MPD: JaxKOMP-EAP genotype: Scgb1c1<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Scgb1c1^em1(IMPC)J -/- Gene Scgb1c1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-2.4764	1.5732	-0.93125	0.555	0.135
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.70755	2.8520	-0.14289	0.949	0.807
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	3.3387	2.3993	0.50414	0.543	0.183
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	3.1771	3.3864	0.42097	0.717	0.363
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	1.3377	3.8861	0.17330	0.891	0.735
body composition	body length	-0.067939	0.054042	-0.59264	0.514	0.215
body composition	body weight (at time of DXA)	-0.32300	0.57100	-0.16794	0.762	0.574
body composition	bone area, whole body scan, head excluded	0.032612	0.14733	0.31649	0.927	0.826
body composition	bone mineral content of whole body scan, head excluded	0.0092589	0.010398	0.67792	0.659	0.378
body composition	bone mineral content to body weight ratio	0.00013345	0.00046491	0.33087	0.900	0.775
body composition	bone mineral density of whole body scan, head excluded	0.00088778	0.00050467	1.0071	0.308	0.0849
body composition	fat tissue mass of whole body scan, head excluded	-0.32587	0.31370	-0.60414	0.561	0.304
body composition	fat tissue mass to body weight ratio	-0.012708	0.010927	-0.55568	0.488	0.251
body composition	lean tissue mass of whole body scan, head excluded	0.92430	0.24225	1.5419	0.0209	0.000389
body composition	lean tissue mass to body weight ratio	0.025899	0.0097596	1.2800	0.0927	0.0108
body composition	percent fat, whole body scan, head excluded	-1.5043	1.0576	-0.70742	0.382	0.161
body composition	ratio of soft-tissue attenuation coefficients	0.0016776	0.0011758	0.71631	0.382	0.160
body composition	tissue area	0.085397	0.23761	0.49978	0.901	0.721
body composition	total tissue mass, whole body scan, head excluded	0.60049	0.22093	1.0052	0.0653	0.00911
clinical blood chemistry	alanine transaminase (plasma ALT)	4.4639	4.5010	0.36124	0.689	0.328
clinical blood chemistry	albumin (plasma Alb)	-0.49510	0.39377	-0.62952	0.529	0.217
clinical blood chemistry	alkaline phosphatase (plasma ALP)	8.1155	3.2004	0.85339	0.0929	0.0157
clinical blood chemistry	aspartate transaminase (plasma AST)	38.667	17.321	1.2841	0.237	0.0319
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.56121	0.29267	1.4617	0.405	0.0631
clinical blood chemistry	blood urea nitrogen (BUN)	-1.6883	1.4099	-0.72997	0.507	0.239
clinical blood chemistry	calcium (plasma Ca)	0.10235	0.072559	1.0449	0.386	0.167
clinical blood chemistry	creatinine (plasma)	-0.025486	0.022915	-0.48518	0.524	0.274
clinical blood chemistry	glucose (plasma GLU, no fast)	-27.940	8.6992	-0.70850	0.0206	0.00278
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.18992	2.9279	-0.27919	0.984	0.949
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.00097357	0.013513	-0.22318	0.986	0.943
clinical blood chemistry	phosphorus (plasma phosphate)	0.18858	0.40546	0.26455	0.830	0.645
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0076645	0.010171	0.51109	0.764	0.456
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	1.1750	3.3941	-0.024884	0.902	0.731
clinical blood chemistry	total protein (plasma TP)	-3.7873	3.1043	-2.1458	0.511	0.230
clinical blood chemistry	triglyceride (plasma TG, no fast)	-3.8676	7.6573	0.0057229	0.814	0.617
EKG	duration of PQ interval	-0.23942	0.84132	-0.094846	0.942	0.778
EKG	duration of PR interval	-0.10923	0.92561	-0.014105	0.982	0.907
EKG	duration of QRS interval	0.20250	0.37447	0.39489	0.951	0.593
EKG	duration of QT interval	0.41991	0.90183	0.55988	0.914	0.645
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.50184	0.90567	0.61983	0.934	0.584
EKG	duration of RR interval	1.1525	1.0562	0.85839	0.708	0.284
EKG	duration of ST interval	0.25018	0.87728	0.47463	0.958	0.778
EKG	heart rate coefficient of variation (signal intensity)	1.8459	1.2327	1.5457	0.841	0.145
EKG	heart rate variability, mean of differences between sequential beats; beats per min	12.575	8.8319	1.4585	0.853	0.165
EKG	heart rate, beats per min	-9.1354	8.6949	-0.85491	0.704	0.302
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.12475	0.095679	0.81772	0.580	0.202
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.13105	0.13304	0.66126	0.674	0.332
EKG	number of signals	0.42736	4.2843	0.046361	0.986	0.921
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	6.1709	4.7038	1.2116	0.814	0.200
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.75000	2.0878	0.26919	0.968	0.722
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	0.67117	2.2929	0.18850	0.966	0.772
EKG	root mean square of successive differences of neighboring RR intervals	-1.9031	1.6460	-0.97496	0.843	0.257
glucose tolerance test	amount glucose injected	-4.8346	2.3197	-0.98253	0.300	0.0441
glucose tolerance test	plasma glucose, 0min	-3.4796	4.3801	-0.57194	0.655	0.432
glucose tolerance test	plasma glucose, 15min	-36.063	18.705	-0.86374	0.289	0.0613
glucose tolerance test	plasma glucose, 30min	10.552	17.157	0.42271	0.793	0.542
glucose tolerance test	plasma glucose, 60min	0.88272	12.233	0.16827	0.974	0.943
glucose tolerance test	plasma glucose, 120min	-8.9449	6.5473	-0.74786	0.492	0.180
grip strength	body weight (at time of grip strength test)	-0.30671	0.45337	-0.091515	0.687	0.504
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-33.199	8.1669	-1.9232	0.00546	0.000335
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.5707	0.36183	-1.8875	0.00406	0.000148
grip strength	forelimb and hindlimb grip strength by trial, trial1	-26.798	10.865	-1.4622	0.130	0.0196
grip strength	forelimb and hindlimb grip strength by trial, trial2	-38.195	8.0866	-2.1389	0.00509	0.0000547
grip strength	forelimb and hindlimb grip strength by trial, trial3	-35.976	8.1807	-1.9050	0.00547	0.000127
grip strength	forelimb grip strength (mean of trials), average	-3.8582	6.0723	-0.22406	0.759	0.530
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.20503	0.27664	-0.29163	0.726	0.464
grip strength	forelimb grip strength by trial, trial1	-3.0355	7.9342	-0.090163	0.879	0.705
grip strength	forelimb grip strength by trial, trial2	-10.433	6.6532	-0.90150	0.426	0.128
grip strength	forelimb grip strength by trial, trial3	2.7520	6.5402	0.55092	0.874	0.677
heart weight	heart weight, normalized to body weight	0.29239	0.11501	0.56912	0.0768	0.0147
heart weight	heart weight, weight	8.7616	3.2422	0.77056	0.0661	0.00982
hematology	basophil differential (percent of total WBC)	0.19870	0.060282	2.0159	0.127	0.00230
hematology	calculated hemoglobin (cHGB)	0.24389	0.12486	0.47438	0.258	0.0591
hematology	eosinophil differential (percent of total WBC)	-0.22996	0.20204	-0.57031	0.647	0.263
hematology	hematocrit (HCT)	0.48288	0.42970	0.16198	0.570	0.269
hematology	hemoglobin concentration distribution width (HDW)	0.011819	0.015962	0.31818	0.729	0.464
hematology	large unstained cells (percent of total WBC)	0.099209	0.11307	0.64373	0.710	0.386
hematology	lymphocyte differential (percent of total WBC)	0.92074	1.1056	0.35153	0.639	0.411
hematology	mean corpuscular hemoglobin (CHr)	-0.058615	0.064584	-0.46025	0.614	0.370
hematology	mean platelet volume (MPV)	0.26546	0.092328	1.2264	0.0420	0.00692
hematology	mean RBC corpuscular hemoglobin (MCH)	0.38168	0.71794	1.3053	0.830	0.598
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	1.3951	1.5780	1.8194	0.726	0.383
hematology	mean RBC corpuscular volume (MCV)	-0.57958	0.30860	-1.0090	0.209	0.0690
hematology	measured hemoglobin (mHGB)	0.69894	0.72482	1.5190	0.635	0.342
hematology	monocyte differential (percent of total WBC)	-0.031645	0.099959	0.10406	0.910	0.753
hematology	neutrophil differential (percent of total WBC)	-0.96183	1.0272	-0.44477	0.588	0.356
hematology	platelet count (PLT; units per volume x 10³)	-38.792	42.451	-0.48128	0.702	0.367
hematology	RBC corpuscular distribution width (RDW)	-0.052949	0.13324	-0.17703	0.844	0.694
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.35233	0.20423	0.87943	0.284	0.0936
hematology	red blood cell count (RBC; per volume x 10⁶)	0.19397	0.098990	0.50659	0.258	0.0583
hematology	reticulocyte count (Retic; units per volume x 10⁹)	9.3551	10.238	0.50168	0.737	0.367
hematology	reticulocyte differential (percent of total RBC)	0.038011	0.10166	0.37928	0.885	0.711
hematology	white blood cell count (WBC; units per volume x 10³)	0.66143	0.57531	0.62304	0.462	0.258
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.31134	0.61726	0.35954	0.883	0.616
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.078963	0.38889	0.26907	0.977	0.840
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.65000	0.36186	-1.0242	0.602	0.0785
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.75547	0.58499	0.79676	0.673	0.202
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.062500	0.37631	0.014348	0.970	0.869
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.11250	0.23579	-0.30492	0.938	0.635
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.075000	0.21448	-0.22933	0.971	0.728
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.55000	0.39410	1.0328	0.707	0.169
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.75873	0.37689	1.3105	0.450	0.0495
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.30707	0.29454	0.84984	0.837	0.302
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.030111	0.21757	-0.060845	0.979	0.890
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.77500	0.39355	1.2140	0.473	0.0545
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.48993	0.67537	0.56906	0.804	0.472
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.16500	0.51287	-0.16778	0.928	0.749
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.73620	0.43453	1.1828	0.561	0.0966
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.062500	0.93601	-0.015182	0.978	0.947
holeboard	total number of hole pokes, 20 min test	3.8068	3.5587	0.62963	0.577	0.290
light / dark	fecal boli count, 20 min test	-0.96386	0.71155	-1.0805	0.587	0.182
light / dark	latency to enter dark zone, 20 min test	-2.8803	57.225	-0.16433	0.988	0.960
light / dark	number of transitions between light and dark zones, 20 min test	12.797	7.5955	1.2585	0.382	0.0985
light / dark	percentage of total time in dark zone, 20 min test	-3.9557	5.4035	-0.59913	0.767	0.468
light / dark	percentage of total time in light zone, 20 min test	3.9557	5.4035	0.59590	0.765	0.468
light / dark	time mobile in dark zone, 20 min test	12.543	15.231	0.63016	0.701	0.414
light / dark	time mobile in light zone, 20 min test	28.032	8.2188	1.2235	0.0204	0.00132
light / dark	time spent in dark zone, 20 min test	-59.857	62.874	-0.67704	0.727	0.346
light / dark	time spent in light zone, 20 min test	59.857	62.874	0.67704	0.727	0.346
open field	average speed in center of arena, 20 min test	-0.042375	0.36195	-0.17748	0.971	0.907
open field	average speed in periphery of arena, 20 min test	0.084224	0.15758	-0.16658	0.773	0.595
open field	distance traveled habituation ratio, 20 min test	1.3314	7.4591	0.14755	0.947	0.859
open field	distance traveled in center of arena, 20 min test	164.83	76.435	0.67238	0.159	0.0359
open field	distance traveled in periphery of arena, 20 min test	8.4062	150.84	-0.40776	0.985	0.956
open field	distance traveled slope, 20 min test	3.3305	7.3493	0.36150	0.862	0.652
open field	distance traveled, 20 min test, 1st 5min	35.591	72.797	-0.040961	0.828	0.627
open field	distance traveled, 20 min test, 2nd 5min	6.9940	59.934	-0.41214	0.955	0.908
open field	distance traveled, 20 min test, 3rd 5min	60.015	55.725	0.22681	0.538	0.287
open field	distance traveled, 20 min test, 4th 5min	45.012	48.609	0.047680	0.606	0.359
open field	number of clockwise revolution episodes, 20 min test	-0.54687	1.3278	-0.73916	0.884	0.682
open field	number of counter-clockwise revolution episodes, 20 min test	1.3625	1.2298	0.29770	0.554	0.273
open field	number of fecal boli, 20 min test	-2.9750	0.95955	-1.8435	0.0670	0.00317
open field	number of rears in 5 min bins, 20 min test, 1st 5min	0.44916	2.1351	-0.084730	0.938	0.834
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.6213	2.1102	0.054402	0.705	0.446
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-0.15063	2.2776	-0.32730	0.970	0.948
open field	number of rears in 5 min bins, 20 min test, 4th 5min	2.8875	2.6360	0.30894	0.556	0.279
open field	percentage of total time in center of arena, 20 min test	4.4030	2.4980	0.78993	0.363	0.0841
open field	percentage of total time in center of arena, slope, 20 min test	1.5986	1.4453	1.0183	0.741	0.274
open field	percentage of total time in center, habituation ratio, 20 min test	1.4247	1.5101	0.90129	0.798	0.350
open field	percentage of total time in corners of arena, 20 min test	-4.0051	3.4129	-0.42239	0.557	0.246
open field	percentage of total time in corners, habituation ratio, 20 min test	1.4725	1.8271	0.38308	0.849	0.424
open field	percentage of total time in corners, slope, 20 min test	1.1863	1.7364	0.26418	0.885	0.498
open field	permanence time in center of arena, 20 min test	52.827	29.975	0.78993	0.363	0.0841
open field	permanence time in corners of arena, 20 min test	-48.051	40.953	-0.42239	0.558	0.246
open field	permanence time in periphery of arena, 20 min test	-52.778	29.974	-0.78993	0.364	0.0844
open field	total distance traveled, 20 min test	171.09	201.87	0.036930	0.616	0.401
open field	total number of rears, 20 min test	3.7697	7.6716	-0.082664	0.804	0.625
open field	whole arena average speed, 20 min test	0.14282	0.16804	0.038273	0.614	0.399
open field	whole arena resting time, 20 min test	-15.093	20.311	0.11369	0.656	0.461
open field	whole arena time spent mobile, 20 min test	15.124	20.298	0.11910	0.661	0.460
open field	whole arena time spent vertical, 20 min test	2.9996	7.9109	0.12857	0.887	0.706
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	2.8085	1.4421	1.3161	0.287	0.0609
startle / PPI	average baseline movement during background noise	2.7622	1.7269	1.5470	0.662	0.125
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.28617	0.090977	1.9669	0.124	0.00509
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.29634	0.093680	2.4165	0.112	0.00489
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	8.9599	10.015	1.0206	0.879	0.382
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	21.972	8.5173	2.2305	0.239	0.0179
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	14.934	6.3296	1.4246	0.183	0.0286
startle / PPI	average startle response to full pulse (120 dB)	-125.36	26.634	-1.6809	0.00272	0.000135
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-130.85	29.892	-1.7879	0.00493	0.000291
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-117.61	26.309	-1.7543	0.00448	0.000234
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-81.707	20.195	-1.5022	0.0110	0.000632
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.47343	1.8192	0.40220	0.972	0.797
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	1.7537	2.2011	0.95004	0.864	0.435
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	2.4593	1.9846	0.88184	0.674	0.230
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.068883	0.11897	0.68907	0.922	0.569
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.42198	0.12471	2.5366	0.0941	0.00295
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.39871	0.099332	2.3677	0.0178	0.000681
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-128.29	26.536	-1.7043	0.00214	0.000101
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-130.60	30.103	-1.7609	0.00528	0.000319
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-119.81	27.141	-1.7543	0.00503	0.000267
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-84.415	20.203	-1.5198	0.00829	0.000464
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.046291	0.13081	0.43894	0.954	0.727
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.40736	0.12216	2.3035	0.0968	0.00330
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.44147	0.097106	2.1530	0.00836	0.000196
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-424.59	91.179	-1.6473	0.00316	0.000152
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-483.15	114.84	-1.8464	0.00625	0.000433
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-436.33	92.366	-1.7811	0.00307	0.000148
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-307.36	66.817	-1.5198	0.00397	0.000173
startle / PPI	maximum baseline movement during background noise	6.4111	4.4489	1.4726	0.668	0.166
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	12.895	10.528	1.3442	0.884	0.235
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	41.634	11.645	2.9333	0.0807	0.00189
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	41.615	9.8495	2.8428	0.0210	0.000458
startle / PPI	maximum startle response to full pulse (120 dB)	-418.77	91.086	-1.6312	0.00354	0.000174
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-484.74	114.40	-1.8541	0.00583	0.000404
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-432.29	89.906	-1.7811	0.00266	0.000122
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-300.35	65.889	-1.4979	0.00432	0.000191
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	2.1633	3.7997	0.69977	0.890	0.575
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	2.6175	4.7300	0.71778	0.903	0.586
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	6.3811	4.8364	0.88391	0.588	0.203

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	9.0 %	0.359
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	4.0 %	0.428
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	11.0 %	0.316
eye morphology	lens opacity	males	35.0 %	0.00545
eye morphology	lens opacity	both	18.0 %	0.0309
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	6.0 %	0.690
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	3.0 %	0.790
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	7.0 %	0.750
eye morphology	retina	both	7.0 %	0.888
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	9.0 %	0.529
eye morphology	retinal pigmentation	both	7.0 %	0.794
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	11.0 %	0.142
SHIRPA	tail elevation	both	5.0 %	0.202
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Scgb1c1^em1(IMPC)J -/- with genotype: