MPD: JaxKOMP-LAP genotype: Nup37<sup>tm1.1(KOMP)Vlcg</sup>/2J -/-

JaxKOMP-LAP effect sizes: Nup37^{tm1.1(KOMP)Vlcg}/2J -/- Gene Nup37

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-LAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-LAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

body composition	body length	0.0076204	0.11871	0.39120	0.958	0.950
body composition	body weight (at time of DXA)	-5.3800	3.2442	-0.97899	0.274	0.117
body composition	bone area, whole body scan, head excluded	0.46255	0.46676	1.3645	0.612	0.337
body composition	bone mineral content of whole body scan, head excluded	0.020123	0.028592	0.97899	0.726	0.492
body composition	bone mineral content to body weight ratio	-0.000076309	0.00064455	0.15184	0.966	0.907
body composition	bone mineral density of whole body scan, head excluded	-0.00040769	0.0011495	0.086543	0.896	0.727
body composition	fat tissue mass of whole body scan, head excluded	1.8445	0.88460	1.0897	0.224	0.0546
body composition	fat tissue mass to body weight ratio	0.038448	0.025467	1.0513	0.416	0.152
body composition	lean tissue mass of whole body scan, head excluded	-1.4517	1.0417	-1.0897	0.466	0.182
body composition	lean tissue mass to body weight ratio	-0.039271	0.026312	-1.2621	0.461	0.156
body composition	percent fat, whole body scan, head excluded	3.8801	2.5091	1.1715	0.408	0.143
body composition	ratio of soft-tissue attenuation coefficients	-0.0043080	0.0027889	-1.1243	0.408	0.143
body composition	tissue area	1.7475	0.54935	2.1144	0.0891	0.00620
body composition	total tissue mass, whole body scan, head excluded	1.2408	0.64645	1.1297	0.371	0.0742
EKG	duration of PQ interval	-0.053226	1.6691	-0.18001	0.979	0.975
EKG	duration of PR interval	-0.13790	1.5990	-0.28517	0.994	0.933
EKG	duration of QRS interval	0.032258	0.27899	-0.12824	0.987	0.910
EKG	duration of QT interval	2.0038	2.2915	1.5446	0.841	0.402
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.9458	2.5423	1.5446	0.842	0.462
EKG	duration of RR interval	1.4134	1.1472	1.0676	0.613	0.246
EKG	duration of ST interval	2.0308	2.2823	1.5446	0.816	0.394
EKG	heart rate coefficient of variation (signal intensity)	5.2330	2.3975	2.0454	0.478	0.0540
EKG	heart rate variability, mean of differences between sequential beats; beats per min	37.132	17.499	2.0454	0.475	0.0598
EKG	heart rate, beats per min	-7.5919	8.8327	-0.90145	0.757	0.410
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.24435	0.087688	-2.0454	0.170	0.0177
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.45137	0.16497	-2.0454	0.232	0.0194
EKG	number of signals	-2.9113	4.9234	0.12824	0.877	0.566
EKG	QT dispersion, measured as inter-lead variability of QT intervals	0.50830	2.9265	0.28517	0.966	0.866
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	1.0050	2.7918	0.39360	0.968	0.726
EKG	root mean square of successive differences of neighboring RR intervals	7.8137	3.4853	2.0454	0.391	0.0488
glucose tolerance test	amount glucose injected	6.6897	5.0546	0.63629	0.553	0.205
glucose tolerance test	plasma glucose, 0min	-1.5231	12.556	-0.44581	0.986	0.905
glucose tolerance test	plasma glucose, 15min	-27.287	49.303	-0.68744	0.889	0.588
glucose tolerance test	plasma glucose, 30min	-45.752	48.161	-0.85339	0.686	0.357
glucose tolerance test	plasma glucose, 60min	18.246	55.417	0.24911	0.886	0.747
glucose tolerance test	plasma glucose, 120min	24.871	76.797	0.53860	0.877	0.751
grip strength	body weight (at time of grip strength test)	-5.4495	3.7292	-1.0364	0.342	0.161
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-21.126	13.326	-1.5689	0.375	0.130
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.57649	0.33898	-1.3830	0.294	0.107
grip strength	forelimb and hindlimb grip strength by trial, trial1	-22.089	19.200	-1.6449	0.595	0.266
grip strength	forelimb and hindlimb grip strength by trial, trial2	-20.155	17.695	-1.2816	0.594	0.270
grip strength	forelimb and hindlimb grip strength by trial, trial3	-32.759	11.056	-1.5689	0.151	0.00833
grip strength	forelimb grip strength (mean of trials), average	-0.91954	8.8352	-0.10463	0.968	0.918
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.050409	0.26638	-0.18912	0.949	0.852
grip strength	forelimb grip strength by trial, trial1	3.3621	10.691	0.31864	0.895	0.757
grip strength	forelimb grip strength by trial, trial2	3.2586	12.055	0.31864	0.979	0.790
grip strength	forelimb grip strength by trial, trial3	-9.3793	11.650	-1.3306	0.790	0.431
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.70690	1.0629	0.39360	0.864	0.514
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.82759	0.92655	-1.3830	0.898	0.384
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.22414	0.86080	-0.19504	0.944	0.798
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.93103	1.4012	-0.90145	0.886	0.515
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.43103	0.17973	-1.0272	0.417	0.0275
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.12069	0.72427	0.28517	0.973	0.870
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.65517	0.70514	0.98113	0.754	0.365
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.55172	0.39190	-1.1503	0.761	0.176
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-1.1207	0.53216	-2.3149	0.546	0.0495
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.62069	0.84512	-0.90145	0.941	0.472
holeboard	number of hole pokes by individual hole number, 20 min test, 13	1.1379	1.3031	0.86370	0.776	0.394
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.40966	0.85573	-0.47800	0.909	0.638
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-1.2414	0.86138	-1.4599	0.620	0.167
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.7586	1.3690	-1.6350	0.709	0.215
holeboard	total number of hole pokes, 20 min test	-4.3621	7.7687	-0.62707	0.786	0.581
light / dark	fecal boli count, 20 min test	1.4521	1.2262	1.0300	0.475	0.253
light / dark	latency to enter dark zone, 20 min test	-334.88	175.85	-2.4089	0.552	0.0730
light / dark	number of transitions between light and dark zones, 20 min test	-4.0173	11.843	-0.35846	0.953	0.739
light / dark	percentage of total time in dark zone, 20 min test	8.2048	6.0161	0.90023	0.602	0.189
light / dark	percentage of total time in light zone, 20 min test	-8.2048	6.0161	-0.90023	0.602	0.189
light / dark	time mobile in dark zone, 20 min test	5.3003	27.109	-0.050154	0.947	0.847
light / dark	time mobile in light zone, 20 min test	-15.124	22.869	-1.0985	0.791	0.517
light / dark	time spent in dark zone, 20 min test	319.82	174.01	2.1444	0.453	0.0826
light / dark	time spent in light zone, 20 min test	-319.82	174.01	-2.1444	0.453	0.0826
open field	average speed in center of arena, 20 min test	0.85183	0.49533	0.89695	0.410	0.104
open field	average speed in periphery of arena, 20 min test	-0.35060	0.29404	-1.5647	0.652	0.249
open field	distance traveled habituation ratio, 20 min test	-6.9616	11.518	-0.66789	0.837	0.553
open field	distance traveled in center of arena, 20 min test	-88.476	157.41	-0.61612	0.816	0.581
open field	distance traveled in periphery of arena, 20 min test	-213.73	257.04	-1.2306	0.834	0.417
open field	distance traveled slope, 20 min test	-4.1584	10.917	-0.37739	0.898	0.708
open field	distance traveled, 20 min test, 1st 5min	-6.8621	97.489	-0.26642	0.992	0.945
open field	distance traveled, 20 min test, 2nd 5min	-127.63	108.68	-1.3784	0.556	0.256
open field	distance traveled, 20 min test, 3rd 5min	-68.154	98.495	-1.2306	0.828	0.498
open field	distance traveled, 20 min test, 4th 5min	-129.15	95.049	-1.5647	0.527	0.192
open field	number of clockwise revolution episodes, 20 min test	-1.6953	1.4205	-1.4351	0.794	0.249
open field	number of counter-clockwise revolution episodes, 20 min test	-0.11610	1.7473	-0.40011	0.981	0.948
open field	number of fecal boli, 20 min test	-0.32759	1.2373	0.15731	0.861	0.794
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-3.8621	4.5400	-0.89695	0.780	0.406
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-1.0345	4.7620	-0.26642	0.912	0.830
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.5517	6.8101	0.20146	0.880	0.712
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.2241	5.6543	-0.44619	0.876	0.831
open field	percentage of total time in center of arena, 20 min test	-24.716	7.3247	-1.9564	0.0664	0.00338
open field	percentage of total time in center of arena, slope, 20 min test	4.1997	3.5060	1.4351	0.744	0.247
open field	percentage of total time in center, habituation ratio, 20 min test	5.5510	3.4186	1.8302	0.691	0.122
open field	percentage of total time in corners of arena, 20 min test	22.278	10.937	2.3909	0.350	0.0566
open field	percentage of total time in corners, habituation ratio, 20 min test	3.4391	3.4446	0.92890	0.754	0.332
open field	percentage of total time in corners, slope, 20 min test	2.8835	3.6099	0.56595	0.790	0.435
open field	permanence time in center of arena, 20 min test	-296.59	87.901	-1.9564	0.0665	0.00338
open field	permanence time in corners of arena, 20 min test	267.38	131.25	2.3909	0.350	0.0566
open field	permanence time in periphery of arena, 20 min test	296.69	87.884	1.9564	0.0662	0.00337
open field	total distance traveled, 20 min test	-367.52	345.98	-1.3784	0.624	0.303
open field	total number of rears, 20 min test	-3.5690	18.518	-0.31034	0.912	0.849
open field	whole arena average speed, 20 min test	-0.30295	0.28851	-1.3784	0.627	0.308
open field	whole arena resting time, 20 min test	28.082	35.857	0.86588	0.667	0.444
open field	whole arena time spent mobile, 20 min test	-28.039	35.809	-1.1868	0.686	0.444
open field	whole arena time spent vertical, 20 min test	9.6138	19.567	0.51716	0.912	0.629
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	4.4655	1.7098	1.6607	0.109	0.0177

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-LAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-LAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	2.0 %	1.0
eye morphology	bulging eye	2.0 %	1.0
eye morphology	cornea	5.0 %	1.0
eye morphology	cornea opacity	6.0 %	0.333
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.0
eye morphology	corneal mineralization	14.0 %	0.858
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	2.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	2.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	5.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	2.0 %	1.0
eye morphology	irispupil	5.0 %	0.444
eye morphology	lacrimation	6.0 %	0.175
eye morphology	lens	61.0 %	0.000147
eye morphology	lens opacity	9.0 %	1.0
eye morphology	narrow eye opening	7.0 %	0.0750
eye morphology	optic disc	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	9.0 %	1.0
eye morphology	pupil dilation	3.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	5.0 %	0.664
eye morphology	retinal blood vessels	5.0 %	1.0
eye morphology	retinal blood vessels pattern	5.0 %	1.0
eye morphology	retinal blood vessels structure	5.0 %	1.0
eye morphology	retinal pigmentation	7.0 %	1.0
eye morphology	retinal structure	6.0 %	1.0
eye morphology	synechia	5.0 %	1.0
eye morphology	vitreous	5.0 %	1.0
SHIRPA	activity body position	5.0 %	1.0
SHIRPA	aggression	0.0 %	1.0
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	4.0 %	1.0
SHIRPA	body thickness	4.0 %	1.0
SHIRPA	coat color abdomen	20.0 %	0.0320
SHIRPA	coat color back	16.0 %	0.0902
SHIRPA	coat color head	4.0 %	1.0
SHIRPA	coat color pattern abdomen	4.0 %	1.0
SHIRPA	coat color pattern back	9.0 %	0.387
SHIRPA	coat color pattern head	4.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	0.0 %	1.0
SHIRPA	coat hair back texture appearance	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	0.553
SHIRPA	coat hair distribution back	9.0 %	0.386
SHIRPA	coat hair distribution head	8.0 %	0.616
SHIRPA	coat hair head texture appearance	2.0 %	1.00
SHIRPA	contact righting	22.0 %	0.0804
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	eye morphology	5.0 %	0.261
SHIRPA	fat distribution	11.0 %	0.221
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.00
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	2.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.0
SHIRPA	hindlimb digit position	0.0 %	1.00
SHIRPA	hindlimb digit shape	1.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	4.0 %	0.380
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.00
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	1.0 %	1.00
SHIRPA	hindlimbs position	1.0 %	1.0
SHIRPA	hindlimbs shape	3.0 %	1.0
SHIRPA	hindlimbs size	1.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.00
SHIRPA	hindpaw shape	24.0 %	2.46e-7
SHIRPA	hindpaw size	1.0 %	1.0
SHIRPA	limb grasp	19.0 %	0.0752
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.00
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	1.0 %	1.00
SHIRPA	startle response	26.0 %	0.00967
SHIRPA	tail curvature	1.0 %	1.0
SHIRPA	tail elevation	2.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	2.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	1.0 %	1.00
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	7.0 %	0.645
SHIRPA	tremor	2.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	4.0 %	1.00
SHIRPA	vibrissae presence	36.0 %	0.00332
SHIRPA	vocalization	7.0 %	0.618

GENOTYPE CORRELATION PLOT

Correlate Nup37^{tm1.1(KOMP)Vlcg}/2J -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.