MPD: JaxKOMP-EAP genotype: Cuedc1<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Cuedc1^em1(IMPC)J -/- Gene Cuedc1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	5.4257	1.6042	1.2007	0.130	0.00545
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	0.11364	2.1561	0.029052	0.984	0.959
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	5.5682	2.1601	0.85792	0.218	0.0230
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	12.159	3.2541	1.6397	0.0599	0.00249
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	7.5711	3.2607	1.1544	0.294	0.0386
body composition	body length	-0.077483	0.044186	-0.68878	0.303	0.0874
body composition	body weight (at time of DXA)	0.86835	0.64851	0.78539	0.397	0.188
body composition	bone area, whole body scan, head excluded	0.38608	0.17376	1.7663	0.165	0.0320
body composition	bone mineral content of whole body scan, head excluded	0.024259	0.013317	1.5286	0.277	0.0762
body composition	bone mineral content to body weight ratio	0.0010925	0.00056349	1.6080	0.231	0.0598
body composition	bone mineral density of whole body scan, head excluded	0.00089462	0.00059174	1.0116	0.406	0.139
body composition	fat tissue mass of whole body scan, head excluded	-0.51622	0.28782	-0.99616	0.268	0.0806
body composition	fat tissue mass to body weight ratio	-0.019026	0.010334	-0.85768	0.229	0.0732
body composition	lean tissue mass of whole body scan, head excluded	-0.011197	0.22551	-0.18676	0.990	0.961
body composition	lean tissue mass to body weight ratio	0.0041971	0.0092950	0.17228	0.835	0.654
body composition	percent fat, whole body scan, head excluded	-1.6743	1.0022	-0.78313	0.289	0.103
body composition	ratio of soft-tissue attenuation coefficients	0.0019208	0.0011202	0.81922	0.277	0.0943
body composition	tissue area	-0.37959	0.16252	-1.0603	0.163	0.0247
body composition	total tissue mass, whole body scan, head excluded	-0.51460	0.17385	-1.4986	0.0454	0.00521
clinical blood chemistry	alanine transaminase (plasma ALT)	-6.0211	5.3924	-0.56168	0.640	0.274
clinical blood chemistry	albumin (plasma Alb)	-1.3621	0.42114	-1.7269	0.0556	0.00312
clinical blood chemistry	alkaline phosphatase (plasma ALP)	29.996	7.1374	2.5331	0.00673	0.000244
clinical blood chemistry	aspartate transaminase (plasma AST)	-12.696	21.367	-0.61857	0.817	0.557
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.21381	0.40284	0.68074	0.870	0.600
clinical blood chemistry	blood urea nitrogen (BUN)	-1.7582	1.5776	-0.74502	0.550	0.284
clinical blood chemistry	calcium (plasma Ca)	-0.072481	0.095577	-0.17073	0.679	0.455
clinical blood chemistry	creatinine (plasma)	-0.060761	0.038935	-1.1924	0.357	0.141
clinical blood chemistry	glucose (plasma GLU, no fast)	-30.810	12.545	-0.79962	0.0849	0.0208
clinical blood chemistry	HDL cholesterol (plasma HDL)	-6.8334	2.3158	-1.6418	0.0836	0.00648
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0053505	0.017859	-0.46694	0.934	0.767
clinical blood chemistry	phosphorus (plasma phosphate)	0.0052235	0.31022	-0.029217	0.995	0.987
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.053796	0.025373	-2.6551	0.237	0.0430
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-12.492	3.3444	-1.9607	0.0240	0.000888
clinical blood chemistry	total protein (plasma TP)	11.778	4.8314	2.7048	0.167	0.0226
clinical blood chemistry	triglyceride (plasma TG, no fast)	-9.5545	16.754	-0.30962	0.793	0.578
EKG	duration of PQ interval	0.89500	0.80291	1.1253	0.814	0.278
EKG	duration of PR interval	1.0448	0.78758	1.1842	0.757	0.199
EKG	duration of QRS interval	0.11223	0.32828	0.18235	0.967	0.736
EKG	duration of QT interval	0.62125	0.94838	0.76052	0.898	0.520
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.44625	1.0575	0.54112	0.946	0.677
EKG	duration of RR interval	1.2019	1.8869	0.89389	0.837	0.531
EKG	duration of ST interval	0.51125	0.83204	0.75247	0.880	0.546
EKG	heart rate coefficient of variation (signal intensity)	0.59833	1.0610	0.56696	0.914	0.579
EKG	heart rate variability, mean of differences between sequential beats; beats per min	2.9641	7.0153	0.42117	0.935	0.677
EKG	heart rate, beats per min	-8.8568	15.286	-0.83760	0.828	0.568
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.021750	0.12739	0.069629	0.959	0.866
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.13294	0.16585	-0.84047	0.747	0.432
EKG	number of signals	2.9544	3.4585	0.55048	0.841	0.403
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	1.8500	3.6694	0.42107	0.911	0.619
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.2330	2.4803	0.39053	0.964	0.624
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	1.2128	2.4569	0.33458	0.947	0.627
EKG	root mean square of successive differences of neighboring RR intervals	0.36450	1.4577	0.30278	0.956	0.805
glucose tolerance test	amount glucose injected	-2.8281	3.6785	-0.45906	0.784	0.458
glucose tolerance test	plasma glucose, 0min	0.27418	9.5360	-0.21019	0.988	0.978
glucose tolerance test	plasma glucose, 15min	-44.600	23.466	-1.1069	0.339	0.0816
glucose tolerance test	plasma glucose, 30min	77.584	20.928	2.0265	0.0613	0.00346
glucose tolerance test	plasma glucose, 60min	39.979	21.935	1.5905	0.356	0.0934
glucose tolerance test	plasma glucose, 120min	24.960	13.384	1.4833	0.360	0.0868
grip strength	body weight (at time of grip strength test)	0.38233	0.55775	0.58085	0.682	0.498
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-19.646	6.6562	-1.0639	0.0393	0.00609
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.80494	0.33398	-0.95055	0.0964	0.0221
grip strength	forelimb and hindlimb grip strength by trial, trial1	-14.847	9.2394	-0.72363	0.357	0.119
grip strength	forelimb and hindlimb grip strength by trial, trial2	-20.389	9.2641	-1.0537	0.168	0.0356
grip strength	forelimb and hindlimb grip strength by trial, trial3	-22.722	7.4427	-1.2078	0.0505	0.00472
grip strength	forelimb grip strength (mean of trials), average	-10.277	6.4985	-0.96665	0.350	0.124
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.37857	0.32919	-0.73120	0.535	0.259
grip strength	forelimb grip strength by trial, trial1	-16.002	6.8508	-1.4414	0.210	0.0264
grip strength	forelimb grip strength by trial, trial2	-20.368	5.9155	-1.7377	0.0422	0.00172
grip strength	forelimb grip strength by trial, trial3	5.8447	9.4778	0.85662	0.788	0.542
heart weight	heart weight, normalized to body weight	0.17926	0.27727	0.18963	0.711	0.524
heart weight	heart weight, weight	4.4090	7.0386	0.20893	0.719	0.537
hematology	basophil differential (percent of total WBC)	0.13290	0.078579	1.6003	0.517	0.106
hematology	calculated hemoglobin (cHGB)	-1.3575	0.73559	-2.5397	0.292	0.0791
hematology	eosinophil differential (percent of total WBC)	-0.13986	0.26497	-0.31486	0.872	0.603
hematology	hematocrit (HCT)	-6.1359	2.3002	-2.7192	0.126	0.0148
hematology	hemoglobin concentration distribution width (HDW)	0.011295	0.018885	0.30177	0.777	0.556
hematology	large unstained cells (percent of total WBC)	0.25736	0.11434	1.5075	0.259	0.0352
hematology	lymphocyte differential (percent of total WBC)	0.66340	0.88615	0.23729	0.681	0.462
hematology	mean corpuscular hemoglobin (CHr)	-0.12526	0.080937	-0.99237	0.341	0.137
hematology	mean platelet volume (MPV)	-0.31598	0.079912	-1.6055	0.00824	0.000725
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.34214	0.45784	-0.96418	0.773	0.464
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.50905	1.0979	0.99851	0.867	0.648
hematology	mean RBC corpuscular volume (MCV)	-1.7774	0.42193	-2.1096	0.00523	0.000391
hematology	measured hemoglobin (mHGB)	-1.5063	0.91506	-1.9583	0.387	0.115
hematology	monocyte differential (percent of total WBC)	0.074202	0.11997	0.46447	0.811	0.543
hematology	neutrophil differential (percent of total WBC)	-0.94786	0.80869	-0.43273	0.506	0.254
hematology	platelet count (PLT; units per volume x 10³)	-71.341	79.363	-0.86682	0.708	0.379
hematology	RBC corpuscular distribution width (RDW)	0.13537	0.099993	0.45289	0.448	0.190
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.91707	0.24738	1.8932	0.0186	0.00131
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.85534	0.56145	-2.4256	0.395	0.143
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-37.278	27.023	-1.3691	0.579	0.182
hematology	reticulocyte differential (percent of total RBC)	-0.0037695	0.24794	0.19808	0.995	0.988
hematology	white blood cell count (WBC; units per volume x 10³)	0.33793	0.63106	0.42075	0.760	0.598
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.73100	0.61195	-0.67927	0.708	0.240
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.37342	0.35136	-0.47185	0.776	0.295
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.061621	0.33334	0.0059079	0.955	0.854
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.37872	0.63775	0.45493	0.866	0.556
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.31101	0.32220	0.61068	0.790	0.341
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.061106	0.27949	0.22108	0.970	0.828
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.33945	0.29065	-0.94914	0.827	0.251
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.43128	0.42900	0.87579	0.799	0.321
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.11571	0.30921	-0.11681	0.945	0.710
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.0016264	0.22548	0.094859	1.0	0.994
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.020911	0.28320	0.062538	0.987	0.942
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.20400	0.40376	-0.26451	0.906	0.616
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.51603	0.51224	0.58901	0.722	0.320
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.91177	0.44450	-1.3649	0.413	0.0478
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.25720	0.46126	-0.32441	0.886	0.581
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.26208	0.91135	-0.20210	0.938	0.775
holeboard	total number of hole pokes, 20 min test	-0.64684	3.1686	0.010121	0.927	0.839
light / dark	fecal boli count, 20 min test	-0.55000	0.86633	-0.56153	0.840	0.529
light / dark	latency to enter dark zone, 20 min test	-38.245	56.317	-0.83164	0.837	0.501
light / dark	number of transitions between light and dark zones, 20 min test	5.9083	7.7276	0.64009	0.725	0.449
light / dark	percentage of total time in dark zone, 20 min test	0.28625	6.0009	0.17805	0.989	0.962
light / dark	percentage of total time in light zone, 20 min test	-0.28625	6.0009	-0.18492	0.988	0.962
light / dark	time mobile in dark zone, 20 min test	4.5786	16.323	0.21942	0.905	0.781
light / dark	time mobile in light zone, 20 min test	8.5817	10.453	0.31189	0.673	0.417
light / dark	time spent in dark zone, 20 min test	5.1296	67.712	0.28081	0.981	0.940
light / dark	time spent in light zone, 20 min test	-5.1296	67.712	-0.28081	0.981	0.940
open field	average speed in center of arena, 20 min test	1.1472	0.41911	1.7487	0.121	0.00956
open field	average speed in periphery of arena, 20 min test	0.16893	0.14126	0.15570	0.455	0.240
open field	distance traveled habituation ratio, 20 min test	-9.5721	8.9367	-0.79177	0.616	0.291
open field	distance traveled in center of arena, 20 min test	-36.078	77.746	-0.60811	0.801	0.645
open field	distance traveled in periphery of arena, 20 min test	315.52	150.26	0.77534	0.171	0.0428
open field	distance traveled slope, 20 min test	-9.6480	9.1065	-0.84814	0.622	0.296
open field	distance traveled, 20 min test, 1st 5min	117.03	71.933	0.58087	0.312	0.112
open field	distance traveled, 20 min test, 2nd 5min	77.271	55.479	0.37299	0.393	0.172
open field	distance traveled, 20 min test, 3rd 5min	49.569	50.508	0.10154	0.592	0.333
open field	distance traveled, 20 min test, 4th 5min	28.056	55.124	-0.12857	0.798	0.614
open field	number of clockwise revolution episodes, 20 min test	0.90750	1.2426	0.12255	0.771	0.470
open field	number of counter-clockwise revolution episodes, 20 min test	-0.64500	1.5259	-0.76271	0.840	0.675
open field	number of fecal boli, 20 min test	-1.4750	1.1915	-0.93633	0.559	0.224
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-1.1417	2.6628	-0.51947	0.838	0.671
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	1.8876	2.2226	0.12857	0.678	0.402
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	1.3972	2.3444	0.011412	0.765	0.555
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.81844	2.9909	-0.18430	0.898	0.786
open field	percentage of total time in center of arena, 20 min test	-4.7750	2.2977	-1.3677	0.270	0.0449
open field	percentage of total time in center of arena, slope, 20 min test	-1.3995	1.1498	-0.65565	0.692	0.231
open field	percentage of total time in center, habituation ratio, 20 min test	-1.8176	1.1821	-0.82528	0.585	0.133
open field	percentage of total time in corners of arena, 20 min test	6.9605	3.2577	1.5328	0.238	0.0395
open field	percentage of total time in corners, habituation ratio, 20 min test	2.5537	1.5136	0.84430	0.570	0.100
open field	percentage of total time in corners, slope, 20 min test	2.2024	1.4053	0.73781	0.626	0.126
open field	permanence time in center of arena, 20 min test	-57.291	27.574	-1.3677	0.269	0.0449
open field	permanence time in corners of arena, 20 min test	83.533	39.093	1.5328	0.238	0.0395
open field	permanence time in periphery of arena, 20 min test	57.272	27.576	1.3677	0.270	0.0450
open field	total distance traveled, 20 min test	272.03	179.27	0.29069	0.319	0.138
open field	total number of rears, 20 min test	2.3051	9.2465	-0.17748	0.910	0.805
open field	whole arena average speed, 20 min test	0.22620	0.14951	0.28929	0.321	0.139
open field	whole arena resting time, 20 min test	-33.075	18.647	-0.35863	0.229	0.0846
open field	whole arena time spent mobile, 20 min test	33.080	18.647	0.61458	0.230	0.0845
open field	whole arena time spent vertical, 20 min test	14.159	8.8788	1.0116	0.386	0.120
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.0637	1.5378	0.63118	0.753	0.494
startle / PPI	average baseline movement during background noise	0.88249	1.7645	0.65223	0.918	0.621
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.082289	0.070629	0.66092	0.615	0.253
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.088184	0.065742	0.78958	0.539	0.190
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-1.7208	8.1501	-0.13562	0.989	0.834
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	7.7363	6.3022	0.72870	0.604	0.229
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	4.9992	6.0715	0.43740	0.704	0.417
startle / PPI	average startle response to full pulse (120 dB)	-67.785	30.905	-0.99731	0.150	0.0359
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-63.515	33.802	-0.94784	0.221	0.0697
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-56.002	24.430	-0.86950	0.120	0.0288
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-37.579	21.223	-0.68198	0.264	0.0864
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.72500	1.3292	0.55798	0.913	0.589
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.55782	1.4079	0.40068	0.948	0.695
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	2.7356	2.2020	0.94784	0.668	0.224
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.078048	0.094746	-0.70515	0.890	0.416
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.13449	0.074724	1.0270	0.374	0.0816
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.19809	0.081709	1.3201	0.131	0.0214
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-70.015	31.106	-1.0066	0.138	0.0316
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-64.240	33.480	-0.95225	0.209	0.0643
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-58.969	24.699	-0.91541	0.106	0.0232
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-42.721	21.606	-0.76952	0.194	0.0570
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.050649	0.10707	-0.42203	0.936	0.639
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.15899	0.094967	1.1654	0.405	0.104
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.16899	0.077938	1.0039	0.179	0.0379
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-276.75	109.79	-1.1226	0.0914	0.0171
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-257.56	121.57	-1.0690	0.153	0.0422
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-230.01	89.099	-0.98131	0.0783	0.0148
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-149.78	78.514	-0.73420	0.208	0.0657
startle / PPI	maximum baseline movement during background noise	2.0049	4.6649	0.64877	0.932	0.670
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.27168	9.4386	-0.0021017	1.00	0.977
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	12.076	7.7618	1.0518	0.466	0.130
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.9626	6.1552	0.21819	0.780	0.524
startle / PPI	maximum startle response to full pulse (120 dB)	-271.08	108.78	-1.0992	0.0949	0.0183
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-254.87	122.35	-1.0518	0.162	0.0456
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-221.90	88.367	-0.95225	0.0854	0.0175
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-137.87	77.395	-0.69085	0.248	0.0846
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	2.6640	3.0198	0.81360	0.791	0.384
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	2.5035	3.2386	0.69441	0.830	0.445
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	5.1514	5.2229	0.69620	0.711	0.332

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	9.0 %	0.359
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	4.0 %	0.428
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	16.0 %	0.0444
eye morphology	lens opacity	males	10.0 %	0.368
eye morphology	lens opacity	both	11.0 %	0.0521
eye morphology	narrow eye opening	females	23.0 %	0.0116
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	11.0 %	0.0177
eye morphology	optic disc	females	12.0 %	0.0709
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	6.0 %	0.138
eye morphology	persistence of hyaloid vascular system	females	12.0 %	0.178
eye morphology	persistence of hyaloid vascular system	males	11.0 %	0.333
eye morphology	persistence of hyaloid vascular system	both	9.0 %	0.132
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	9.0 %	0.417
eye morphology	retina	both	2.0 %	0.721
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	25.0 %	0.00657
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	12.0 %	0.00909
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	25.0 %	0.0424
eye morphology	retinal pigmentation	males	9.0 %	0.529
eye morphology	retinal pigmentation	both	12.0 %	0.164
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	12.0 %	0.0522
SHIRPA	aggression	both	6.0 %	0.0878
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	11.0 %	0.142
SHIRPA	tail elevation	both	5.0 %	0.202
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Cuedc1^em1(IMPC)J -/- with genotype: