MPD: JaxKOMP-EAP genotype: Acy3<sup>em1(IMPC)J</sup>/Mmjax -/-

JaxKOMP-EAP effect sizes: Acy3^em1(IMPC)J/Mmjax -/- Gene Acy3

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	2.7498	1.4205	0.57467	0.410	0.0672
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	4.1647	1.8858	0.86982	0.375	0.0391
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	4.5000	1.5660	0.70922	0.146	0.00939
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	6.4042	3.0238	0.89329	0.302	0.0469
body composition	body length	-0.017350	0.034962	-0.0089278	0.819	0.622
body composition	body weight (at time of DXA)	0.79254	0.68812	0.74876	0.470	0.255
body composition	bone area, whole body scan, head excluded	0.0024198	0.13980	0.19232	0.997	0.986
body composition	bone mineral content of whole body scan, head excluded	0.0039882	0.010915	0.37446	0.873	0.716
body composition	bone mineral content to body weight ratio	-0.00016215	0.00047937	-0.046436	0.874	0.737
body composition	bone mineral density of whole body scan, head excluded	0.00044095	0.00052693	0.50801	0.690	0.407
body composition	fat tissue mass of whole body scan, head excluded	0.19817	0.31118	0.34098	0.751	0.527
body composition	fat tissue mass to body weight ratio	0.0052135	0.010756	0.30645	0.807	0.630
body composition	lean tissue mass of whole body scan, head excluded	0.50367	0.29485	0.85375	0.351	0.0941
body composition	lean tissue mass to body weight ratio	0.0063468	0.012324	0.28593	0.810	0.609
body composition	percent fat, whole body scan, head excluded	0.33417	1.0454	0.25109	0.886	0.751
body composition	ratio of soft-tissue attenuation coefficients	-0.00036562	0.0011622	-0.25306	0.889	0.754
body composition	tissue area	0.38611	0.18101	1.3049	0.208	0.0381
body composition	total tissue mass, whole body scan, head excluded	0.69339	0.23386	1.1677	0.0429	0.00470
clinical blood chemistry	alanine transaminase (plasma ALT)	-2.2178	6.8978	-0.24108	0.926	0.751
clinical blood chemistry	albumin (plasma Alb)	-0.17622	0.50094	-0.21553	0.901	0.729
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-0.074457	3.2891	-0.53696	0.990	0.982
clinical blood chemistry	aspartate transaminase (plasma AST)	-8.5335	22.446	-0.41728	0.902	0.708
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.090850	0.39135	0.31155	0.940	0.819
clinical blood chemistry	blood urea nitrogen (BUN)	5.3093	1.9786	1.9573	0.103	0.0139
clinical blood chemistry	calcium (plasma Ca)	-0.29471	0.11056	-1.6739	0.0909	0.0145
clinical blood chemistry	creatinine (plasma)	0.090827	0.029457	2.0629	0.0552	0.00612
clinical blood chemistry	glucose (plasma GLU, no fast)	-41.631	10.200	-1.1081	0.00665	0.000535
clinical blood chemistry	HDL cholesterol (plasma HDL)	1.0315	3.2650	-0.070198	0.907	0.755
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.028506	0.017576	-1.6733	0.430	0.120
clinical blood chemistry	phosphorus (plasma phosphate)	-0.12207	0.35231	-0.24394	0.873	0.732
clinical blood chemistry	total bilirubin (plasma TBIL)	0.024417	0.025369	1.3690	0.691	0.347
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	4.3017	4.6874	0.52098	0.672	0.370
clinical blood chemistry	total protein (plasma TP)	-0.14625	0.97426	-0.17359	0.948	0.882
clinical blood chemistry	triglyceride (plasma TG, no fast)	10.054	8.5697	0.74631	0.553	0.255
EKG	duration of PQ interval	1.5725	1.0951	1.7392	0.734	0.167
EKG	duration of PR interval	1.1300	1.1581	1.2519	0.864	0.341
EKG	duration of QRS interval	-0.41843	0.45909	-1.2608	0.897	0.373
EKG	duration of QT interval	0.64000	1.1350	0.78496	0.898	0.579
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.039754	1.0913	0.012090	0.999	0.971
EKG	duration of RR interval	0.99125	1.9311	0.79321	0.866	0.614
EKG	duration of ST interval	0.83750	1.0774	1.0701	0.858	0.447
EKG	heart rate coefficient of variation (signal intensity)	1.0894	1.4198	0.96849	0.878	0.452
EKG	heart rate variability, mean of differences between sequential beats; beats per min	7.0075	9.7710	0.89991	0.887	0.482
EKG	heart rate, beats per min	-6.4625	14.920	-0.68401	0.876	0.670
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.20488	0.10811	1.4640	0.369	0.0734
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.26675	0.13727	1.4408	0.346	0.0669
EKG	number of signals	0.82500	5.0768	0.14763	0.976	0.873
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	6.0260	5.2033	1.1743	0.816	0.261
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-5.6625	2.6900	-1.5728	0.858	0.0488
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-6.5438	2.5613	-1.6159	0.654	0.0194
EKG	root mean square of successive differences of neighboring RR intervals	1.0405	2.2246	0.68210	0.935	0.645
glucose tolerance test	amount glucose injected	-5.2163	3.1885	-1.0858	0.455	0.118
glucose tolerance test	plasma glucose, 0min	0.76381	8.4556	-0.15019	0.969	0.929
glucose tolerance test	plasma glucose, 15min	-19.113	18.120	-0.40924	0.636	0.304
glucose tolerance test	plasma glucose, 30min	-25.401	20.472	-0.67363	0.571	0.230
glucose tolerance test	plasma glucose, 60min	-5.6553	14.230	-0.12940	0.888	0.695
glucose tolerance test	plasma glucose, 120min	20.701	14.283	1.2438	0.475	0.164
grip strength	body weight (at time of grip strength test)	-0.32073	0.48816	-0.095886	0.695	0.517
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-16.782	6.5901	-0.89281	0.0802	0.0177
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.55237	0.29396	-0.62516	0.212	0.0724
grip strength	forelimb and hindlimb grip strength by trial, trial1	-19.155	7.5056	-1.0092	0.119	0.0172
grip strength	forelimb and hindlimb grip strength by trial, trial2	-14.449	10.684	-0.67723	0.432	0.188
grip strength	forelimb and hindlimb grip strength by trial, trial3	-15.448	8.2418	-0.80333	0.272	0.0731
grip strength	forelimb grip strength (mean of trials), average	-15.696	5.3366	-1.5624	0.0607	0.00695
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.51298	0.24301	-1.0362	0.203	0.0454
grip strength	forelimb grip strength by trial, trial1	-17.221	6.2516	-1.5824	0.131	0.0108
grip strength	forelimb grip strength by trial, trial2	-20.902	6.1823	-1.8075	0.0477	0.00238
grip strength	forelimb grip strength by trial, trial3	-8.9247	5.7041	-0.70862	0.413	0.130
heart weight	heart weight, normalized to body weight	-0.024560	0.13013	-0.54545	0.924	0.852
heart weight	heart weight, weight	0.47519	2.8607	-0.30817	0.927	0.869
hematology	basophil differential (percent of total WBC)	-0.034603	0.047697	-0.51153	0.815	0.476
hematology	calculated hemoglobin (cHGB)	-0.32482	0.17839	-1.1411	0.299	0.0823
hematology	eosinophil differential (percent of total WBC)	-0.10324	0.23886	-0.21567	0.894	0.670
hematology	hematocrit (HCT)	0.31241	0.58234	-0.042382	0.785	0.597
hematology	hemoglobin concentration distribution width (HDW)	-0.027897	0.023796	-0.77276	0.563	0.254
hematology	large unstained cells (percent of total WBC)	0.14415	0.13614	0.91997	0.641	0.301
hematology	lymphocyte differential (percent of total WBC)	-2.8898	2.1077	-1.2057	0.442	0.184
hematology	mean corpuscular hemoglobin (CHr)	-0.088509	0.053341	-0.71720	0.304	0.112
hematology	mean platelet volume (MPV)	0.89167	0.24508	2.2736	0.0132	0.00145
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.0020833	0.082284	-0.033974	0.988	0.980
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.76875	0.21092	-1.1082	0.0505	0.00143
hematology	mean RBC corpuscular volume (MCV)	1.0292	0.24676	1.6025	0.00524	0.000398
hematology	measured hemoglobin (mHGB)	-0.31979	0.17964	-0.92149	0.342	0.0889
hematology	monocyte differential (percent of total WBC)	-0.16880	0.23575	-0.34572	0.774	0.482
hematology	neutrophil differential (percent of total WBC)	2.9246	2.0044	1.3276	0.394	0.159
hematology	platelet count (PLT; units per volume x 10³)	32.597	30.033	0.49823	0.646	0.290
hematology	RBC corpuscular distribution width (RDW)	0.0041667	0.16917	0.0089083	0.992	0.981
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.84167	0.21482	-1.8828	0.0120	0.000736
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.18754	0.12719	-1.0621	0.409	0.155
hematology	reticulocyte count (Retic; units per volume x 10⁹)	24.021	13.528	1.0477	0.433	0.0903
hematology	reticulocyte differential (percent of total RBC)	0.30167	0.14759	1.3146	0.345	0.0531
hematology	white blood cell count (WBC; units per volume x 10³)	-0.38633	0.51252	-0.093074	0.649	0.459
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.84703	0.45846	0.85858	0.494	0.0707
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.46455	0.41975	0.85128	0.775	0.274
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.23228	0.46716	-0.31132	0.918	0.621
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.17313	0.54482	0.25335	0.928	0.752
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.27659	0.44478	0.56058	0.880	0.537
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.35634	0.24147	0.94786	0.777	0.146
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.30458	0.30002	0.77964	0.849	0.315
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.36211	0.30947	-0.49080	0.757	0.248
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.67207	0.38139	1.2132	0.513	0.0844
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.42024	0.25724	1.0727	0.711	0.109
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.92833	0.35694	1.8568	0.491	0.0123
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.19590	0.38234	0.44434	0.906	0.611
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.87053	0.54298	0.92692	0.505	0.115
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.061101	0.50220	0.19350	0.982	0.904
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.72948	0.44542	1.1761	0.570	0.108
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.7181	0.80702	1.4809	0.372	0.0383
holeboard	total number of hole pokes, 20 min test	7.7080	3.2409	1.0865	0.159	0.0213
light / dark	fecal boli count, 20 min test	-0.64185	0.61708	-0.67449	0.711	0.303
light / dark	latency to enter dark zone, 20 min test	-60.444	40.364	-1.2379	0.579	0.141
light / dark	number of transitions between light and dark zones, 20 min test	12.875	6.5886	1.2645	0.291	0.0563
light / dark	percentage of total time in dark zone, 20 min test	-0.94087	4.6960	-0.033807	0.951	0.842
light / dark	percentage of total time in light zone, 20 min test	0.94087	4.6960	0.032454	0.952	0.842
light / dark	time mobile in dark zone, 20 min test	44.822	13.485	1.8253	0.0271	0.00167
light / dark	time mobile in light zone, 20 min test	31.406	10.359	1.3436	0.0443	0.00385
light / dark	time spent in dark zone, 20 min test	41.205	53.312	0.85675	0.797	0.443
light / dark	time spent in light zone, 20 min test	-41.205	53.312	-0.85675	0.797	0.443
open field	average speed in center of arena, 20 min test	-0.13502	0.37478	-0.35005	0.899	0.720
open field	average speed in periphery of arena, 20 min test	0.36858	0.12654	0.86950	0.0379	0.00534
open field	distance traveled habituation ratio, 20 min test	-9.7550	7.7409	-0.81963	0.534	0.213
open field	distance traveled in center of arena, 20 min test	39.297	86.924	-0.14212	0.805	0.653
open field	distance traveled in periphery of arena, 20 min test	388.64	122.59	1.0297	0.0267	0.00260
open field	distance traveled slope, 20 min test	-11.468	6.8385	-1.0071	0.373	0.0998
open field	distance traveled, 20 min test, 1st 5min	150.50	74.314	0.81027	0.185	0.0482
open field	distance traveled, 20 min test, 2nd 5min	134.11	50.227	0.96993	0.0670	0.0102
open field	distance traveled, 20 min test, 3rd 5min	69.537	44.762	0.32872	0.329	0.127
open field	distance traveled, 20 min test, 4th 5min	66.620	41.584	0.27810	0.312	0.115
open field	number of clockwise revolution episodes, 20 min test	1.1625	1.0371	0.26363	0.623	0.268
open field	number of counter-clockwise revolution episodes, 20 min test	1.9750	1.1632	0.61458	0.344	0.0957
open field	number of fecal boli, 20 min test	-0.47500	0.98906	-0.081874	0.839	0.633
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.5625	2.3901	0.23315	0.745	0.516
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.9125	2.4788	0.13534	0.705	0.444
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-1.1671	2.8418	-0.55719	0.843	0.683
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.6616	3.2807	0.024841	0.809	0.615
open field	percentage of total time in center of arena, 20 min test	1.6407	2.5686	0.18021	0.793	0.526
open field	percentage of total time in center of arena, slope, 20 min test	0.67895	1.1287	0.50463	0.868	0.550
open field	percentage of total time in center, habituation ratio, 20 min test	0.43228	1.1928	0.34150	0.928	0.719
open field	percentage of total time in corners of arena, 20 min test	-3.0621	3.6522	-0.23923	0.692	0.406
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.80258	1.7515	-0.67913	0.931	0.649
open field	percentage of total time in corners, slope, 20 min test	-0.80588	1.6559	-0.67407	0.918	0.629
open field	permanence time in center of arena, 20 min test	19.679	30.823	0.18021	0.794	0.526
open field	permanence time in corners of arena, 20 min test	-36.738	43.825	-0.23923	0.692	0.406
open field	permanence time in periphery of arena, 20 min test	-19.735	30.826	-0.18021	0.792	0.525
open field	total distance traveled, 20 min test	424.89	172.68	0.71855	0.0804	0.0174
open field	total number of rears, 20 min test	4.6057	9.7374	-0.020812	0.812	0.638
open field	whole arena average speed, 20 min test	0.35412	0.14399	0.71855	0.0807	0.0174
open field	whole arena resting time, 20 min test	-57.710	17.722	-0.96778	0.0170	0.00203
open field	whole arena time spent mobile, 20 min test	57.646	17.712	1.1671	0.0180	0.00204
open field	whole arena time spent vertical, 20 min test	-2.3392	9.3000	-0.30050	0.920	0.802
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.18409	1.6236	0.098153	0.974	0.911
startle / PPI	average baseline movement during background noise	-0.20094	1.5327	-0.068007	0.992	0.897
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.052351	0.081927	0.38404	0.796	0.528
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.027147	0.068804	0.19837	0.878	0.696
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	3.4647	9.1521	0.42970	0.957	0.708
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	9.2403	7.6936	0.89431	0.616	0.240
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	11.963	6.7293	1.0941	0.325	0.0867
startle / PPI	average startle response to full pulse (120 dB)	-76.921	48.966	-1.1122	0.325	0.127
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-76.078	44.103	-1.0992	0.272	0.0955
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-74.581	39.076	-1.1658	0.213	0.0666
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-62.157	36.049	-1.1493	0.278	0.0961
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	1.0033	1.8125	0.70875	0.913	0.584
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.6296	2.1553	-1.1200	0.866	0.456
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.2023	1.9416	-0.80970	0.855	0.541
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.015470	0.097098	0.18958	0.978	0.875
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.062306	0.090486	0.43792	0.765	0.497
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.13572	0.075432	0.84683	0.271	0.0832
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-76.663	48.869	-1.0992	0.324	0.128
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-77.230	44.106	-1.1096	0.264	0.0909
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-73.098	39.745	-1.1359	0.231	0.0765
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-61.005	35.759	-1.1148	0.271	0.0995
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.013066	0.10628	0.14553	0.989	0.903
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.061163	0.098176	0.40016	0.790	0.538
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.10427	0.080705	0.59224	0.465	0.207
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-307.15	173.79	-1.2531	0.258	0.0881
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-266.22	151.90	-1.0865	0.266	0.0906
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-268.72	144.43	-1.1685	0.222	0.0733
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-224.42	128.22	-1.1122	0.254	0.0914
startle / PPI	maximum baseline movement during background noise	-1.1028	4.0319	-0.25856	0.960	0.786
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	1.7755	10.114	0.22969	0.988	0.862
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.5745	8.9801	0.60443	0.726	0.406
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	9.7935	7.3802	0.77707	0.485	0.196
startle / PPI	maximum startle response to full pulse (120 dB)	-308.51	174.14	-1.2531	0.255	0.0873
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-263.71	152.30	-1.0840	0.273	0.0944
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-272.93	143.05	-1.1910	0.210	0.0667
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-228.30	129.08	-1.1332	0.252	0.0882
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	2.2592	4.0463	0.71960	0.895	0.581
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-4.5257	4.5695	-1.2141	0.782	0.331
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-4.2090	4.5274	-1.0591	0.730	0.360

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	15.0 %	0.173
eye morphology	irispupil	both	6.0 %	0.394
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.00
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.00
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	15.0 %	0.262
eye morphology	persistence of hyaloid vascular system	both	3.0 %	0.745
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.00
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	25.0 %	0.0294
eye morphology	retinal pigmentation	males	13.0 %	0.423
eye morphology	retinal pigmentation	both	16.0 %	0.0521
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	12.0 %	0.0740
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	5.0 %	0.202
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Acy3^em1(IMPC)J/Mmjax -/- with genotype: