MPD: JaxKOMP-EAP genotype: Otogl<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Otogl^em1(IMPC)J -/- Gene Otogl

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

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Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

body composition	body length	-0.082461	0.042349	-0.73840	0.246	0.0574
body composition	body weight (at time of DXA)	-0.82359	0.46567	-0.51052	0.234	0.0832
body composition	bone area, whole body scan, head excluded	-0.24192	0.14307	-0.78128	0.316	0.0973
body composition	bone mineral content of whole body scan, head excluded	-0.013896	0.0095413	-0.62392	0.408	0.152
body composition	bone mineral content to body weight ratio	-0.00084874	0.00036294	-0.87758	0.129	0.0235
body composition	bone mineral density of whole body scan, head excluded	-0.00021315	0.00044261	-0.19729	0.821	0.632
body composition	fat tissue mass of whole body scan, head excluded	0.025947	0.28330	0.043702	0.966	0.927
body composition	fat tissue mass to body weight ratio	-0.00073636	0.0099114	0.021846	0.980	0.941
body composition	lean tissue mass of whole body scan, head excluded	0.51323	0.28194	0.86958	0.314	0.0749
body composition	lean tissue mass to body weight ratio	0.011069	0.0082855	0.54251	0.438	0.188
body composition	percent fat, whole body scan, head excluded	-0.21443	0.95229	-0.043702	0.918	0.823
body composition	ratio of soft-tissue attenuation coefficients	0.00024247	0.0010582	0.047907	0.927	0.820
body composition	tissue area	-0.075847	0.17453	-0.083469	0.868	0.666
body composition	total tissue mass, whole body scan, head excluded	0.55256	0.25351	0.91221	0.159	0.0342
clinical blood chemistry	alanine transaminase (plasma ALT)	-4.3794	19.068	-0.42710	0.950	0.821
clinical blood chemistry	albumin (plasma Alb)	-0.16249	0.60494	-0.18934	0.926	0.791
clinical blood chemistry	alkaline phosphatase (plasma ALP)	2.4895	3.2276	-0.10149	0.683	0.450
clinical blood chemistry	aspartate transaminase (plasma AST)	-19.209	23.427	-0.86942	0.722	0.422
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.42740	0.29102	-1.2425	0.540	0.157
clinical blood chemistry	blood urea nitrogen (BUN)	-2.9322	2.0805	-1.1577	0.423	0.176
clinical blood chemistry	calcium (plasma Ca)	0.13983	0.081761	1.2697	0.288	0.103
clinical blood chemistry	creatinine (plasma)	-0.045644	0.022062	-0.89952	0.213	0.0551
clinical blood chemistry	glucose (plasma GLU, no fast)	10.835	9.7674	0.70118	0.487	0.280
clinical blood chemistry	HDL cholesterol (plasma HDL)	4.9167	2.9034	0.82717	0.357	0.106
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.030645	0.012342	1.4602	0.185	0.0220
clinical blood chemistry	phosphorus (plasma phosphate)	-0.31667	0.22469	-0.56189	0.439	0.174
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.025730	0.013189	-1.6249	0.306	0.0652
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	4.2099	4.4387	0.49992	0.657	0.354
clinical blood chemistry	total protein (plasma TP)	-0.073260	0.80028	-0.11301	0.970	0.928
clinical blood chemistry	triglyceride (plasma TG, no fast)	-21.046	9.3302	-0.89459	0.191	0.0361
EKG	duration of PQ interval	-1.3064	0.66523	-1.1641	0.535	0.0567
EKG	duration of PR interval	-1.7873	0.75240	-1.5069	0.469	0.0225
EKG	duration of QRS interval	-0.53788	0.30495	-1.6310	0.885	0.0856
EKG	duration of QT interval	-1.6971	0.80462	-1.3406	0.508	0.0414
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-1.3895	0.81199	-1.4079	0.687	0.0950
EKG	duration of RR interval	-1.8582	1.2687	-0.71814	0.566	0.151
EKG	duration of ST interval	-1.2782	0.79493	-1.0180	0.632	0.116
EKG	heart rate coefficient of variation (signal intensity)	1.5761	0.91037	1.3406	0.799	0.0913
EKG	heart rate variability, mean of differences between sequential beats; beats per min	12.528	6.5716	1.4470	0.761	0.0640
EKG	heart rate, beats per min	17.565	10.576	0.80930	0.481	0.105
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.17677	0.070608	-1.4640	0.216	0.0166
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.18638	0.10522	-1.1597	0.386	0.0843
EKG	number of signals	-3.5686	2.9656	-0.77132	0.744	0.236
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	1.5959	3.1076	0.37482	0.903	0.610
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.33355	3.3573	0.13745	0.989	0.921
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	1.0628	3.9198	0.29646	0.971	0.788
EKG	root mean square of successive differences of neighboring RR intervals	1.9763	1.6976	1.0882	0.843	0.251
glucose tolerance test	amount glucose injected	-5.9232	3.3180	-1.2639	0.406	0.0851
glucose tolerance test	plasma glucose, 0min	-14.977	6.1700	-1.5000	0.0958	0.0219
glucose tolerance test	plasma glucose, 15min	-47.395	20.220	-1.1781	0.196	0.0261
glucose tolerance test	plasma glucose, 30min	-8.9394	18.106	-0.14325	0.841	0.625
glucose tolerance test	plasma glucose, 60min	10.138	13.478	0.54308	0.757	0.458
glucose tolerance test	plasma glucose, 120min	2.1818	7.5746	0.020593	0.920	0.775
grip strength	body weight (at time of grip strength test)	-2.3745	0.36444	-1.6415	0.0000218	3.91e-7
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-30.436	5.5858	-1.8001	0.000449	0.00000729
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.5725	0.37102	-1.8962	0.00523	0.000221
grip strength	forelimb and hindlimb grip strength by trial, trial1	-25.744	8.3486	-1.4132	0.0514	0.00456
grip strength	forelimb and hindlimb grip strength by trial, trial2	-26.314	6.3223	-1.4212	0.0117	0.000257
grip strength	forelimb and hindlimb grip strength by trial, trial3	-37.366	10.507	-1.9817	0.0247	0.00136
grip strength	forelimb grip strength (mean of trials), average	-22.146	4.7314	-2.1534	0.00279	0.0000616
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.89105	0.32233	-1.7510	0.0808	0.00997
grip strength	forelimb grip strength by trial, trial1	-23.457	5.3980	-2.2339	0.0122	0.000155
grip strength	forelimb grip strength by trial, trial2	-19.971	6.0027	-1.6934	0.0477	0.00239
grip strength	forelimb grip strength by trial, trial3	-21.975	5.1676	-1.9325	0.0124	0.000201
heart weight	heart weight, normalized to body weight	-0.20083	0.10417	-1.2295	0.203	0.0637
heart weight	heart weight, weight	-5.4737	2.8376	-1.1217	0.213	0.0636
hematology	basophil differential (percent of total WBC)	-0.075130	0.073865	-1.0385	0.729	0.321
hematology	calculated hemoglobin (cHGB)	0.081239	0.19677	-0.045211	0.843	0.684
hematology	eosinophil differential (percent of total WBC)	-0.15476	0.27165	-0.35974	0.859	0.575
hematology	hematocrit (HCT)	0.19405	0.51214	-0.16752	0.856	0.709
hematology	hemoglobin concentration distribution width (HDW)	-0.025644	0.012698	-0.73124	0.300	0.0578
hematology	large unstained cells (percent of total WBC)	0.16870	0.096795	1.0929	0.419	0.0967
hematology	lymphocyte differential (percent of total WBC)	1.7618	1.2065	0.64140	0.412	0.161
hematology	mean corpuscular hemoglobin (CHr)	0.057617	0.065252	0.48498	0.629	0.388
hematology	mean platelet volume (MPV)	-0.079919	0.085685	-0.71953	0.595	0.363
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.89167	0.91974	-1.5170	0.701	0.344
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-1.8664	2.0701	-1.6215	0.722	0.378
hematology	mean RBC corpuscular volume (MCV)	-0.026986	0.25087	-0.041014	0.963	0.915
hematology	measured hemoglobin (mHGB)	-0.96749	0.98995	-1.6536	0.634	0.341
hematology	monocyte differential (percent of total WBC)	-0.30278	0.15028	-0.76573	0.350	0.0583
hematology	neutrophil differential (percent of total WBC)	-1.4468	1.0929	-0.65998	0.451	0.201
hematology	platelet count (PLT; units per volume x 10³)	-26.131	54.107	-0.30967	0.857	0.634
hematology	RBC corpuscular distribution width (RDW)	-0.16370	0.093431	-0.60593	0.315	0.0959
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.083571	0.18468	0.19976	0.838	0.656
hematology	red blood cell count (RBC; per volume x 10⁶)	0.023463	0.12031	-0.25589	0.928	0.847
hematology	reticulocyte count (Retic; units per volume x 10⁹)	15.261	13.543	0.72047	0.661	0.273
hematology	reticulocyte differential (percent of total RBC)	0.12393	0.12988	0.72175	0.698	0.351
hematology	white blood cell count (WBC; units per volume x 10³)	1.0055	0.58117	0.84905	0.251	0.0990
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.39417	0.52401	0.43258	0.814	0.456
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.44757	0.37822	-0.58845	0.766	0.242
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.18204	0.29151	-0.22382	0.895	0.535
holeboard	number of hole pokes by individual hole number, 20 min test, 4	1.6226	0.63523	1.5553	0.297	0.0139
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.020874	0.37901	0.14142	0.985	0.956
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.057767	0.22209	-0.097993	0.968	0.796
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.27476	0.29739	-0.75693	0.863	0.360
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.19563	0.34064	0.45119	0.906	0.568
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.063592	0.39228	-0.033788	0.984	0.872
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.079126	0.27032	-0.14598	0.952	0.771
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.15922	0.20769	-0.40614	0.870	0.447
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.56472	0.29987	0.99934	0.492	0.0656
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.64080	0.79770	0.73173	0.770	0.426
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.46204	0.39767	0.80656	0.686	0.251
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.11995	0.40456	-0.072597	0.914	0.768
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.89627	0.76504	-0.76070	0.666	0.247
holeboard	total number of hole pokes, 20 min test	2.8830	3.5783	0.48379	0.681	0.424
light / dark	fecal boli count, 20 min test	-1.1063	0.51317	-1.2394	0.365	0.0360
light / dark	latency to enter dark zone, 20 min test	21.094	27.890	0.30480	0.811	0.453
light / dark	number of transitions between light and dark zones, 20 min test	9.8647	6.4628	1.0048	0.430	0.133
light / dark	percentage of total time in dark zone, 20 min test	-13.832	4.0602	-2.0119	0.0579	0.00132
light / dark	percentage of total time in light zone, 20 min test	13.832	4.0602	2.0119	0.0579	0.00132
light / dark	time mobile in dark zone, 20 min test	13.581	11.525	0.69758	0.545	0.244
light / dark	time mobile in light zone, 20 min test	45.281	10.616	1.8778	0.00306	0.0000909
light / dark	time spent in dark zone, 20 min test	-121.54	54.111	-1.4911	0.286	0.0293
light / dark	time spent in light zone, 20 min test	121.54	54.111	1.4911	0.286	0.0293
open field	average speed in center of arena, 20 min test	0.14501	0.49159	0.16930	0.918	0.769
open field	average speed in periphery of arena, 20 min test	0.25022	0.12552	0.44452	0.168	0.0518
open field	distance traveled habituation ratio, 20 min test	-1.8056	6.8808	-0.10424	0.918	0.794
open field	distance traveled in center of arena, 20 min test	115.41	95.406	0.42239	0.487	0.232
open field	distance traveled in periphery of arena, 20 min test	231.66	142.31	0.46088	0.304	0.110
open field	distance traveled slope, 20 min test	-1.5326	6.6157	-0.078623	0.940	0.818
open field	distance traveled, 20 min test, 1st 5min	70.884	62.755	0.20894	0.510	0.264
open field	distance traveled, 20 min test, 2nd 5min	78.551	44.143	0.39031	0.257	0.0814
open field	distance traveled, 20 min test, 3rd 5min	100.52	49.423	0.65066	0.184	0.0474
open field	distance traveled, 20 min test, 4th 5min	61.004	45.718	0.20894	0.411	0.188
open field	number of clockwise revolution episodes, 20 min test	-0.40230	1.0908	-0.65689	0.898	0.714
open field	number of counter-clockwise revolution episodes, 20 min test	2.5163	1.1780	0.89928	0.216	0.0377
open field	number of fecal boli, 20 min test	0.23852	0.86175	0.43897	0.907	0.783
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.0024	2.2516	0.057795	0.834	0.658
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-0.95982	2.4502	-0.58724	0.851	0.697
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-1.2492	2.7182	-0.57452	0.822	0.648
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-0.90584	2.3249	-0.55093	0.850	0.698
open field	percentage of total time in center of arena, 20 min test	0.57863	3.7034	-0.059781	0.956	0.876
open field	percentage of total time in center of arena, slope, 20 min test	0.97919	1.6632	0.67913	0.868	0.559
open field	percentage of total time in center, habituation ratio, 20 min test	1.2611	1.7244	0.79177	0.845	0.468
open field	percentage of total time in corners of arena, 20 min test	-0.45504	4.0497	0.23233	0.965	0.911
open field	percentage of total time in corners, habituation ratio, 20 min test	0.93714	1.7007	0.14891	0.908	0.584
open field	percentage of total time in corners, slope, 20 min test	0.87243	1.6572	0.12586	0.911	0.601
open field	permanence time in center of arena, 20 min test	6.9398	44.439	-0.058436	0.955	0.877
open field	permanence time in corners of arena, 20 min test	-5.4488	48.599	0.23233	0.965	0.911
open field	permanence time in periphery of arena, 20 min test	-6.8960	44.428	0.059781	0.956	0.877
open field	total distance traveled, 20 min test	306.02	161.74	0.39466	0.195	0.0644
open field	total number of rears, 20 min test	-0.80012	7.8288	-0.39466	0.963	0.919
open field	whole arena average speed, 20 min test	0.25525	0.13500	0.40048	0.196	0.0646
open field	whole arena resting time, 20 min test	-23.516	15.960	-0.12993	0.319	0.147
open field	whole arena time spent mobile, 20 min test	23.538	15.963	0.38164	0.324	0.147
open field	whole arena time spent vertical, 20 min test	-11.225	7.3510	-0.96993	0.409	0.133
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.9763	1.5702	-0.66022	0.541	0.218
startle / PPI	average baseline movement during background noise	0.11589	1.1431	0.17676	0.995	0.920
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.074156	0.077390	0.58105	0.686	0.345
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.10187	0.071481	0.90404	0.506	0.163
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	3.0075	9.6206	0.37952	0.965	0.757
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-7.8134	7.5738	-0.80582	0.667	0.310
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-6.8408	6.9431	-0.73603	0.631	0.331
startle / PPI	average startle response to full pulse (120 dB)	-105.95	20.207	-1.4936	0.000356	0.00000831
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-112.85	22.147	-1.5470	0.000502	0.0000129
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-77.772	20.743	-1.1996	0.00959	0.000660
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-61.259	16.294	-1.1412	0.0110	0.000641
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	4.1993	2.0986	1.9767	0.524	0.0534
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	4.4390	2.5142	1.9669	0.585	0.0867
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.55289	1.4803	0.093311	0.925	0.711
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.16479	0.12637	1.6207	0.850	0.201
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.057004	0.10677	0.39812	0.838	0.597
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.054170	0.084167	0.27250	0.753	0.524
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-106.14	20.117	-1.4936	0.000328	0.00000753
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-116.86	21.884	-1.5852	0.000295	0.00000621
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-80.525	20.769	-1.2259	0.00760	0.000460
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-61.754	16.221	-1.1279	0.00955	0.000561
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.14438	0.13052	1.2686	0.853	0.277
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.026769	0.11714	0.099701	0.927	0.821
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.016109	0.086736	-0.058915	0.949	0.854
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-391.92	75.586	-1.5198	0.000376	0.00000988
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-416.72	80.462	-1.6002	0.000375	0.0000101
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-283.84	75.823	-1.2141	0.00976	0.000671
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-222.50	60.632	-1.1044	0.0124	0.000825
startle / PPI	maximum baseline movement during background noise	0.69216	2.5987	0.31698	0.960	0.792
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.1271	10.060	0.44048	0.951	0.684
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-8.9836	8.6590	-0.86950	0.661	0.307
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-6.1609	7.6095	-0.68730	0.698	0.424
startle / PPI	maximum startle response to full pulse (120 dB)	-391.17	75.776	-1.5378	0.000394	0.0000106
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-407.85	80.619	-1.5564	0.000495	0.0000144
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-273.86	75.138	-1.1939	0.0111	0.000885
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-224.44	60.862	-1.1070	0.0121	0.000785
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	9.4027	5.2945	1.9387	0.552	0.0847
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	14.454	6.3628	2.2656	0.429	0.0298
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-1.7683	3.4039	-0.55144	0.862	0.607

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

Download Plot

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.0
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.0
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	18.0 %	0.199
eye morphology	lens opacity	males	6.0 %	1.00
eye morphology	lens opacity	both	10.0 %	0.269
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	3.0 %	1.0
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	18.0 %	0.314
eye morphology	retina	males	45.0 %	0.0601
eye morphology	retina	both	29.0 %	0.0514
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.00
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.0
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.00
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.620
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	12.0 %	0.0146
SHIRPA	startle response	males	14.0 %	0.0206
SHIRPA	startle response	both	13.0 %	0.000548
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	13.0 %	0.125
SHIRPA	tail elevation	both	5.0 %	0.191
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	25.0 %	0.000157
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	13.0 %	0.000317
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Otogl^em1(IMPC)J -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.