MPD: JaxKOMP-EAP genotype: Aptx<sup>tm1b(EUCOMM)Hmgu</sup> -/-

JaxKOMP-EAP effect sizes: Aptx^{tm1b(EUCOMM)Hmgu} -/- Gene Aptx

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	5.0298	1.2417	1.1108	0.0673	0.00105
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	9.0309	3.8994	1.5650	0.366	0.0351
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.41850	4.0444	-0.076053	0.975	0.919
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-4.2076	3.2919	-0.75865	0.609	0.221
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-2.2542	2.4150	-0.38200	0.702	0.365
body composition	body length	-0.10835	0.045235	-0.95254	0.147	0.0228
body composition	body weight (at time of DXA)	-0.67260	0.67548	-0.41481	0.547	0.327
body composition	bone area, whole body scan, head excluded	-0.95930	0.16257	-2.5827	0.000280	0.00000163
body composition	bone mineral content of whole body scan, head excluded	-0.066381	0.011206	-2.4012	0.000240	0.00000153
body composition	bone mineral content to body weight ratio	-0.0027242	0.00051350	-2.4012	0.000747	0.00000895
body composition	bone mineral density of whole body scan, head excluded	-0.0023560	0.00047695	-2.0733	0.00204	0.0000255
body composition	fat tissue mass of whole body scan, head excluded	1.3177	0.33079	1.7106	0.0108	0.000382
body composition	fat tissue mass to body weight ratio	0.048058	0.012196	1.8209	0.0101	0.000431
body composition	lean tissue mass of whole body scan, head excluded	-0.88943	0.27660	-1.7166	0.0552	0.00304
body composition	lean tissue mass to body weight ratio	-0.033484	0.011460	-1.6383	0.0679	0.00644
body composition	percent fat, whole body scan, head excluded	4.5783	1.2030	1.8428	0.0141	0.000625
body composition	ratio of soft-tissue attenuation coefficients	-0.0050882	0.0013369	-1.8805	0.0139	0.000624
body composition	tissue area	-0.11428	0.13630	-0.21206	0.707	0.408
body composition	total tissue mass, whole body scan, head excluded	0.43676	0.16363	0.70217	0.0784	0.0120
clinical blood chemistry	alanine transaminase (plasma ALT)	58.621	35.161	2.0701	0.469	0.110
clinical blood chemistry	albumin (plasma Alb)	0.21168	0.46266	0.34917	0.863	0.652
clinical blood chemistry	alkaline phosphatase (plasma ALP)	5.4284	4.9826	0.48051	0.547	0.289
clinical blood chemistry	aspartate transaminase (plasma AST)	66.444	30.078	1.8110	0.259	0.0384
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.10104	0.31793	0.34752	0.927	0.754
clinical blood chemistry	blood urea nitrogen (BUN)	-2.8436	1.4071	-1.1383	0.223	0.0562
clinical blood chemistry	calcium (plasma Ca)	0.024714	0.091538	0.50638	0.890	0.790
clinical blood chemistry	creatinine (plasma)	0.011466	0.034479	0.38191	0.859	0.743
clinical blood chemistry	glucose (plasma GLU, no fast)	-2.8050	14.636	0.19767	0.915	0.850
clinical blood chemistry	HDL cholesterol (plasma HDL)	5.0325	3.1071	0.85543	0.385	0.121
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.021271	0.010401	-1.2916	0.305	0.0542
clinical blood chemistry	phosphorus (plasma phosphate)	0.21369	0.35231	0.30312	0.784	0.551
clinical blood chemistry	total bilirubin (plasma TBIL)	0.022894	0.012994	1.3098	0.366	0.0926
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	7.9659	3.7394	1.0622	0.226	0.0458
clinical blood chemistry	total protein (plasma TP)	0.23983	0.55985	0.12307	0.837	0.673
clinical blood chemistry	triglyceride (plasma TG, no fast)	18.557	7.3842	1.1150	0.141	0.0202
EKG	duration of PQ interval	0.78375	0.72734	0.99459	0.824	0.293
EKG	duration of PR interval	0.77750	0.88225	0.91206	0.877	0.388
EKG	duration of QRS interval	0.31375	0.33397	0.76321	0.885	0.358
EKG	duration of QT interval	-0.72996	0.67133	-0.55752	0.766	0.289
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.62081	0.77016	-0.59079	0.904	0.429
EKG	duration of RR interval	-0.36000	1.0964	0.060486	0.917	0.746
EKG	duration of ST interval	-0.95080	0.58743	-0.71554	0.632	0.120
EKG	heart rate coefficient of variation (signal intensity)	0.29800	1.4662	0.33458	0.971	0.841
EKG	heart rate variability, mean of differences between sequential beats; beats per min	2.4463	10.771	0.35597	0.970	0.822
EKG	heart rate, beats per min	4.2125	9.0454	-0.019159	0.870	0.646
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.37062	0.10253	-2.4451	0.0770	0.00154
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.45748	0.13558	-2.3095	0.101	0.00273
EKG	number of signals	-0.68569	4.0579	-0.19261	0.976	0.867
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-4.7469	4.1998	-0.86327	0.816	0.271
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.3325	4.1054	0.40580	0.969	0.749
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	2.7858	4.4643	0.73388	0.932	0.539
EKG	root mean square of successive differences of neighboring RR intervals	2.0503	2.8600	1.1215	0.897	0.481
glucose tolerance test	amount glucose injected	-2.8373	1.8221	-0.46365	0.480	0.130
glucose tolerance test	plasma glucose, 0min	21.358	6.1411	1.6849	0.0159	0.00148
glucose tolerance test	plasma glucose, 15min	27.787	28.187	0.90432	0.656	0.332
glucose tolerance test	plasma glucose, 30min	-1.8816	27.331	0.085213	0.979	0.946
glucose tolerance test	plasma glucose, 60min	41.939	23.493	1.6518	0.336	0.0837
glucose tolerance test	plasma glucose, 120min	-4.3250	14.059	-0.43928	0.915	0.760
grip strength	body weight (at time of grip strength test)	-1.6855	0.53432	-1.2361	0.0234	0.00392
grip strength	forelimb and hindlimb grip strength (mean of trials), average	19.059	8.7219	1.5575	0.133	0.0381
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	1.0446	0.33431	1.5978	0.0342	0.00422
grip strength	forelimb and hindlimb grip strength by trial, trial1	3.9551	11.371	0.52240	0.886	0.731
grip strength	forelimb and hindlimb grip strength by trial, trial2	17.812	11.520	1.3174	0.360	0.134
grip strength	forelimb and hindlimb grip strength by trial, trial3	29.204	8.1915	1.9715	0.0256	0.00144
grip strength	forelimb grip strength (mean of trials), average	4.2270	3.6008	0.82355	0.514	0.251
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.21798	0.21490	0.80936	0.597	0.320
grip strength	forelimb grip strength by trial, trial1	6.5636	4.5425	1.0238	0.488	0.160
grip strength	forelimb grip strength by trial, trial2	-0.34377	5.8243	0.17516	0.983	0.953
grip strength	forelimb grip strength by trial, trial3	5.3843	6.9463	0.81745	0.740	0.445
heart weight	heart weight, normalized to body weight	0.065581	0.12093	-0.21861	0.760	0.592
heart weight	heart weight, weight	0.88036	2.9909	-0.25056	0.874	0.771
hematology	basophil differential (percent of total WBC)	0.051199	0.082717	0.78282	0.843	0.543
hematology	calculated hemoglobin (cHGB)	-0.015329	0.11356	-0.32734	0.957	0.894
hematology	eosinophil differential (percent of total WBC)	0.19345	0.17812	0.61928	0.672	0.290
hematology	hematocrit (HCT)	0.37058	0.41280	0.025971	0.643	0.380
hematology	hemoglobin concentration distribution width (HDW)	-0.011803	0.026275	-0.29268	0.841	0.658
hematology	large unstained cells (percent of total WBC)	0.11818	0.14220	0.78032	0.736	0.416
hematology	lymphocyte differential (percent of total WBC)	-0.51721	1.0011	-0.27117	0.788	0.611
hematology	mean corpuscular hemoglobin (CHr)	-0.13014	0.077671	-1.0199	0.297	0.109
hematology	mean platelet volume (MPV)	0.041710	0.081043	0.11205	0.796	0.612
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.20863	0.36586	-0.74107	0.818	0.575
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.60953	0.81382	-1.0076	0.777	0.463
hematology	mean RBC corpuscular volume (MCV)	0.043614	0.42906	0.097192	0.964	0.920
hematology	measured hemoglobin (mHGB)	-0.16868	0.35856	-0.64769	0.829	0.643
hematology	monocyte differential (percent of total WBC)	-0.021175	0.14344	0.13572	0.955	0.884
hematology	neutrophil differential (percent of total WBC)	0.18113	0.79158	0.10818	0.908	0.821
hematology	platelet count (PLT; units per volume x 10³)	-114.26	54.376	-1.3178	0.323	0.0479
hematology	RBC corpuscular distribution width (RDW)	-0.098877	0.19736	-0.35472	0.801	0.622
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.28423	0.24786	-0.77878	0.523	0.264
hematology	red blood cell count (RBC; per volume x 10⁶)	0.072958	0.084049	-0.026000	0.654	0.395
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-8.4204	13.507	-0.29184	0.833	0.540
hematology	reticulocyte differential (percent of total RBC)	-0.10724	0.14401	-0.23946	0.768	0.465
hematology	white blood cell count (WBC; units per volume x 10³)	0.38178	0.75016	0.44024	0.771	0.616
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.4500	0.75886	-1.4042	0.485	0.0650
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.12500	0.49972	0.35774	0.968	0.804
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.60184	0.32149	-0.93950	0.602	0.0704
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.32203	0.73451	-0.22382	0.904	0.664
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.71250	0.46237	-1.0710	0.643	0.133
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.34013	0.36022	0.91147	0.870	0.352
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.30000	0.31671	0.77051	0.860	0.351
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.26250	0.39552	0.56453	0.876	0.512
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.71059	0.54216	-1.1520	0.671	0.199
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.50352	0.28036	-1.4031	0.664	0.0819
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.46250	0.24571	-1.2274	0.650	0.0689
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.52824	0.39601	-0.78113	0.630	0.192
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.3735	0.80971	-1.2994	0.495	0.0995
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-1.3339	0.53864	-2.0931	0.324	0.0187
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-1.1418	0.40842	-1.7541	0.300	0.00869
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-3.0353	0.91394	-2.5964	0.148	0.00231
holeboard	total number of hole pokes, 20 min test	-11.063	3.5127	-1.4610	0.0570	0.00353
light / dark	fecal boli count, 20 min test	1.7243	0.96681	1.7548	0.451	0.0840
light / dark	latency to enter dark zone, 20 min test	21.628	31.882	0.31047	0.838	0.502
light / dark	number of transitions between light and dark zones, 20 min test	-14.724	8.6555	-1.3605	0.382	0.0986
light / dark	percentage of total time in dark zone, 20 min test	1.9357	4.2773	0.47871	0.884	0.654
light / dark	percentage of total time in light zone, 20 min test	-1.9357	4.2773	-0.48022	0.883	0.654
light / dark	time mobile in dark zone, 20 min test	-27.080	15.219	-1.5604	0.323	0.0847
light / dark	time mobile in light zone, 20 min test	-8.6825	13.470	-0.87444	0.758	0.524
light / dark	time spent in dark zone, 20 min test	8.9412	48.469	0.35189	0.958	0.855
light / dark	time spent in light zone, 20 min test	-8.9412	48.469	-0.35189	0.958	0.855
open field	average speed in center of arena, 20 min test	-0.58963	0.42285	-1.2276	0.509	0.173
open field	average speed in periphery of arena, 20 min test	0.15729	0.13838	0.11505	0.486	0.264
open field	distance traveled habituation ratio, 20 min test	7.0923	8.9933	0.59844	0.723	0.436
open field	distance traveled in center of arena, 20 min test	149.77	95.155	0.58883	0.343	0.125
open field	distance traveled in periphery of arena, 20 min test	-131.37	152.09	-0.96350	0.639	0.394
open field	distance traveled slope, 20 min test	5.3140	8.6716	0.50616	0.800	0.544
open field	distance traveled, 20 min test, 1st 5min	-48.453	77.415	-0.73429	0.755	0.536
open field	distance traveled, 20 min test, 2nd 5min	122.93	57.301	0.84047	0.166	0.0396
open field	distance traveled, 20 min test, 3rd 5min	83.492	50.098	0.48944	0.296	0.105
open field	distance traveled, 20 min test, 4th 5min	-40.465	59.939	-0.93610	0.732	0.505
open field	number of clockwise revolution episodes, 20 min test	1.7777	1.4080	0.62554	0.573	0.216
open field	number of counter-clockwise revolution episodes, 20 min test	0.40213	1.1624	-0.22957	0.871	0.732
open field	number of fecal boli, 20 min test	1.6914	1.3652	1.4747	0.561	0.225
open field	number of rears in 5 min bins, 20 min test, 1st 5min	0.41143	2.4100	-0.092822	0.943	0.866
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.1048	2.8797	0.19250	0.717	0.470
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.0775	2.8038	0.18021	0.713	0.464
open field	number of rears in 5 min bins, 20 min test, 4th 5min	1.5174	2.8287	-0.0087270	0.795	0.595
open field	percentage of total time in center of arena, 20 min test	5.3731	2.4246	0.96778	0.234	0.0339
open field	percentage of total time in center of arena, slope, 20 min test	1.2065	1.3491	0.80469	0.808	0.378
open field	percentage of total time in center, habituation ratio, 20 min test	0.90515	1.2426	0.60005	0.845	0.472
open field	percentage of total time in corners of arena, 20 min test	-7.7370	4.3123	-1.1461	0.360	0.0822
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.3616	2.0611	-0.92987	0.877	0.514
open field	percentage of total time in corners, slope, 20 min test	-1.5629	2.1404	-1.0161	0.873	0.471
open field	permanence time in center of arena, 20 min test	64.478	29.097	0.96778	0.234	0.0339
open field	permanence time in corners of arena, 20 min test	-92.826	51.745	-1.1461	0.360	0.0823
open field	permanence time in periphery of arena, 20 min test	-64.453	29.097	-0.96778	0.234	0.0340
open field	total distance traveled, 20 min test	171.34	189.18	0.038273	0.594	0.372
open field	total number of rears, 20 min test	6.0102	9.4136	0.079970	0.737	0.528
open field	whole arena average speed, 20 min test	0.14179	0.15811	0.032900	0.597	0.377
open field	whole arena resting time, 20 min test	-15.289	19.310	0.10964	0.633	0.434
open field	whole arena time spent mobile, 20 min test	15.292	19.323	0.12586	0.639	0.435
open field	whole arena time spent vertical, 20 min test	2.7720	9.7810	0.10964	0.911	0.779
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.8143	1.4596	-0.56941	0.545	0.225
startle / PPI	average baseline movement during background noise	-2.4083	0.90727	-1.5706	0.372	0.0123
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.082431	0.059864	0.66441	0.535	0.178
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.074679	0.062641	0.66527	0.589	0.242
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.0482	7.2062	0.80582	0.879	0.335
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	4.9614	7.9244	0.44203	0.805	0.536
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	7.1795	6.7000	0.65396	0.591	0.292
startle / PPI	average startle response to full pulse (120 dB)	-15.863	33.259	-0.14411	0.831	0.637
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-21.508	28.206	-0.25277	0.676	0.451
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-21.381	23.883	-0.26146	0.590	0.377
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-22.190	22.598	-0.34957	0.560	0.334
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.85732	1.4070	0.63842	0.904	0.547
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.86882	1.0503	-0.59939	0.859	0.414
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.5542	1.1901	-1.0066	0.650	0.201
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.099946	0.078489	0.97453	0.850	0.212
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.070514	0.087555	0.51493	0.718	0.427
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.065773	0.077623	0.35798	0.663	0.403
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-13.454	33.245	-0.089090	0.856	0.688
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-20.296	28.502	-0.22106	0.698	0.482
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-20.250	24.060	-0.23545	0.611	0.406
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-20.635	23.138	-0.29935	0.588	0.379
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.091503	0.080980	0.82931	0.853	0.267
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.078911	0.087616	0.54120	0.688	0.375
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.084412	0.078568	0.45081	0.556	0.291
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-61.777	123.71	-0.16680	0.819	0.621
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-86.671	98.938	-0.31256	0.611	0.388
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-78.669	91.079	-0.26146	0.605	0.394
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-83.621	87.219	-0.34362	0.558	0.345
startle / PPI	maximum baseline movement during background noise	-3.8342	2.5031	-1.0518	0.624	0.136
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.1263	7.7819	0.75639	0.890	0.367
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	6.4598	8.2882	0.49679	0.750	0.441
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	8.9394	7.0312	0.70156	0.500	0.213
startle / PPI	maximum startle response to full pulse (120 dB)	-67.481	123.91	-0.18673	0.799	0.590
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-90.331	98.251	-0.32879	0.592	0.365
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-82.183	90.807	-0.27598	0.594	0.372
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-86.917	85.938	-0.37200	0.541	0.319
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	2.5267	3.2562	0.78468	0.830	0.444
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-2.8558	2.6616	-0.79424	0.764	0.291
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-3.2958	2.8464	-0.85932	0.641	0.255

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	12.0 %	0.195
eye morphology	cornea opacity	males	12.0 %	0.111
eye morphology	cornea opacity	both	9.0 %	0.0962
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	12.0 %	0.0271
eye morphology	cornea vascularization	both	6.0 %	0.234
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	11.0 %	0.220
eye morphology	corneal scleralization	males	12.0 %	0.0947
eye morphology	corneal scleralization	both	12.0 %	0.0355
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	12.0 %	0.0253
eye morphology	eyelid morphology	males	12.0 %	0.00640
eye morphology	eyelid morphology	both	12.0 %	0.000717
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	11.0 %	0.275
eye morphology	irispupil	males	11.0 %	0.223
eye morphology	irispupil	both	11.0 %	0.108
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	53.0 %	0.0000443
eye morphology	lens opacity	males	32.0 %	0.00108
eye morphology	lens opacity	both	43.0 %	1.32e-7
eye morphology	narrow eye opening	females	12.0 %	0.0786
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	6.0 %	0.0890
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	12.0 %	0.0619
eye morphology	optic disc	both	6.0 %	0.0690
eye morphology	persistence of hyaloid vascular system	females	74.0 %	0.00000763
eye morphology	persistence of hyaloid vascular system	males	45.0 %	0.000236
eye morphology	persistence of hyaloid vascular system	both	59.0 %	2.86e-8
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	0.457
eye morphology	retina	males	22.0 %	0.155
eye morphology	retina	both	12.0 %	0.240
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	35.0 %	0.0141
eye morphology	retinal pigmentation	males	9.0 %	0.529
eye morphology	retinal pigmentation	both	16.0 %	0.0569
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	4.0 %	0.524
SHIRPA	limb grasp	males	19.0 %	0.0730
SHIRPA	limb grasp	both	11.0 %	0.106
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	12.0 %	0.00594
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	6.0 %	0.00891
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Aptx^{tm1b(EUCOMM)Hmgu} -/- with genotype: