinical blood chemistry	triglyceride (plasma TG, no fast)	-1.8000	17.162	-0.037236	0.953	0.918
glucose tolerance test	amount glucose injected	-6.7307	4.0232	-1.0470	0.463	0.108
glucose tolerance test	plasma glucose, 0min	3.5951	6.3150	0.020548	0.781	0.575
glucose tolerance test	plasma glucose, 15min	46.850	29.146	0.76777	0.409	0.122
glucose tolerance test	plasma glucose, 30min	39.062	31.704	0.94578	0.649	0.230
glucose tolerance test	plasma glucose, 60min	44.611	23.350	0.88335	0.330	0.0686
glucose tolerance test	plasma glucose, 120min	21.680	14.700	0.42322	0.443	0.154
grip strength	body weight (at time of grip strength test)	-2.6623	2.4135	-0.54852	0.506	0.280
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-2.6959	9.2915	-0.21043	0.871	0.774
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.10480	0.26015	-0.29674	0.847	0.691
grip strength	forelimb and hindlimb grip strength by trial, trial1	1.4590	13.800	-0.041789	0.943	0.917
grip strength	forelimb and hindlimb grip strength by trial, trial2	-13.150	10.795	-1.0364	0.571	0.235
grip strength	forelimb and hindlimb grip strength by trial, trial3	-1.2999	9.3389	-0.10463	0.932	0.890
grip strength	forelimb grip strength (mean of trials), average	-0.36787	4.9644	-0.062707	0.968	0.942
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.0035161	0.12484	0.10463	0.978	0.978
grip strength	forelimb grip strength by trial, trial1	-4.0796	7.0046	-0.59776	0.895	0.565
grip strength	forelimb grip strength by trial, trial2	-4.3625	6.1636	-0.64849	0.844	0.486
grip strength	forelimb grip strength by trial, trial3	4.2157	6.2807	0.57297	0.807	0.508
heart weight	heart weight, normalized to body weight	-0.35841	0.23482	-1.7198	0.501	0.143
heart weight	heart weight, weight	-5.1543	6.1390	-0.84780	0.723	0.411
hematology	basophil differential (percent of total WBC)	-0.10303	0.069676	-0.84162	0.848	0.160
hematology	eosinophil differential (percent of total WBC)	-0.76500	0.45647	-1.0927	0.456	0.113
hematology	hematocrit (HCT)	0.90500	2.6946	0.46770	0.946	0.741
hematology	lymphocyte differential (percent of total WBC)	-0.61000	7.7816	-0.037236	0.962	0.938
hematology	mean corpuscular hemoglobin (CHr)	0.49029	0.21535	1.6449	0.289	0.0379
hematology	mean platelet volume (MPV)	-0.31535	0.37825	-1.2323	0.724	0.418
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.050000	0.38069	0.21254	0.915	0.897
hematology	mean RBC corpuscular volume (MCV)	0.69369	0.66471	0.71397	0.626	0.312
hematology	measured hemoglobin (mHGB)	0.29688	0.83339	0.45868	0.863	0.726
hematology	monocyte differential (percent of total WBC)	2.3991	2.6260	1.5696	0.720	0.374
hematology	neutrophil differential (percent of total WBC)	-0.90000	5.3862	-0.23800	0.945	0.869
hematology	platelet count (PLT; units per volume x 10³)	-2.2702	213.98	0.11191	0.992	0.992
hematology	RBC corpuscular distribution width (RDW)	0.20838	0.83105	0.30548	0.960	0.805
hematology	red blood cell count (RBC; per volume x 10⁶)	0.089557	0.61893	0.086973	0.933	0.887
hematology	reticulocyte count (Retic; units per volume x 10⁹)	73.080	70.979	1.2872	0.941	0.319
hematology	reticulocyte differential (percent of total RBC)	0.80900	0.86210	1.2437	0.852	0.362
hematology	white blood cell count (WBC; units per volume x 10³)	0.38900	1.1316	0.16202	0.928	0.736
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.27574	1.1587	0.025581	0.955	0.814
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.24779	0.59048	0.21043	0.949	0.678
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-1.1018	0.50426	-1.7365	0.607	0.0385
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.44501	1.0564	-0.50687	0.909	0.677
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.89141	0.61532	-1.3238	0.951	0.160
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.14015	0.40314	0.22619	0.898	0.731
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.43805	0.47204	1.0745	0.701	0.362
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.42035	0.98116	-0.56595	0.905	0.672
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.46903	0.44932	-0.72348	0.738	0.307
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.14072	0.45680	-0.21043	0.957	0.761
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.32301	0.41193	0.78409	0.805	0.440
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-1.3363	0.69923	-1.6350	0.574	0.0675
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-2.0133	0.86170	-1.6350	0.270	0.0278
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.20596	0.48596	0.28517	0.909	0.675
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.20090	0.65917	-0.30169	0.883	0.763
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.71239	0.97518	0.47800	0.882	0.472
holeboard	total number of hole pokes, 20 min test	-5.2743	5.4945	-0.75712	0.759	0.346
light / dark	latency to enter dark zone, 20 min test	-180.84	107.57	-1.3047	0.552	0.107
light / dark	number of transitions between light and dark zones, 20 min test	2.3966	4.4190	0.42340	0.908	0.593
light / dark	percentage of total time in dark zone, 20 min test	1.3536	7.7640	0.070243	0.981	0.863
light / dark	percentage of total time in light zone, 20 min test	-1.3536	7.7640	-0.070243	0.981	0.863
light / dark	time mobile in dark zone, 20 min test	7.9818	8.7798	0.15097	0.768	0.373
light / dark	time mobile in light zone, 20 min test	-6.6626	5.1850	-0.53594	0.539	0.213
light / dark	time spent in dark zone, 20 min test	143.86	110.19	1.1750	0.583	0.205
light / dark	time spent in light zone, 20 min test	-143.86	110.18	-1.1750	0.583	0.205
open field	average speed in center of arena, 20 min test	-0.19145	0.40597	-0.59085	0.833	0.642
open field	average speed in periphery of arena, 20 min test	-0.064549	0.18639	-0.44619	0.889	0.733
open field	distance traveled habituation ratio, 20 min test	-6.3941	11.061	-0.56595	0.841	0.569
open field	distance traveled in center of arena, 20 min test	-58.066	142.47	-0.44619	0.885	0.688
open field	distance traveled in periphery of arena, 20 min test	-9.8258	221.47	-0.28831	0.998	0.965
open field	distance traveled slope, 20 min test	-6.6396	11.569	-0.61612	0.849	0.572
open field	distance traveled, 20 min test, 1st 5min	29.756	85.231	0.052685	0.927	0.730
open field	distance traveled, 20 min test, 2nd 5min	-33.995	80.197	-0.51716	0.822	0.676
open field	distance traveled, 20 min test, 3rd 5min	-50.404	94.537	-0.96183	0.835	0.600
open field	distance traveled, 20 min test, 4th 5min	-22.239	58.894	-0.59085	0.897	0.710
open field	number of clockwise revolution episodes, 20 min test	-0.10973	1.5352	-0.33252	0.968	0.944
open field	number of counter-clockwise revolution episodes, 20 min test	-0.20801	1.1630	-0.49323	0.966	0.860
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.5105	4.4612	0.35487	0.943	0.738
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	3.7268	5.1464	0.44619	0.678	0.477
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-4.8693	4.0962	-0.99584	0.542	0.248
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-2.8131	4.0998	-0.59085	0.770	0.500
open field	percentage of total time in center of arena, 20 min test	-1.4476	9.2724	-0.15864	0.963	0.877
open field	percentage of total time in center of arena, slope, 20 min test	3.6937	3.6140	1.2768	0.744	0.318
open field	percentage of total time in center, habituation ratio, 20 min test	4.1354	3.8681	1.2768	0.715	0.297
open field	percentage of total time in corners of arena, 20 min test	-6.4927	6.4544	-0.80613	0.633	0.325
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.58380	2.4492	-0.31034	0.925	0.814
open field	percentage of total time in corners, slope, 20 min test	0.049575	2.4898	-0.28831	0.986	0.984
open field	permanence time in center of arena, 20 min test	-17.367	111.28	-0.15864	0.963	0.877
open field	permanence time in corners of arena, 20 min test	-77.912	77.452	-0.80613	0.633	0.325
open field	permanence time in periphery of arena, 20 min test	17.370	111.28	0.15864	0.964	0.877
open field	total distance traveled, 20 min test	-59.132	229.76	-0.54140	0.946	0.799
open field	total number of rears, 20 min test	-2.1060	15.133	-0.22301	0.924	0.891
open field	whole arena average speed, 20 min test	-0.047655	0.19103	-0.51716	0.948	0.805
open field	whole arena resting time, 20 min test	9.8826	37.073	0.35487	0.866	0.792
open field	whole arena time spent mobile, 20 min test	-1.6495	5.0351	-0.35487	0.872	0.746
open field	whole arena time spent vertical, 20 min test	-26.564	22.121	-1.0310	0.673	0.243
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.6062	1.2828	-0.98917	0.217	0.0530

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

Procedure	JaxKOMP-LAP Trait	Trait Effect	P-value
eye morphology	anterior chamber depth	2.0 %	1.0
eye morphology	bulging eye	2.0 %	1.0
eye morphology	cornea	5.0 %	1.0
eye morphology	cornea opacity	5.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.0
eye morphology	corneal mineralization	19.0 %	0.0970
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	2.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	2.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.00
eye morphology	fusion between cornea and lens	5.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	2.0 %	1.0
eye morphology	irispupil	4.0 %	1.0
eye morphology	lacrimation	4.0 %	1.0
eye morphology	lens	43.0 %	0.00588
eye morphology	lens opacity	9.0 %	1.0
eye morphology	narrow eye opening	2.0 %	1.0
eye morphology	optic disc	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	5.0 %	0.615
eye morphology	pupil dilation	6.0 %	0.0776
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	6.0 %	0.0844
eye morphology	retinal blood vessels	5.0 %	1.0
eye morphology	retinal blood vessels pattern	5.0 %	1.0
eye morphology	retinal blood vessels structure	5.0 %	1.0
eye morphology	retinal pigmentation	7.0 %	1.0
eye morphology	retinal structure	6.0 %	1.0
eye morphology	synechia	5.0 %	1.0
eye morphology	vitreous	5.0 %	1.0
SHIRPA	activity body position	5.0 %	1.0
SHIRPA	aggression	0.0 %	1.0
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	4.0 %	1.00
SHIRPA	body thickness	4.0 %	1.0
SHIRPA	coat color abdomen	20.0 %	0.0345
SHIRPA	coat color back	16.0 %	0.0569
SHIRPA	coat color head	4.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	0.558
SHIRPA	coat color pattern back	9.0 %	0.396
SHIRPA	coat color pattern head	4.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	0.0 %	1.0
SHIRPA	coat hair back texture appearance	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	6.0 %	0.223
SHIRPA	coat hair distribution back	18.0 %	0.0230
SHIRPA	coat hair distribution head	20.0 %	0.0928
SHIRPA	coat hair head texture appearance	2.0 %	1.0
SHIRPA	contact righting	22.0 %	0.0373
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	eye morphology	2.0 %	1.00
SHIRPA	fat distribution	8.0 %	0.371
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.00
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	2.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.00
SHIRPA	hindlimb digit shape	1.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	6.0 %	1.00
SHIRPA	hindlimb nail number	10.0 %	0.00182
SHIRPA	hindlimb nail position	0.0 %	1.00
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	1.0 %	1.00
SHIRPA	hindlimbs position	1.0 %	1.00
SHIRPA	hindlimbs shape	3.0 %	1.00
SHIRPA	hindlimbs size	1.0 %	1.00
SHIRPA	hindpaw position	0.0 %	1.00
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	1.0 %	1.00
SHIRPA	limb grasp	19.0 %	0.0577
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.00
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	1.0 %	1.00
SHIRPA	startle response	5.0 %	0.794
SHIRPA	tail curvature	1.0 %	1.0
SHIRPA	tail elevation	2.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	2.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	5.0 %	0.0982
SHIRPA	tail thickness	1.0 %	1.00
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	7.0 %	0.657
SHIRPA	tremor	2.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	4.0 %	1.00
SHIRPA	vibrissae presence	13.0 %	0.327
SHIRPA	vocalization	7.0 %	0.626

GENOTYPE CORRELATION PLOT

Correlate Cdc42bpb^em1(IMPC)J -/+ with genotype:

This genotype correlation visualization can include both EAP and LAP measures.