MPD: JaxKOMP-LAP genotype: Kcnd3<sup>em1(IMPC)J</sup> -/-

JaxKOMP-LAP effect sizes: Kcnd3^em1(IMPC)J -/- Gene Kcnd3

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-LAP

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Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-LAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

EKG	duration of PQ interval	0.17000	1.5667	0.025581	0.979	0.915
EKG	duration of PR interval	1.8075	2.0515	0.98113	0.883	0.394
EKG	duration of QRS interval	1.0400	0.33587	2.0454	0.189	0.00789
EKG	duration of QT interval	0.43000	0.74991	0.33889	0.841	0.575
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.74385	1.0853	0.62707	0.842	0.505
EKG	duration of RR interval	-0.22464	0.91599	0.076809	0.948	0.810
EKG	duration of ST interval	-0.61000	0.63514	-0.33889	0.807	0.353
EKG	heart rate coefficient of variation (signal intensity)	-0.23500	1.2109	-0.23227	0.886	0.849
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-1.4200	8.7979	-0.23227	0.893	0.874
EKG	heart rate, beats per min	10.500	6.1003	0.90145	0.541	0.107
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.30500	0.10544	1.7413	0.142	0.0118
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.30700	0.14030	1.7413	0.443	0.0461
EKG	number of signals	-7.5240	6.1358	-0.50687	0.810	0.240
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.3438	6.0596	0.44951	0.966	0.828
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	1.3143	6.7069	0.50687	0.986	0.848
EKG	root mean square of successive differences of neighboring RR intervals	-1.8440	2.6941	-0.33889	0.713	0.505
glucose tolerance test	amount glucose injected	-8.2339	3.8355	-1.1604	0.286	0.0449
glucose tolerance test	plasma glucose, 0min	-7.7843	6.9154	-0.76777	0.615	0.274
glucose tolerance test	plasma glucose, 15min	-48.217	23.836	-1.2450	0.364	0.0567
glucose tolerance test	plasma glucose, 30min	-52.614	26.961	-0.94578	0.343	0.0651
glucose tolerance test	plasma glucose, 60min	-78.084	23.489	-1.5772	0.0682	0.00338
glucose tolerance test	plasma glucose, 120min	-96.819	34.257	-1.8413	0.141	0.0104
grip strength	body weight (at time of grip strength test)	-3.5463	3.1000	-0.67449	0.487	0.266
grip strength	forelimb and hindlimb grip strength (mean of trials), average	8.8186	11.563	0.52440	0.623	0.455
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.69360	0.52048	-1.5689	0.463	0.198
grip strength	forelimb and hindlimb grip strength by trial, trial1	7.9697	11.710	0.31864	0.779	0.504
grip strength	forelimb and hindlimb grip strength by trial, trial2	0.48928	14.673	-0.020890	0.979	0.974
grip strength	forelimb and hindlimb grip strength by trial, trial3	5.7668	13.956	0.29674	0.822	0.684
grip strength	forelimb grip strength (mean of trials), average	3.2202	5.9845	0.52440	0.848	0.596
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.48093	0.33458	-2.1280	0.513	0.167
grip strength	forelimb grip strength by trial, trial1	6.3214	8.1442	0.84162	0.818	0.447
grip strength	forelimb grip strength by trial, trial2	-1.5767	9.3116	-0.34069	0.985	0.867
grip strength	forelimb grip strength by trial, trial3	-0.10843	9.3831	0.10463	0.991	0.991
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-2.3137	0.88913	-2.0454	0.251	0.0180
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-1.4869	0.74521	-2.0368	0.449	0.0614
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.19277	0.52492	0.52737	0.944	0.717
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.6481	1.0701	-1.5446	0.801	0.141
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.096386	0.51419	0.30169	0.986	0.853
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.53205	0.25620	1.0946	0.573	0.0516
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.47874	0.36282	-1.1243	0.701	0.204
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.69880	0.59914	1.1139	0.799	0.258
holeboard	number of hole pokes by individual hole number, 20 min test, 9	2.0577	0.51511	2.3188	0.0425	0.000776
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.56384	0.41258	1.4544	0.775	0.188
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.24598	0.54320	-0.49790	0.805	0.656
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.11308	0.77731	-0.20607	0.955	0.886
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-2.0629	0.83448	-1.7413	0.255	0.0236
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.18072	0.53629	0.20607	0.920	0.740
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.56958	0.90399	-0.65035	0.797	0.537
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.012048	0.94187	-0.18001	0.998	0.990
holeboard	total number of hole pokes, 20 min test	-8.8237	6.3263	-1.3942	0.595	0.180
light / dark	latency to enter dark zone, 20 min test	19.683	102.76	0.37993	0.917	0.850
light / dark	number of transitions between light and dark zones, 20 min test	-4.3133	10.208	-0.40157	0.953	0.678
light / dark	percentage of total time in dark zone, 20 min test	-8.6900	5.1881	-0.99446	0.476	0.111
light / dark	percentage of total time in light zone, 20 min test	8.6900	5.1881	0.99446	0.476	0.111
light / dark	time mobile in dark zone, 20 min test	-43.997	22.956	-1.4611	0.421	0.0713
light / dark	time mobile in light zone, 20 min test	73.796	24.784	2.4089	0.111	0.00807
light / dark	time spent in dark zone, 20 min test	-184.25	86.816	-1.4051	0.390	0.0472
light / dark	time spent in light zone, 20 min test	184.25	86.816	1.4051	0.390	0.0472
open field	average speed in center of arena, 20 min test	1.4324	0.66501	1.4351	0.261	0.0443
open field	average speed in periphery of arena, 20 min test	0.61363	0.34535	1.3259	0.360	0.0916
open field	distance traveled habituation ratio, 20 min test	12.433	13.503	1.2306	0.775	0.368
open field	distance traveled in center of arena, 20 min test	477.73	190.83	1.7277	0.273	0.0211
open field	distance traveled in periphery of arena, 20 min test	535.68	381.63	1.1453	0.557	0.177
open field	distance traveled slope, 20 min test	11.476	13.601	1.0676	0.827	0.409
open field	distance traveled, 20 min test, 1st 5min	278.46	169.98	1.4968	0.436	0.118
open field	distance traveled, 20 min test, 2nd 5min	217.74	127.37	1.3259	0.378	0.104
open field	distance traveled, 20 min test, 3rd 5min	358.04	116.62	1.8302	0.141	0.00604
open field	distance traveled, 20 min test, 4th 5min	262.00	138.04	1.9564	0.352	0.0730
open field	number of clockwise revolution episodes, 20 min test	3.1687	2.0176	1.1868	0.550	0.132
open field	number of counter-clockwise revolution episodes, 20 min test	7.3041	3.0153	2.1247	0.274	0.0256
open field	number of fecal boli, 20 min test	-0.092242	1.1500	0.40225	0.937	0.937
open field	number of rears in 5 min bins, 20 min test, 1st 5min	6.1325	3.2248	1.4351	0.404	0.0717
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	10.446	5.7703	1.3784	0.350	0.0861
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	15.210	6.1540	1.9564	0.227	0.0231
open field	number of rears in 5 min bins, 20 min test, 4th 5min	7.3870	5.6446	0.96183	0.518	0.206
open field	percentage of total time in center of arena, 20 min test	-0.49723	7.1414	-0.052685	0.963	0.945
open field	percentage of total time in center of arena, slope, 20 min test	-2.7871	1.9134	-0.72152	0.744	0.161
open field	percentage of total time in center, habituation ratio, 20 min test	-3.5782	2.2188	-0.96183	0.691	0.122
open field	percentage of total time in corners of arena, 20 min test	-1.3959	7.4521	0.073791	0.910	0.853
open field	percentage of total time in corners, habituation ratio, 20 min test	-2.2486	2.3929	-1.0310	0.779	0.359
open field	percentage of total time in corners, slope, 20 min test	-2.0472	2.2335	-0.86588	0.736	0.370
open field	permanence time in center of arena, 20 min test	-5.9518	85.696	-0.052685	0.963	0.945
open field	permanence time in corners of arena, 20 min test	-16.742	89.422	0.073791	0.910	0.853
open field	permanence time in periphery of arena, 20 min test	5.9096	85.702	0.052685	0.964	0.946
open field	total distance traveled, 20 min test	962.10	479.11	1.5647	0.268	0.0591
open field	total number of rears, 20 min test	37.013	17.021	1.5647	0.250	0.0425
open field	whole arena average speed, 20 min test	0.80181	0.39902	1.5647	0.268	0.0589
open field	whole arena resting time, 20 min test	-142.28	35.071	-2.1247	0.0182	0.000616
open field	whole arena time spent mobile, 20 min test	142.32	35.077	2.3909	0.0242	0.000615
open field	whole arena time spent vertical, 20 min test	23.564	20.570	1.1056	0.673	0.266
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.6200	1.4942	-1.0227	0.299	0.0949

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-LAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-LAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	2.0 %	1.00
eye morphology	bulging eye	2.0 %	1.00
eye morphology	cornea	5.0 %	1.00
eye morphology	cornea opacity	5.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	14.0 %	1.00
eye morphology	corneal scleralization	10.0 %	0.101
eye morphology	corneal ulcer	2.0 %	1.00
eye morphology	eye closure	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	2.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.00
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	5.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	2.0 %	1.00
eye morphology	irispupil	4.0 %	1.00
eye morphology	lacrimation	4.0 %	1.00
eye morphology	lens	43.0 %	0.0874
eye morphology	lens opacity	11.0 %	0.0470
eye morphology	narrow eye opening	2.0 %	1.00
eye morphology	optic disc	5.0 %	1.00
eye morphology	persistence of hyaloid vascular system	7.0 %	0.382
eye morphology	pupil dilation	3.0 %	1.00
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.00
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	11.0 %	1.00
eye morphology	retinal blood vessels	5.0 %	1.00
eye morphology	retinal blood vessels pattern	5.0 %	1.00
eye morphology	retinal blood vessels structure	5.0 %	1.00
eye morphology	retinal pigmentation	13.0 %	0.0151
eye morphology	retinal structure	6.0 %	1.00
eye morphology	synechia	5.0 %	1.00
eye morphology	vitreous	5.0 %	1.00
SHIRPA	activity body position	5.0 %	1.0
SHIRPA	aggression	0.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	4.0 %	1.0
SHIRPA	body thickness	4.0 %	1.00
SHIRPA	coat color abdomen	2.0 %	1.0
SHIRPA	coat color back	2.0 %	0.691
SHIRPA	coat color head	15.0 %	0.0618
SHIRPA	coat color pattern abdomen	14.0 %	0.0785
SHIRPA	coat color pattern back	9.0 %	0.257
SHIRPA	coat color pattern head	14.0 %	0.0658
SHIRPA	coat hair abdomen texture appearance	0.0 %	1.0
SHIRPA	coat hair back texture appearance	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	5.0 %	0.407
SHIRPA	coat hair distribution back	9.0 %	0.612
SHIRPA	coat hair distribution head	10.0 %	0.550
SHIRPA	coat hair head texture appearance	2.0 %	1.0
SHIRPA	contact righting	22.0 %	0.172
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	eye morphology	2.0 %	1.00
SHIRPA	fat distribution	18.0 %	0.229
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	2.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.00
SHIRPA	head morphology	0.0 %	1.00
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	1.0 %	1.00
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	6.0 %	1.0
SHIRPA	hindlimb nail number	0.0 %	1.0
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	1.0 %	1.0
SHIRPA	hindlimbs position	1.0 %	1.0
SHIRPA	hindlimbs shape	7.0 %	0.328
SHIRPA	hindlimbs size	1.0 %	1.00
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	1.0 %	1.00
SHIRPA	limb grasp	19.0 %	0.244
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.00
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	1.0 %	1.0
SHIRPA	startle response	74.0 %	4.46e-7
SHIRPA	tail curvature	1.0 %	1.0
SHIRPA	tail elevation	2.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	2.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	1.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	7.0 %	1.0
SHIRPA	tremor	2.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	4.0 %	1.00
SHIRPA	vibrissae presence	34.0 %	0.0195
SHIRPA	vocalization	7.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Kcnd3^em1(IMPC)J -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.