MPD: JaxKOMP-EAP genotype: Foxo1<sup>tm1b(EUCOMM)Wtsi</sup> -/+

JaxKOMP-EAP effect sizes: Foxo1^{tm1b(EUCOMM)Wtsi} -/+ Gene Foxo1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.51472	2.8255	-0.12711	0.962	0.858
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	2.0701	3.3422	0.49007	0.862	0.548
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	7.4466	2.7091	1.0960	0.201	0.0189
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-1.9627	4.9311	-0.43330	0.886	0.698
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-5.0000	5.2042	-0.79191	0.696	0.356
body composition	body length	0.018399	0.030210	0.46005	0.784	0.546
body composition	body weight (at time of DXA)	-1.0741	0.48251	-0.68179	0.123	0.0311
body composition	bone area, whole body scan, head excluded	0.18776	0.14006	0.97838	0.451	0.187
body composition	bone mineral content of whole body scan, head excluded	0.021451	0.010405	1.3416	0.207	0.0452
body composition	bone mineral content to body weight ratio	0.00093710	0.00047322	1.3654	0.213	0.0539
body composition	bone mineral density of whole body scan, head excluded	0.0013349	0.00045583	1.3971	0.0711	0.00538
body composition	fat tissue mass of whole body scan, head excluded	0.0033789	0.24922	0.0027305	0.993	0.989
body composition	fat tissue mass to body weight ratio	0.0018030	0.0093511	0.16042	0.932	0.848
body composition	lean tissue mass of whole body scan, head excluded	-0.15252	0.23531	-0.49455	0.775	0.520
body composition	lean tissue mass to body weight ratio	-0.0024401	0.0089234	-0.17367	0.898	0.786
body composition	percent fat, whole body scan, head excluded	0.20168	0.91317	0.17427	0.918	0.826
body composition	ratio of soft-tissue attenuation coefficients	-0.00024039	0.0010134	-0.18995	0.922	0.814
body composition	tissue area	-0.19711	0.14610	-0.47821	0.468	0.184
body composition	total tissue mass, whole body scan, head excluded	-0.14567	0.16192	-0.57007	0.625	0.373
clinical blood chemistry	alanine transaminase (plasma ALT)	-38.794	28.381	-2.2613	0.554	0.182
clinical blood chemistry	albumin (plasma Alb)	-0.97135	0.59538	-1.2127	0.417	0.114
clinical blood chemistry	alkaline phosphatase (plasma ALP)	15.555	4.4582	1.6755	0.0221	0.00157
clinical blood chemistry	aspartate transaminase (plasma AST)	-42.401	42.767	-1.6526	0.648	0.330
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.051846	0.43107	-0.15677	0.972	0.905
clinical blood chemistry	blood urea nitrogen (BUN)	-1.4610	1.6650	-0.62362	0.656	0.388
clinical blood chemistry	calcium (plasma Ca)	-0.069906	0.12087	-0.15344	0.756	0.568
clinical blood chemistry	creatinine (plasma)	-0.073922	0.041507	-1.4005	0.276	0.0871
clinical blood chemistry	glucose (plasma GLU, no fast)	-22.865	11.370	-0.56164	0.166	0.0537
clinical blood chemistry	HDL cholesterol (plasma HDL)	0.48575	3.3734	-0.21345	0.963	0.887
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.022880	0.014398	1.1076	0.432	0.123
clinical blood chemistry	phosphorus (plasma phosphate)	-0.14427	0.42283	-0.28972	0.875	0.735
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0069195	0.017153	0.47264	0.881	0.690
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-3.4323	3.0856	-0.81279	0.589	0.275
clinical blood chemistry	total protein (plasma TP)	-1.4844	0.61950	-1.1799	0.169	0.0232
clinical blood chemistry	triglyceride (plasma TG, no fast)	-5.0090	8.3730	-0.047231	0.780	0.554
EKG	duration of PQ interval	-1.9195	0.92830	-1.6703	0.509	0.0496
EKG	duration of PR interval	-1.9597	0.99657	-1.6310	0.596	0.0609
EKG	duration of QRS interval	-0.13978	0.48286	-0.53181	0.976	0.775
EKG	duration of QT interval	-0.86807	1.1102	-0.64444	0.874	0.442
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-1.1517	1.0579	-1.1330	0.828	0.287
EKG	duration of RR interval	0.67090	1.5533	0.61252	0.879	0.670
EKG	duration of ST interval	-0.85734	0.99530	-0.63455	0.823	0.398
EKG	heart rate coefficient of variation (signal intensity)	0.44541	1.3174	0.44774	0.960	0.738
EKG	heart rate variability, mean of differences between sequential beats; beats per min	0.025227	9.3551	0.10295	0.999	0.998
EKG	heart rate, beats per min	-5.1939	13.034	-0.59734	0.883	0.694
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.10839	0.098990	0.71753	0.662	0.284
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.20009	0.11700	1.0804	0.429	0.100
EKG	number of signals	-0.0079541	4.8645	-0.050396	1.0	0.999
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	2.2609	5.2714	0.49797	0.938	0.672
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-2.4341	4.1248	-0.70775	0.964	0.561
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-2.6123	4.7000	-0.70258	0.945	0.583
EKG	root mean square of successive differences of neighboring RR intervals	0.70717	2.2810	0.50874	0.947	0.759
glucose tolerance test	amount glucose injected	-6.6015	1.9605	-1.4346	0.0545	0.00159
glucose tolerance test	plasma glucose, 0min	-0.33743	3.3886	-0.27524	0.966	0.921
glucose tolerance test	plasma glucose, 15min	-20.327	22.575	-0.43928	0.695	0.373
glucose tolerance test	plasma glucose, 30min	29.047	23.205	0.98585	0.560	0.217
glucose tolerance test	plasma glucose, 60min	26.483	15.856	1.1431	0.372	0.102
glucose tolerance test	plasma glucose, 120min	16.076	9.6073	0.94002	0.389	0.101
grip strength	body weight (at time of grip strength test)	-0.73163	0.48662	-0.44670	0.307	0.143
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-21.793	9.2249	-1.2511	0.101	0.0251
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.0534	0.43916	-1.2935	0.0990	0.0231
grip strength	forelimb and hindlimb grip strength by trial, trial1	-35.431	10.643	-1.9050	0.0355	0.00232
grip strength	forelimb and hindlimb grip strength by trial, trial2	-20.381	12.251	-1.0512	0.309	0.107
grip strength	forelimb and hindlimb grip strength by trial, trial3	-12.313	12.202	-0.59022	0.589	0.321
grip strength	forelimb grip strength (mean of trials), average	-8.0389	5.6932	-0.73500	0.408	0.169
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.32713	0.27026	-0.58850	0.511	0.236
grip strength	forelimb grip strength by trial, trial1	-8.8346	6.8324	-0.75803	0.552	0.206
grip strength	forelimb grip strength by trial, trial2	-3.4370	7.5485	-0.16485	0.871	0.652
grip strength	forelimb grip strength by trial, trial3	-11.998	6.6165	-1.0141	0.335	0.0801
heart weight	heart weight, normalized to body weight	-0.066647	0.12982	-0.71360	0.774	0.610
heart weight	heart weight, weight	-2.1684	3.4443	-0.65720	0.715	0.532
hematology	basophil differential (percent of total WBC)	-0.039281	0.054439	-0.58655	0.815	0.476
hematology	calculated hemoglobin (cHGB)	-0.44198	0.26333	-1.3229	0.344	0.104
hematology	eosinophil differential (percent of total WBC)	0.30225	0.26234	0.89669	0.647	0.260
hematology	hematocrit (HCT)	-1.3387	0.75635	-1.4897	0.342	0.0872
hematology	hemoglobin concentration distribution width (HDW)	0.053145	0.050997	1.4162	0.607	0.306
hematology	large unstained cells (percent of total WBC)	0.078628	0.13906	0.51030	0.826	0.576
hematology	lymphocyte differential (percent of total WBC)	-5.5056	2.0431	-1.8133	0.102	0.0118
hematology	mean corpuscular hemoglobin (CHr)	0.33648	0.068800	1.9726	0.000724	0.0000344
hematology	mean platelet volume (MPV)	0.092280	0.13129	0.43827	0.706	0.488
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.52834	0.35713	-1.1843	0.495	0.150
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-1.8907	0.69662	-1.6370	0.138	0.0111
hematology	mean RBC corpuscular volume (MCV)	1.1958	0.39025	1.8133	0.0329	0.00468
hematology	measured hemoglobin (mHGB)	-0.95352	0.41027	-1.6325	0.201	0.0273
hematology	monocyte differential (percent of total WBC)	0.54118	0.49253	1.6025	0.633	0.281
hematology	neutrophil differential (percent of total WBC)	-0.14839	2.7051	-0.053329	0.979	0.957
hematology	platelet count (PLT; units per volume x 10³)	139.21	90.978	1.7161	0.504	0.137
hematology	RBC corpuscular distribution width (RDW)	0.53371	0.30098	1.5400	0.302	0.0871
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.18138	0.23404	-0.53441	0.689	0.445
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.49920	0.17914	-1.8344	0.0931	0.00929
hematology	reticulocyte count (Retic; units per volume x 10⁹)	32.002	14.844	1.3518	0.320	0.0398
hematology	reticulocyte differential (percent of total RBC)	0.62763	0.20142	1.9195	0.133	0.00421
hematology	white blood cell count (WBC; units per volume x 10³)	-0.32513	0.79047	-0.042382	0.824	0.684
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-1.7258	1.1054	-1.6084	0.639	0.129
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-1.6294	0.42902	-2.2124	0.170	0.000663
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.38323	0.51683	-0.57446	0.864	0.464
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.2051	0.98220	-1.1394	0.693	0.229
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-1.6023	0.54037	-2.3226	0.255	0.00600
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.84755	0.33392	-2.1407	0.408	0.0168
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.73039	0.33292	-1.9725	0.621	0.0364
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.49878	0.56381	-0.72023	0.817	0.383
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.082661	0.62326	-0.065923	0.987	0.895
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.054032	0.32486	-0.062622	0.969	0.869
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.20806	0.34161	-0.54232	0.896	0.547
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-2.0871	0.81233	-3.0009	0.267	0.0154
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.13003	0.94862	0.21244	0.977	0.892
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.037638	0.48666	0.0084342	0.985	0.939
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.74315	0.54376	-1.0957	0.652	0.182
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-1.1524	0.82224	-0.97463	0.588	0.172
holeboard	total number of hole pokes, 20 min test	-11.785	5.4884	-1.5226	0.227	0.0400
light / dark	fecal boli count, 20 min test	1.5835	0.94102	1.5980	0.487	0.0995
light / dark	latency to enter dark zone, 20 min test	9.9074	30.777	0.090709	0.934	0.749
light / dark	number of transitions between light and dark zones, 20 min test	-5.8314	6.9815	-0.46812	0.702	0.408
light / dark	percentage of total time in dark zone, 20 min test	1.1638	3.0072	0.35045	0.895	0.701
light / dark	percentage of total time in light zone, 20 min test	-1.1638	3.0072	-0.35621	0.897	0.701
light / dark	time mobile in dark zone, 20 min test	6.0120	12.684	0.30763	0.844	0.638
light / dark	time mobile in light zone, 20 min test	-4.6081	11.586	-0.58143	0.850	0.693
light / dark	time spent in dark zone, 20 min test	4.5366	35.922	0.27098	0.965	0.900
light / dark	time spent in light zone, 20 min test	-4.5366	35.922	-0.27098	0.965	0.900
open field	average speed in center of arena, 20 min test	0.99125	0.47742	1.5415	0.281	0.0430
open field	average speed in periphery of arena, 20 min test	0.37858	0.15876	0.89928	0.0928	0.0209
open field	distance traveled habituation ratio, 20 min test	-12.095	7.7119	-1.0251	0.425	0.123
open field	distance traveled in center of arena, 20 min test	3.7981	74.519	-0.36150	0.977	0.960
open field	distance traveled in periphery of arena, 20 min test	432.04	178.92	1.1805	0.102	0.0194
open field	distance traveled slope, 20 min test	-10.611	7.2172	-0.92574	0.458	0.148
open field	distance traveled, 20 min test, 1st 5min	200.01	73.849	1.1618	0.0617	0.00923
open field	distance traveled, 20 min test, 2nd 5min	87.175	55.402	0.47586	0.320	0.122
open field	distance traveled, 20 min test, 3rd 5min	95.437	56.184	0.59844	0.282	0.0956
open field	distance traveled, 20 min test, 4th 5min	91.162	58.746	0.52764	0.328	0.127
open field	number of clockwise revolution episodes, 20 min test	2.3750	1.1549	0.90698	0.264	0.0450
open field	number of counter-clockwise revolution episodes, 20 min test	1.5156	1.3792	0.38453	0.558	0.277
open field	number of fecal boli, 20 min test	0.60000	0.80340	0.69647	0.744	0.459
open field	number of rears in 5 min bins, 20 min test, 1st 5min	3.1500	1.9929	0.66357	0.354	0.120
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.38750	2.3023	-0.25168	0.947	0.867
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-0.36787	2.5810	-0.38019	0.948	0.887
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.8016	2.5803	-0.73429	0.726	0.488
open field	percentage of total time in center of arena, 20 min test	-0.92204	2.3247	-0.41946	0.884	0.693
open field	percentage of total time in center of arena, slope, 20 min test	0.31250	1.4684	0.29209	0.958	0.832
open field	percentage of total time in center, habituation ratio, 20 min test	0.21912	1.5528	0.23647	0.973	0.888
open field	percentage of total time in corners of arena, 20 min test	-4.6243	3.3169	-0.55093	0.480	0.169
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.72513	2.0691	-0.63744	0.947	0.727
open field	percentage of total time in corners, slope, 20 min test	-0.41750	1.9867	-0.46088	0.964	0.834
open field	permanence time in center of arena, 20 min test	-11.047	27.898	-0.41946	0.885	0.694
open field	permanence time in corners of arena, 20 min test	-55.476	39.802	-0.55093	0.480	0.170
open field	permanence time in periphery of arena, 20 min test	11.033	27.898	0.41800	0.885	0.694
open field	total distance traveled, 20 min test	473.84	207.90	0.82339	0.110	0.0270
open field	total number of rears, 20 min test	1.1278	7.7432	-0.26418	0.947	0.885
open field	whole arena average speed, 20 min test	0.39425	0.17307	0.81963	0.110	0.0270
open field	whole arena resting time, 20 min test	-49.226	20.026	-0.78444	0.0790	0.0175
open field	whole arena time spent mobile, 20 min test	49.292	20.010	1.0183	0.0792	0.0173
open field	whole arena time spent vertical, 20 min test	6.7718	9.3274	0.41653	0.748	0.471
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.16250	1.2647	0.11297	0.974	0.899
startle / PPI	average baseline movement during background noise	0.51035	1.1619	0.42050	0.928	0.663
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.070755	0.068008	-0.76013	0.660	0.304
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.073008	0.066989	-0.83048	0.629	0.282
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-9.1763	7.3146	-0.95004	0.855	0.217
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-8.7896	7.6174	-0.89014	0.632	0.255
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-3.6661	5.8997	-0.47942	0.798	0.538
startle / PPI	average startle response to full pulse (120 dB)	9.5019	30.731	0.44048	0.901	0.759
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	23.320	28.387	0.67141	0.646	0.416
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	26.842	28.925	0.76200	0.573	0.359
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	16.992	23.795	0.60107	0.671	0.479
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	1.0578	1.1981	0.73971	0.825	0.383
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.22014	1.1728	0.16965	0.974	0.852
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	1.9433	1.8345	0.68552	0.714	0.296
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.11961	0.080154	-1.0640	0.809	0.143
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.085170	0.085316	-0.77814	0.653	0.324
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.014245	0.072671	-0.29586	0.937	0.846
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	9.3566	30.922	0.42817	0.903	0.764
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	23.481	28.606	0.66966	0.643	0.417
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	26.622	28.984	0.75453	0.573	0.364
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	16.713	24.237	0.60275	0.686	0.494
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.11652	0.082911	-0.99271	0.804	0.168
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.090445	0.087608	-0.78046	0.651	0.308
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.0052971	0.072796	-0.23198	0.979	0.942
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	26.669	117.26	0.35553	0.926	0.821
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	72.944	100.11	0.56948	0.683	0.470
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	95.349	106.89	0.71055	0.597	0.378
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	47.489	89.254	0.49520	0.752	0.598
startle / PPI	maximum baseline movement during background noise	1.0097	2.7393	0.41591	0.938	0.714
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-9.5104	7.8457	-0.90270	0.884	0.233
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-8.8741	8.1739	-0.86338	0.643	0.284
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-1.9888	6.3746	-0.32583	0.901	0.757
startle / PPI	maximum startle response to full pulse (120 dB)	26.764	116.77	0.35404	0.925	0.820
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	72.066	99.703	0.55798	0.685	0.474
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	94.314	106.55	0.69441	0.597	0.381
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	48.081	88.176	0.49996	0.749	0.589
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	2.2900	2.5835	0.72688	0.791	0.381
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-1.0185	2.7145	-0.27017	0.943	0.709
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	3.9070	5.0104	0.51910	0.789	0.440

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	33.0 %	0.0332
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	9.0 %	0.0930
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	10.0 %	1.0
eye morphology	lens	males	8.0 %	1.0
eye morphology	lens	both	9.0 %	1.00
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	11.0 %	0.156
eye morphology	lens opacity	both	8.0 %	0.329
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	31.0 %	0.207
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	7.0 %	0.405
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	32.0 %	0.0636
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	7.0 %	0.498
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	12.0 %	1.00
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.00
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	37.0 %	0.0000190
SHIRPA	aggression	both	18.0 %	0.000109
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	16.0 %	0.154
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	5.0 %	0.327
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Foxo1^{tm1b(EUCOMM)Wtsi} -/+ with genotype: