MPD: JaxKOMP-EAP genotype: Acot2<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Acot2^em1(IMPC)J -/- Gene Acot2

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	5.1936	10.712	1.1324	0.892	0.645
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	8.0696	7.5556	1.4626	0.751	0.327
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	4.1081	2.0341	0.63446	0.427	0.0900
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	8.1518	7.9291	1.1548	0.705	0.344
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	8.7245	4.0579	1.3268	0.401	0.0751
body composition	body length	-0.085650	0.031473	-0.77312	0.0770	0.00828
body composition	body weight (at time of DXA)	-0.18582	0.51159	-0.055291	0.854	0.718
body composition	bone area, whole body scan, head excluded	-0.048814	0.099352	-0.017749	0.822	0.625
body composition	bone mineral content of whole body scan, head excluded	-0.010362	0.0071179	-0.43373	0.405	0.150
body composition	bone mineral content to body weight ratio	-0.00045886	0.00030758	-0.40836	0.381	0.140
body composition	bone mineral density of whole body scan, head excluded	-0.00089261	0.00039442	-0.92853	0.164	0.0269
body composition	fat tissue mass of whole body scan, head excluded	0.23399	0.23321	0.39948	0.578	0.319
body composition	fat tissue mass to body weight ratio	0.0076698	0.0080170	0.41133	0.586	0.342
body composition	lean tissue mass of whole body scan, head excluded	-0.0073881	0.21081	-0.17981	0.994	0.972
body composition	lean tissue mass to body weight ratio	-0.0038393	0.0078752	-0.27456	0.821	0.627
body composition	percent fat, whole body scan, head excluded	0.66279	0.78319	0.39357	0.639	0.400
body composition	ratio of soft-tissue attenuation coefficients	-0.00073416	0.00087062	-0.38414	0.640	0.402
body composition	tissue area	0.18699	0.16626	0.77862	0.568	0.265
body composition	total tissue mass, whole body scan, head excluded	0.22373	0.16147	0.27370	0.407	0.170
clinical blood chemistry	alanine transaminase (plasma ALT)	-29.732	11.699	-1.9338	0.264	0.0218
clinical blood chemistry	albumin (plasma Alb)	2.6715	0.79307	2.7652	0.0631	0.00391
clinical blood chemistry	alkaline phosphatase (plasma ALP)	5.3605	2.9941	0.46625	0.285	0.0923
clinical blood chemistry	aspartate transaminase (plasma AST)	-5.6720	25.743	-0.28599	0.948	0.828
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.99216	0.50717	2.1929	0.413	0.0681
clinical blood chemistry	blood urea nitrogen (BUN)	-3.7368	1.6417	-1.3896	0.178	0.0369
clinical blood chemistry	calcium (plasma Ca)	0.20245	0.15507	1.6187	0.441	0.209
clinical blood chemistry	creatinine (plasma)	-0.043204	0.043903	-0.87229	0.586	0.341
clinical blood chemistry	glucose (plasma GLU, no fast)	52.615	18.213	2.1046	0.0540	0.0107
clinical blood chemistry	HDL cholesterol (plasma HDL)	32.667	1.9700	3.2558	1.49e-8	1.68e-11
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0020276	0.022864	-0.024912	0.981	0.930
clinical blood chemistry	phosphorus (plasma phosphate)	-0.10144	0.52882	-0.21322	0.938	0.850
clinical blood chemistry	total bilirubin (plasma TBIL)	0.029384	0.015193	1.5690	0.310	0.0710
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	39.122	2.9736	3.0526	2.59e-7	2.43e-10
clinical blood chemistry	total protein (plasma TP)	3.5664	1.0699	1.8865	0.0566	0.00394
clinical blood chemistry	triglyceride (plasma TG, no fast)	22.963	7.7445	1.3396	0.0868	0.00868
EKG	duration of PQ interval	-0.98865	0.69604	-0.90294	0.734	0.167
EKG	duration of PR interval	-0.67125	0.73527	-0.58839	0.877	0.369
EKG	duration of QRS interval	0.23875	0.36248	0.51333	0.931	0.515
EKG	duration of QT interval	0.057500	0.81526	0.22143	0.990	0.944
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.14625	0.82582	0.22143	0.986	0.861
EKG	duration of RR interval	-0.29948	1.1423	0.090798	0.931	0.795
EKG	duration of ST interval	-0.21125	0.78384	-0.0060450	0.960	0.790
EKG	heart rate coefficient of variation (signal intensity)	-0.60416	0.91224	-0.39489	0.891	0.513
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-4.4851	6.5633	-0.44997	0.887	0.500
EKG	heart rate, beats per min	1.7000	9.3394	-0.14877	0.957	0.857
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.024000	0.087640	0.083787	0.928	0.786
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.056750	0.11308	0.22885	0.846	0.620
EKG	number of signals	-9.6248	4.1805	-1.6159	0.439	0.0290
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	0.88524	2.9904	0.26766	0.973	0.769
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.65328	3.6823	0.24420	0.987	0.860
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	1.1814	4.0284	0.33032	0.966	0.771
EKG	root mean square of successive differences of neighboring RR intervals	-0.92194	1.8754	-0.38402	0.926	0.627
glucose tolerance test	amount glucose injected	-32.550	13.408	-2.5436	0.244	0.0274
glucose tolerance test	plasma glucose, 0min	-35.106	6.1564	-2.5442	0.000974	0.0000259
glucose tolerance test	plasma glucose, 15min	-110.85	42.025	-2.7776	0.155	0.0173
glucose tolerance test	plasma glucose, 30min	-91.277	33.919	-2.3531	0.143	0.0155
glucose tolerance test	plasma glucose, 60min	-25.671	23.485	-0.97255	0.617	0.291
glucose tolerance test	plasma glucose, 120min	-19.455	10.940	-1.4393	0.374	0.0932
grip strength	body weight (at time of grip strength test)	-0.34271	0.37699	-0.11339	0.562	0.369
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-28.690	6.4232	-1.6754	0.00180	0.0000691
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.3763	0.32288	-1.6695	0.00386	0.000134
grip strength	forelimb and hindlimb grip strength by trial, trial1	-26.718	7.8585	-1.4538	0.0279	0.00160
grip strength	forelimb and hindlimb grip strength by trial, trial2	-25.182	8.6245	-1.3492	0.0578	0.00586
grip strength	forelimb and hindlimb grip strength by trial, trial3	-33.317	9.3907	-1.7646	0.0213	0.00105
grip strength	forelimb grip strength (mean of trials), average	-9.8089	5.2707	-0.91466	0.258	0.0707
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.46915	0.24482	-0.94373	0.245	0.0629
grip strength	forelimb grip strength by trial, trial1	-11.112	6.6367	-0.98065	0.376	0.102
grip strength	forelimb grip strength by trial, trial2	-10.179	6.2997	-0.88419	0.400	0.115
grip strength	forelimb grip strength by trial, trial3	-9.4790	6.4892	-0.75803	0.446	0.152
heart weight	heart weight, normalized to body weight	0.10539	0.11078	-0.069647	0.563	0.347
heart weight	heart weight, weight	0.40301	2.5572	-0.32522	0.929	0.876
hematology	basophil differential (percent of total WBC)	-0.11118	0.090800	-1.3729	0.679	0.237
hematology	calculated hemoglobin (cHGB)	0.61974	0.25444	1.5816	0.158	0.0255
hematology	eosinophil differential (percent of total WBC)	-0.23360	0.48631	-0.57676	0.885	0.637
hematology	hematocrit (HCT)	-0.81735	1.0464	-1.0628	0.696	0.445
hematology	hemoglobin concentration distribution width (HDW)	-0.078147	0.032423	-1.9261	0.205	0.0275
hematology	large unstained cells (percent of total WBC)	0.046027	0.15590	0.31521	0.905	0.771
hematology	lymphocyte differential (percent of total WBC)	26.782	6.9392	3.2661	0.0274	0.00126
hematology	mean corpuscular hemoglobin (CHr)	-0.44813	0.17254	-2.2357	0.0896	0.0188
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.47670	0.19562	-1.1332	0.211	0.0261
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	1.5541	0.66370	1.9393	0.242	0.0309
hematology	mean RBC corpuscular volume (MCV)	-4.2383	0.53857	-2.7192	0.0000253	4.56e-7
hematology	measured hemoglobin (mHGB)	0.67714	0.31080	1.4771	0.242	0.0429
hematology	monocyte differential (percent of total WBC)	-0.30263	0.27002	-0.76390	0.632	0.277
hematology	neutrophil differential (percent of total WBC)	-25.655	6.7291	-3.2661	0.0293	0.00139
hematology	platelet count (PLT; units per volume x 10³)	0.92763	66.015	0.065651	0.995	0.989
hematology	RBC corpuscular distribution width (RDW)	-1.0324	0.23958	-2.5814	0.0143	0.000476
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	1.8638	0.25053	2.8653	0.0000849	6.79e-7
hematology	red blood cell count (RBC; per volume x 10⁶)	0.73958	0.17270	2.4004	0.0146	0.000504
hematology	reticulocyte count (Retic; units per volume x 10⁹)	36.059	20.837	1.4429	0.462	0.102
hematology	reticulocyte differential (percent of total RBC)	0.068845	0.22786	0.51327	0.909	0.766
hematology	white blood cell count (WBC; units per volume x 10³)	2.3886	0.57666	1.7221	0.00890	0.000612
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.50536	0.60204	0.56058	0.786	0.404
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.26271	0.46003	-0.28661	0.887	0.570
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.40541	0.40657	-0.61475	0.795	0.323
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.90705	0.55859	0.96607	0.568	0.109
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.49903	0.33813	-0.72023	0.650	0.145
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.032210	0.23401	0.15582	0.987	0.891
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.27101	0.22808	0.70830	0.811	0.239
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.000029646	0.35768	0.13971	1.00	1.00
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.45731	0.45335	-0.72410	0.791	0.317
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.51536	0.35262	-1.4450	0.728	0.149
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.070147	0.27515	0.21100	0.968	0.800
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.44056	0.38182	-0.66710	0.704	0.253
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.2737	0.76133	-1.1660	0.495	0.0994
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-1.0371	0.50702	-1.6149	0.405	0.0450
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.24245	0.45464	-0.28905	0.886	0.596
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.33662	0.80311	-0.27851	0.920	0.677
holeboard	total number of hole pokes, 20 min test	-3.7344	3.6281	-0.43690	0.594	0.307
light / dark	fecal boli count, 20 min test	-0.94670	0.49755	-1.0448	0.406	0.0614
light / dark	latency to enter dark zone, 20 min test	21.351	43.388	0.30763	0.880	0.624
light / dark	number of transitions between light and dark zones, 20 min test	-4.3209	5.8468	-0.32897	0.734	0.463
light / dark	percentage of total time in dark zone, 20 min test	-3.4777	3.0379	-0.51234	0.620	0.256
light / dark	percentage of total time in light zone, 20 min test	3.4777	3.0379	0.50926	0.621	0.256
light / dark	time mobile in dark zone, 20 min test	5.4514	9.7941	0.27238	0.812	0.580
light / dark	time mobile in light zone, 20 min test	12.976	7.7280	0.53560	0.305	0.0979
light / dark	time spent in dark zone, 20 min test	-44.837	46.453	-0.46661	0.722	0.338
light / dark	time spent in light zone, 20 min test	44.837	46.453	0.46661	0.722	0.338
open field	average speed in center of arena, 20 min test	0.35868	0.33701	0.55719	0.636	0.292
open field	average speed in periphery of arena, 20 min test	0.32193	0.14615	0.69443	0.124	0.0317
open field	distance traveled habituation ratio, 20 min test	-4.9911	7.0614	-0.39321	0.754	0.483
open field	distance traveled in center of arena, 20 min test	176.23	86.368	0.74842	0.183	0.0460
open field	distance traveled in periphery of arena, 20 min test	271.24	128.05	0.62924	0.158	0.0385
open field	distance traveled slope, 20 min test	-6.8941	6.7209	-0.59684	0.633	0.309
open field	distance traveled, 20 min test, 1st 5min	158.70	63.168	0.88132	0.0848	0.0149
open field	distance traveled, 20 min test, 2nd 5min	109.87	51.805	0.69614	0.164	0.0383
open field	distance traveled, 20 min test, 3rd 5min	44.017	56.229	0.059781	0.680	0.437
open field	distance traveled, 20 min test, 4th 5min	121.77	52.810	0.85974	0.131	0.0248
open field	number of clockwise revolution episodes, 20 min test	0.91433	1.2977	0.12796	0.780	0.484
open field	number of counter-clockwise revolution episodes, 20 min test	1.4947	0.98650	0.37011	0.397	0.135
open field	number of fecal boli, 20 min test	-2.4181	0.88444	-1.5251	0.128	0.00836
open field	number of rears in 5 min bins, 20 min test, 1st 5min	2.7840	2.1907	0.55360	0.473	0.209
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	4.1780	2.1517	0.75734	0.252	0.0571
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	5.2891	2.0030	0.90129	0.0908	0.0107
open field	number of rears in 5 min bins, 20 min test, 4th 5min	3.2830	2.6763	0.38887	0.495	0.225
open field	percentage of total time in center of arena, 20 min test	2.0699	2.9337	0.27253	0.762	0.483
open field	percentage of total time in center of arena, slope, 20 min test	0.30809	1.2940	0.28929	0.957	0.813
open field	percentage of total time in center, habituation ratio, 20 min test	0.22694	1.3147	0.24614	0.967	0.864
open field	percentage of total time in corners of arena, 20 min test	-5.0795	3.6643	-0.64900	0.481	0.171
open field	percentage of total time in corners, habituation ratio, 20 min test	2.9937	1.8101	1.0116	0.574	0.104
open field	percentage of total time in corners, slope, 20 min test	2.7477	1.7699	0.97639	0.626	0.126
open field	permanence time in center of arena, 20 min test	24.848	35.203	0.27253	0.761	0.483
open field	permanence time in corners of arena, 20 min test	-60.950	43.971	-0.64900	0.482	0.171
open field	permanence time in periphery of arena, 20 min test	-24.825	35.205	-0.27392	0.762	0.484
open field	total distance traveled, 20 min test	453.33	180.97	0.78627	0.0735	0.0151
open field	total number of rears, 20 min test	15.914	7.1590	0.74665	0.148	0.0302
open field	whole arena average speed, 20 min test	0.37723	0.15072	0.78262	0.0737	0.0152
open field	whole arena resting time, 20 min test	-41.947	18.234	-0.60327	0.100	0.0251
open field	whole arena time spent mobile, 20 min test	41.901	18.217	0.85200	0.102	0.0251
open field	whole arena time spent vertical, 20 min test	12.897	6.9277	0.88926	0.301	0.0678
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.42416	1.3979	0.38270	0.919	0.763
startle / PPI	average baseline movement during background noise	0.13482	0.88085	0.19386	0.989	0.879
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.14411	0.060155	1.1548	0.210	0.0208
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.14618	0.054857	1.3131	0.161	0.0106
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	15.100	6.4859	1.8164	0.714	0.0244
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	14.265	5.7466	1.4363	0.231	0.0168
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	11.542	5.3203	1.0469	0.203	0.0353
startle / PPI	average startle response to full pulse (120 dB)	-13.351	29.780	-0.087683	0.846	0.656
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-50.364	32.919	-0.73603	0.334	0.133
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-37.793	27.080	-0.57277	0.376	0.170
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-30.176	21.210	-0.53520	0.362	0.162
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.88223	1.2315	-0.57443	0.867	0.477
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.29575	1.5902	0.21676	0.974	0.853
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.5231	1.4974	0.51430	0.728	0.314
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.15451	0.072739	1.5333	0.743	0.0391
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.14185	0.065503	1.0808	0.266	0.0357
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.12921	0.063112	0.80541	0.195	0.0464
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-13.994	29.710	-0.097533	0.836	0.640
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-43.952	33.522	-0.62304	0.421	0.196
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-38.732	27.476	-0.58271	0.369	0.165
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-32.155	21.478	-0.55307	0.328	0.141
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.14174	0.079322	1.2439	0.751	0.0805
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.16146	0.074299	1.1766	0.267	0.0351
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.14822	0.067628	0.87116	0.164	0.0335
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-52.732	102.74	-0.11867	0.811	0.610
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-165.87	115.54	-0.67317	0.373	0.158
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-140.85	96.350	-0.58105	0.352	0.151
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-122.67	79.198	-0.56948	0.309	0.128
startle / PPI	maximum baseline movement during background noise	-0.37556	2.3105	0.0077063	0.969	0.872
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	14.253	7.2576	1.5333	0.778	0.0556
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	17.059	6.9908	1.5110	0.228	0.0186
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	13.708	6.0597	1.1096	0.175	0.0285
startle / PPI	maximum startle response to full pulse (120 dB)	-54.448	102.96	-0.12291	0.805	0.599
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-168.43	114.64	-0.68907	0.357	0.149
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-140.04	95.276	-0.58105	0.346	0.148
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-117.13	78.667	-0.54656	0.340	0.143
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.0493	3.3548	-0.85124	0.791	0.368
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.39667	4.0585	-0.096125	0.994	0.923
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	4.3082	3.4288	0.58105	0.598	0.215

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.00
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	28.0 %	0.00195
eye morphology	lens opacity	males	16.0 %	0.113
eye morphology	lens opacity	both	21.0 %	0.000753
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	6.0 %	0.690
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	3.0 %	0.745
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.00
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.00
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	24.0 %	0.00256
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	11.0 %	0.0329
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Acot2^em1(IMPC)J -/- with genotype: