MPD: JaxKOMP-EAP genotype: Rab40b<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Rab40b^em1(IMPC)J -/- Gene Rab40b

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.0000	1.4201	0.024492	0.825	0.495
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	2.5000	2.9011	0.59011	0.814	0.406
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	2.6250	2.0512	0.37883	0.588	0.225
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	9.1250	3.0603	1.2948	0.142	0.0114
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	8.2500	4.2578	1.2497	0.401	0.0766
body composition	body length	0.0029804	0.040902	0.24909	0.988	0.942
body composition	body weight (at time of DXA)	0.59334	0.62203	0.57374	0.563	0.344
body composition	bone area, whole body scan, head excluded	-0.099266	0.11731	-0.21741	0.659	0.401
body composition	bone mineral content of whole body scan, head excluded	-0.014862	0.0089535	-0.67449	0.326	0.102
body composition	bone mineral content to body weight ratio	-0.00076092	0.00041825	-0.77573	0.261	0.0739
body composition	bone mineral density of whole body scan, head excluded	-0.0010633	0.00045818	-1.0924	0.152	0.0238
body composition	fat tissue mass of whole body scan, head excluded	0.31376	0.34321	0.51627	0.624	0.364
body composition	fat tissue mass to body weight ratio	0.0044131	0.012105	0.26662	0.864	0.717
body composition	lean tissue mass of whole body scan, head excluded	0.15988	0.29381	0.17565	0.816	0.588
body composition	lean tissue mass to body weight ratio	-0.0055513	0.011542	-0.36663	0.822	0.632
body composition	percent fat, whole body scan, head excluded	0.40079	1.1522	0.27512	0.875	0.729
body composition	ratio of soft-tissue attenuation coefficients	-0.00044622	0.0012806	-0.27431	0.875	0.729
body composition	tissue area	0.17775	0.15217	0.74572	0.547	0.247
body composition	total tissue mass, whole body scan, head excluded	0.46017	0.20314	0.74835	0.139	0.0272
clinical blood chemistry	alanine transaminase (plasma ALT)	-0.095745	2.3962	-0.027635	0.989	0.968
clinical blood chemistry	albumin (plasma Alb)	0.45735	0.42807	0.67897	0.605	0.293
clinical blood chemistry	alkaline phosphatase (plasma ALP)	10.017	2.5794	1.1078	0.00962	0.000452
clinical blood chemistry	aspartate transaminase (plasma AST)	-2.4102	7.9242	-0.12223	0.924	0.763
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.025369	0.18898	-0.041174	0.969	0.894
clinical blood chemistry	blood urea nitrogen (BUN)	2.6948	1.0977	1.0348	0.122	0.0192
clinical blood chemistry	calcium (plasma Ca)	-0.0035194	0.078330	0.33382	0.979	0.964
clinical blood chemistry	creatinine (plasma)	0.042691	0.013596	1.1638	0.0404	0.00342
clinical blood chemistry	glucose (plasma GLU, no fast)	-9.5393	8.7706	-0.077920	0.492	0.284
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.65090	2.5263	-0.17446	0.926	0.798
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0063456	0.013585	-0.51837	0.873	0.643
clinical blood chemistry	phosphorus (plasma phosphate)	0.37196	0.19489	0.50278	0.261	0.0648
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.011011	0.0088375	-0.81997	0.566	0.221
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	1.3037	3.8234	-0.0021327	0.902	0.735
clinical blood chemistry	total protein (plasma TP)	0.61227	0.72601	0.40322	0.653	0.405
clinical blood chemistry	triglyceride (plasma TG, no fast)	2.5189	8.5756	0.35803	0.898	0.771
EKG	duration of PQ interval	2.4527	0.89335	2.2068	0.320	0.0101
EKG	duration of PR interval	1.7932	0.92961	1.8071	0.600	0.0632
EKG	duration of QRS interval	-0.68599	0.34242	-1.9897	0.885	0.0542
EKG	duration of QT interval	-0.38847	0.86317	-0.19261	0.920	0.656
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.88069	0.86386	-0.84969	0.849	0.316
EKG	duration of RR interval	0.57841	1.3661	0.55282	0.882	0.675
EKG	duration of ST interval	0.29752	0.89376	0.52255	0.953	0.742
EKG	heart rate coefficient of variation (signal intensity)	-0.47083	1.0359	-0.30911	0.930	0.653
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-3.6291	7.7033	-0.33458	0.931	0.641
EKG	heart rate, beats per min	-4.8089	11.499	-0.56866	0.876	0.679
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.063459	0.094491	0.39849	0.800	0.507
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.092941	0.12003	0.44701	0.757	0.445
EKG	number of signals	3.8720	3.9983	0.72861	0.816	0.341
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-1.1773	2.7852	-0.14702	0.941	0.676
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.28280	5.1956	0.12119	0.995	0.957
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	0.27522	5.9232	0.072603	0.987	0.963
EKG	root mean square of successive differences of neighboring RR intervals	-0.68399	2.3466	-0.24420	0.948	0.773
glucose tolerance test	amount glucose injected	-0.53308	3.3949	0.20282	0.958	0.877
glucose tolerance test	plasma glucose, 0min	-17.301	12.979	-1.6793	0.403	0.198
glucose tolerance test	plasma glucose, 15min	5.1012	21.447	0.26669	0.938	0.815
glucose tolerance test	plasma glucose, 30min	-72.647	36.061	-1.9567	0.289	0.0576
glucose tolerance test	plasma glucose, 60min	-73.723	26.526	-2.3992	0.144	0.0119
glucose tolerance test	plasma glucose, 120min	-19.581	13.074	-1.4471	0.454	0.150
grip strength	body weight (at time of grip strength test)	-0.64304	0.40112	-0.36323	0.264	0.115
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-9.2588	6.1694	-0.42013	0.313	0.140
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.39524	0.28448	-0.36522	0.358	0.171
grip strength	forelimb and hindlimb grip strength by trial, trial1	-10.852	7.4695	-0.50748	0.415	0.153
grip strength	forelimb and hindlimb grip strength by trial, trial2	-10.059	6.6794	-0.39645	0.362	0.138
grip strength	forelimb and hindlimb grip strength by trial, trial3	-9.8428	8.0117	-0.43764	0.488	0.225
grip strength	forelimb grip strength (mean of trials), average	-12.150	3.9128	-1.1959	0.0351	0.00313
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.55152	0.18727	-1.1220	0.0538	0.00493
grip strength	forelimb grip strength by trial, trial1	-12.759	5.2050	-1.1496	0.170	0.0178
grip strength	forelimb grip strength by trial, trial2	-12.677	4.6791	-1.1138	0.104	0.00921
grip strength	forelimb grip strength by trial, trial3	-11.411	4.0397	-0.95284	0.0944	0.00678
heart weight	heart weight, normalized to body weight	0.22154	0.18933	0.32950	0.469	0.249
heart weight	heart weight, weight	0.21715	3.7726	-0.34954	0.971	0.954
hematology	basophil differential (percent of total WBC)	-0.019274	0.054732	-0.28523	0.924	0.727
hematology	calculated hemoglobin (cHGB)	0.47799	0.36367	1.1751	0.475	0.197
hematology	eosinophil differential (percent of total WBC)	-0.28639	0.20395	-0.69567	0.563	0.169
hematology	hematocrit (HCT)	2.7736	1.1221	2.1631	0.145	0.0183
hematology	hemoglobin concentration distribution width (HDW)	-0.061999	0.047415	-1.5816	0.506	0.200
hematology	large unstained cells (percent of total WBC)	0.055851	0.21193	0.39103	0.908	0.794
hematology	lymphocyte differential (percent of total WBC)	-0.57027	2.5655	-0.29393	0.925	0.825
hematology	mean corpuscular hemoglobin (CHr)	-0.043648	0.065781	-0.36537	0.735	0.511
hematology	mean platelet volume (MPV)	0.13071	0.050253	0.64338	0.0682	0.0134
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.031236	0.088174	-0.14245	0.885	0.725
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.59525	0.22037	-0.98953	0.135	0.0106
hematology	mean RBC corpuscular volume (MCV)	0.59150	0.19888	1.0045	0.0361	0.00522
hematology	measured hemoglobin (mHGB)	0.66489	0.40640	1.4414	0.378	0.111
hematology	monocyte differential (percent of total WBC)	-0.018952	0.13170	0.14539	0.957	0.886
hematology	neutrophil differential (percent of total WBC)	1.1662	2.5486	0.60488	0.813	0.650
hematology	platelet count (PLT; units per volume x 10³)	-81.795	65.584	-0.99320	0.589	0.220
hematology	RBC corpuscular distribution width (RDW)	-0.40457	0.47004	-1.4287	0.637	0.395
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.66211	0.18893	-1.5810	0.0185	0.00127
hematology	red blood cell count (RBC; per volume x 10⁶)	0.44575	0.26130	1.5363	0.331	0.0966
hematology	reticulocyte count (Retic; units per volume x 10⁹)	4.0708	25.467	0.27896	0.962	0.874
hematology	reticulocyte differential (percent of total RBC)	-0.20262	0.45221	-0.67027	0.864	0.657
hematology	white blood cell count (WBC; units per volume x 10³)	0.55578	0.62681	0.55795	0.585	0.381
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.25504	0.66292	-0.19965	0.918	0.702
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.11556	0.38650	0.33801	0.952	0.766
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.092502	0.39681	0.24986	0.951	0.817
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.59655	0.53874	0.65816	0.720	0.273
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.33979	0.46359	-0.45493	0.857	0.467
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.30917	0.23169	-0.85662	0.811	0.188
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.17867	0.24397	-0.51840	0.910	0.467
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.21626	0.33716	0.49270	0.881	0.524
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.066441	0.37896	0.23351	0.984	0.861
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.024104	0.25982	0.14085	0.983	0.926
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.16724	0.41513	0.44685	0.933	0.689
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.026861	0.39004	0.064143	0.985	0.945
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.34457	0.54486	0.43320	0.839	0.530
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.34244	0.49211	-0.45928	0.845	0.490
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.53847	0.42582	0.92692	0.669	0.211
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.64769	0.72472	0.60919	0.740	0.375
holeboard	total number of hole pokes, 20 min test	0.93836	3.6938	0.22280	0.908	0.800
light / dark	fecal boli count, 20 min test	-0.079046	0.47520	-0.054784	0.943	0.868
light / dark	latency to enter dark zone, 20 min test	74.384	58.871	1.1763	0.637	0.212
light / dark	number of transitions between light and dark zones, 20 min test	3.6521	7.0861	0.42628	0.830	0.608
light / dark	percentage of total time in dark zone, 20 min test	-2.7604	4.3847	-0.36198	0.802	0.532
light / dark	percentage of total time in light zone, 20 min test	2.7604	4.3847	0.35765	0.800	0.532
light / dark	time mobile in dark zone, 20 min test	20.811	13.858	1.0026	0.424	0.139
light / dark	time mobile in light zone, 20 min test	1.1440	9.9249	-0.16022	0.954	0.909
light / dark	time spent in dark zone, 20 min test	-33.285	55.447	-0.27940	0.855	0.551
light / dark	time spent in light zone, 20 min test	33.285	55.447	0.27940	0.855	0.551
open field	average speed in center of arena, 20 min test	0.34872	0.33564	0.54313	0.641	0.303
open field	average speed in periphery of arena, 20 min test	0.15389	0.13997	0.10289	0.503	0.276
open field	distance traveled habituation ratio, 20 min test	-4.3283	5.7469	-0.33014	0.736	0.454
open field	distance traveled in center of arena, 20 min test	-38.620	83.712	-0.62597	0.801	0.646
open field	distance traveled in periphery of arena, 20 min test	228.47	135.58	0.45194	0.283	0.0972
open field	distance traveled slope, 20 min test	-5.8901	5.4511	-0.49095	0.613	0.284
open field	distance traveled, 20 min test, 1st 5min	82.590	61.665	0.31740	0.414	0.186
open field	distance traveled, 20 min test, 2nd 5min	57.441	47.435	0.12586	0.467	0.231
open field	distance traveled, 20 min test, 3rd 5min	-3.8071	52.533	-0.48793	0.984	0.942
open field	distance traveled, 20 min test, 4th 5min	46.602	50.890	0.070545	0.607	0.364
open field	number of clockwise revolution episodes, 20 min test	1.7958	1.1013	0.64031	0.427	0.108
open field	number of counter-clockwise revolution episodes, 20 min test	0.57299	1.0356	-0.13670	0.785	0.582
open field	number of fecal boli, 20 min test	-0.71110	0.73302	-0.29240	0.650	0.336
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-0.90144	1.8886	-0.46040	0.820	0.635
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	3.1298	2.4280	0.46088	0.493	0.202
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.4808	2.8624	0.28649	0.661	0.390
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.96875	3.0595	-0.14891	0.885	0.753
open field	percentage of total time in center of arena, 20 min test	-2.8179	3.2256	-0.87146	0.692	0.386
open field	percentage of total time in center of arena, slope, 20 min test	-0.20800	1.3855	0.016783	0.965	0.881
open field	percentage of total time in center, habituation ratio, 20 min test	-0.55453	1.4227	-0.16930	0.913	0.698
open field	percentage of total time in corners of arena, 20 min test	1.2406	3.5813	0.52455	0.895	0.730
open field	percentage of total time in corners, habituation ratio, 20 min test	2.8866	1.4939	0.98290	0.474	0.0581
open field	percentage of total time in corners, slope, 20 min test	2.9088	1.4827	1.0458	0.487	0.0545
open field	permanence time in center of arena, 20 min test	-33.801	38.709	-0.86950	0.692	0.386
open field	permanence time in corners of arena, 20 min test	14.884	42.975	0.52455	0.896	0.730
open field	permanence time in periphery of arena, 20 min test	33.807	38.715	0.86950	0.692	0.386
open field	total distance traveled, 20 min test	187.63	184.12	0.077276	0.535	0.312
open field	total number of rears, 20 min test	5.6779	8.7304	0.058436	0.728	0.518
open field	whole arena average speed, 20 min test	0.15688	0.15334	0.079970	0.532	0.310
open field	whole arena resting time, 20 min test	-24.358	18.015	-0.14891	0.367	0.182
open field	whole arena time spent mobile, 20 min test	24.379	18.021	0.39466	0.368	0.181
open field	whole arena time spent vertical, 20 min test	-1.9091	8.5615	-0.26140	0.929	0.824
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.4821	1.2400	0.81094	0.551	0.238
startle / PPI	average baseline movement during background noise	0.97700	1.9262	0.68907	0.918	0.617
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.38167	0.69881	2.1532	0.820	0.590
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.20764	0.088392	-1.9862	0.240	0.0282
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-25.494	11.382	-2.3917	0.765	0.0351
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-12.641	7.6759	-1.2812	0.460	0.114
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-17.858	6.0668	-1.7351	0.0897	0.00752
startle / PPI	average startle response to full pulse (120 dB)	-46.028	39.133	-0.64359	0.493	0.252
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-5.2147	41.568	0.094718	0.957	0.901
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-19.078	39.999	-0.21963	0.787	0.638
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.1157	34.646	0.26871	0.969	0.929
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	1.8101	2.4801	1.0790	0.862	0.473
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	2.6509	2.5106	1.3477	0.814	0.302
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	2.7655	2.2388	0.95666	0.674	0.229
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.28892	0.14177	-2.1392	0.744	0.0532
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.13975	0.094502	-1.2463	0.493	0.153
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.16971	0.065480	-1.4641	0.113	0.0166
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-47.054	38.465	-0.64359	0.468	0.234
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	12.745	40.908	0.47158	0.883	0.758
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-21.656	40.524	-0.26581	0.761	0.598
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	0.35024	34.320	0.20387	0.996	0.992
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.34863	1.0981	2.1980	0.954	0.754
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.92214	1.0774	2.6593	0.708	0.401
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.11961	0.071481	-1.0612	0.323	0.108
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-38.358	129.71	-0.038541	0.904	0.770
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	100.72	139.94	0.69085	0.690	0.479
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	20.942	143.82	0.29057	0.933	0.885
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	68.623	125.39	0.60612	0.747	0.589
startle / PPI	maximum baseline movement during background noise	5.2290	4.4857	1.2876	0.737	0.256
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-21.269	12.213	-1.8781	0.781	0.0956
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-7.6611	8.3470	-0.73420	0.706	0.368
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-13.644	6.8205	-1.3137	0.258	0.0574
startle / PPI	maximum startle response to full pulse (120 dB)	-32.781	130.51	-0.0077063	0.918	0.804
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	109.10	140.63	0.73971	0.665	0.446
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	27.596	141.96	0.32583	0.910	0.848
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	99.100	123.29	0.82931	0.633	0.430
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	8.5117	7.0856	1.8164	0.727	0.242
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	6.6493	7.1985	1.4603	0.798	0.365
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	7.9960	5.0271	1.0740	0.502	0.125

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	males	19.0 %	0.0800
eye morphology	irispupil	both	19.0 %	0.102
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	males	18.0 %	0.250
eye morphology	lens opacity	both	17.0 %	0.316
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	males	19.0 %	0.0786
eye morphology	persistence of hyaloid vascular system	both	18.0 %	0.180
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.00
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.00
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.00
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.0
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.00
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.00
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.00
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.00
SHIRPA	limb grasp	both	7.0 %	0.630
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.00
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.0
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	21.0 %	0.0120
SHIRPA	tail elevation	both	10.0 %	0.0361
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	10.0 %	0.0734
SHIRPA	transfer arousal	both	5.0 %	0.116
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.00
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.00
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Rab40b^em1(IMPC)J -/- with genotype: