MPD: JaxKOMP-EAP genotype: Prkch<sup>tm1b(EUCOMM)Hmgu</sup> -/-

JaxKOMP-EAP effect sizes: Prkch^{tm1b(EUCOMM)Hmgu} -/- Gene Prkch

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.7733	1.6048	0.29373	0.715	0.285
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	1.0465	3.2559	0.23670	0.933	0.752
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.97275	3.0632	0.041908	0.915	0.755
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	8.0268	3.7582	1.1412	0.302	0.0475
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	3.4991	3.0241	0.52988	0.642	0.263
body composition	body length	-0.055504	0.039454	-0.45091	0.450	0.165
body composition	body weight (at time of DXA)	-2.5700	0.47032	-1.4621	0.0000417	9.81e-7
body composition	bone area, whole body scan, head excluded	-0.11835	0.14714	-0.29645	0.679	0.425
body composition	bone mineral content of whole body scan, head excluded	-0.0028529	0.010365	-0.023212	0.913	0.784
body composition	bone mineral content to body weight ratio	-0.00024214	0.00046352	-0.13282	0.789	0.603
body composition	bone mineral density of whole body scan, head excluded	0.00027085	0.00054367	0.31308	0.814	0.620
body composition	fat tissue mass of whole body scan, head excluded	-0.23492	0.33878	-0.42624	0.717	0.491
body composition	fat tissue mass to body weight ratio	-0.0090082	0.012210	-0.37300	0.687	0.464
body composition	lean tissue mass of whole body scan, head excluded	0.62984	0.27905	1.0563	0.181	0.0278
body composition	lean tissue mass to body weight ratio	0.021276	0.010355	1.0441	0.197	0.0444
body composition	percent fat, whole body scan, head excluded	-1.0635	1.1551	-0.48685	0.608	0.361
body composition	ratio of soft-tissue attenuation coefficients	0.0011909	0.0012866	0.48646	0.602	0.359
body composition	tissue area	-0.048605	0.20400	0.020503	0.941	0.813
body composition	total tissue mass, whole body scan, head excluded	0.36716	0.20701	0.56686	0.260	0.0814
clinical blood chemistry	alanine transaminase (plasma ALT)	49.350	7.6749	1.9431	0.00286	0.0000113
clinical blood chemistry	albumin (plasma Alb)	-2.8750	0.44865	-2.6536	0.00254	0.00000866
clinical blood chemistry	alkaline phosphatase (plasma ALP)	4.2292	4.2098	0.24253	0.579	0.330
clinical blood chemistry	aspartate transaminase (plasma AST)	159.40	12.803	2.6555	4.25e-7	1.20e-9
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.88107	0.15455	1.9614	0.00674	0.0000420
clinical blood chemistry	blood urea nitrogen (BUN)	3.5142	2.1546	1.3564	0.344	0.124
clinical blood chemistry	calcium (plasma Ca)	0.043545	0.088023	0.63703	0.791	0.628
clinical blood chemistry	creatinine (plasma)	0.087530	0.050451	2.0298	0.307	0.105
clinical blood chemistry	glucose (plasma GLU, no fast)	-2.2994	26.640	0.21956	0.959	0.932
clinical blood chemistry	HDL cholesterol (plasma HDL)	-12.137	2.0757	-2.3198	0.00237	0.0000321
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.030649	0.023747	-1.7738	0.552	0.216
clinical blood chemistry	phosphorus (plasma phosphate)	2.8370	0.45100	2.5679	0.00141	0.0000145
clinical blood chemistry	total bilirubin (plasma TBIL)	0.039571	0.016436	2.0125	0.202	0.0294
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-13.427	4.2360	-2.0227	0.0726	0.00634
clinical blood chemistry	total protein (plasma TP)	-3.5892	1.4909	-2.1181	0.189	0.0294
clinical blood chemistry	triglyceride (plasma TG, no fast)	-9.5771	11.908	-0.31112	0.697	0.434
EKG	duration of PQ interval	0.63855	0.73000	0.81549	0.872	0.386
EKG	duration of PR interval	0.16234	0.77990	0.24005	0.965	0.836
EKG	duration of QRS interval	0.056250	0.33035	0.022167	0.988	0.865
EKG	duration of QT interval	-0.64096	0.79140	-0.45443	0.861	0.422
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.59769	0.86553	-0.56224	0.920	0.493
EKG	duration of RR interval	-0.73375	0.77806	-0.10902	0.757	0.350
EKG	duration of ST interval	-0.60274	0.73382	-0.38836	0.834	0.415
EKG	heart rate coefficient of variation (signal intensity)	-0.84199	0.98181	-0.59079	0.867	0.395
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-6.4981	7.2737	-0.69744	0.865	0.376
EKG	heart rate, beats per min	5.5625	6.9370	0.063566	0.770	0.427
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.082625	0.064997	0.54043	0.583	0.210
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.13213	0.083361	0.67639	0.465	0.119
EKG	number of signals	-6.5140	3.7016	-1.2431	0.605	0.0847
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-1.5019	3.7379	-0.20904	0.943	0.690
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-1.9054	2.7474	-0.53879	0.945	0.491
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-1.9197	2.9526	-0.51794	0.931	0.519
EKG	root mean square of successive differences of neighboring RR intervals	-1.7183	1.5895	-0.85839	0.843	0.285
glucose tolerance test	amount glucose injected	-2.5720	2.0986	-0.39430	0.614	0.226
glucose tolerance test	plasma glucose, 0min	30.158	7.4311	2.1206	0.00348	0.000181
glucose tolerance test	plasma glucose, 15min	39.019	21.727	1.1753	0.332	0.0787
glucose tolerance test	plasma glucose, 30min	20.060	21.802	0.72446	0.678	0.362
glucose tolerance test	plasma glucose, 60min	-1.8064	15.626	0.070067	0.958	0.908
glucose tolerance test	plasma glucose, 120min	7.4474	7.6711	0.36192	0.629	0.336
heart weight	heart weight, normalized to body weight	-0.14245	0.15150	-0.99845	0.572	0.356
heart weight	heart weight, weight	-3.9542	3.8409	-0.90494	0.527	0.313
hematology	basophil differential (percent of total WBC)	0.076686	0.080642	1.0868	0.754	0.357
hematology	calculated hemoglobin (cHGB)	-0.59364	0.21131	-1.6946	0.114	0.0126
hematology	eosinophil differential (percent of total WBC)	0.065723	0.27936	0.26494	0.945	0.817
hematology	hematocrit (HCT)	-0.90417	0.56980	-1.1484	0.406	0.132
hematology	hemoglobin concentration distribution width (HDW)	-0.073352	0.028894	-1.7897	0.182	0.0227
hematology	large unstained cells (percent of total WBC)	0.11445	0.11499	0.75466	0.664	0.334
hematology	lymphocyte differential (percent of total WBC)	-2.6458	1.2899	-1.1198	0.237	0.0570
hematology	mean corpuscular hemoglobin (CHr)	-0.059813	0.14197	-0.46640	0.842	0.679
hematology	mean platelet volume (MPV)	-0.76302	0.21543	-2.5109	0.0211	0.00271
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-3.2935	0.89365	-2.0962	0.0584	0.00220
hematology	mean RBC corpuscular volume (MCV)	1.0510	0.55347	1.6380	0.222	0.0770
hematology	measured hemoglobin (mHGB)	-1.7007	0.44020	-2.0612	0.0384	0.00153
hematology	monocyte differential (percent of total WBC)	-0.22500	0.16054	-0.54998	0.545	0.180
hematology	neutrophil differential (percent of total WBC)	1.2316	2.1889	0.63136	0.764	0.582
hematology	platelet count (PLT; units per volume x 10³)	-101.97	85.875	-1.1945	0.624	0.252
hematology	RBC corpuscular distribution width (RDW)	0.40000	0.097267	1.2447	0.0189	0.000815
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.57270	0.28455	-1.4395	0.219	0.0625
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.38667	0.12162	-1.6642	0.0727	0.00582
hematology	reticulocyte count (Retic; units per volume x 10⁹)	31.246	28.965	1.3086	0.684	0.298
hematology	reticulocyte differential (percent of total RBC)	0.49953	0.27042	1.7438	0.413	0.0845
hematology	white blood cell count (WBC; units per volume x 10³)	-3.1670	0.91668	-1.8062	0.0296	0.00354
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.29970	0.55356	0.35055	0.872	0.591
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.038557	0.39814	0.18933	0.989	0.923
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.031940	0.30468	0.039678	0.973	0.917
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.60859	0.56702	0.66867	0.738	0.288
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.51968	0.38335	0.88824	0.683	0.181
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.074012	0.22597	-0.15411	0.963	0.745
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.20093	0.30999	-0.58533	0.925	0.520
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.49905	0.35705	-0.72242	0.707	0.168
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.11963	0.35730	0.32309	0.950	0.739
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.37262	0.25772	0.97828	0.728	0.155
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.21875	0.26888	0.56793	0.857	0.420
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.37726	0.40017	0.69690	0.776	0.350
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.072533	0.87408	0.15752	0.988	0.934
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-1.0750	0.54143	-1.6736	0.415	0.0527
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.079962	0.44101	-0.030368	0.958	0.857
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.73932	0.87865	-0.62142	0.754	0.404
holeboard	total number of hole pokes, 20 min test	-1.1742	4.0369	-0.069215	0.893	0.772
light / dark	fecal boli count, 20 min test	-0.64007	0.62120	-0.66434	0.713	0.307
light / dark	latency to enter dark zone, 20 min test	22.173	51.146	0.32184	0.899	0.666
light / dark	number of transitions between light and dark zones, 20 min test	13.467	7.7457	1.3046	0.358	0.0876
light / dark	percentage of total time in dark zone, 20 min test	-4.6637	4.7723	-0.72018	0.679	0.333
light / dark	percentage of total time in light zone, 20 min test	4.6637	4.7723	0.71843	0.678	0.333
light / dark	time mobile in dark zone, 20 min test	35.150	15.376	1.5120	0.163	0.0261
light / dark	time mobile in light zone, 20 min test	12.998	11.679	0.53716	0.534	0.270
light / dark	time spent in dark zone, 20 min test	-22.109	56.524	-0.13289	0.908	0.697
light / dark	time spent in light zone, 20 min test	22.109	56.524	0.13289	0.908	0.697
open field	average speed in center of arena, 20 min test	-0.00072525	0.34565	-0.10019	1.00	0.998
open field	average speed in periphery of arena, 20 min test	0.097658	0.13057	-0.11234	0.685	0.457
open field	distance traveled habituation ratio, 20 min test	-0.38532	6.3862	0.014098	0.977	0.952
open field	distance traveled in center of arena, 20 min test	-63.279	93.854	-0.76811	0.715	0.503
open field	distance traveled in periphery of arena, 20 min test	154.48	113.15	0.18430	0.398	0.177
open field	distance traveled slope, 20 min test	-1.3199	5.9981	-0.061126	0.947	0.827
open field	distance traveled, 20 min test, 1st 5min	0.65089	61.807	-0.34150	0.995	0.992
open field	distance traveled, 20 min test, 2nd 5min	62.325	45.095	0.18703	0.393	0.172
open field	distance traveled, 20 min test, 3rd 5min	35.222	51.566	-0.040961	0.721	0.497
open field	distance traveled, 20 min test, 4th 5min	61.764	61.506	0.21993	0.567	0.319
open field	number of clockwise revolution episodes, 20 min test	-0.10143	1.0779	-0.46638	0.976	0.925
open field	number of counter-clockwise revolution episodes, 20 min test	2.1793	1.4792	0.70128	0.411	0.146
open field	number of fecal boli, 20 min test	-1.2468	0.76917	-0.72809	0.394	0.110
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-2.4869	2.0298	-0.88292	0.494	0.225
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-0.25277	2.1373	-0.42680	0.963	0.906
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	3.4622	2.5575	0.50768	0.447	0.181
open field	number of rears in 5 min bins, 20 min test, 4th 5min	5.9221	2.9232	0.94027	0.231	0.0474
open field	percentage of total time in center of arena, 20 min test	-3.4172	2.5801	-1.0669	0.503	0.190
open field	percentage of total time in center of arena, slope, 20 min test	-0.089296	1.1341	0.067853	0.980	0.938
open field	percentage of total time in center, habituation ratio, 20 min test	0.68060	1.5986	0.48641	0.902	0.672
open field	percentage of total time in corners of arena, 20 min test	5.0745	3.3954	1.2106	0.440	0.140
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.7279	1.3613	-1.0812	0.709	0.209
open field	percentage of total time in corners, slope, 20 min test	-1.4799	1.2860	-0.98073	0.742	0.254
open field	permanence time in center of arena, 20 min test	-41.005	30.960	-1.0669	0.503	0.190
open field	permanence time in corners of arena, 20 min test	60.898	40.745	1.2106	0.440	0.140
open field	permanence time in periphery of arena, 20 min test	41.015	30.961	1.0645	0.502	0.190
open field	total distance traveled, 20 min test	95.614	171.63	-0.21718	0.764	0.580
open field	total number of rears, 20 min test	7.2854	9.3616	0.16250	0.681	0.440
open field	whole arena average speed, 20 min test	0.079319	0.14324	-0.21856	0.762	0.582
open field	whole arena resting time, 20 min test	-11.989	17.580	0.19798	0.687	0.498
open field	whole arena time spent mobile, 20 min test	11.956	17.573	0.016783	0.692	0.499
open field	whole arena time spent vertical, 20 min test	2.6455	8.6036	0.10424	0.909	0.760
startle / PPI	average baseline movement during background noise	-0.041976	0.96725	0.051164	0.997	0.966
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.23324	0.051359	1.8020	0.0115	0.0000550
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.21815	0.048182	2.0175	0.00931	0.0000574
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	14.546	5.1274	1.7351	0.554	0.00727
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	18.334	5.6814	1.9206	0.121	0.00258
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	20.646	4.7334	1.9867	0.00810	0.0000952
startle / PPI	average startle response to full pulse (120 dB)	-96.103	33.670	-1.3689	0.0505	0.00703
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-128.19	30.852	-1.7351	0.00361	0.000178
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-109.32	27.344	-1.6695	0.00535	0.000284
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-89.215	20.772	-1.6002	0.00316	0.000117
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.60962	1.0068	-0.40676	0.904	0.548
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.23910	1.3387	-0.15687	0.974	0.859
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.61154	1.5613	0.12573	0.921	0.697
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.16355	0.056610	1.6155	0.494	0.00635
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.22462	0.066688	1.8015	0.0739	0.00174
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.26739	0.061110	1.7673	0.00583	0.0000913
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-95.222	33.768	-1.3408	0.0534	0.00768
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-127.58	30.997	-1.7164	0.00393	0.000200
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-109.08	27.890	-1.6473	0.00656	0.000367
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-89.827	20.964	-1.6155	0.00316	0.000120
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.16291	0.057382	1.4851	0.434	0.00723
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.23816	0.068772	1.7285	0.0613	0.00134
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.30155	0.064466	1.8235	0.00269	0.0000361
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-375.94	100.05	-1.4685	0.00841	0.000576
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-451.42	110.96	-1.7226	0.00389	0.000230
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-397.04	98.281	-1.6583	0.00458	0.000251
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-344.48	78.008	-1.6695	0.00224	0.0000807
startle / PPI	maximum baseline movement during background noise	0.081798	1.9558	0.15687	0.992	0.967
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	14.808	5.3114	1.5803	0.550	0.00824
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	20.769	6.1262	1.8863	0.0787	0.00164
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	25.382	5.4808	2.1980	0.00415	0.0000417
startle / PPI	maximum startle response to full pulse (120 dB)	-377.36	100.15	-1.4685	0.00798	0.000558
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-452.16	110.52	-1.7288	0.00381	0.000215
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-398.14	96.934	-1.6695	0.00390	0.000205
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-342.29	77.366	-1.6866	0.00220	0.0000787
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.74359	2.0184	-0.11444	0.942	0.715
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.82565	3.5021	-0.22250	0.973	0.815
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	2.0870	3.5845	0.21676	0.843	0.564

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.0
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.00
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	11.0 %	0.484
eye morphology	lens opacity	males	19.0 %	0.0555
eye morphology	lens opacity	both	13.0 %	0.105
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	11.0 %	0.333
eye morphology	persistence of hyaloid vascular system	both	3.0 %	0.769
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	12.0 %	0.513
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	6.0 %	0.872
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	12.0 %	0.00879
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	6.0 %	0.0234
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	1.0 %	1.0
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	12.0 %	0.0740
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	5.0 %	0.202
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Prkch^{tm1b(EUCOMM)Hmgu} -/- with genotype: