MPD: JaxKOMP-EAP genotype: H2-Ke6<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: H2-Ke6^em1(IMPC)J -/- Gene H2-Ke6

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	4.3750	1.4030	0.97899	0.262	0.0206
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-1.8815	2.1725	-0.39932	0.826	0.420
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-0.15889	5.1489	-0.21394	0.995	0.976
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	1.4574	7.4701	0.10929	0.946	0.852
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	0.35187	4.0794	0.019628	0.979	0.934
body composition	body length	-0.050323	0.033792	-0.38052	0.413	0.141
body composition	body weight (at time of DXA)	-0.41548	0.45961	-0.23058	0.586	0.369
body composition	bone area, whole body scan, head excluded	-0.22219	0.12028	-0.72152	0.268	0.0691
body composition	bone mineral content of whole body scan, head excluded	-0.020239	0.0086233	-0.93522	0.135	0.0218
body composition	bone mineral content to body weight ratio	-0.00083762	0.00036939	-0.85768	0.140	0.0265
body composition	bone mineral density of whole body scan, head excluded	-0.0010862	0.00040841	-1.1201	0.0974	0.00975
body composition	fat tissue mass of whole body scan, head excluded	0.19432	0.24320	0.33231	0.679	0.427
body composition	fat tissue mass to body weight ratio	0.0085638	0.0081816	0.45331	0.542	0.299
body composition	lean tissue mass of whole body scan, head excluded	-0.096677	0.20162	-0.36131	0.846	0.633
body composition	lean tissue mass to body weight ratio	-0.00016883	0.0076345	-0.052616	0.993	0.982
body composition	percent fat, whole body scan, head excluded	0.71996	0.79241	0.42474	0.613	0.367
body composition	ratio of soft-tissue attenuation coefficients	-0.00080324	0.00088101	-0.42723	0.609	0.365
body composition	tissue area	0.026659	0.16856	0.28111	0.961	0.875
body composition	total tissue mass, whole body scan, head excluded	0.10115	0.17720	0.012288	0.765	0.570
clinical blood chemistry	alanine transaminase (plasma ALT)	56.378	46.306	2.0352	0.603	0.231
clinical blood chemistry	albumin (plasma Alb)	0.15354	0.54655	0.26987	0.925	0.780
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.6250	4.4974	0.11717	0.667	0.426
clinical blood chemistry	aspartate transaminase (plasma AST)	19.542	36.472	0.75881	0.833	0.595
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.086562	0.45732	0.29224	0.957	0.851
clinical blood chemistry	blood urea nitrogen (BUN)	-2.4294	1.1217	-0.98240	0.179	0.0372
clinical blood chemistry	calcium (plasma Ca)	-0.038997	0.080563	0.066162	0.793	0.631
clinical blood chemistry	creatinine (plasma)	0.0042324	0.038760	0.21095	0.956	0.914
clinical blood chemistry	glucose (plasma GLU, no fast)	-16.581	10.339	-0.34448	0.285	0.118
clinical blood chemistry	HDL cholesterol (plasma HDL)	1.7306	3.1940	0.082988	0.821	0.591
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.022057	0.013096	-1.3149	0.399	0.101
clinical blood chemistry	phosphorus (plasma phosphate)	0.65797	0.31156	0.93200	0.203	0.0417
clinical blood chemistry	total bilirubin (plasma TBIL)	0.026792	0.012012	1.4827	0.211	0.0322
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	4.0882	3.7553	0.48228	0.596	0.284
clinical blood chemistry	total protein (plasma TP)	1.2063	0.57821	0.90045	0.230	0.0443
clinical blood chemistry	triglyceride (plasma TG, no fast)	1.4933	9.3038	0.30362	0.944	0.873
EKG	duration of PQ interval	-1.2062	0.61180	-1.0524	0.533	0.0544
EKG	duration of PR interval	-1.2964	0.69534	-1.1178	0.620	0.0682
EKG	duration of QRS interval	-0.010000	0.27707	-0.17621	0.999	0.971
EKG	duration of QT interval	-0.20310	0.70582	-0.042327	0.958	0.775
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.025455	0.69230	0.020151	0.999	0.971
EKG	duration of RR interval	-0.74657	1.2259	-0.11714	0.839	0.545
EKG	duration of ST interval	-0.13000	0.61138	0.088775	0.960	0.833
EKG	heart rate coefficient of variation (signal intensity)	-1.2029	0.84905	-0.92435	0.841	0.163
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-8.3870	5.7823	-0.93365	0.853	0.153
EKG	heart rate, beats per min	5.0413	9.7121	0.027227	0.845	0.606
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.014062	0.071218	-0.24960	0.955	0.844
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.035335	0.092298	0.11419	0.894	0.703
EKG	number of signals	-2.6300	3.7287	-0.58600	0.876	0.484
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-4.9567	4.8459	-0.89927	0.835	0.311
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-2.9932	2.2303	-0.85548	0.865	0.186
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-3.2266	2.3043	-0.88193	0.856	0.168
EKG	root mean square of successive differences of neighboring RR intervals	-1.1829	0.94033	-0.52486	0.843	0.214
glucose tolerance test	amount glucose injected	-3.0007	2.6365	-0.49761	0.643	0.261
glucose tolerance test	plasma glucose, 0min	26.519	4.0302	2.0159	0.0000129	3.89e-8
glucose tolerance test	plasma glucose, 15min	-1.0895	18.869	0.078326	0.983	0.954
glucose tolerance test	plasma glucose, 30min	26.293	21.825	0.89814	0.575	0.234
glucose tolerance test	plasma glucose, 60min	11.258	12.980	0.58167	0.709	0.390
glucose tolerance test	plasma glucose, 120min	12.025	8.4415	0.70145	0.474	0.161
grip strength	body weight (at time of grip strength test)	-0.37841	0.32050	-0.14850	0.433	0.244
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-8.8161	6.3793	-0.38861	0.364	0.173
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.41784	0.30806	-0.42013	0.370	0.181
grip strength	forelimb and hindlimb grip strength by trial, trial1	-5.8872	8.4038	-0.16338	0.747	0.487
grip strength	forelimb and hindlimb grip strength by trial, trial2	-11.324	8.0303	-0.46660	0.398	0.165
grip strength	forelimb and hindlimb grip strength by trial, trial3	-7.3648	9.4317	-0.27048	0.691	0.439
grip strength	forelimb grip strength (mean of trials), average	-1.6789	4.7019	0.039222	0.881	0.723
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.069786	0.23609	0.052306	0.899	0.769
grip strength	forelimb grip strength by trial, trial1	-2.3554	6.6741	-0.0043568	0.891	0.726
grip strength	forelimb grip strength by trial, trial2	-4.6674	5.3722	-0.30530	0.710	0.389
grip strength	forelimb grip strength by trial, trial3	2.1105	6.2234	0.49595	0.894	0.736
heart weight	heart weight, normalized to body weight	0.21532	0.12177	0.30251	0.235	0.0828
heart weight	heart weight, weight	5.4783	3.1251	0.33950	0.245	0.0854
hematology	basophil differential (percent of total WBC)	0.18568	0.077970	1.9121	0.303	0.0227
hematology	calculated hemoglobin (cHGB)	0.64488	0.19192	1.6192	0.0360	0.00185
hematology	eosinophil differential (percent of total WBC)	-0.53255	0.22287	-1.3373	0.268	0.0226
hematology	hematocrit (HCT)	1.8382	0.55051	1.5193	0.0409	0.00197
hematology	hemoglobin concentration distribution width (HDW)	-0.019369	0.015172	-0.53962	0.512	0.210
hematology	large unstained cells (percent of total WBC)	-0.0030934	0.19242	0.014766	0.996	0.987
hematology	lymphocyte differential (percent of total WBC)	-1.3326	1.9829	-0.61807	0.715	0.506
hematology	mean corpuscular hemoglobin (CHr)	0.25899	0.068602	1.6647	0.00775	0.000578
hematology	mean platelet volume (MPV)	0.079698	0.10836	0.34929	0.689	0.467
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.71421	0.95452	-1.3559	0.773	0.459
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-1.8520	2.0608	-1.6113	0.720	0.375
hematology	mean RBC corpuscular volume (MCV)	0.31788	0.31856	0.58368	0.557	0.325
hematology	measured hemoglobin (mHGB)	-0.27562	0.95143	-0.84670	0.897	0.774
hematology	monocyte differential (percent of total WBC)	0.46356	0.51763	1.5064	0.711	0.377
hematology	neutrophil differential (percent of total WBC)	0.25564	2.4105	0.15091	0.961	0.916
hematology	platelet count (PLT; units per volume x 10³)	30.262	74.964	0.47057	0.881	0.689
hematology	RBC corpuscular distribution width (RDW)	0.017699	0.14035	0.066518	0.957	0.900
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.28311	0.20817	0.68987	0.429	0.182
hematology	red blood cell count (RBC; per volume x 10⁶)	0.30613	0.14649	0.99249	0.220	0.0438
hematology	reticulocyte count (Retic; units per volume x 10⁹)	19.013	11.496	0.86535	0.469	0.107
hematology	reticulocyte differential (percent of total RBC)	0.10505	0.11734	0.65907	0.719	0.377
hematology	white blood cell count (WBC; units per volume x 10³)	-0.56491	0.69985	-0.22886	0.618	0.425
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.53135	0.72139	-0.45493	0.816	0.464
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.34195	0.49417	-0.41964	0.872	0.492
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.75962	0.42022	-1.2031	0.602	0.0758
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.60810	0.70957	-0.55861	0.797	0.395
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.42335	0.33015	-0.59650	0.700	0.205
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.50668	0.29505	-1.4229	0.666	0.0913
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.19818	0.21565	-0.57932	0.863	0.362
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.47413	0.44534	-0.68779	0.790	0.291
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.14183	0.41279	0.36430	0.950	0.732
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.031250	0.27718	0.0	0.983	0.911
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.10096	0.24799	-0.23525	0.933	0.685
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.45032	0.51350	-0.68405	0.796	0.384
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.11058	0.80896	-0.028680	0.977	0.892
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.77686	0.39594	-1.1594	0.415	0.0546
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.56438	0.53466	-0.81124	0.744	0.296
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.0115	0.87700	-0.85662	0.677	0.254
holeboard	total number of hole pokes, 20 min test	-6.4245	4.3735	-0.82302	0.418	0.147
light / dark	fecal boli count, 20 min test	-0.16367	0.73317	-0.13835	0.935	0.824
light / dark	latency to enter dark zone, 20 min test	61.124	29.077	0.96958	0.390	0.0392
light / dark	number of transitions between light and dark zones, 20 min test	-3.3052	6.1779	-0.22635	0.821	0.594
light / dark	percentage of total time in dark zone, 20 min test	-1.2687	3.0797	-0.10022	0.893	0.682
light / dark	percentage of total time in light zone, 20 min test	1.2687	3.0797	0.097499	0.893	0.682
light / dark	time mobile in dark zone, 20 min test	-13.230	9.8881	-0.90660	0.476	0.185
light / dark	time mobile in light zone, 20 min test	3.2285	9.6855	-0.033807	0.879	0.740
light / dark	time spent in dark zone, 20 min test	-59.245	38.478	-0.66350	0.541	0.128
light / dark	time spent in light zone, 20 min test	59.245	38.478	0.66350	0.541	0.128
open field	average speed in center of arena, 20 min test	0.032410	0.38435	-0.038273	0.979	0.933
open field	average speed in periphery of arena, 20 min test	-0.093347	0.12930	-0.88528	0.696	0.473
open field	distance traveled habituation ratio, 20 min test	6.5273	6.8424	0.55249	0.659	0.344
open field	distance traveled in center of arena, 20 min test	-49.287	64.426	-0.68591	0.688	0.447
open field	distance traveled in periphery of arena, 20 min test	-60.900	135.42	-0.67744	0.815	0.654
open field	distance traveled slope, 20 min test	6.8570	6.3587	0.63580	0.613	0.285
open field	distance traveled, 20 min test, 1st 5min	-47.385	64.532	-0.72902	0.697	0.465
open field	distance traveled, 20 min test, 2nd 5min	-52.466	44.987	-1.0909	0.481	0.248
open field	distance traveled, 20 min test, 3rd 5min	-28.151	49.022	-0.75555	0.772	0.568
open field	distance traveled, 20 min test, 4th 5min	17.509	47.629	-0.26279	0.865	0.714
open field	number of clockwise revolution episodes, 20 min test	-1.0303	1.0911	-1.0618	0.700	0.348
open field	number of counter-clockwise revolution episodes, 20 min test	1.0109	0.88412	0.13263	0.545	0.257
open field	number of fecal boli, 20 min test	-1.1615	0.82920	-0.67834	0.494	0.166
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-0.73453	1.9397	-0.41750	0.856	0.706
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-0.24152	1.7664	-0.42239	0.958	0.892
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-0.20359	2.0637	-0.33723	0.959	0.922
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.50499	2.6524	-0.24476	0.926	0.850
open field	percentage of total time in center of arena, 20 min test	-1.2463	2.1076	-0.51380	0.816	0.556
open field	percentage of total time in center of arena, slope, 20 min test	-0.70390	1.5701	-0.26696	0.921	0.655
open field	percentage of total time in center, habituation ratio, 20 min test	-0.55869	1.6830	-0.17066	0.937	0.741
open field	percentage of total time in corners of arena, 20 min test	-0.028321	2.9835	0.31317	0.999	0.992
open field	percentage of total time in corners, habituation ratio, 20 min test	1.3925	2.0796	0.33297	0.877	0.505
open field	percentage of total time in corners, slope, 20 min test	1.2609	1.9520	0.30613	0.889	0.520
open field	permanence time in center of arena, 20 min test	-14.949	25.289	-0.51533	0.816	0.556
open field	permanence time in corners of arena, 20 min test	-0.34983	35.802	0.31176	0.998	0.992
open field	permanence time in periphery of arena, 20 min test	14.973	25.287	0.51533	0.815	0.556
open field	total distance traveled, 20 min test	-96.698	168.81	-0.78262	0.754	0.569
open field	total number of rears, 20 min test	-0.67465	6.7066	-0.38887	0.963	0.920
open field	whole arena average speed, 20 min test	-0.080285	0.14058	-0.77898	0.755	0.570
open field	whole arena resting time, 20 min test	4.4831	16.418	0.69443	0.876	0.786
open field	whole arena time spent mobile, 20 min test	-4.5691	16.413	-0.75734	0.877	0.782
open field	whole arena time spent vertical, 20 min test	0.74671	7.0699	-0.055747	0.967	0.916
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-3.1945	1.2562	-1.1783	0.135	0.0142
startle / PPI	average baseline movement during background noise	0.80311	1.0039	0.60443	0.869	0.427
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.15353	0.054390	1.2349	0.134	0.00677
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.15142	0.051575	1.3576	0.112	0.00498
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	11.641	5.8296	1.3547	0.784	0.0512
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	18.141	5.3386	1.9032	0.0911	0.00132
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	12.344	5.4866	1.1466	0.183	0.0288
startle / PPI	average startle response to full pulse (120 dB)	-17.869	32.189	-0.19386	0.788	0.581
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-40.510	34.911	-0.57112	0.491	0.251
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-48.100	27.913	-0.75826	0.257	0.0909
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-38.367	21.758	-0.69441	0.258	0.0838
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.30704	1.4334	-0.18245	0.973	0.831
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.89191	1.5111	0.58936	0.905	0.558
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	3.4857	1.2816	1.1939	0.196	0.00891
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.11213	0.067742	1.0890	0.782	0.104
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.19893	0.058698	1.5946	0.0674	0.00136
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.14192	0.064847	0.90653	0.165	0.0332
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-18.862	32.099	-0.20816	0.776	0.559
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-40.214	35.480	-0.56126	0.498	0.262
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-49.002	28.186	-0.76388	0.249	0.0882
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-42.223	21.829	-0.76013	0.197	0.0586
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.10501	0.069290	0.92182	0.802	0.136
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.18103	0.063600	1.3370	0.142	0.00635
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.17332	0.066850	1.0441	0.0971	0.0124
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-73.989	116.58	-0.22537	0.749	0.528
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-130.07	128.22	-0.49520	0.553	0.315
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-169.23	103.32	-0.70156	0.287	0.108
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-169.05	83.327	-0.82536	0.171	0.0477
startle / PPI	maximum baseline movement during background noise	1.9134	2.5195	0.62304	0.846	0.451
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	10.879	6.1462	1.1253	0.781	0.0827
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	17.315	5.8554	1.5378	0.133	0.00469
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	15.570	5.9572	1.2781	0.113	0.0117
startle / PPI	maximum startle response to full pulse (120 dB)	-71.453	116.93	-0.21103	0.756	0.544
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-132.56	126.70	-0.51910	0.536	0.300
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-168.37	102.64	-0.69798	0.287	0.107
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-158.94	83.363	-0.79232	0.204	0.0622
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-2.5108	3.7087	-0.69441	0.854	0.501
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	0.79368	3.8872	0.25132	0.976	0.839
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	9.0354	2.9184	1.1769	0.0985	0.00318

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	11.0 %	0.135
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	7.0 %	0.128
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	18.0 %	0.250
eye morphology	lens opacity	both	4.0 %	0.654
eye morphology	narrow eye opening	females	11.0 %	0.0364
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	7.0 %	0.0323
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	20.0 %	0.0243
eye morphology	pupil light response	both	7.0 %	0.0785
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	24.0 %	0.189
eye morphology	retina	both	3.0 %	0.661
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	9.0 %	0.567
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	6.0 %	0.745
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.00
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.00
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.00
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.00
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.00
SHIRPA	coat color pattern abdomen	females	1.0 %	1.00
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.00
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.00
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.00
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.00
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.00
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.00
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.00
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.00
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.00
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.00
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.00
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.00
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.00
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.00
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.00
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.00
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.0
SHIRPA	limb grasp	males	7.0 %	0.375
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.00
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.00
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.00
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.0
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.00
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.0
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.00
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.00
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.00
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.00
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.0
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate H2-Ke6^em1(IMPC)J -/- with genotype: