MPD: JaxKOMP-LAP genotype: Pacrg<sup>em1(IMPC)J</sup> -/-

JaxKOMP-LAP effect sizes: Pacrg^em1(IMPC)J -/- Gene Pacrg

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-LAP

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Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-LAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

clinical blood chemistry	alanine transaminase (plasma ALT)	-9.5302	7.3155	-0.80642	0.672	0.215
clinical blood chemistry	albumin (plasma Alb)	-0.90444	0.44988	-1.1139	0.732	0.0656
clinical blood chemistry	alkaline phosphatase (plasma ALP)	12.258	20.048	0.92890	0.878	0.551
clinical blood chemistry	aspartate transaminase (plasma AST)	-5.4000	6.0549	-0.59110	0.735	0.388
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.073208	0.12563	0.44895	0.826	0.570
clinical blood chemistry	blood urea nitrogen (BUN)	-3.3122	2.3307	-1.0866	0.599	0.177
clinical blood chemistry	calcium (plasma Ca)	0.040000	0.10583	0.050154	0.988	0.711
clinical blood chemistry	creatinine (plasma)	-0.034146	0.047163	-0.84872	0.884	0.483
clinical blood chemistry	glucose (plasma GLU, no fast)	-25.039	18.051	-1.4810	0.510	0.189
clinical blood chemistry	HDL cholesterol (plasma HDL)	5.8609	3.2368	0.54140	0.393	0.0933
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.051600	0.011734	1.7553	0.0608	0.000608
clinical blood chemistry	phosphorus (plasma phosphate)	-1.8200	0.62993	-1.7553	0.198	0.0119
clinical blood chemistry	total bilirubin (plasma TBIL)	0.016009	0.014690	1.1202	0.755	0.296
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	1.9018	4.5984	-0.086973	0.907	0.686
clinical blood chemistry	total protein (plasma TP)	1.1791	0.84920	0.78685	0.618	0.188
clinical blood chemistry	triglyceride (plasma TG, no fast)	-4.2168	18.036	-0.16202	0.950	0.819
glucose tolerance test	amount glucose injected	-5.4488	4.1070	-0.91412	0.547	0.199
glucose tolerance test	plasma glucose, 0min	-11.667	10.298	-1.0833	0.615	0.269
glucose tolerance test	plasma glucose, 15min	-81.114	42.383	-1.6529	0.364	0.0687
glucose tolerance test	plasma glucose, 30min	-109.10	36.230	-1.5772	0.113	0.00642
glucose tolerance test	plasma glucose, 60min	-58.763	31.707	-1.2909	0.334	0.0773
glucose tolerance test	plasma glucose, 120min	-42.838	26.099	-1.2016	0.405	0.115
heart weight	heart weight, normalized to body weight	0.15137	0.18401	0.43073	0.702	0.424
heart weight	heart weight, weight	11.333	5.8958	1.2156	0.339	0.0738
hematology	basophil differential (percent of total WBC)	0.023404	0.078004	0.33185	0.875	0.769
hematology	calculated hemoglobin (cHGB)	0.32114	0.92515	0.56595	0.919	0.734
hematology	eosinophil differential (percent of total WBC)	15.568	1.1652	2.3338	5.76e-7	5.70e-9
hematology	hematocrit (HCT)	0.87930	3.3213	0.43991	0.946	0.796
hematology	hemoglobin concentration distribution width (HDW)	-0.083077	0.10931	-1.1310	0.762	0.462
hematology	large unstained cells (percent of total WBC)	-0.80213	0.15908	-1.8557	0.0140	0.000225
hematology	lymphocyte differential (percent of total WBC)	-3.6340	2.9823	-0.68230	0.644	0.245
hematology	mean corpuscular hemoglobin (CHr)	-0.055319	0.27127	-0.22754	0.919	0.842
hematology	mean platelet volume (MPV)	-0.83160	0.25670	-1.8852	0.164	0.00709
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.14413	0.28112	-0.32929	0.836	0.617
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.16170	0.66630	0.47658	0.902	0.812
hematology	mean RBC corpuscular volume (MCV)	-0.62979	1.4231	-0.68230	0.858	0.665
hematology	measured hemoglobin (mHGB)	0.44740	1.1836	0.87085	0.863	0.712
hematology	monocyte differential (percent of total WBC)	-0.14810	0.76863	-0.18355	0.974	0.850
hematology	neutrophil differential (percent of total WBC)	1.7787	2.2173	0.65130	0.806	0.437
hematology	platelet count (PLT; units per volume x 10³)	144.23	210.54	0.71397	0.795	0.505
hematology	RBC corpuscular distribution width (RDW)	-0.064943	1.8049	-0.20189	0.982	0.972
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.62128	0.44266	1.0873	0.512	0.184
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.11340	0.62268	-0.44895	0.914	0.858
hematology	reticulocyte count (Retic; units per volume x 10⁹)	42.066	61.722	0.96084	0.941	0.507
hematology	reticulocyte differential (percent of total RBC)	1.3379	1.7400	1.5696	0.852	0.456
hematology	white blood cell count (WBC; units per volume x 10³)	0.77731	2.0003	0.47658	0.927	0.704
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	4.4939	2.5499	1.8486	0.299	0.0933

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-LAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-LAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	2.0 %	1.0
eye morphology	bulging eye	2.0 %	1.0
eye morphology	cornea	5.0 %	1.0
eye morphology	cornea opacity	5.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.0
eye morphology	corneal mineralization	9.0 %	0.667
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	2.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	2.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	5.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	2.0 %	1.0
eye morphology	irispupil	4.0 %	1.0
eye morphology	lacrimation	8.0 %	0.131
eye morphology	lens	11.0 %	0.710
eye morphology	lens opacity	9.0 %	1.0
eye morphology	narrow eye opening	2.0 %	1.0
eye morphology	optic disc	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	9.0 %	1.0
eye morphology	pupil dilation	3.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	11.0 %	1.0
eye morphology	retinal blood vessels	5.0 %	1.0
eye morphology	retinal blood vessels pattern	5.0 %	1.0
eye morphology	retinal blood vessels structure	5.0 %	1.0
eye morphology	retinal pigmentation	7.0 %	1.0
eye morphology	retinal structure	6.0 %	1.0
eye morphology	synechia	5.0 %	1.0
eye morphology	vitreous	5.0 %	1.0
SHIRPA	activity body position	51.0 %	4.07e-8
SHIRPA	aggression	0.0 %	1.0
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	40.0 %	4.75e-8
SHIRPA	body thickness	4.0 %	1.0
SHIRPA	coat color abdomen	17.0 %	0.113
SHIRPA	coat color back	59.0 %	4.24e-7
SHIRPA	coat color head	4.0 %	1.0
SHIRPA	coat color pattern abdomen	4.0 %	1.0
SHIRPA	coat color pattern back	9.0 %	0.385
SHIRPA	coat color pattern head	4.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	0.0 %	1.0
SHIRPA	coat hair back texture appearance	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	5.0 %	1.0
SHIRPA	coat hair distribution back	9.0 %	0.386
SHIRPA	coat hair distribution head	6.0 %	0.795
SHIRPA	coat hair head texture appearance	2.0 %	1.0
SHIRPA	contact righting	4.0 %	1.0
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	eye morphology	2.0 %	1.0
SHIRPA	fat distribution	18.0 %	0.0907
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	2.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	6.0 %	0.0633
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.0
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	1.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	6.0 %	1.0
SHIRPA	hindlimb nail number	0.0 %	1.0
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	1.0 %	1.00
SHIRPA	hindlimbs position	1.0 %	1.0
SHIRPA	hindlimbs shape	3.0 %	1.0
SHIRPA	hindlimbs size	1.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	1.0 %	1.0
SHIRPA	limb grasp	0.0 %	1.0
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	6.0 %	0.0426
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	1.0 %	1.00
SHIRPA	startle response	26.0 %	0.0164
SHIRPA	tail curvature	12.0 %	0.0113
SHIRPA	tail elevation	2.0 %	1.00
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	2.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	1.0 %	1.00
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	49.0 %	1.78e-7
SHIRPA	tremor	2.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	4.0 %	1.0
SHIRPA	vibrissae presence	34.0 %	0.00209
SHIRPA	vocalization	7.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Pacrg^em1(IMPC)J -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.