MPD: JaxKOMP-EAP genotype: Zfyve1<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Zfyve1^em1(IMPC)J -/- Gene Zfyve1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

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Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.54266	3.2947	-0.11986	0.966	0.875
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	3.9431	3.1526	0.83117	0.715	0.258
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.9225	1.9552	0.24749	0.720	0.363
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	1.5375	5.8318	0.12630	0.929	0.801
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	3.7606	3.6269	0.57727	0.690	0.340
body composition	body length	-0.095297	0.036445	-0.86136	0.0911	0.0110
body composition	body weight (at time of DXA)	0.36902	0.51094	0.40591	0.682	0.473
body composition	bone area, whole body scan, head excluded	-0.23160	0.12447	-0.74655	0.262	0.0671
body composition	bone mineral content of whole body scan, head excluded	-0.017022	0.0089749	-0.78685	0.250	0.0621
body composition	bone mineral content to body weight ratio	-0.00072975	0.00034720	-0.74835	0.178	0.0393
body composition	bone mineral density of whole body scan, head excluded	-0.00061638	0.00045591	-0.67406	0.469	0.181
body composition	fat tissue mass of whole body scan, head excluded	0.41639	0.26167	0.66765	0.326	0.116
body composition	fat tissue mass to body weight ratio	0.011871	0.0093348	0.59760	0.436	0.208
body composition	lean tissue mass of whole body scan, head excluded	-0.017673	0.21749	-0.19510	0.981	0.935
body composition	lean tissue mass to body weight ratio	-0.0076657	0.0079705	-0.47105	0.597	0.340
body composition	percent fat, whole body scan, head excluded	1.0760	0.87731	0.57974	0.465	0.224
body composition	ratio of soft-tissue attenuation coefficients	-0.0011946	0.00097499	-0.58765	0.467	0.225
body composition	tissue area	0.021235	0.13618	0.26550	0.961	0.877
body composition	total tissue mass, whole body scan, head excluded	0.40045	0.14261	0.63557	0.0521	0.00650
clinical blood chemistry	alanine transaminase (plasma ALT)	-2.9724	8.9549	-0.29395	0.926	0.743
clinical blood chemistry	albumin (plasma Alb)	-0.18273	0.57741	-0.22722	0.914	0.755
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.8597	3.7339	0.16009	0.564	0.314
clinical blood chemistry	aspartate transaminase (plasma AST)	-30.043	14.521	-1.2939	0.297	0.0517
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.75623	0.26477	-1.9150	0.178	0.0101
clinical blood chemistry	blood urea nitrogen (BUN)	-2.1778	1.7073	-0.87644	0.483	0.219
clinical blood chemistry	calcium (plasma Ca)	0.23616	0.10678	1.7743	0.164	0.0388
clinical blood chemistry	creatinine (plasma)	-0.071519	0.030278	-1.3582	0.154	0.0304
clinical blood chemistry	glucose (plasma GLU, no fast)	51.693	15.340	2.0669	0.0231	0.00322
clinical blood chemistry	HDL cholesterol (plasma HDL)	8.3043	3.5958	1.5602	0.199	0.0323
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.014927	0.018389	-0.95950	0.728	0.427
clinical blood chemistry	phosphorus (plasma phosphate)	0.26964	0.40412	0.37406	0.761	0.512
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0010927	0.013459	-0.078145	0.982	0.936
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	15.336	4.6269	2.0011	0.0542	0.00364
clinical blood chemistry	total protein (plasma TP)	2.5092	2.5288	1.6168	0.604	0.334
clinical blood chemistry	triglyceride (plasma TG, no fast)	7.4045	9.2455	0.62501	0.697	0.434
EKG	duration of PQ interval	1.2746	1.2580	1.4412	0.836	0.324
EKG	duration of PR interval	1.5480	1.4139	1.6310	0.840	0.287
EKG	duration of QRS interval	0.25011	0.32303	0.54579	0.911	0.449
EKG	duration of QT interval	1.3516	0.85634	1.3606	0.644	0.131
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.59374	1.1287	0.72075	0.935	0.605
EKG	duration of RR interval	1.1953	2.4662	0.88491	0.873	0.633
EKG	duration of ST interval	1.0799	0.95671	1.3210	0.754	0.273
EKG	heart rate coefficient of variation (signal intensity)	1.3795	1.4150	1.2006	0.867	0.342
EKG	heart rate variability, mean of differences between sequential beats; beats per min	8.6058	9.8144	1.0559	0.867	0.392
EKG	heart rate, beats per min	-10.075	18.698	-0.89936	0.837	0.596
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.14344	0.10634	0.96474	0.572	0.193
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.067153	0.14084	0.29144	0.858	0.639
EKG	number of signals	4.3939	7.0502	0.83247	0.883	0.541
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	11.207	6.9944	1.9303	0.791	0.126
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.95983	2.6276	0.31758	0.968	0.719
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	0.52620	2.9519	0.14559	0.976	0.860
EKG	root mean square of successive differences of neighboring RR intervals	-0.0027074	2.6263	0.10295	0.999	0.999
glucose tolerance test	amount glucose injected	2.6695	1.6159	1.0858	0.438	0.107
glucose tolerance test	plasma glucose, 0min	1.2273	7.2260	-0.10866	0.935	0.866
glucose tolerance test	plasma glucose, 15min	-24.419	23.210	-0.55906	0.630	0.300
glucose tolerance test	plasma glucose, 30min	27.776	19.071	0.93576	0.486	0.154
glucose tolerance test	plasma glucose, 60min	9.2456	13.446	0.49129	0.778	0.496
glucose tolerance test	plasma glucose, 120min	10.860	8.9288	0.62615	0.542	0.232
grip strength	body weight (at time of grip strength test)	-0.40583	0.43854	-0.18380	0.551	0.360
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-11.024	5.5141	-0.54080	0.166	0.0528
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.65540	0.26156	-0.77165	0.0805	0.0166
grip strength	forelimb and hindlimb grip strength by trial, trial1	0.77525	6.2100	0.27500	0.961	0.901
grip strength	forelimb and hindlimb grip strength by trial, trial2	-12.382	7.2945	-0.54417	0.295	0.0978
grip strength	forelimb and hindlimb grip strength by trial, trial3	-20.431	8.3242	-1.0639	0.121	0.0188
grip strength	forelimb grip strength (mean of trials), average	-7.5671	4.2048	-0.69376	0.273	0.0799
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.41731	0.20039	-0.82968	0.200	0.0439
grip strength	forelimb grip strength by trial, trial1	-9.3795	5.5943	-0.81138	0.375	0.102
grip strength	forelimb grip strength by trial, trial2	-8.4682	5.2429	-0.69007	0.400	0.115
grip strength	forelimb grip strength by trial, trial3	-3.5201	5.1088	-0.14281	0.765	0.495
heart weight	heart weight, normalized to body weight	0.12948	0.17448	0.020946	0.662	0.462
heart weight	heart weight, weight	0.76549	3.4667	-0.27293	0.906	0.826
hematology	basophil differential (percent of total WBC)	-0.10261	0.064818	-1.3056	0.562	0.129
hematology	calculated hemoglobin (cHGB)	0.15931	0.16088	0.20836	0.612	0.334
hematology	eosinophil differential (percent of total WBC)	-0.68288	0.30109	-1.6274	0.303	0.0346
hematology	hematocrit (HCT)	-0.43759	0.64052	-0.77677	0.729	0.502
hematology	hemoglobin concentration distribution width (HDW)	-0.019269	0.023913	-0.53360	0.711	0.430
hematology	large unstained cells (percent of total WBC)	0.18436	0.084951	1.1825	0.278	0.0422
hematology	lymphocyte differential (percent of total WBC)	6.2805	3.7936	1.8810	0.344	0.114
hematology	mean corpuscular hemoglobin (CHr)	-0.15381	0.11836	-1.2018	0.436	0.209
hematology	mean platelet volume (MPV)	-0.038212	0.089379	-0.44583	0.832	0.674
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.18515	0.24736	-0.66958	0.773	0.463
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.65463	0.58435	1.2187	0.642	0.276
hematology	mean RBC corpuscular volume (MCV)	-1.3806	0.44254	-1.7857	0.0364	0.00540
hematology	measured hemoglobin (mHGB)	0.17624	0.29129	0.20030	0.771	0.552
hematology	monocyte differential (percent of total WBC)	-0.18680	0.15046	-0.41926	0.592	0.230
hematology	neutrophil differential (percent of total WBC)	-5.3477	3.7676	-1.7857	0.412	0.171
hematology	platelet count (PLT; units per volume x 10³)	83.340	35.759	1.1121	0.259	0.0309
hematology	RBC corpuscular distribution width (RDW)	-0.32578	0.18165	-1.1985	0.304	0.0880
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.53565	0.27023	1.2543	0.216	0.0614
hematology	red blood cell count (RBC; per volume x 10⁶)	0.19688	0.11762	0.52377	0.348	0.110
hematology	reticulocyte count (Retic; units per volume x 10⁹)	11.120	11.280	0.57634	0.712	0.337
hematology	reticulocyte differential (percent of total RBC)	0.018211	0.12073	0.28906	0.953	0.882
hematology	white blood cell count (WBC; units per volume x 10³)	2.6249	0.81928	1.7924	0.0340	0.00446
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.022630	0.53657	0.024478	0.990	0.966
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.30248	0.38029	-0.35235	0.833	0.429
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.30624	0.40888	-0.44187	0.861	0.456
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.29484	0.53973	-0.18762	0.879	0.587
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.66630	0.37183	-0.99059	0.570	0.0775
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.074315	0.26987	0.25056	0.968	0.784
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.23952	0.26462	-0.67608	0.870	0.369
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.40555	0.40614	-0.57247	0.799	0.322
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.047328	0.36808	0.19376	0.988	0.898
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.36044	0.32316	-1.0031	0.827	0.269
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.21070	0.30375	-0.55213	0.884	0.490
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.86403	0.37710	-1.2916	0.341	0.0250
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.12336	0.63487	-0.045560	0.964	0.847
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.58578	0.41258	-0.82776	0.592	0.160
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.39669	0.38492	-0.53371	0.749	0.306
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.17237	0.70734	-0.12345	0.946	0.808
holeboard	total number of hole pokes, 20 min test	-4.8133	3.5819	-0.59303	0.464	0.183
light / dark	fecal boli count, 20 min test	-0.26732	0.71965	-0.27730	0.922	0.711
light / dark	latency to enter dark zone, 20 min test	11.910	60.488	0.13289	0.965	0.844
light / dark	number of transitions between light and dark zones, 20 min test	-4.7810	6.4008	-0.37355	0.731	0.458
light / dark	percentage of total time in dark zone, 20 min test	-8.1608	4.9786	-1.3403	0.444	0.106
light / dark	percentage of total time in light zone, 20 min test	8.1608	4.9786	1.3370	0.443	0.106
light / dark	time mobile in dark zone, 20 min test	-20.027	12.888	-1.2292	0.397	0.125
light / dark	time mobile in light zone, 20 min test	11.081	10.524	0.44710	0.559	0.296
light / dark	time spent in dark zone, 20 min test	-66.437	58.848	-0.77015	0.673	0.263
light / dark	time spent in light zone, 20 min test	66.437	58.848	0.77015	0.673	0.263
open field	average speed in center of arena, 20 min test	0.30131	0.28911	0.45492	0.641	0.301
open field	average speed in periphery of arena, 20 min test	0.23211	0.15537	0.37299	0.329	0.140
open field	distance traveled habituation ratio, 20 min test	17.589	6.6123	1.4359	0.120	0.00986
open field	distance traveled in center of arena, 20 min test	-3.0296	89.723	-0.39757	0.983	0.973
open field	distance traveled in periphery of arena, 20 min test	262.53	149.44	0.58883	0.255	0.0838
open field	distance traveled slope, 20 min test	16.785	6.3635	1.4321	0.128	0.0105
open field	distance traveled, 20 min test, 1st 5min	-23.541	66.511	-0.53847	0.870	0.725
open field	distance traveled, 20 min test, 2nd 5min	54.383	55.146	0.10019	0.576	0.328
open field	distance traveled, 20 min test, 3rd 5min	82.331	48.783	0.46536	0.282	0.0963
open field	distance traveled, 20 min test, 4th 5min	134.25	53.861	0.99384	0.0908	0.0153
open field	number of clockwise revolution episodes, 20 min test	1.6824	1.2942	0.55517	0.553	0.198
open field	number of counter-clockwise revolution episodes, 20 min test	0.025494	1.0967	-0.42533	0.991	0.982
open field	number of fecal boli, 20 min test	-1.7359	0.82023	-1.1050	0.243	0.0382
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-2.5180	2.1546	-0.89089	0.511	0.247
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-2.0024	2.2493	-0.84430	0.652	0.377
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-0.64026	2.4001	-0.45790	0.899	0.791
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.2003	2.7942	-0.096144	0.832	0.669
open field	percentage of total time in center of arena, 20 min test	0.48552	2.6239	-0.082664	0.952	0.854
open field	percentage of total time in center of arena, slope, 20 min test	0.99335	1.2837	0.68931	0.835	0.442
open field	percentage of total time in center, habituation ratio, 20 min test	0.44666	1.3597	0.35148	0.937	0.744
open field	percentage of total time in corners of arena, 20 min test	0.23946	3.0958	0.35434	0.974	0.939
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.9468	1.4539	-1.1968	0.671	0.185
open field	percentage of total time in corners, slope, 20 min test	-1.9940	1.3572	-1.2219	0.629	0.147
open field	permanence time in center of arena, 20 min test	5.8194	31.485	-0.081317	0.952	0.854
open field	permanence time in corners of arena, 20 min test	2.8833	37.149	0.35434	0.973	0.938
open field	permanence time in periphery of arena, 20 min test	-5.8275	31.486	0.081317	0.952	0.854
open field	total distance traveled, 20 min test	245.32	194.08	0.22957	0.417	0.211
open field	total number of rears, 20 min test	-4.0972	7.8137	-0.61458	0.786	0.602
open field	whole arena average speed, 20 min test	0.20556	0.16163	0.23371	0.414	0.208
open field	whole arena resting time, 20 min test	-22.793	19.323	-0.10559	0.441	0.243
open field	whole arena time spent mobile, 20 min test	22.856	19.317	0.36150	0.441	0.241
open field	whole arena time spent vertical, 20 min test	-3.5401	9.1057	-0.41653	0.882	0.699
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.29568	1.4496	0.049386	0.955	0.839
startle / PPI	average baseline movement during background noise	-0.12614	1.1290	-0.017515	0.995	0.911
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.052328	0.053973	0.38253	0.682	0.336
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.019061	0.050612	0.10751	0.882	0.708
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	2.5039	7.6660	0.32288	0.963	0.745
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-6.5766	5.3221	-0.67317	0.599	0.221
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	4.6315	4.7229	0.39310	0.631	0.331
startle / PPI	average startle response to full pulse (120 dB)	-69.760	21.262	-1.0253	0.0191	0.00174
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-68.128	21.626	-1.0112	0.0244	0.00256
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-40.579	16.439	-0.62134	0.0854	0.0165
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-43.023	15.558	-0.79041	0.0549	0.00758
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.47174	1.0586	0.40068	0.935	0.657
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.5920	1.1650	-1.0865	0.692	0.177
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.1845	1.2312	0.37801	0.739	0.340
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.035768	0.081769	0.38706	0.927	0.663
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.071739	0.059529	-0.67053	0.576	0.233
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.093155	0.053434	0.55423	0.278	0.0865
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-69.566	21.216	-0.99962	0.0193	0.00175
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-68.641	21.540	-1.0066	0.0224	0.00230
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-39.194	16.864	-0.59772	0.106	0.0236
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-44.440	15.734	-0.79616	0.0478	0.00645
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.070168	0.086836	0.65570	0.887	0.422
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.043306	0.063303	-0.40777	0.770	0.497
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.13012	0.056725	0.74853	0.144	0.0254
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-242.09	75.909	-0.96779	0.0224	0.00228
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-255.04	80.378	-1.0469	0.0239	0.00240
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-145.80	61.985	-0.60275	0.102	0.0220
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-172.56	57.583	-0.85124	0.0350	0.00399
startle / PPI	maximum baseline movement during background noise	-1.7008	2.7032	-0.47471	0.866	0.532
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	5.7241	8.4118	0.61286	0.916	0.499
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-4.5352	6.0469	-0.46376	0.762	0.456
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	8.7707	5.3761	0.69085	0.361	0.108
startle / PPI	maximum startle response to full pulse (120 dB)	-243.52	75.901	-0.96779	0.0210	0.00216
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-253.27	80.576	-1.0349	0.0255	0.00261
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-154.09	60.098	-0.64186	0.0702	0.0130
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-167.68	57.039	-0.82733	0.0393	0.00468
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.7865	2.5419	0.61286	0.847	0.485
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-5.0188	3.4389	-1.3477	0.650	0.150
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	4.0916	2.8174	0.55307	0.519	0.152

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

Download Plot

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	16.0 %	0.0418
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	10.0 %	0.0379
eye morphology	bulging eye	females	16.0 %	0.0268
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	10.0 %	0.0251
eye morphology	cornea	females	16.0 %	0.0547
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	10.0 %	0.0601
eye morphology	cornea opacity	females	16.0 %	0.0562
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	10.0 %	0.0482
eye morphology	cornea vascularization	females	16.0 %	0.0383
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	10.0 %	0.0399
eye morphology	corneal deposits	females	16.0 %	0.0714
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	10.0 %	0.0657
eye morphology	corneal mineralization	females	16.0 %	0.0783
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	10.0 %	0.0359
eye morphology	corneal scleralization	females	16.0 %	0.0469
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	10.0 %	0.0503
eye morphology	corneal ulcer	females	16.0 %	0.0447
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	10.0 %	0.0460
eye morphology	eye closure	females	16.0 %	0.0268
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	10.0 %	0.0250
eye morphology	eye hemorrhage or blood presence	females	16.0 %	0.0525
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	10.0 %	0.0555
eye morphology	eyelid morphology	females	16.0 %	0.0332
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	10.0 %	0.0304
eye morphology	eyes (present, absent)	females	16.0 %	0.0327
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	10.0 %	0.0311
eye morphology	fusion between cornea and lens	females	15.0 %	0.108
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	9.0 %	0.109
eye morphology	iris pigmentation	females	16.0 %	0.127
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	9.0 %	0.0905
eye morphology	iris transillumination	females	16.0 %	0.112
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	9.0 %	0.0732
eye morphology	irispupil	females	16.0 %	0.147
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	10.0 %	0.0957
eye morphology	lacrimation	females	16.0 %	0.190
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	9.0 %	0.162
eye morphology	lens	females	16.0 %	0.197
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	0.200
eye morphology	lens opacity	females	17.0 %	0.0185
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	10.0 %	0.0187
eye morphology	narrow eye opening	females	16.0 %	0.0350
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	10.0 %	0.0317
eye morphology	optic disc	females	17.0 %	0.0117
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	10.0 %	0.0114
eye morphology	persistence of hyaloid vascular system	females	20.0 %	0.0325
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	11.0 %	0.0377
eye morphology	pupil dilation	females	16.0 %	0.131
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	9.0 %	0.104
eye morphology	pupil light response	females	16.0 %	0.137
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	9.0 %	0.155
eye morphology	pupil position	females	16.0 %	0.163
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	9.0 %	0.104
eye morphology	pupil shape	females	16.0 %	0.135
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	10.0 %	0.116
eye morphology	retina	females	15.0 %	0.210
eye morphology	retina	males	19.0 %	0.500
eye morphology	retina	both	9.0 %	0.176
eye morphology	retinal blood vessels	females	15.0 %	0.116
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	9.0 %	0.121
eye morphology	retinal blood vessels pattern	females	15.0 %	0.165
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	9.0 %	0.179
eye morphology	retinal blood vessels structure	females	15.0 %	0.124
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	9.0 %	0.134
eye morphology	retinal pigmentation	females	17.0 %	0.0228
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	10.0 %	0.0250
eye morphology	retinal structure	females	15.0 %	0.126
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	9.0 %	0.139
eye morphology	synechia	females	15.0 %	0.122
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	9.0 %	0.125
eye morphology	vitreous	females	15.0 %	0.114
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	9.0 %	0.116
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.00
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.00
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.00
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.00
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.00
SHIRPA	coat color pattern abdomen	females	1.0 %	1.00
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.00
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.00
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.00
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.00
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.00
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.00
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.00
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.00
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.00
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.00
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.00
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.00
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.00
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.00
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.00
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.00
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.0
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.630
SHIRPA	lower lip morphology	females	0.0 %	1.00
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.00
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.00
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.0
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	36.0 %	0.000173
SHIRPA	tail elevation	both	16.0 %	0.000540
SHIRPA	tail length	females	0.0 %	1.00
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.0
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.00
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.00
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.00
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.00
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.0
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Zfyve1^em1(IMPC)J -/- with genotype: