MPD: JaxKOMP-EAP genotype: Pcnx2<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Pcnx2^em1(IMPC)J -/- Gene Pcnx2

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-3.7330	5.5225	-1.2339	0.847	0.536
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-4.0188	3.3983	-0.85339	0.742	0.302
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-1.7132	3.9739	-0.55148	0.895	0.689
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-6.4673	9.9237	-1.1068	0.821	0.550
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-9.4129	8.7986	-1.2809	0.690	0.345
body composition	body length	0.024759	0.038421	0.56825	0.776	0.522
body composition	body weight (at time of DXA)	0.10607	0.59830	0.19430	0.942	0.860
body composition	bone area, whole body scan, head excluded	-0.27919	0.13249	-0.89987	0.191	0.0402
body composition	bone mineral content of whole body scan, head excluded	-0.018395	0.0088634	-0.84396	0.202	0.0433
body composition	bone mineral content to body weight ratio	-0.0010039	0.00038929	-1.0563	0.0911	0.0130
body composition	bone mineral density of whole body scan, head excluded	-0.00062914	0.00042283	-0.68438	0.414	0.143
body composition	fat tissue mass of whole body scan, head excluded	0.37275	0.26948	0.60578	0.408	0.173
body composition	fat tissue mass to body weight ratio	0.0065425	0.0098752	0.36715	0.727	0.511
body composition	lean tissue mass of whole body scan, head excluded	0.087825	0.26766	0.027309	0.898	0.744
body composition	lean tissue mass to body weight ratio	-0.013195	0.010811	-0.76797	0.484	0.228
body composition	percent fat, whole body scan, head excluded	0.71261	0.95357	0.42176	0.684	0.459
body composition	ratio of soft-tissue attenuation coefficients	-0.00079243	0.0010564	-0.41974	0.684	0.457
body composition	tissue area	0.074418	0.16667	0.46599	0.868	0.657
body composition	total tissue mass, whole body scan, head excluded	0.45956	0.18346	0.74655	0.0976	0.0157
clinical blood chemistry	alanine transaminase (plasma ALT)	-6.2972	5.7615	-0.58674	0.650	0.285
clinical blood chemistry	albumin (plasma Alb)	0.90293	0.41489	1.3311	0.245	0.0396
clinical blood chemistry	alkaline phosphatase (plasma ALP)	8.5784	3.6201	0.91627	0.132	0.0262
clinical blood chemistry	aspartate transaminase (plasma AST)	-25.489	37.740	-1.1233	0.783	0.506
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.0066278	0.42923	0.048278	0.997	0.988
clinical blood chemistry	blood urea nitrogen (BUN)	-0.84707	1.5393	-0.37938	0.794	0.587
clinical blood chemistry	calcium (plasma Ca)	-0.081033	0.077016	-0.23606	0.539	0.303
clinical blood chemistry	creatinine (plasma)	-0.0099970	0.022075	-0.13215	0.817	0.655
clinical blood chemistry	glucose (plasma GLU, no fast)	11.310	9.2862	0.72141	0.435	0.235
clinical blood chemistry	HDL cholesterol (plasma HDL)	4.7459	2.5655	0.77636	0.302	0.0767
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0030624	0.010507	0.037729	0.936	0.773
clinical blood chemistry	phosphorus (plasma phosphate)	-0.29384	0.27434	-0.52391	0.582	0.295
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.00023537	0.0095371	-0.021292	0.995	0.981
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	4.0242	3.7576	0.46954	0.601	0.295
clinical blood chemistry	total protein (plasma TP)	1.4643	0.80706	1.0825	0.329	0.0821
clinical blood chemistry	triglyceride (plasma TG, no fast)	2.4195	11.331	0.35194	0.920	0.833
EKG	duration of PQ interval	0.72249	0.90814	0.92744	0.886	0.433
EKG	duration of PR interval	0.80778	0.89841	0.96207	0.877	0.377
EKG	duration of QRS interval	0.44405	0.31558	1.1484	0.885	0.171
EKG	duration of QT interval	0.16607	0.96627	0.32394	0.982	0.865
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.49983	1.0550	0.61739	0.939	0.639
EKG	duration of RR interval	-1.4779	1.2927	-0.49959	0.684	0.263
EKG	duration of ST interval	-0.17657	0.90129	0.038294	0.963	0.846
EKG	heart rate coefficient of variation (signal intensity)	-1.1614	0.91947	-0.89089	0.841	0.217
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-8.0931	6.6467	-0.89991	0.853	0.234
EKG	heart rate, beats per min	9.4215	10.957	0.31678	0.747	0.397
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.081718	0.082314	0.52880	0.694	0.330
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.10607	0.10214	0.52417	0.662	0.309
EKG	number of signals	5.9118	4.7141	1.0918	0.734	0.221
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-1.2003	2.1284	-0.15525	0.893	0.577
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-1.1492	2.7234	-0.30911	0.968	0.676
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-1.8749	2.9184	-0.49731	0.931	0.526
EKG	root mean square of successive differences of neighboring RR intervals	-2.9209	1.8327	-1.4585	0.843	0.123
glucose tolerance test	amount glucose injected	-3.3282	1.8957	-0.59173	0.410	0.0872
glucose tolerance test	plasma glucose, 0min	15.229	4.6194	1.2588	0.0197	0.00213
glucose tolerance test	plasma glucose, 15min	-24.655	19.537	-0.56871	0.545	0.215
glucose tolerance test	plasma glucose, 30min	-25.256	18.716	-0.67191	0.529	0.185
glucose tolerance test	plasma glucose, 60min	4.1511	11.661	0.31107	0.900	0.724
glucose tolerance test	plasma glucose, 120min	7.5074	9.1186	0.36778	0.685	0.415
grip strength	body weight (at time of grip strength test)	-1.1165	0.48511	-0.79022	0.100	0.0287
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-26.740	8.4126	-1.5875	0.0278	0.00359
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.3753	0.34837	-1.6637	0.00736	0.000461
grip strength	forelimb and hindlimb grip strength by trial, trial1	-22.995	11.732	-1.2835	0.250	0.0600
grip strength	forelimb and hindlimb grip strength by trial, trial2	-38.461	8.3893	-2.1534	0.00630	0.0000804
grip strength	forelimb and hindlimb grip strength by trial, trial3	-22.407	10.334	-1.1959	0.188	0.0388
grip strength	forelimb grip strength (mean of trials), average	-19.940	5.3302	-1.9232	0.0152	0.000804
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-1.1658	0.31976	-2.0723	0.0216	0.00108
grip strength	forelimb grip strength by trial, trial1	-20.043	5.9455	-1.8622	0.0522	0.00214
grip strength	forelimb grip strength by trial, trial2	-25.813	6.1617	-2.2705	0.0130	0.000239
grip strength	forelimb grip strength by trial, trial3	-13.800	6.0433	-1.1525	0.197	0.0299
heart weight	heart weight, normalized to body weight	0.21926	0.14115	0.32380	0.312	0.132
heart weight	heart weight, weight	5.1150	3.7952	0.28698	0.393	0.190
hematology	basophil differential (percent of total WBC)	0.034035	0.043615	0.54786	0.802	0.443
hematology	calculated hemoglobin (cHGB)	0.18997	0.12866	0.30723	0.419	0.153
hematology	eosinophil differential (percent of total WBC)	0.12177	0.30603	0.44125	0.903	0.694
hematology	hematocrit (HCT)	1.0917	0.49540	0.90116	0.225	0.0374
hematology	hemoglobin concentration distribution width (HDW)	-0.028061	0.016365	-0.77745	0.369	0.0993
hematology	large unstained cells (percent of total WBC)	0.069168	0.078147	0.44987	0.709	0.385
hematology	lymphocyte differential (percent of total WBC)	1.2695	0.92854	0.45839	0.442	0.185
hematology	mean corpuscular hemoglobin (CHr)	-0.031667	0.065263	-0.24508	0.818	0.632
hematology	mean platelet volume (MPV)	0.16549	0.093161	0.81915	0.242	0.0883
hematology	mean RBC corpuscular hemoglobin (MCH)	0.21489	0.23139	0.80688	0.716	0.362
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.16735	0.54267	0.39641	0.921	0.760
hematology	mean RBC corpuscular volume (MCV)	-0.046794	0.33268	-0.083469	0.953	0.889
hematology	measured hemoglobin (mHGB)	0.46596	0.27598	0.97289	0.368	0.104
hematology	monocyte differential (percent of total WBC)	-0.28464	0.12664	-0.71010	0.277	0.0341
hematology	neutrophil differential (percent of total WBC)	-1.2035	0.66503	-0.53573	0.279	0.0834
hematology	platelet count (PLT; units per volume x 10³)	-5.6253	44.164	-0.023237	0.970	0.900
hematology	RBC corpuscular distribution width (RDW)	0.0069779	0.12228	0.015761	0.982	0.955
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.026114	0.22432	-0.090641	0.956	0.908
hematology	red blood cell count (RBC; per volume x 10⁶)	0.14873	0.10918	0.33451	0.450	0.186
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-7.2879	12.720	-0.23213	0.841	0.572
hematology	reticulocyte differential (percent of total RBC)	-0.14288	0.14108	-0.41002	0.679	0.322
hematology	white blood cell count (WBC; units per volume x 10³)	1.7055	0.44849	1.3113	0.0111	0.000866
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.11964	0.58608	0.17218	0.950	0.839
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.56253	0.40623	-0.74898	0.697	0.172
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.66796	0.43604	-1.0532	0.661	0.132
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.072252	0.41482	0.016036	0.960	0.862
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.10000	0.45985	0.27432	0.967	0.829
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.098058	0.19681	-0.26276	0.936	0.621
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.19395	0.24660	-0.56340	0.902	0.435
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.055264	0.49959	0.029544	0.986	0.912
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.31214	0.42543	0.67237	0.865	0.467
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.24201	0.23021	-0.58677	0.834	0.298
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.088835	0.17450	-0.20238	0.918	0.613
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.42913	0.27340	-0.65242	0.556	0.123
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.71216	0.64033	-0.61123	0.697	0.271
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.65292	0.44690	-0.94521	0.581	0.150
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.86165	0.31482	-1.2724	0.300	0.00861
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.35967	0.86458	-0.29785	0.920	0.679
holeboard	total number of hole pokes, 20 min test	-4.1358	2.8296	-0.50668	0.423	0.150
light / dark	fecal boli count, 20 min test	0.80137	0.78601	0.89848	0.715	0.313
light / dark	latency to enter dark zone, 20 min test	79.587	67.514	1.2350	0.662	0.244
light / dark	number of transitions between light and dark zones, 20 min test	10.434	9.1666	1.0390	0.588	0.261
light / dark	percentage of total time in dark zone, 20 min test	-15.895	5.2287	-2.2279	0.109	0.00383
light / dark	percentage of total time in light zone, 20 min test	15.895	5.2287	2.2279	0.109	0.00383
light / dark	time mobile in dark zone, 20 min test	-3.3630	13.605	-0.34184	0.917	0.806
light / dark	time mobile in light zone, 20 min test	39.090	13.590	1.6538	0.0573	0.00598
light / dark	time spent in dark zone, 20 min test	-169.18	66.365	-1.9540	0.205	0.0140
light / dark	time spent in light zone, 20 min test	169.18	66.365	1.9540	0.205	0.0140
open field	average speed in center of arena, 20 min test	0.26077	0.49699	0.38597	0.834	0.603
open field	average speed in periphery of arena, 20 min test	0.53088	0.14424	1.3310	0.00841	0.000658
open field	distance traveled habituation ratio, 20 min test	-10.507	6.6939	-0.88330	0.428	0.124
open field	distance traveled in center of arena, 20 min test	119.42	98.687	0.43564	0.488	0.233
open field	distance traveled in periphery of arena, 20 min test	525.23	140.01	1.4511	0.00896	0.000533
open field	distance traveled slope, 20 min test	-10.510	6.4849	-0.91753	0.396	0.113
open field	distance traveled, 20 min test, 1st 5min	213.56	62.482	1.2626	0.0190	0.00141
open field	distance traveled, 20 min test, 2nd 5min	156.02	52.354	1.1592	0.0421	0.00478
open field	distance traveled, 20 min test, 3rd 5min	134.46	61.698	0.96137	0.150	0.0350
open field	distance traveled, 20 min test, 4th 5min	141.56	53.355	1.0528	0.0742	0.0112
open field	number of clockwise revolution episodes, 20 min test	3.5769	1.4365	1.3989	0.147	0.0168
open field	number of counter-clockwise revolution episodes, 20 min test	3.2669	1.0828	1.2626	0.0661	0.00437
open field	number of fecal boli, 20 min test	-1.0341	0.86660	-0.55706	0.574	0.239
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.3336	2.3750	0.16054	0.792	0.577
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.4822	2.5223	0.29349	0.614	0.331
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	0.59631	3.1495	-0.18430	0.928	0.851
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-0.61570	3.5539	-0.46986	0.933	0.863
open field	percentage of total time in center of arena, 20 min test	-0.50096	3.3871	-0.32447	0.959	0.883
open field	percentage of total time in center of arena, slope, 20 min test	-2.8517	1.5477	-1.2960	0.486	0.0725
open field	percentage of total time in center, habituation ratio, 20 min test	-2.7802	1.5917	-1.2746	0.530	0.0880
open field	percentage of total time in corners of arena, 20 min test	-0.71630	4.0568	0.17475	0.949	0.861
open field	percentage of total time in corners, habituation ratio, 20 min test	3.6923	2.1566	1.3149	0.552	0.0943
open field	percentage of total time in corners, slope, 20 min test	3.6675	2.1223	1.3475	0.545	0.0913
open field	permanence time in center of arena, 20 min test	-6.0173	40.644	-0.32306	0.958	0.883
open field	permanence time in corners of arena, 20 min test	-8.5985	48.680	0.17475	0.949	0.861
open field	permanence time in periphery of arena, 20 min test	6.0308	40.645	0.32447	0.958	0.883
open field	total distance traveled, 20 min test	644.65	190.35	1.2163	0.0156	0.00155
open field	total number of rears, 20 min test	3.9756	10.148	-0.066508	0.851	0.697
open field	whole arena average speed, 20 min test	0.53750	0.15883	1.2219	0.0158	0.00156
open field	whole arena resting time, 20 min test	-76.327	20.007	-1.3409	0.00517	0.000440
open field	whole arena time spent mobile, 20 min test	76.156	19.985	1.5241	0.00552	0.000446
open field	whole arena time spent vertical, 20 min test	-4.8571	9.6702	-0.51227	0.843	0.618
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.93274	1.4488	0.58158	0.772	0.525
startle / PPI	average baseline movement during background noise	-0.071827	1.5375	0.021719	0.997	0.963
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.10197	0.062940	0.83326	0.440	0.113
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.086001	0.059505	0.77435	0.493	0.156
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.5161	7.2900	0.55307	0.910	0.539
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.95080	6.9986	0.065199	0.965	0.893
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-1.2301	5.8270	-0.22681	0.937	0.834
startle / PPI	average startle response to full pulse (120 dB)	-34.260	40.484	-0.46689	0.647	0.402
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-32.750	37.329	-0.46845	0.620	0.385
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-29.410	34.146	-0.43124	0.603	0.394
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-22.484	26.924	-0.35702	0.616	0.408
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.98560	1.2971	0.70156	0.848	0.451
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.5082	1.5740	-1.0230	0.844	0.343
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	7.0316	1.9618	1.9969	0.0603	0.000873
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.085477	0.079093	0.84522	0.868	0.286
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.010556	0.077050	0.018938	0.972	0.892
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.067614	0.067654	0.36846	0.590	0.323
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-34.750	40.554	-0.46689	0.641	0.396
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-33.901	37.594	-0.47785	0.609	0.372
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-27.760	34.396	-0.38404	0.625	0.424
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-29.770	27.275	-0.49837	0.498	0.281
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.075933	0.084451	0.70156	0.860	0.374
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.099077	0.078087	0.69755	0.557	0.211
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.13064	0.065795	0.75597	0.217	0.0535
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-147.90	146.89	-0.54981	0.562	0.320
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-131.44	138.06	-0.50632	0.578	0.347
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-130.77	126.75	-0.53844	0.529	0.308
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-128.41	100.04	-0.61456	0.413	0.206
startle / PPI	maximum baseline movement during background noise	-0.35624	3.4690	0.013311	0.980	0.919
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	4.8914	7.9726	0.51430	0.930	0.543
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	9.2737	7.2248	0.77518	0.573	0.206
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	6.5315	6.1031	0.47315	0.580	0.291
startle / PPI	maximum startle response to full pulse (120 dB)	-147.26	146.81	-0.54981	0.567	0.322
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-130.56	137.51	-0.50791	0.578	0.348
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-135.81	126.05	-0.55798	0.506	0.287
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-109.65	99.329	-0.50473	0.496	0.276
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.36080	3.1073	0.24265	0.978	0.908
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-4.8069	3.7855	-1.3071	0.713	0.211
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	18.282	4.8591	2.0747	0.0384	0.000515

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	17.0 %	0.243
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	7.0 %	0.319
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	19.0 %	0.144
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	8.0 %	0.211
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	38.0 %	0.000902
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	17.0 %	0.00202
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.00
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	71.0 %	0.0000757
eye morphology	lens opacity	males	6.0 %	1.00
eye morphology	lens opacity	both	29.0 %	0.00217
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	20.0 %	0.0367
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	9.0 %	0.0837
eye morphology	persistence of hyaloid vascular system	females	33.0 %	0.177
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	14.0 %	0.338
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.00
eye morphology	retina	males	11.0 %	0.647
eye morphology	retina	both	5.0 %	0.778
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.00
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.00
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.00
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.620
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	12.0 %	0.0740
SHIRPA	tail elevation	males	13.0 %	0.125
SHIRPA	tail elevation	both	12.0 %	0.0299
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Pcnx2^em1(IMPC)J -/- with genotype: