MPD: JaxKOMP-LAP genotype: Nt5dc1<sup>em1(IMPC)J</sup> -/-

JaxKOMP-LAP effect sizes: Nt5dc1^em1(IMPC)J -/- Gene Nt5dc1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-LAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-LAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

clinical blood chemistry	alanine transaminase (plasma ALT)	-13.824	8.4550	-1.1264	0.633	0.122
clinical blood chemistry	albumin (plasma Alb)	-0.87924	0.90316	-1.0676	0.732	0.345
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-19.288	13.538	-1.2928	0.846	0.173
clinical blood chemistry	aspartate transaminase (plasma AST)	-29.144	12.503	-1.7553	0.415	0.0332
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.23290	0.28359	-0.92218	0.782	0.424
clinical blood chemistry	blood urea nitrogen (BUN)	-1.1545	1.0819	-0.42167	0.615	0.302
clinical blood chemistry	calcium (plasma Ca)	-0.14703	0.055679	-1.1264	0.349	0.0178
clinical blood chemistry	creatinine (plasma)	-0.0016737	0.012547	0.28940	0.999	0.896
clinical blood chemistry	glucose (plasma GLU, no fast)	6.6903	11.702	0.012409	0.822	0.575
clinical blood chemistry	HDL cholesterol (plasma HDL)	-0.82467	5.0327	-0.45785	0.984	0.872
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.013322	0.026250	-0.50457	0.897	0.619
clinical blood chemistry	phosphorus (plasma phosphate)	-0.13114	0.20369	-0.062085	0.707	0.529
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0017761	0.012486	-0.43073	0.969	0.889
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-0.68437	6.3835	-0.26361	0.925	0.916
clinical blood chemistry	total protein (plasma TP)	-1.5106	1.9138	-0.96742	0.794	0.441
clinical blood chemistry	triglyceride (plasma TG, no fast)	26.388	10.695	1.2872	0.579	0.0253
EKG	duration of PQ interval	1.7911	1.5245	1.0676	0.690	0.255
EKG	duration of PR interval	1.5692	1.4999	0.90145	0.871	0.309
EKG	duration of QRS interval	-0.60577	0.32883	-1.1628	0.487	0.0811
EKG	duration of QT interval	-0.60288	0.92967	-0.39360	0.841	0.524
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.40595	1.1351	-0.12824	0.889	0.725
EKG	duration of RR interval	-0.84685	1.0496	-0.50687	0.773	0.430
EKG	duration of ST interval	-0.017587	0.74388	0.076809	1.00	0.981
EKG	heart rate coefficient of variation (signal intensity)	-0.66012	1.4145	-0.39360	0.779	0.646
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-4.3277	10.268	-0.39360	0.791	0.678
EKG	heart rate, beats per min	6.1168	8.6182	0.33889	0.805	0.486
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.13574	0.077572	-1.2700	0.601	0.0963
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.12020	0.11282	-0.69063	0.814	0.300
EKG	number of signals	-8.4966	5.5544	-0.75712	0.810	0.143
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-4.5316	3.9672	-1.1349	0.780	0.268
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-4.7298	4.7418	-0.56595	0.802	0.331
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-4.7782	5.3764	-0.44951	0.684	0.385
EKG	root mean square of successive differences of neighboring RR intervals	-2.1952	3.6293	-0.56595	0.719	0.552
grip strength	body weight (at time of grip strength test)	3.6861	2.1585	0.81222	0.241	0.101
grip strength	forelimb and hindlimb grip strength (mean of trials), average	8.2290	7.6600	0.47704	0.533	0.294
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.20818	0.35842	-0.47704	0.776	0.567
grip strength	forelimb and hindlimb grip strength by trial, trial1	15.878	13.273	0.81222	0.580	0.244
grip strength	forelimb and hindlimb grip strength by trial, trial2	6.5616	9.9098	0.38532	0.827	0.514
grip strength	forelimb and hindlimb grip strength by trial, trial3	2.4677	13.818	0.12566	0.930	0.860
grip strength	forelimb grip strength (mean of trials), average	1.2027	5.0568	0.16789	0.897	0.814
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.18931	0.16570	-1.0364	0.631	0.265
grip strength	forelimb grip strength by trial, trial1	-2.3362	6.0986	-0.40792	0.895	0.705
grip strength	forelimb grip strength by trial, trial2	2.2684	7.2114	0.14674	0.972	0.756
grip strength	forelimb grip strength by trial, trial3	3.6837	7.2108	0.52440	0.874	0.614
heart weight	heart weight, normalized to body weight	-0.18867	0.13514	-0.95046	0.527	0.179
heart weight	heart weight, weight	8.6043	4.3704	0.91143	0.305	0.0637
hematology	basophil differential (percent of total WBC)	0.021822	0.10224	0.30548	0.917	0.834
hematology	calculated hemoglobin (cHGB)	-0.29915	0.45432	-0.51984	0.772	0.520
hematology	eosinophil differential (percent of total WBC)	-0.13623	0.41248	-0.48532	0.910	0.745
hematology	hematocrit (HCT)	-0.98581	1.1712	-0.80642	0.768	0.412
hematology	hemoglobin concentration distribution width (HDW)	0.036946	0.037348	0.37229	0.643	0.337
hematology	large unstained cells (percent of total WBC)	-0.039534	0.12319	-0.13971	0.882	0.752
hematology	lymphocyte differential (percent of total WBC)	1.3551	2.9952	0.36800	0.892	0.657
hematology	mean corpuscular hemoglobin (CHr)	0.35890	0.21254	1.4051	0.406	0.111
hematology	mean platelet volume (MPV)	0.080390	0.14237	0.42167	0.806	0.580
hematology	mean RBC corpuscular hemoglobin (MCH)	0.25307	0.26152	0.92524	0.654	0.348
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.50074	0.38098	-0.81366	0.584	0.207
hematology	mean RBC corpuscular volume (MCV)	1.3540	1.1081	1.1809	0.532	0.239
hematology	measured hemoglobin (mHGB)	-0.45951	0.51022	-0.87085	0.716	0.381
hematology	monocyte differential (percent of total WBC)	-0.24407	0.34604	-0.33468	0.807	0.491
hematology	neutrophil differential (percent of total WBC)	-0.95360	2.7089	-0.31538	0.912	0.729
hematology	platelet count (PLT; units per volume x 10³)	-56.547	210.95	-0.23800	0.977	0.792
hematology	RBC corpuscular distribution width (RDW)	0.34423	0.39694	0.67449	0.752	0.399
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.12347	0.29649	0.057878	0.753	0.683
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.43689	0.41591	-1.1809	0.640	0.309
hematology	reticulocyte count (Retic; units per volume x 10⁹)	93.770	115.20	1.6497	0.941	0.428
hematology	reticulocyte differential (percent of total RBC)	1.8226	1.9540	1.8938	0.852	0.365
hematology	white blood cell count (WBC; units per volume x 10³)	1.1669	0.79882	0.56179	0.495	0.163
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.080119	0.90489	-0.051178	0.958	0.930
holeboard	number of hole pokes by individual hole number, 20 min test, 2	1.1039	0.80765	1.1503	0.740	0.187
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.46884	0.60061	-0.74941	0.892	0.444
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.24036	1.2081	-0.25863	0.910	0.844
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.55205	0.56877	-0.93359	0.960	0.343
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.044510	0.51874	-0.14563	0.971	0.932
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.61128	0.56724	-1.6041	0.701	0.294
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.79685	0.67281	-1.1139	0.799	0.250
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.55828	0.50785	-0.79164	0.738	0.285
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.11936	0.36322	-0.18380	0.957	0.746
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.54896	0.42169	-1.2086	0.700	0.208
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.57742	0.66723	-0.79164	0.941	0.397
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.11035	0.93102	-0.20607	0.956	0.907
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.95846	0.77288	-1.2700	0.649	0.229
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.14243	0.89904	0.090569	0.924	0.876
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.2085	1.2736	-1.2147	0.763	0.354
holeboard	total number of hole pokes, 20 min test	-6.5608	7.2105	-1.0234	0.759	0.374
light / dark	fecal boli count, 20 min test	2.3729	1.0947	1.3352	0.186	0.0408
light / dark	latency to enter dark zone, 20 min test	-97.117	76.843	-0.55924	0.662	0.219
light / dark	number of transitions between light and dark zones, 20 min test	22.995	9.0687	1.7507	0.164	0.0185
light / dark	percentage of total time in dark zone, 20 min test	-8.8841	5.0817	-1.0625	0.445	0.0938
light / dark	percentage of total time in light zone, 20 min test	8.8841	5.0817	1.0625	0.445	0.0938
light / dark	time mobile in dark zone, 20 min test	20.652	19.863	0.81338	0.697	0.309
light / dark	time mobile in light zone, 20 min test	30.288	19.035	1.4051	0.494	0.125
light / dark	time spent in dark zone, 20 min test	-21.964	66.630	-0.44544	0.971	0.745
light / dark	time spent in light zone, 20 min test	21.964	66.630	0.44544	0.971	0.745
open field	average speed in center of arena, 20 min test	0.24435	0.26736	0.094931	0.712	0.370
open field	average speed in periphery of arena, 20 min test	0.099890	0.23694	0.094931	0.888	0.677
open field	distance traveled habituation ratio, 20 min test	5.5880	7.7728	0.61612	0.775	0.479
open field	distance traveled in center of arena, 20 min test	85.432	178.84	0.22301	0.855	0.637
open field	distance traveled in periphery of arena, 20 min test	93.377	130.54	0.15864	0.886	0.482
open field	distance traveled slope, 20 min test	8.5766	7.2768	0.96183	0.672	0.251
open field	distance traveled, 20 min test, 1st 5min	6.6410	98.482	-0.11611	0.992	0.947
open field	distance traveled, 20 min test, 2nd 5min	4.5703	73.741	-0.26642	0.968	0.951
open field	distance traveled, 20 min test, 3rd 5min	110.55	67.857	0.69446	0.425	0.117
open field	distance traveled, 20 min test, 4th 5min	57.061	71.266	0.33252	0.760	0.432
open field	number of clockwise revolution episodes, 20 min test	1.2603	1.4926	0.46958	0.858	0.407
open field	number of counter-clockwise revolution episodes, 20 min test	0.69432	1.5366	0.031601	0.916	0.656
open field	number of fecal boli, 20 min test	1.7975	0.80651	1.3180	0.185	0.0359
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-1.5406	3.1396	-0.51716	0.921	0.628
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-1.5432	4.3227	-0.33252	0.872	0.724
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	0.081223	5.0215	-0.13735	0.995	0.987
open field	number of rears in 5 min bins, 20 min test, 4th 5min	0.93362	4.5509	-0.31034	0.876	0.839
open field	percentage of total time in center of arena, 20 min test	0.71340	6.3362	0.052685	0.963	0.911
open field	percentage of total time in center of arena, slope, 20 min test	0.37337	3.0400	0.26642	0.947	0.903
open field	percentage of total time in center, habituation ratio, 20 min test	-0.62762	3.1703	-0.073791	0.946	0.845
open field	percentage of total time in corners of arena, 20 min test	1.3409	5.4957	0.35487	0.907	0.809
open field	percentage of total time in corners, habituation ratio, 20 min test	-3.4450	3.3175	-1.2306	0.754	0.310
open field	percentage of total time in corners, slope, 20 min test	-3.5261	3.1829	-1.3259	0.728	0.279
open field	permanence time in center of arena, 20 min test	8.5559	76.036	0.052685	0.963	0.911
open field	permanence time in corners of arena, 20 min test	16.100	65.948	0.35487	0.907	0.809
open field	permanence time in periphery of arena, 20 min test	-8.5409	76.038	-0.052685	0.964	0.912
open field	total distance traveled, 20 min test	178.81	282.55	0.18001	0.874	0.533
open field	total number of rears, 20 min test	-2.0690	15.474	-0.20146	0.924	0.895
open field	whole arena average speed, 20 min test	0.14929	0.23542	0.18001	0.872	0.532
open field	whole arena resting time, 20 min test	-23.413	28.096	-0.26642	0.667	0.413
open field	whole arena time spent mobile, 20 min test	23.467	28.079	0.64179	0.685	0.412
open field	whole arena time spent vertical, 20 min test	16.519	25.202	0.92890	0.805	0.519
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.35371	1.8195	-0.16243	0.905	0.848

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-LAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-LAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	2.0 %	1.0
eye morphology	bulging eye	2.0 %	1.0
eye morphology	cornea	22.0 %	0.00415
eye morphology	cornea opacity	5.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.0
eye morphology	corneal mineralization	14.0 %	0.858
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	2.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	2.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	5.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	2.0 %	1.0
eye morphology	irispupil	4.0 %	1.0
eye morphology	lacrimation	6.0 %	0.175
eye morphology	lens	43.0 %	0.0177
eye morphology	lens opacity	9.0 %	1.0
eye morphology	narrow eye opening	2.0 %	1.0
eye morphology	optic disc	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	9.0 %	1.0
eye morphology	pupil dilation	3.0 %	1.0
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	6.0 %	0.222
eye morphology	retina	11.0 %	0.122
eye morphology	retinal blood vessels	5.0 %	1.0
eye morphology	retinal blood vessels pattern	5.0 %	1.0
eye morphology	retinal blood vessels structure	5.0 %	1.0
eye morphology	retinal pigmentation	33.0 %	0.00000143
eye morphology	retinal structure	6.0 %	1.0
eye morphology	synechia	5.0 %	1.0
eye morphology	vitreous	5.0 %	1.0
SHIRPA	activity body position	5.0 %	1.0
SHIRPA	aggression	0.0 %	1.0
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	4.0 %	1.0
SHIRPA	body thickness	4.0 %	1.0
SHIRPA	coat color abdomen	27.0 %	0.0130
SHIRPA	coat color back	31.0 %	0.00309
SHIRPA	coat color head	43.0 %	1.48e-7
SHIRPA	coat color pattern abdomen	4.0 %	1.0
SHIRPA	coat color pattern back	9.0 %	0.387
SHIRPA	coat color pattern head	4.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	0.0 %	1.0
SHIRPA	coat hair back texture appearance	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	5.0 %	1.0
SHIRPA	coat hair distribution back	9.0 %	0.386
SHIRPA	coat hair distribution head	38.0 %	0.000510
SHIRPA	coat hair head texture appearance	2.0 %	1.00
SHIRPA	contact righting	22.0 %	0.0804
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	eye morphology	5.0 %	0.261
SHIRPA	fat distribution	18.0 %	0.0537
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.00
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	2.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.0
SHIRPA	hindlimb digit position	0.0 %	1.00
SHIRPA	hindlimb digit shape	1.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	6.0 %	1.0
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.00
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	1.0 %	1.00
SHIRPA	hindlimbs position	1.0 %	1.0
SHIRPA	hindlimbs shape	3.0 %	1.0
SHIRPA	hindlimbs size	1.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.00
SHIRPA	hindpaw shape	6.0 %	0.0243
SHIRPA	hindpaw size	1.0 %	1.0
SHIRPA	limb grasp	19.0 %	0.0752
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.00
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	1.0 %	1.00
SHIRPA	startle response	68.0 %	8.45e-9
SHIRPA	tail curvature	1.0 %	1.0
SHIRPA	tail elevation	2.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	2.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	1.0 %	1.00
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	7.0 %	0.645
SHIRPA	tremor	2.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	4.0 %	1.00
SHIRPA	vibrissae presence	34.0 %	0.00121
SHIRPA	vocalization	7.0 %	0.618

GENOTYPE CORRELATION PLOT

Correlate Nt5dc1^em1(IMPC)J -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.