JaxKOMP-LAP
effect sizes: Ano8em1(IMPC)J -/-
Gene Ano8
MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)
In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls,
for all measured numeric phenotypes in
JaxKOMP-LAP
Procedure |
JaxKOMP-LAP Trait |
Trait Effect |
Trait Effect SE |
Trait Effect RankZ |
Adjusted p-value |
Unadjusted p-value |
|---|---|---|---|---|---|---|
| body composition | body length | 0.020512 | 0.10906 | 0.48724 | 0.918 | 0.853 |
| body composition | body weight (at time of DXA) | 9.4541 | 2.4026 | 1.7158 | 0.00885 | 0.000759 |
| body composition | bone area, whole body scan, head excluded | -0.35426 | 0.37088 | -0.28472 | 0.612 | 0.350 |
| body composition | bone mineral content of whole body scan, head excluded | -0.037099 | 0.019520 | -0.54434 | 0.248 | 0.0712 |
| body composition | bone mineral content to body weight ratio | -0.0011620 | 0.00077045 | -0.97899 | 0.497 | 0.147 |
| body composition | bone mineral density of whole body scan, head excluded | -0.0020422 | 0.00069443 | -0.97899 | 0.0816 | 0.00781 |
| body composition | fat tissue mass of whole body scan, head excluded | -0.21795 | 0.92625 | -0.35293 | 0.930 | 0.816 |
| body composition | fat tissue mass to body weight ratio | -0.0013503 | 0.022061 | -0.19572 | 0.960 | 0.952 |
| body composition | lean tissue mass of whole body scan, head excluded | 1.4702 | 0.96499 | 1.4835 | 0.451 | 0.143 |
| body composition | lean tissue mass to body weight ratio | 0.021269 | 0.020848 | 0.75829 | 0.632 | 0.320 |
| body composition | percent fat, whole body scan, head excluded | -0.94910 | 2.1087 | -0.42284 | 0.850 | 0.657 |
| body composition | ratio of soft-tissue attenuation coefficients | 0.0011227 | 0.0023446 | 0.39120 | 0.816 | 0.637 |
| body composition | tissue area | 0.34387 | 0.41567 | 0.59518 | 0.733 | 0.418 |
| body composition | total tissue mass, whole body scan, head excluded | 1.2523 | 0.33839 | 1.1715 | 0.0814 | 0.00142 |
| clinical blood chemistry | alanine transaminase (plasma ALT) | 348.24 | 157.17 | 2.0537 | 0.560 | 0.0438 |
| clinical blood chemistry | albumin (plasma Alb) | -3.2604 | 0.76949 | -2.3188 | 0.0590 | 0.000829 |
| clinical blood chemistry | alkaline phosphatase (plasma ALP) | 5.9442 | 21.030 | 0.37739 | 0.912 | 0.782 |
| clinical blood chemistry | aspartate transaminase (plasma AST) | 433.96 | 119.80 | 2.0579 | 0.114 | 0.00229 |
| clinical blood chemistry | aspartate transaminase to alanine transaminase ratio (plasma AST:ALT) | -0.16900 | 0.12453 | -0.53296 | 0.657 | 0.194 |
| clinical blood chemistry | blood urea nitrogen (BUN) | 10.350 | 2.1121 | 2.3301 | 0.0117 | 0.000234 |
| clinical blood chemistry | calcium (plasma Ca) | -0.028814 | 0.13616 | -0.58284 | 0.988 | 0.835 |
| clinical blood chemistry | creatinine (plasma) | 0.13450 | 0.041245 | 2.0579 | 0.0914 | 0.00619 |
| clinical blood chemistry | glucose (plasma GLU, no fast) | -52.888 | 24.143 | -1.8852 | 0.255 | 0.0459 |
| clinical blood chemistry | HDL cholesterol (plasma HDL) | -0.44866 | 9.4197 | -0.35113 | 0.984 | 0.963 |
| clinical blood chemistry | HDL cholesterol to total cholesterol ratio | -0.079321 | 0.034769 | -2.3301 | 0.293 | 0.0387 |
| clinical blood chemistry | phosphorus (plasma phosphate) | -1.7119 | 0.70693 | -1.6497 | 0.231 | 0.0277 |
| clinical blood chemistry | total cholesterol (plasma CHOL, no fast) | 4.7051 | 12.564 | 0.13693 | 0.907 | 0.714 |
| clinical blood chemistry | total protein (plasma TP) | -2.2254 | 1.2059 | -1.2928 | 0.576 | 0.0862 |
| clinical blood chemistry | triglyceride (plasma TG, no fast) | 20.627 | 10.353 | 1.0866 | 0.579 | 0.0637 |
| glucose tolerance test | amount glucose injected | 18.640 | 8.1636 | 1.5096 | 0.250 | 0.0329 |
| glucose tolerance test | plasma glucose, 0min | -9.8571 | 11.285 | -0.94578 | 0.707 | 0.391 |
| glucose tolerance test | plasma glucose, 15min | -34.676 | 37.634 | -0.79566 | 0.708 | 0.366 |
| glucose tolerance test | plasma glucose, 30min | -80.929 | 35.911 | -1.3397 | 0.221 | 0.0341 |
| glucose tolerance test | plasma glucose, 60min | 38.181 | 43.855 | 0.71370 | 0.708 | 0.394 |
| glucose tolerance test | plasma glucose, 120min | -28.052 | 24.102 | -0.82418 | 0.564 | 0.256 |
| heart weight | heart weight, normalized to body weight | 0.31373 | 0.18856 | 1.0568 | 0.480 | 0.116 |
| heart weight | heart weight, weight | 11.897 | 4.5370 | 1.3645 | 0.205 | 0.0185 |
| hematology | basophil differential (percent of total WBC) | -0.23994 | 0.21947 | -1.6449 | 0.865 | 0.293 |
| hematology | calculated hemoglobin (cHGB) | -0.97228 | 0.51982 | -1.8557 | 0.493 | 0.0798 |
| hematology | eosinophil differential (percent of total WBC) | 2.6336 | 0.79427 | 1.7599 | 0.172 | 0.00510 |
| hematology | hematocrit (HCT) | -2.4379 | 1.3889 | -1.8808 | 0.608 | 0.0983 |
| hematology | hemoglobin concentration distribution width (HDW) | -0.034797 | 0.061930 | -0.50593 | 0.847 | 0.583 |
| hematology | large unstained cells (percent of total WBC) | 0.19935 | 0.37446 | 0.43073 | 0.803 | 0.602 |
| hematology | lymphocyte differential (percent of total WBC) | -10.464 | 4.4769 | -1.8852 | 0.339 | 0.0327 |
| hematology | mean corpuscular hemoglobin (CHr) | 0.064407 | 0.16455 | 0.17637 | 0.894 | 0.701 |
| hematology | mean platelet volume (MPV) | -0.17842 | 0.19987 | -0.62092 | 0.724 | 0.385 |
| hematology | mean RBC corpuscular hemoglobin (MCH) | 0.18305 | 0.18073 | 0.37229 | 0.654 | 0.326 |
| hematology | mean RBC corpuscular hemoglobin concentration (MCHC) | -0.71690 | 0.38706 | -1.0866 | 0.567 | 0.0852 |
| hematology | mean RBC corpuscular volume (MCV) | 0.37119 | 0.48944 | 0.56179 | 0.749 | 0.459 |
| hematology | measured hemoglobin (mHGB) | -1.7820 | 0.73988 | -2.3226 | 0.535 | 0.0304 |
| hematology | monocyte differential (percent of total WBC) | 0.20630 | 0.64701 | 0.25838 | 0.961 | 0.754 |
| hematology | neutrophil differential (percent of total WBC) | 8.5836 | 3.2929 | 2.0579 | 0.212 | 0.0191 |
| hematology | platelet count (PLT; units per volume x 103) | 156.88 | 229.47 | 0.77957 | 0.795 | 0.504 |
| hematology | RBC corpuscular distribution width (RDW) | -0.18387 | 0.34369 | -0.46770 | 0.846 | 0.601 |
| hematology | RBC corpuscular hemoglobin concentration mean (CHCM) | -0.49571 | 0.39279 | -0.89792 | 0.563 | 0.228 |
| hematology | red blood cell count (RBC; per volume x 106) | -0.44271 | 0.31132 | -1.2323 | 0.512 | 0.174 |
| hematology | reticulocyte count (Retic; units per volume x 109) | -2.4442 | 30.273 | -0.037236 | 0.984 | 0.937 |
| hematology | reticulocyte differential (percent of total RBC) | 0.34783 | 0.47570 | 0.76109 | 0.852 | 0.475 |
| hematology | white blood cell count (WBC; units per volume x 103) | -4.7306 | 2.2194 | -2.0579 | 0.401 | 0.0489 |
| SHIRPA | locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test) | 7.9501 | 2.6776 | 2.4060 | 0.0851 | 0.00758 |
MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)
In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls,
for all measured categorical phenotypes in
JaxKOMP-LAP
GENOTYPE CORRELATION PLOT
This genotype correlation visualization can include both EAP and LAP measures.
Correlate Ano8em1(IMPC)J -/- with genotype:
This genotype correlation visualization can include both EAP and LAP measures.
