MPD: JaxKOMP-EAP genotype: Tmem222<sup>tm1b(KOMP)Mbp</sup> -/+

JaxKOMP-EAP effect sizes: Tmem222^{tm1b(KOMP)Mbp} -/+ Gene Tmem222

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.60606	1.5104	-0.096670	0.905	0.694
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	4.7408	1.9221	0.98300	0.344	0.0272
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.45455	1.7234	-0.067510	0.937	0.796
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-4.2622	3.4229	-0.76807	0.625	0.234
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-9.3182	2.5851	-1.2683	0.0747	0.00287
body composition	body length	-0.14220	0.036755	-1.2646	0.0128	0.000525
body composition	body weight (at time of DXA)	-0.61982	0.71771	-0.36767	0.615	0.394
body composition	bone area, whole body scan, head excluded	-0.47821	0.14310	-1.5242	0.0313	0.00218
body composition	bone mineral content of whole body scan, head excluded	-0.029281	0.010317	-1.3217	0.0724	0.00793
body composition	bone mineral content to body weight ratio	-0.0011127	0.00043854	-1.1623	0.104	0.0162
body composition	bone mineral density of whole body scan, head excluded	-0.00070767	0.00046579	-0.76065	0.406	0.139
body composition	fat tissue mass of whole body scan, head excluded	1.0075	0.28411	1.3937	0.0230	0.00127
body composition	fat tissue mass to body weight ratio	0.043169	0.011487	1.6819	0.0143	0.000687
body composition	lean tissue mass of whole body scan, head excluded	-0.76267	0.28355	-1.5242	0.120	0.0114
body composition	lean tissue mass to body weight ratio	-0.023231	0.0095812	-1.2556	0.133	0.0211
body composition	percent fat, whole body scan, head excluded	3.9648	1.0958	1.6491	0.0189	0.00101
body composition	ratio of soft-tissue attenuation coefficients	-0.0043975	0.0012169	-1.6480	0.0191	0.00102
body composition	tissue area	-0.20252	0.13093	-0.49669	0.400	0.132
body composition	total tissue mass, whole body scan, head excluded	0.20061	0.20091	0.23282	0.579	0.326
clinical blood chemistry	alanine transaminase (plasma ALT)	0.72043	4.4340	0.050324	0.961	0.873
clinical blood chemistry	albumin (plasma Alb)	0.032258	0.50362	0.11719	0.989	0.950
clinical blood chemistry	alkaline phosphatase (plasma ALP)	4.8518	4.7907	0.37185	0.579	0.331
clinical blood chemistry	aspartate transaminase (plasma AST)	4.8925	17.060	0.23903	0.932	0.779
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.19468	0.29879	0.64188	0.830	0.526
clinical blood chemistry	blood urea nitrogen (BUN)	-0.71184	1.1633	-0.30641	0.762	0.551
clinical blood chemistry	calcium (plasma Ca)	0.040240	0.085791	0.61971	0.801	0.647
clinical blood chemistry	creatinine (plasma)	0.0089651	0.021166	0.30818	0.824	0.679
clinical blood chemistry	glucose (plasma GLU, no fast)	-20.144	13.635	-0.47185	0.354	0.163
clinical blood chemistry	HDL cholesterol (plasma HDL)	9.2822	3.7116	1.6990	0.178	0.0265
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.020500	0.010104	-1.2257	0.330	0.0635
clinical blood chemistry	phosphorus (plasma phosphate)	0.33156	0.33772	0.45325	0.635	0.344
clinical blood chemistry	total bilirubin (plasma TBIL)	0.019785	0.0087812	1.1890	0.235	0.0422
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	11.856	4.6708	1.5537	0.161	0.0260
clinical blood chemistry	total protein (plasma TP)	0.27057	0.55604	0.14612	0.809	0.635
clinical blood chemistry	triglyceride (plasma TG, no fast)	22.628	10.143	1.3155	0.222	0.0455
EKG	duration of PQ interval	-0.77815	0.74512	-0.67449	0.829	0.309
EKG	duration of PR interval	-0.30577	0.84478	-0.22349	0.938	0.721
EKG	duration of QRS interval	0.50930	0.39731	1.3259	0.885	0.215
EKG	duration of QT interval	2.3107	1.0639	2.0045	0.508	0.0421
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.8938	1.1264	1.9613	0.687	0.108
EKG	duration of RR interval	2.6444	1.6404	1.5591	0.531	0.123
EKG	duration of ST interval	1.8050	0.81479	1.9477	0.460	0.0385
EKG	heart rate coefficient of variation (signal intensity)	3.1956	1.5179	2.3398	0.709	0.0488
EKG	heart rate variability, mean of differences between sequential beats; beats per min	21.528	10.403	2.2068	0.740	0.0524
EKG	heart rate, beats per min	-20.130	12.381	-1.4941	0.496	0.120
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.060642	0.090547	0.38109	0.804	0.511
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.038970	0.11595	0.13044	0.910	0.740
EKG	number of signals	7.3424	4.5241	1.3114	0.608	0.120
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	19.548	6.4086	2.4841	0.648	0.00632
EKG	QT dispersion, measured as inter-lead variability of QT intervals	3.3411	2.6623	0.94304	0.881	0.225
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	1.4480	2.6990	0.38836	0.947	0.598
EKG	root mean square of successive differences of neighboring RR intervals	4.3267	3.2339	1.8282	0.843	0.196
glucose tolerance test	amount glucose injected	-0.41825	1.9595	0.24229	0.948	0.833
glucose tolerance test	plasma glucose, 0min	14.179	7.1133	1.1564	0.179	0.0572
glucose tolerance test	plasma glucose, 15min	38.993	26.902	1.1726	0.462	0.160
glucose tolerance test	plasma glucose, 30min	37.275	25.697	1.2232	0.495	0.159
glucose tolerance test	plasma glucose, 60min	2.2113	20.295	0.21862	0.961	0.914
glucose tolerance test	plasma glucose, 120min	9.4246	12.306	0.51623	0.713	0.451
grip strength	body weight (at time of grip strength test)	-1.9007	0.88569	-1.3792	0.128	0.0418
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-33.138	10.154	-1.9140	0.0263	0.00329
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.8266	0.46074	-2.2000	0.00800	0.000543
grip strength	forelimb and hindlimb grip strength by trial, trial1	-20.545	10.965	-1.1165	0.277	0.0732
grip strength	forelimb and hindlimb grip strength by trial, trial2	-33.138	16.538	-1.8075	0.218	0.0565
grip strength	forelimb and hindlimb grip strength by trial, trial3	-43.910	13.771	-2.2901	0.0445	0.00395
grip strength	forelimb grip strength (mean of trials), average	-12.546	7.3500	-1.2323	0.314	0.101
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.60847	0.33630	-1.2139	0.281	0.0824
grip strength	forelimb grip strength by trial, trial1	-12.573	10.002	-1.1329	0.572	0.220
grip strength	forelimb grip strength by trial, trial2	-11.879	11.928	-1.0165	0.656	0.329
grip strength	forelimb grip strength by trial, trial3	-14.837	7.5074	-1.2323	0.283	0.0597
heart weight	heart weight, normalized to body weight	-0.10199	0.16593	-0.83586	0.725	0.543
heart weight	heart weight, weight	-2.4119	3.5941	-0.69973	0.695	0.507
hematology	basophil differential (percent of total WBC)	0.026190	0.057482	0.43023	0.894	0.656
hematology	calculated hemoglobin (cHGB)	0.29489	0.14455	0.63465	0.264	0.0622
hematology	eosinophil differential (percent of total WBC)	-0.26429	0.26802	-0.63928	0.725	0.342
hematology	hematocrit (HCT)	1.5740	0.38998	1.3243	0.0349	0.00141
hematology	hemoglobin concentration distribution width (HDW)	-0.040714	0.022816	-1.1116	0.369	0.0977
hematology	large unstained cells (percent of total WBC)	0.11077	0.14832	0.71821	0.769	0.468
hematology	lymphocyte differential (percent of total WBC)	1.4492	0.94427	0.51065	0.398	0.149
hematology	mean platelet volume (MPV)	0.056182	0.071465	0.19817	0.669	0.446
hematology	mean RBC corpuscular hemoglobin (MCH)	-1.8929	1.6529	-2.0651	0.623	0.273
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-5.3144	3.8193	-2.3763	0.550	0.189
hematology	mean RBC corpuscular volume (MCV)	-0.21582	0.32818	-0.39994	0.730	0.522
hematology	measured hemoglobin (mHGB)	-1.3000	1.6549	-1.8728	0.702	0.446
hematology	monocyte differential (percent of total WBC)	0.15375	0.19602	0.71362	0.747	0.447
hematology	neutrophil differential (percent of total WBC)	-1.4335	0.87598	-0.64813	0.349	0.126
hematology	platelet count (PLT; units per volume x 10³)	39.190	71.672	0.57238	0.840	0.594
hematology	RBC corpuscular distribution width (RDW)	-0.29067	0.10383	-1.0805	0.118	0.0150
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.36905	0.23512	-1.0187	0.360	0.141
hematology	red blood cell count (RBC; per volume x 10⁶)	0.37214	0.10687	1.2947	0.0584	0.00405
hematology	white blood cell count (WBC; units per volume x 10³)	1.4734	0.74646	1.1537	0.203	0.0700
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.1228	0.98673	-1.0710	0.726	0.266
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.16226	0.56301	-0.12439	0.955	0.776
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.75094	0.50429	-1.1927	0.672	0.149
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.5843	0.94531	-1.5441	0.563	0.106
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.32830	0.61001	0.64148	0.903	0.595
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.48465	0.36900	1.2035	0.811	0.201
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.54717	0.32627	-1.5324	0.731	0.106
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.56604	0.42149	-0.82965	0.729	0.191
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-1.2131	0.42643	-1.8474	0.255	0.00874
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.094340	0.33618	-0.18542	0.958	0.781
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.30566	0.22686	-0.80325	0.754	0.190
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.36226	0.53881	-0.53956	0.869	0.508
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.3132	1.3088	-1.2175	0.722	0.325
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.28801	0.53574	-0.36920	0.868	0.596
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.92075	0.53492	-1.3735	0.561	0.0976
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-2.2830	0.86340	-1.9853	0.293	0.0139
holeboard	total number of hole pokes, 20 min test	-10.445	5.4598	-1.3779	0.287	0.0673
light / dark	fecal boli count, 20 min test	1.6951	0.85680	1.6837	0.386	0.0560
light / dark	latency to enter dark zone, 20 min test	-33.994	61.862	-0.75030	0.867	0.586
light / dark	number of transitions between light and dark zones, 20 min test	0.66365	9.9374	0.17805	0.978	0.947
light / dark	percentage of total time in dark zone, 20 min test	5.5283	5.4224	1.1497	0.670	0.315
light / dark	percentage of total time in light zone, 20 min test	-5.5283	5.4224	-1.1523	0.669	0.315
light / dark	time mobile in dark zone, 20 min test	15.813	17.983	0.79773	0.677	0.385
light / dark	time mobile in light zone, 20 min test	-5.7452	13.721	-0.67874	0.838	0.678
light / dark	time spent in dark zone, 20 min test	58.433	61.842	1.0939	0.732	0.351
light / dark	time spent in light zone, 20 min test	-58.433	61.842	-1.0939	0.732	0.351
open field	average speed in center of arena, 20 min test	0.0079167	0.40809	-0.079970	0.998	0.985
open field	average speed in periphery of arena, 20 min test	0.19064	0.14761	0.23509	0.412	0.204
open field	distance traveled habituation ratio, 20 min test	-4.1856	6.2384	-0.31599	0.762	0.506
open field	distance traveled in center of arena, 20 min test	272.39	95.581	1.2655	0.0563	0.00681
open field	distance traveled in periphery of arena, 20 min test	68.559	149.14	-0.16522	0.810	0.648
open field	distance traveled slope, 20 min test	-4.8665	6.3732	-0.38597	0.731	0.449
open field	distance traveled, 20 min test, 1st 5min	136.55	75.562	0.71508	0.249	0.0781
open field	distance traveled, 20 min test, 2nd 5min	78.223	53.643	0.38308	0.366	0.152
open field	distance traveled, 20 min test, 3rd 5min	33.041	46.820	-0.063817	0.714	0.484
open field	distance traveled, 20 min test, 4th 5min	92.060	55.856	0.53847	0.297	0.107
open field	number of clockwise revolution episodes, 20 min test	2.1190	1.1410	0.80060	0.337	0.0705
open field	number of counter-clockwise revolution episodes, 20 min test	3.1524	1.2538	1.2023	0.140	0.0161
open field	number of fecal boli, 20 min test	1.8351	0.95508	1.5518	0.301	0.0616
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-3.3611	1.9929	-1.1203	0.322	0.0995
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-2.0707	2.3459	-0.85974	0.656	0.383
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-2.9783	2.5572	-0.99825	0.531	0.251
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-4.7068	2.6037	-1.3442	0.299	0.0780
open field	percentage of total time in center of arena, 20 min test	5.9385	2.7633	1.0958	0.245	0.0376
open field	percentage of total time in center of arena, slope, 20 min test	-0.18979	1.2751	0.026184	0.965	0.882
open field	percentage of total time in center, habituation ratio, 20 min test	-0.20925	1.3200	0.015440	0.970	0.875
open field	percentage of total time in corners of arena, 20 min test	-8.3118	3.6491	-1.2051	0.205	0.0280
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.73287	1.9178	-0.63909	0.947	0.704
open field	percentage of total time in corners, slope, 20 min test	-0.92659	1.9309	-0.75198	0.918	0.634
open field	permanence time in center of arena, 20 min test	71.276	33.162	1.0958	0.245	0.0376
open field	permanence time in corners of arena, 20 min test	-99.751	43.791	-1.2051	0.205	0.0280
open field	permanence time in periphery of arena, 20 min test	-71.282	33.167	-1.0958	0.245	0.0376
open field	total distance traveled, 20 min test	331.01	190.75	0.46088	0.244	0.0902
open field	total number of rears, 20 min test	-12.982	7.4061	-1.2420	0.283	0.0873
open field	whole arena average speed, 20 min test	0.27592	0.15885	0.46536	0.244	0.0899
open field	whole arena resting time, 20 min test	-32.615	19.172	-0.34720	0.249	0.0965
open field	whole arena time spent mobile, 20 min test	32.621	19.162	0.60327	0.249	0.0963
open field	whole arena time spent vertical, 20 min test	-20.565	7.6452	-1.6113	0.105	0.0104
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.15472	1.8173	0.11891	0.984	0.933
startle / PPI	average baseline movement during background noise	-0.85971	1.2312	-0.59772	0.877	0.491
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.35070	0.10225	-2.3037	0.0776	0.00178
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.33265	0.086253	-2.4165	0.0374	0.000565
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-27.745	11.317	-2.5035	0.642	0.0203
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-29.636	8.3471	-2.4725	0.0911	0.00129
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-27.783	7.4500	-2.2656	0.0291	0.000799
startle / PPI	average startle response to full pulse (120 dB)	14.108	41.825	0.53359	0.891	0.738
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	73.095	36.119	1.3238	0.181	0.0520
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	64.504	31.584	1.3006	0.179	0.0500
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	67.205	23.627	1.4363	0.0558	0.00794
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-2.8265	1.0649	-1.8020	0.413	0.0126
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.30260	1.1897	-0.20673	0.961	0.801
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-0.43624	1.3877	-0.41591	0.939	0.755
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.32338	0.12297	-2.2656	0.637	0.0133
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.32700	0.090750	-2.3675	0.0646	0.00112
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.30994	0.080703	-2.1978	0.0168	0.000591
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	15.634	41.840	0.56126	0.871	0.711
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	76.930	36.168	1.3833	0.157	0.0418
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	65.239	31.255	1.3071	0.165	0.0455
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	69.615	23.327	1.5066	0.0442	0.00561
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.28726	0.14014	-2.0288	0.700	0.0492
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.35872	0.10918	-2.3035	0.0909	0.00259
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.34953	0.091421	-2.2475	0.0179	0.000619
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	50.452	163.38	0.49362	0.900	0.760
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	255.24	143.00	1.3104	0.254	0.0844
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	237.43	114.08	1.3104	0.167	0.0460
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	267.11	78.557	1.5333	0.0210	0.00192
startle / PPI	maximum baseline movement during background noise	-1.3609	2.5195	-0.35553	0.894	0.593
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-26.244	13.413	-2.1677	0.778	0.0598
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-33.661	10.427	-2.5737	0.106	0.00301
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-32.538	8.7347	-2.3679	0.0273	0.000808
startle / PPI	maximum startle response to full pulse (120 dB)	47.585	163.22	0.47942	0.906	0.773
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	246.27	143.25	1.2655	0.276	0.0959
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	235.95	114.60	1.3071	0.172	0.0483
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	266.19	79.238	1.5333	0.0221	0.00214
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-5.9571	2.4215	-1.5378	0.428	0.0199
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.83460	2.6366	-0.22537	0.955	0.754
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-1.7953	3.0793	-0.55634	0.843	0.564

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

Download Plot

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	11.0 %	0.275
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	6.0 %	0.372
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	12.0 %	0.197
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	0.194
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	12.0 %	0.0709
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	7.0 %	0.105
eye morphology	persistence of hyaloid vascular system	females	24.0 %	0.155
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	14.0 %	0.177
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	60.0 %	0.00000152
eye morphology	pupil light response	both	23.0 %	0.0000652
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	60.0 %	0.0000710
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	34.0 %	0.00735
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.00
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.00
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.620
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Tmem222^{tm1b(KOMP)Mbp} -/+ with genotype: