MPD: JaxKOMP-EAP genotype: Cachd1<sup>em1(IMPC)J</sup> -/+

JaxKOMP-EAP effect sizes: Cachd1^em1(IMPC)J -/+ Gene Cachd1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-0.19850	3.9388	-0.33764	0.988	0.962
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.22427	2.7777	-0.026217	0.976	0.939
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	2.3577	2.6093	0.31995	0.744	0.408
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	0.90960	7.8607	0.014779	0.972	0.912
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	3.2324	5.0999	0.48996	0.824	0.554
body composition	body length	0.010920	0.036403	0.34968	0.900	0.765
body composition	body weight (at time of DXA)	0.49060	0.53810	0.50431	0.583	0.366
body composition	bone area, whole body scan, head excluded	0.27170	0.12796	1.3483	0.187	0.0389
body composition	bone mineral content of whole body scan, head excluded	0.027904	0.010549	1.7286	0.0878	0.0110
body composition	bone mineral content to body weight ratio	0.0011438	0.00043643	1.6598	0.0878	0.0117
body composition	bone mineral density of whole body scan, head excluded	0.0015325	0.00050716	1.5978	0.0580	0.00402
body composition	fat tissue mass of whole body scan, head excluded	-0.085463	0.33498	-0.14937	0.905	0.800
body composition	fat tissue mass to body weight ratio	-0.0057649	0.010989	-0.20764	0.785	0.602
body composition	lean tissue mass of whole body scan, head excluded	0.43807	0.32636	0.75378	0.492	0.186
body composition	lean tissue mass to body weight ratio	0.016546	0.0095907	0.81658	0.293	0.0909
body composition	percent fat, whole body scan, head excluded	-0.82326	1.0548	-0.36277	0.669	0.439
body composition	ratio of soft-tissue attenuation coefficients	0.00091626	0.0011724	0.35776	0.669	0.438
body composition	tissue area	-0.11606	0.17964	-0.22326	0.795	0.521
body composition	total tissue mass, whole body scan, head excluded	0.36362	0.27527	0.56046	0.430	0.193
clinical blood chemistry	alanine transaminase (plasma ALT)	2.5336	1.9391	0.22651	0.585	0.208
clinical blood chemistry	albumin (plasma Alb)	1.2365	0.41184	1.7082	0.101	0.00765
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.3895	2.4786	0.065937	0.433	0.188
clinical blood chemistry	aspartate transaminase (plasma AST)	23.295	5.9063	0.88820	0.0336	0.000951
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.59047	0.14746	1.5358	0.0663	0.000919
clinical blood chemistry	blood urea nitrogen (BUN)	4.1051	2.1408	1.5403	0.254	0.0712
clinical blood chemistry	calcium (plasma Ca)	0.72331	0.091712	2.6546	0.0000881	3.00e-7
clinical blood chemistry	creatinine (plasma)	0.036326	0.017097	0.98885	0.200	0.0477
clinical blood chemistry	glucose (plasma GLU, no fast)	4.8569	10.943	0.47984	0.811	0.662
clinical blood chemistry	HDL cholesterol (plasma HDL)	6.0834	4.5333	1.0495	0.498	0.197
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0060700	0.013692	0.19989	0.884	0.663
clinical blood chemistry	phosphorus (plasma phosphate)	0.49868	0.22652	0.69748	0.200	0.0410
clinical blood chemistry	total bilirubin (plasma TBIL)	0.013353	0.010790	0.84608	0.579	0.232
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	8.7159	5.4443	1.1459	0.407	0.128
clinical blood chemistry	total protein (plasma TP)	5.0376	0.79154	2.1181	0.00101	0.00000706
clinical blood chemistry	triglyceride (plasma TG, no fast)	-2.4015	10.112	0.091695	0.917	0.815
EKG	duration of PQ interval	-0.45198	1.0920	-0.34098	0.939	0.684
EKG	duration of PR interval	-0.33347	1.0704	-0.24836	0.938	0.759
EKG	duration of QRS interval	-0.10524	0.36416	-0.43220	0.976	0.776
EKG	duration of QT interval	-0.12366	0.75063	0.036277	0.982	0.871
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.86186	1.0421	-0.82678	0.896	0.419
EKG	duration of RR interval	3.6258	2.2744	2.0198	0.533	0.127
EKG	duration of ST interval	-0.11366	0.62686	0.10092	0.969	0.858
EKG	heart rate coefficient of variation (signal intensity)	0.97608	1.1638	0.89089	0.867	0.412
EKG	heart rate variability, mean of differences between sequential beats; beats per min	5.8127	8.0848	0.73916	0.887	0.481
EKG	heart rate, beats per min	-29.294	18.208	-1.9610	0.496	0.124
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.13374	0.11374	-1.1716	0.623	0.254
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.22998	0.15551	-1.4020	0.516	0.156
EKG	number of signals	3.7542	5.5236	0.70517	0.877	0.505
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.54031	4.9396	-0.042740	0.990	0.914
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.4417	3.9845	0.44997	0.968	0.721
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	2.8589	4.2707	0.76052	0.931	0.511
EKG	root mean square of successive differences of neighboring RR intervals	2.2082	1.8698	1.1924	0.843	0.252
glucose tolerance test	amount glucose injected	-1.2784	3.7567	-0.021314	0.918	0.747
glucose tolerance test	plasma glucose, 0min	-15.016	16.007	-1.5085	0.618	0.391
glucose tolerance test	plasma glucose, 15min	15.836	21.207	0.57356	0.776	0.489
glucose tolerance test	plasma glucose, 30min	27.786	20.666	0.93789	0.575	0.237
glucose tolerance test	plasma glucose, 60min	22.292	11.302	0.97696	0.382	0.106
glucose tolerance test	plasma glucose, 120min	-1.1239	15.631	-0.19478	0.971	0.945
grip strength	body weight (at time of grip strength test)	0.25479	0.47861	0.45795	0.754	0.598
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-22.310	7.0466	-1.2869	0.0262	0.00325
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.93277	0.33344	-1.1165	0.0533	0.00853
grip strength	forelimb and hindlimb grip strength by trial, trial1	-23.275	9.2925	-1.2969	0.119	0.0172
grip strength	forelimb and hindlimb grip strength by trial, trial2	-25.984	7.2106	-1.3976	0.0219	0.000992
grip strength	forelimb and hindlimb grip strength by trial, trial3	-17.188	9.2981	-0.89281	0.272	0.0732
grip strength	forelimb grip strength (mean of trials), average	-15.371	4.8429	-1.5150	0.0355	0.00319
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.71668	0.25599	-1.4212	0.0714	0.00848
grip strength	forelimb grip strength by trial, trial1	-15.973	5.2107	-1.4373	0.0770	0.00424
grip strength	forelimb grip strength by trial, trial2	-18.163	6.1006	-1.5723	0.0792	0.00533
grip strength	forelimb grip strength by trial, trial3	-11.719	5.7640	-0.98772	0.254	0.0499
heart weight	heart weight, normalized to body weight	0.17843	0.12148	0.18551	0.358	0.160
heart weight	heart weight, weight	3.4331	3.4427	0.096767	0.547	0.332
hematology	basophil differential (percent of total WBC)	-0.012936	0.071077	-0.19198	0.966	0.857
hematology	calculated hemoglobin (cHGB)	0.46274	0.42069	1.1411	0.565	0.283
hematology	eosinophil differential (percent of total WBC)	-0.80517	0.23127	-1.8060	0.0775	0.00212
hematology	hematocrit (HCT)	1.0737	1.3461	0.87681	0.688	0.433
hematology	hemoglobin concentration distribution width (HDW)	-0.091731	0.067464	-2.1121	0.490	0.188
hematology	large unstained cells (percent of total WBC)	-0.28311	0.29178	-1.6392	0.669	0.342
hematology	lymphocyte differential (percent of total WBC)	4.4096	1.9197	1.4340	0.166	0.0315
hematology	mean corpuscular hemoglobin (CHr)	0.099332	0.10767	0.79069	0.611	0.366
hematology	mean platelet volume (MPV)	-0.24155	0.11654	-1.3911	0.168	0.0496
hematology	mean RBC corpuscular hemoglobin (MCH)	0.18956	0.12115	0.71608	0.467	0.132
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.61647	0.31496	1.1631	0.345	0.0631
hematology	mean RBC corpuscular volume (MCV)	-0.39378	0.27238	-0.71892	0.356	0.162
hematology	measured hemoglobin (mHGB)	0.25205	0.49531	0.42773	0.816	0.616
hematology	monocyte differential (percent of total WBC)	-0.10101	0.15151	-0.13710	0.790	0.512
hematology	neutrophil differential (percent of total WBC)	-3.5229	1.8269	-1.3376	0.248	0.0668
hematology	platelet count (PLT; units per volume x 10³)	-86.201	50.648	-1.0297	0.450	0.103
hematology	RBC corpuscular distribution width (RDW)	-0.59442	0.67328	-1.8486	0.633	0.386
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.48016	0.24416	1.1639	0.218	0.0620
hematology	red blood cell count (RBC; per volume x 10⁶)	0.31941	0.29452	1.0597	0.561	0.289
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-28.037	32.797	-1.0940	0.754	0.401
hematology	reticulocyte differential (percent of total RBC)	-0.54459	0.62695	-1.8090	0.726	0.394
hematology	white blood cell count (WBC; units per volume x 10³)	-0.31378	0.68648	-0.038278	0.802	0.652
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.88161	0.42108	0.88574	0.457	0.0422
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.081115	0.36859	0.27607	0.969	0.827
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.10093	0.36698	0.26732	0.949	0.785
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.59352	0.61801	0.65397	0.765	0.342
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.23695	0.35678	0.50225	0.870	0.510
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.12508	0.23985	-0.33153	0.930	0.605
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.050774	0.19317	-0.16727	0.983	0.794
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.094737	0.42708	-0.059959	0.965	0.825
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.065066	0.40374	0.22831	0.984	0.873
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.37461	0.23892	-1.0431	0.728	0.124
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.22601	0.23260	-0.60403	0.818	0.337
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.27348	0.35293	-0.39096	0.825	0.443
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.61772	0.72690	-0.52983	0.755	0.400
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.18140	0.35679	-0.19006	0.873	0.614
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.22245	0.42761	-0.26102	0.890	0.606
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.69969	0.61321	-0.56906	0.679	0.260
holeboard	total number of hole pokes, 20 min test	-0.65449	3.0459	0.0067474	0.927	0.831
light / dark	fecal boli count, 20 min test	0.10714	0.62691	0.12403	0.943	0.865
light / dark	latency to enter dark zone, 20 min test	46.739	53.470	0.71145	0.763	0.387
light / dark	number of transitions between light and dark zones, 20 min test	-3.7121	6.7209	-0.27098	0.815	0.584
light / dark	percentage of total time in dark zone, 20 min test	-2.4308	4.4006	-0.31757	0.841	0.584
light / dark	percentage of total time in light zone, 20 min test	2.4308	4.4006	0.31331	0.840	0.584
light / dark	time mobile in dark zone, 20 min test	-8.7701	12.547	-0.66856	0.756	0.488
light / dark	time mobile in light zone, 20 min test	1.4781	12.236	-0.14108	0.954	0.904
light / dark	time spent in dark zone, 20 min test	-68.460	62.407	-0.81457	0.681	0.279
light / dark	time spent in light zone, 20 min test	68.460	62.407	0.81457	0.681	0.279
open field	average speed in center of arena, 20 min test	0.33401	0.38020	0.51533	0.714	0.384
open field	average speed in periphery of arena, 20 min test	0.10225	0.14970	-0.10019	0.716	0.498
open field	distance traveled habituation ratio, 20 min test	-3.8105	6.1166	-0.27810	0.780	0.536
open field	distance traveled in center of arena, 20 min test	36.738	83.320	-0.16113	0.812	0.661
open field	distance traveled in periphery of arena, 20 min test	132.54	148.03	0.10559	0.620	0.375
open field	distance traveled slope, 20 min test	-3.2641	6.1676	-0.22406	0.834	0.599
open field	distance traveled, 20 min test, 1st 5min	33.797	62.476	-0.055747	0.800	0.591
open field	distance traveled, 20 min test, 2nd 5min	43.288	52.430	0.0020139	0.651	0.413
open field	distance traveled, 20 min test, 3rd 5min	53.069	58.779	0.14619	0.625	0.371
open field	distance traveled, 20 min test, 4th 5min	26.067	46.954	-0.15298	0.776	0.581
open field	number of clockwise revolution episodes, 20 min test	-0.063401	1.3851	-0.44107	0.985	0.964
open field	number of counter-clockwise revolution episodes, 20 min test	0.66636	1.2215	-0.075930	0.787	0.588
open field	number of fecal boli, 20 min test	-0.90073	0.74432	-0.45478	0.566	0.232
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.9592	2.0805	0.60444	0.412	0.161
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.5746	2.6612	0.036930	0.775	0.557
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	0.70182	2.7204	-0.15570	0.904	0.797
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.3214	2.6016	-0.061126	0.809	0.614
open field	percentage of total time in center of arena, 20 min test	-1.6738	3.0861	-0.61458	0.841	0.590
open field	percentage of total time in center of arena, slope, 20 min test	-2.1609	1.3726	-1.0005	0.574	0.122
open field	percentage of total time in center, habituation ratio, 20 min test	-2.2776	1.4251	-1.0161	0.566	0.116
open field	percentage of total time in corners of arena, 20 min test	5.2279	3.6290	1.2507	0.460	0.156
open field	percentage of total time in corners, habituation ratio, 20 min test	0.58552	1.6027	-0.014098	0.947	0.716
open field	percentage of total time in corners, slope, 20 min test	0.65366	1.6124	0.028870	0.931	0.687
open field	permanence time in center of arena, 20 min test	-20.083	37.030	-0.61458	0.841	0.590
open field	permanence time in corners of arena, 20 min test	62.726	43.551	1.2507	0.461	0.156
open field	permanence time in periphery of arena, 20 min test	20.050	37.029	0.61458	0.841	0.591
open field	total distance traveled, 20 min test	179.61	194.74	0.058436	0.583	0.361
open field	total number of rears, 20 min test	6.5733	8.5951	0.12586	0.685	0.448
open field	whole arena average speed, 20 min test	0.14958	0.16239	0.057091	0.584	0.362
open field	whole arena resting time, 20 min test	-18.155	18.764	0.024841	0.541	0.338
open field	whole arena time spent mobile, 20 min test	18.158	18.768	0.22406	0.550	0.338
open field	whole arena time spent vertical, 20 min test	10.250	8.7799	0.67575	0.548	0.249
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.0884	1.0931	0.64200	0.633	0.326
startle / PPI	average baseline movement during background noise	1.7023	1.6019	1.0591	0.798	0.295
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.37960	0.56759	-2.3454	0.783	0.508
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.045032	0.10255	-0.51974	0.866	0.663
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-10.931	12.085	-1.1575	0.879	0.372
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.097269	9.0814	-0.031531	0.995	0.992
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.6523	5.9590	0.28619	0.805	0.544
startle / PPI	average startle response to full pulse (120 dB)	-10.795	36.418	-0.035737	0.904	0.769
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	3.4662	33.599	0.27017	0.963	0.918
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-15.873	30.373	-0.15829	0.764	0.605
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-18.459	23.904	-0.26581	0.644	0.445
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.47135	1.4162	-0.28473	0.958	0.741
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.5297	1.8354	-1.0349	0.858	0.410
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	2.1550	1.9820	0.75639	0.699	0.285
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.17201	0.15624	-1.4522	0.859	0.279
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.017284	0.11534	-0.25306	0.970	0.882
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.032937	0.066523	0.099701	0.822	0.624
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-12.043	36.113	-0.051164	0.887	0.741
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-6.0632	33.148	0.062391	0.934	0.856
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-14.678	29.846	-0.11867	0.774	0.626
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-20.409	23.274	-0.29349	0.596	0.387
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.71714	0.88650	-2.7709	0.887	0.424
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.44134	0.85991	-2.4167	0.823	0.611
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.044505	0.071904	0.15057	0.759	0.540
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-23.420	117.70	0.051164	0.937	0.843
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	31.978	114.24	0.34957	0.896	0.781
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-42.451	105.17	-0.042748	0.815	0.689
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-69.069	83.761	-0.23833	0.620	0.415
startle / PPI	maximum baseline movement during background noise	1.2419	3.6365	0.47315	0.947	0.735
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-16.657	15.125	-1.5154	0.884	0.279
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-2.1953	10.848	-0.26436	0.940	0.841
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.6205	6.4654	0.19529	0.803	0.579
startle / PPI	maximum startle response to full pulse (120 dB)	-23.245	117.89	0.049761	0.937	0.845
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	27.240	114.85	0.31846	0.912	0.814
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-45.508	105.91	-0.072221	0.804	0.670
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-66.099	85.003	-0.23545	0.645	0.442
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.5833	3.1459	-0.97003	0.738	0.263
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-3.3798	3.6808	-0.93475	0.798	0.365
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	3.4320	4.2007	0.44512	0.776	0.420

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.0
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.0
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	27.0 %	0.356
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	21.0 %	0.324
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	31.0 %	0.265
eye morphology	retina	males	97.0 %	0.0465
eye morphology	retina	both	37.0 %	0.0601
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	31.0 %	0.234
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	22.0 %	0.226
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	12.0 %	0.0206
SHIRPA	hindlimb digit number	both	6.0 %	0.0603
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	11.0 %	0.142
SHIRPA	tail elevation	both	5.0 %	0.202
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	12.0 %	0.128
SHIRPA	transfer arousal	both	6.0 %	0.202
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Cachd1^em1(IMPC)J -/+ with genotype: