MPD: JaxKOMP-EAP genotype: Shisa7<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Shisa7^em1(IMPC)J -/- Gene Shisa7

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	2.5	1.6880	0.49732	0.665	0.235
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	1.6667	2.3447	0.39779	0.851	0.528
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	4.1667	1.9465	0.65544	0.472	0.122
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	6.4583	4.3285	0.90171	0.625	0.232
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	5.4167	4.2012	0.83088	0.664	0.288
body composition	body length	0.022381	0.035811	0.52834	0.780	0.537
body composition	body weight (at time of DXA)	-3.1356	0.63112	-1.7050	0.000533	0.0000218
body composition	bone area, whole body scan, head excluded	0.42484	0.15061	1.9145	0.0707	0.00828
body composition	bone mineral content of whole body scan, head excluded	0.024839	0.011591	1.5601	0.194	0.0401
body composition	bone mineral content to body weight ratio	0.0011666	0.00050409	1.6875	0.141	0.0275
body composition	bone mineral density of whole body scan, head excluded	0.00043540	0.00064415	0.50026	0.753	0.504
body composition	fat tissue mass of whole body scan, head excluded	-0.65311	0.41706	-1.2178	0.344	0.127
body composition	fat tissue mass to body weight ratio	-0.026885	0.014039	-1.2064	0.216	0.0648
body composition	lean tissue mass of whole body scan, head excluded	0.95187	0.35577	1.5601	0.120	0.0118
body composition	lean tissue mass to body weight ratio	0.042689	0.013135	1.9682	0.0408	0.00278
body composition	percent fat, whole body scan, head excluded	-2.9340	1.3363	-1.3937	0.152	0.0357
body composition	ratio of soft-tissue attenuation coefficients	0.0032649	0.0014847	1.3926	0.151	0.0355
body composition	tissue area	0.41891	0.17071	1.4040	0.142	0.0200
body composition	total tissue mass, whole body scan, head excluded	0.28870	0.32145	0.41728	0.626	0.376
clinical blood chemistry	alanine transaminase (plasma ALT)	11.050	4.1917	0.80935	0.603	0.231
clinical blood chemistry	albumin (plasma Alb)	0.91590	1.0462	1.3521	0.807	0.542
clinical blood chemistry	alkaline phosphatase (plasma ALP)	4.1127	16.238	0.20765	0.925	0.842
clinical blood chemistry	aspartate transaminase (plasma AST)	47.750	8.3122	1.4875	0.410	0.110
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.99610	0.31840	2.2089	0.600	0.197
clinical blood chemistry	blood urea nitrogen (BUN)	-0.18215	4.2866	-0.099771	0.987	0.973
clinical blood chemistry	calcium (plasma Ca)	0.25534	0.15745	1.9232	0.595	0.352
clinical blood chemistry	creatinine (plasma)	0.015000	0.18586	0.46688	0.977	0.949
clinical blood chemistry	glucose (plasma GLU, no fast)	49.973	8.1561	1.9992	0.258	0.103
clinical blood chemistry	HDL cholesterol (plasma HDL)	7.1616	4.7342	1.2845	0.665	0.372
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.019704	0.015027	-1.1845	0.719	0.415
clinical blood chemistry	phosphorus (plasma phosphate)	1.2194	0.39667	1.6446	0.479	0.200
clinical blood chemistry	total bilirubin (plasma TBIL)	0.017758	0.025682	1.0937	0.844	0.615
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	7.7613	6.6230	1.0351	0.740	0.450
clinical blood chemistry	total protein (plasma TP)	4.3757	4.0048	2.0101	0.708	0.472
clinical blood chemistry	triglyceride (plasma TG, no fast)	7.3755	11.147	0.62154	0.823	0.628
EKG	duration of PQ interval	-0.68361	0.89341	-0.59559	0.889	0.453
EKG	duration of PR interval	-0.010642	0.81729	0.076644	0.999	0.990
EKG	duration of QRS interval	1.2777	0.74206	2.7250	0.885	0.0998
EKG	duration of QT interval	-0.25541	1.2970	-0.086753	0.982	0.846
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.11385	1.3443	0.18850	0.999	0.933
EKG	duration of RR interval	-0.79745	2.2441	-0.14966	0.907	0.726
EKG	duration of ST interval	-0.56882	1.6617	-0.35597	0.953	0.736
EKG	heart rate coefficient of variation (signal intensity)	0.39576	1.5847	0.41018	0.968	0.805
EKG	heart rate variability, mean of differences between sequential beats; beats per min	3.1878	11.058	0.43663	0.965	0.776
EKG	heart rate, beats per min	7.5511	18.286	0.19585	0.877	0.684
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.12290	0.13532	-1.0840	0.726	0.374
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.16043	0.21230	-1.0007	0.763	0.458
EKG	number of signals	-3.2780	8.2330	-0.71814	0.936	0.695
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-1.8030	2.4608	-0.26977	0.862	0.472
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.73142	3.2104	0.26293	0.979	0.822
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	2.1740	3.8696	0.55282	0.945	0.580
EKG	root mean square of successive differences of neighboring RR intervals	1.1465	3.0751	0.72337	0.947	0.713
glucose tolerance test	amount glucose injected	-6.4397	3.3309	-1.3899	0.676	0.304
glucose tolerance test	plasma glucose, 0min	-14.525	8.7417	-1.4432	0.571	0.345
glucose tolerance test	plasma glucose, 15min	9.3449	55.066	0.38399	0.960	0.893
glucose tolerance test	plasma glucose, 30min	-6.7946	16.129	-0.068691	0.901	0.746
glucose tolerance test	plasma glucose, 60min	9.8453	26.784	0.52409	0.914	0.776
glucose tolerance test	plasma glucose, 120min	2.0125	12.368	0.0082365	0.959	0.897
heart weight	heart weight, normalized to body weight	0.29149	0.12359	0.56278	0.125	0.0281
heart weight	heart weight, weight	-0.28610	4.3469	-0.39882	0.970	0.948
hematology	basophil differential (percent of total WBC)	0.059259	0.039944	0.87174	0.594	0.155
hematology	calculated hemoglobin (cHGB)	-0.28158	0.15933	-1.0706	0.324	0.0941
hematology	eosinophil differential (percent of total WBC)	-0.18704	0.23482	-0.45942	0.789	0.436
hematology	hematocrit (HCT)	-0.39530	0.78145	-0.74032	0.802	0.619
hematology	hemoglobin concentration distribution width (HDW)	-0.029582	0.022668	-0.81323	0.511	0.208
hematology	large unstained cells (percent of total WBC)	0.22585	0.18864	1.3841	0.592	0.248
hematology	lymphocyte differential (percent of total WBC)	-0.61968	1.3446	-0.31828	0.816	0.651
hematology	mean corpuscular hemoglobin (CHr)	-0.055602	0.098466	-0.43123	0.782	0.580
hematology	mean platelet volume (MPV)	-0.51737	0.078502	-2.0833	0.000133	0.00000344
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.84935	0.47197	-1.4744	0.393	0.0897
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.96746	1.1347	-1.2601	0.743	0.406
hematology	mean RBC corpuscular volume (MCV)	-0.22418	0.18585	-0.41628	0.472	0.243
hematology	measured hemoglobin (mHGB)	-0.62962	0.51595	-1.3440	0.556	0.239
hematology	monocyte differential (percent of total WBC)	-0.54994	0.23037	-1.1807	0.256	0.0289
hematology	neutrophil differential (percent of total WBC)	1.1822	1.2356	0.61146	0.586	0.352
hematology	platelet count (PLT; units per volume x 10³)	-7.7593	27.139	-0.053329	0.921	0.778
hematology	RBC corpuscular distribution width (RDW)	0.79250	0.14908	1.8960	0.00306	0.0000569
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.16638	0.40142	0.42500	0.848	0.684
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.20618	0.10661	-1.1372	0.286	0.0690
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-12.070	12.490	-0.43878	0.717	0.347
hematology	reticulocyte differential (percent of total RBC)	-0.095086	0.15732	-0.19045	0.815	0.554
hematology	white blood cell count (WBC; units per volume x 10³)	-0.60273	0.99296	-0.25984	0.719	0.552
holeboard	number of hole pokes by individual hole number, 20 min test, 1	2.1623	0.65675	1.7945	0.164	0.00243
holeboard	number of hole pokes by individual hole number, 20 min test, 2	1.0552	0.52454	1.6942	0.532	0.0527
holeboard	number of hole pokes by individual hole number, 20 min test, 3	1.6375	0.38336	2.0928	0.0536	0.000162
holeboard	number of hole pokes by individual hole number, 20 min test, 4	2.3875	1.0154	1.9973	0.352	0.0250
holeboard	number of hole pokes by individual hole number, 20 min test, 5	1.6125	0.67363	2.2124	0.392	0.0227
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.39020	0.29622	1.0247	0.811	0.197
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.63960	0.33116	1.4799	0.689	0.0623
holeboard	number of hole pokes by individual hole number, 20 min test, 8	1.2404	0.86269	1.8863	0.701	0.160
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.80485	0.39917	1.3599	0.459	0.0522
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.062922	0.34245	0.23731	0.968	0.855
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.85000	0.35178	1.7229	0.496	0.0216
holeboard	number of hole pokes by individual hole number, 20 min test, 12	2.3010	0.78634	2.5088	0.184	0.00637
holeboard	number of hole pokes by individual hole number, 20 min test, 13	2.8052	0.85323	2.1576	0.215	0.00246
holeboard	number of hole pokes by individual hole number, 20 min test, 14	1.7000	0.53258	2.2535	0.234	0.00316
holeboard	number of hole pokes by individual hole number, 20 min test, 15	2.5500	0.59807	2.6489	0.0411	0.000166
holeboard	number of hole pokes by individual hole number, 20 min test, 16	2.6433	0.98484	2.1753	0.270	0.0114
holeboard	total number of hole pokes, 20 min test	25.046	4.7744	2.6489	0.00289	0.00000972
light / dark	fecal boli count, 20 min test	-0.19737	0.77362	-0.19180	0.930	0.800
light / dark	latency to enter dark zone, 20 min test	-70.888	31.550	-1.4135	0.347	0.0322
light / dark	number of transitions between light and dark zones, 20 min test	20.974	7.5951	1.8472	0.114	0.00972
light / dark	percentage of total time in dark zone, 20 min test	-5.3530	2.7111	-0.83739	0.353	0.0576
light / dark	percentage of total time in light zone, 20 min test	5.3530	2.7111	0.83547	0.351	0.0576
light / dark	time mobile in dark zone, 20 min test	98.624	15.610	2.6715	0.0000508	5.75e-7
light / dark	time mobile in light zone, 20 min test	50.840	11.991	2.0119	0.00536	0.000197
light / dark	time spent in dark zone, 20 min test	-0.65592	37.314	0.20007	0.997	0.986
light / dark	time spent in light zone, 20 min test	0.65592	37.314	-0.20007	0.997	0.986
open field	average speed in center of arena, 20 min test	3.0154	0.47989	2.7848	0.0000894	4.79e-7
open field	average speed in periphery of arena, 20 min test	1.0629	0.16673	2.1168	0.0000197	3.68e-7
open field	distance traveled habituation ratio, 20 min test	-24.373	7.0857	-1.8969	0.0371	0.00164
open field	distance traveled in center of arena, 20 min test	421.49	86.098	1.8503	0.000975	0.0000269
open field	distance traveled in periphery of arena, 20 min test	1150.6	184.90	2.2819	0.0000355	5.70e-7
open field	distance traveled slope, 20 min test	-22.271	6.9432	-1.8429	0.0539	0.00304
open field	distance traveled, 20 min test, 1st 5min	539.25	77.108	2.3837	0.00000622	6.34e-8
open field	distance traveled, 20 min test, 2nd 5min	361.75	65.275	2.0575	0.000178	0.00000410
open field	distance traveled, 20 min test, 3rd 5min	345.69	59.040	2.1562	0.0000934	0.00000165
open field	distance traveled, 20 min test, 4th 5min	324.40	52.840	2.0465	0.0000502	7.26e-7
open field	number of clockwise revolution episodes, 20 min test	3.8927	1.3808	1.5069	0.0992	0.00820
open field	number of counter-clockwise revolution episodes, 20 min test	7.0817	1.1459	2.2147	0.0000860	6.46e-7
open field	number of fecal boli, 20 min test	0.63858	1.0520	0.72277	0.793	0.548
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.8123	3.0076	0.84009	0.479	0.214
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	8.0416	3.2657	1.5371	0.128	0.0194
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	8.3204	3.3909	1.4907	0.134	0.0198
open field	number of rears in 5 min bins, 20 min test, 4th 5min	7.4375	3.2752	1.2715	0.181	0.0300
open field	percentage of total time in center of arena, 20 min test	-1.0412	2.7166	-0.47286	0.887	0.704
open field	percentage of total time in center of arena, slope, 20 min test	-2.2840	1.3908	-1.0693	0.568	0.110
open field	percentage of total time in center, habituation ratio, 20 min test	-1.8011	1.3905	-0.81401	0.683	0.204
open field	percentage of total time in corners of arena, 20 min test	-0.78425	3.8464	0.16386	0.939	0.840
open field	percentage of total time in corners, habituation ratio, 20 min test	6.0189	1.6235	2.1168	0.0889	0.000791
open field	percentage of total time in corners, slope, 20 min test	6.1938	1.5956	2.3004	0.0865	0.000488
open field	permanence time in center of arena, 20 min test	-12.515	32.598	-0.47286	0.887	0.704
open field	permanence time in corners of arena, 20 min test	-9.4000	46.155	0.16386	0.939	0.840
open field	permanence time in periphery of arena, 20 min test	12.554	32.606	0.47436	0.887	0.703
open field	total distance traveled, 20 min test	1569.3	219.87	2.1994	0.00000255	4.23e-8
open field	total number of rears, 20 min test	27.650	11.599	1.4549	0.128	0.0232
open field	whole arena average speed, 20 min test	1.3084	0.18321	2.1994	0.00000260	4.18e-8
open field	whole arena resting time, 20 min test	-151.79	19.988	-2.3198	8.88e-7	1.19e-8
open field	whole arena time spent mobile, 20 min test	151.79	19.988	2.4074	8.87e-7	1.19e-8
open field	whole arena time spent vertical, 20 min test	7.1572	10.284	0.44748	0.762	0.491
startle / PPI	average baseline movement during background noise	2.7159	1.9077	1.5243	0.714	0.166
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.24056	0.15642	1.8464	0.474	0.136
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.20966	0.15166	1.8942	0.524	0.179
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	10.741	12.805	1.2379	0.879	0.409
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	15.746	13.735	1.6103	0.635	0.262
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	20.188	11.860	1.9118	0.346	0.101
startle / PPI	average startle response to full pulse (120 dB)	-3.4988	37.699	0.13704	0.970	0.927
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-9.6206	38.626	-0.018916	0.910	0.805
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-20.081	34.021	-0.24265	0.735	0.560
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-26.897	34.260	-0.46376	0.640	0.439
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	6.4731	2.1662	2.3917	0.328	0.00606
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	1.5661	1.2783	0.88806	0.741	0.231
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	2.0170	2.4371	0.70336	0.789	0.415
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.15345	0.15780	1.5243	0.869	0.340
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.20429	0.18003	1.6254	0.608	0.267
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.27371	0.14190	1.8089	0.233	0.0647
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-6.3621	38.212	0.049761	0.947	0.869
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-16.094	38.411	-0.15261	0.842	0.679
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-21.490	33.994	-0.26291	0.721	0.533
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-28.914	33.505	-0.48414	0.604	0.396
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.20327	0.17003	1.7164	0.840	0.243
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.20427	0.17805	1.5107	0.614	0.262
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.31573	0.14846	1.9030	0.193	0.0431
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	8.8023	141.86	0.25856	0.979	0.951
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-60.866	138.05	-0.16680	0.828	0.663
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-70.652	128.46	-0.21389	0.753	0.587
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-117.70	126.21	-0.53359	0.570	0.360
startle / PPI	maximum baseline movement during background noise	4.9197	4.3205	1.2562	0.741	0.265
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	16.031	14.212	1.6984	0.884	0.270
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	16.770	14.803	1.4685	0.628	0.268
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	25.722	12.888	2.2305	0.257	0.0565
startle / PPI	maximum startle response to full pulse (120 dB)	13.722	141.40	0.28619	0.970	0.923
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-41.845	137.41	-0.073626	0.888	0.763
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-69.318	128.24	-0.20816	0.759	0.593
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-114.04	127.75	-0.53036	0.589	0.380
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	19.021	9.6230	2.7110	0.516	0.0588
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	1.7919	2.8347	0.53682	0.876	0.533
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	10.110	6.2754	1.3171	0.496	0.120

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.00
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.0
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.0
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	40.0 %	0.0581
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	19.0 %	0.165
eye morphology	lens opacity	females	91.0 %	0.0000336
eye morphology	lens opacity	males	61.0 %	0.00527
eye morphology	lens opacity	both	78.0 %	5.13e-7
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.0
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.00
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	64.0 %	0.00689
eye morphology	retinal pigmentation	both	26.0 %	0.0819
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.0
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	12.0 %	0.00599
SHIRPA	hindlimb digit number	both	6.0 %	0.0184
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	12.0 %	0.0740
SHIRPA	tail elevation	males	23.0 %	0.00946
SHIRPA	tail elevation	both	17.0 %	0.00147
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	62.0 %	2.60e-12
SHIRPA	tremor	both	31.0 %	1.42e-10
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	11.0 %	0.145
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	4.0 %	0.268

GENOTYPE CORRELATION PLOT

Correlate Shisa7^em1(IMPC)J -/- with genotype: