MPD: JaxKOMP-EAP genotype: Sp5<sup>tm1b(KOMP)Wtsi</sup> -/+

JaxKOMP-EAP effect sizes: Sp5^{tm1b(KOMP)Wtsi} -/+ Gene Sp5

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	5.3257	1.7536	1.1545	0.195	0.0103
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-4.4444	2.1033	-0.93585	0.434	0.0562
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-5.1364	1.1418	-1.2061	0.0257	0.000729
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-13.244	2.8919	-1.8680	0.0289	0.000633
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-18.056	3.7918	-1.9865	0.0288	0.000463
body composition	body length	0.015313	0.052606	0.41321	0.905	0.772
body composition	body weight (at time of DXA)	0.50261	0.73598	0.51519	0.706	0.499
body composition	bone area, whole body scan, head excluded	-0.094572	0.18547	-0.19232	0.814	0.613
body composition	bone mineral content of whole body scan, head excluded	-0.0033162	0.013527	-0.056005	0.919	0.808
body composition	bone mineral content to body weight ratio	-0.00015973	0.00056150	-0.043702	0.900	0.777
body composition	bone mineral density of whole body scan, head excluded	0.00028006	0.00056188	0.32313	0.814	0.621
body composition	fat tissue mass of whole body scan, head excluded	0.79901	0.41539	1.1438	0.235	0.0616
body composition	fat tissue mass to body weight ratio	0.022720	0.014401	0.99169	0.315	0.122
body composition	lean tissue mass of whole body scan, head excluded	-0.64727	0.36649	-1.3620	0.333	0.0850
body composition	lean tissue mass to body weight ratio	-0.019814	0.012878	-1.0752	0.363	0.132
body composition	percent fat, whole body scan, head excluded	2.1798	1.3927	1.0211	0.325	0.125
body composition	ratio of soft-tissue attenuation coefficients	-0.0024340	0.0015498	-1.0313	0.324	0.124
body composition	tissue area	0.28682	0.18523	1.0628	0.397	0.129
body composition	total tissue mass, whole body scan, head excluded	0.25044	0.26851	0.33231	0.609	0.357
ECT	applied stimulus (current), by day, day 2	0.43356	0.31816	0.88606	0.505	0.181
ECT	behavior following applied stimulus (current), by day, day 1	-0.47921	0.35139	-0.84003	0.487	0.181
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.31461	0.22121	0.62293	0.464	0.163
EKG	duration of PQ interval	-2.1263	0.98993	-1.8613	0.505	0.0377
EKG	duration of PR interval	-1.9915	1.1555	-1.6543	0.623	0.0923
EKG	duration of QRS interval	0.11146	0.41567	0.17826	0.976	0.790
EKG	duration of QT interval	-0.36459	0.89799	-0.17212	0.927	0.687
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-1.4633	0.77539	-1.4644	0.647	0.0664
EKG	duration of RR interval	3.8211	1.5735	2.0860	0.305	0.0196
EKG	duration of ST interval	-0.43811	0.79410	-0.22970	0.896	0.584
EKG	heart rate coefficient of variation (signal intensity)	1.9813	1.1418	1.6464	0.797	0.0902
EKG	heart rate variability, mean of differences between sequential beats; beats per min	12.831	8.5015	1.5196	0.846	0.139
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.12088	0.10621	-1.0696	0.639	0.262
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.19200	0.13608	-1.1716	0.531	0.166
EKG	number of signals	13.034	5.3967	1.8728	0.376	0.0203
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	10.534	4.2320	1.8457	0.662	0.0170
EKG	QT dispersion, measured as inter-lead variability of QT intervals	8.7795	4.6937	2.0198	0.858	0.0686
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	8.9892	5.1220	1.8390	0.792	0.0867
EKG	root mean square of successive differences of neighboring RR intervals	1.6198	2.2556	0.92435	0.897	0.477
glucose tolerance test	amount glucose injected	-3.5319	2.4986	-0.65690	0.533	0.168
glucose tolerance test	plasma glucose, 0min	-11.589	3.5677	-1.2088	0.0246	0.00293
glucose tolerance test	plasma glucose, 15min	-3.1948	22.004	0.021966	0.959	0.886
glucose tolerance test	plasma glucose, 30min	5.2514	17.253	0.29669	0.907	0.763
glucose tolerance test	plasma glucose, 60min	12.563	17.758	0.62448	0.775	0.485
glucose tolerance test	plasma glucose, 120min	20.944	15.087	1.2679	0.488	0.175
grip strength	body weight (at time of grip strength test)	0.83193	0.60556	0.98141	0.364	0.185
grip strength	forelimb and hindlimb grip strength (mean of trials), average	9.3220	7.5913	0.93695	0.442	0.234
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.25937	0.32170	0.56619	0.631	0.430
grip strength	forelimb and hindlimb grip strength by trial, trial1	1.2627	16.557	0.31902	0.975	0.940
grip strength	forelimb and hindlimb grip strength by trial, trial2	13.230	10.103	1.0588	0.453	0.205
grip strength	forelimb and hindlimb grip strength by trial, trial3	2.8796	10.932	0.39802	0.916	0.795
grip strength	forelimb grip strength (mean of trials), average	-2.6714	8.0336	-0.075590	0.886	0.743
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.37615	0.40626	-0.72174	0.636	0.366
grip strength	forelimb grip strength by trial, trial1	5.7359	10.338	0.92575	0.823	0.585
grip strength	forelimb grip strength by trial, trial2	-3.7594	10.273	-0.20474	0.897	0.718
grip strength	forelimb grip strength by trial, trial3	-5.3558	8.5712	-0.34819	0.787	0.539
heart weight	heart weight, normalized to body weight	-0.25786	0.15574	-1.4400	0.271	0.106
heart weight	heart weight, weight	-7.6951	4.3309	-1.3993	0.242	0.0834
hematology	basophil differential (percent of total WBC)	-0.013544	0.047984	-0.19898	0.941	0.781
hematology	calculated hemoglobin (cHGB)	0.49636	0.21596	1.2251	0.186	0.0325
hematology	eosinophil differential (percent of total WBC)	0.10464	0.36051	0.39794	0.931	0.775
hematology	hematocrit (HCT)	1.4818	0.68751	1.2493	0.248	0.0435
hematology	hemoglobin concentration distribution width (HDW)	-0.025273	0.029553	-0.70871	0.701	0.403
hematology	large unstained cells (percent of total WBC)	-0.083636	0.14761	-0.58292	0.826	0.577
hematology	lymphocyte differential (percent of total WBC)	3.2336	2.3868	1.0676	0.446	0.191
hematology	mean corpuscular hemoglobin (CHr)	0.0036364	0.089826	0.051870	0.984	0.968
hematology	mean platelet volume (MPV)	0.014569	0.14128	-0.087232	0.963	0.919
hematology	mean RBC corpuscular hemoglobin (MCH)	0.13818	0.11033	0.50987	0.575	0.225
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.49377	0.20870	0.96524	0.231	0.0282
hematology	mean RBC corpuscular volume (MCV)	-0.26632	0.40618	-0.48897	0.729	0.519
hematology	measured hemoglobin (mHGB)	0.67091	0.23367	1.4491	0.117	0.00944
hematology	monocyte differential (percent of total WBC)	-0.13091	0.30090	-0.24010	0.879	0.668
hematology	neutrophil differential (percent of total WBC)	-3.3641	2.0805	-1.2890	0.346	0.122
hematology	platelet count (PLT; units per volume x 10³)	-131.13	68.456	-1.4773	0.378	0.0706
hematology	RBC corpuscular distribution width (RDW)	-0.76364	0.26619	-2.1345	0.0918	0.00949
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.19463	0.22333	0.50255	0.655	0.394
hematology	red blood cell count (RBC; per volume x 10⁶)	0.38182	0.18405	1.3205	0.239	0.0512
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-12.630	25.755	-0.45548	0.879	0.629
hematology	reticulocyte differential (percent of total RBC)	-0.25909	0.25470	-0.90292	0.679	0.321
hematology	white blood cell count (WBC; units per volume x 10³)	-1.7958	0.86328	-1.0390	0.167	0.0513
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.56052	0.87628	-0.50417	0.839	0.526
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-1.0197	0.65409	-1.4656	0.670	0.127
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-1.3265	0.87217	-2.0780	0.661	0.136
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.2042	0.85485	-1.1329	0.651	0.166
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-1.4427	0.59623	-2.1404	0.392	0.0201
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.53876	0.31100	-1.5119	0.666	0.0907
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.083708	0.36060	-0.24498	0.983	0.818
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.37360	0.52234	-0.52150	0.871	0.479
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.26292	0.64702	0.55804	0.938	0.687
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.63371	0.36549	-1.7223	0.687	0.0905
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.56392	0.32767	-1.4956	0.673	0.0928
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.39157	0.61872	-0.58300	0.880	0.530
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.74888	0.97396	-0.64825	0.787	0.446
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.034228	0.56901	0.12515	0.987	0.952
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.070225	0.48747	-0.016869	0.971	0.886
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.54775	1.0356	-0.45741	0.890	0.600
holeboard	total number of hole pokes, 20 min test	-9.1938	6.1429	-1.2140	0.414	0.142
light / dark	fecal boli count, 20 min test	0.25691	0.97399	0.30693	0.930	0.793
light / dark	latency to enter dark zone, 20 min test	11.175	32.254	0.12198	0.926	0.731
light / dark	number of transitions between light and dark zones, 20 min test	-23.394	8.3884	-2.0018	0.104	0.00806
light / dark	percentage of total time in dark zone, 20 min test	6.2802	3.3752	1.3015	0.380	0.0702
light / dark	percentage of total time in light zone, 20 min test	-6.2802	3.3752	-1.3078	0.378	0.0702
light / dark	time mobile in dark zone, 20 min test	-39.144	13.993	-2.0436	0.0800	0.00788
light / dark	time mobile in light zone, 20 min test	-42.078	12.969	-2.5495	0.0317	0.00238
light / dark	time spent in dark zone, 20 min test	66.515	46.094	1.2321	0.588	0.157
light / dark	time spent in light zone, 20 min test	-66.515	46.094	-1.2321	0.588	0.157
open field	average speed in center of arena, 20 min test	0.79988	0.50436	1.2420	0.436	0.120
open field	average speed in periphery of arena, 20 min test	-0.12812	0.21128	-1.0161	0.746	0.548
open field	distance traveled habituation ratio, 20 min test	27.613	10.479	1.9662	0.127	0.0118
open field	distance traveled in center of arena, 20 min test	-139.37	106.50	-1.2685	0.449	0.198
open field	distance traveled in periphery of arena, 20 min test	35.958	196.44	-0.29489	0.935	0.856
open field	distance traveled slope, 20 min test	24.642	9.9845	1.9050	0.166	0.0178
open field	distance traveled, 20 min test, 1st 5min	-179.32	104.50	-1.6679	0.280	0.0937
open field	distance traveled, 20 min test, 2nd 5min	28.395	72.295	-0.16930	0.843	0.697
open field	distance traveled, 20 min test, 3rd 5min	22.037	73.126	-0.17475	0.897	0.765
open field	distance traveled, 20 min test, 4th 5min	50.503	61.161	0.10559	0.647	0.414
open field	number of clockwise revolution episodes, 20 min test	-3.0994	2.0179	-2.0920	0.469	0.132
open field	number of counter-clockwise revolution episodes, 20 min test	2.7492	1.3234	1.0183	0.227	0.0442
open field	number of fecal boli, 20 min test	-3.0824	1.2935	-1.9282	0.195	0.0220
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-5.8335	2.8145	-1.6952	0.204	0.0445
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-2.6180	2.6482	-0.99604	0.613	0.329
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-2.0365	3.1143	-0.75734	0.747	0.517
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-2.8624	3.4002	-0.94027	0.673	0.405
open field	percentage of total time in center of arena, 20 min test	-5.4986	3.1060	-1.5371	0.363	0.0841
open field	percentage of total time in center of arena, slope, 20 min test	-0.44608	1.7322	-0.12993	0.955	0.798
open field	percentage of total time in center, habituation ratio, 20 min test	0.0023764	1.6740	0.13670	1.00	0.999
open field	percentage of total time in corners of arena, 20 min test	6.5020	4.7674	1.4588	0.488	0.180
open field	percentage of total time in corners, habituation ratio, 20 min test	-2.8140	2.1874	-1.5685	0.703	0.206
open field	percentage of total time in corners, slope, 20 min test	-2.3518	2.0648	-1.4100	0.748	0.261
open field	permanence time in center of arena, 20 min test	-65.995	37.275	-1.5371	0.363	0.0841
open field	permanence time in corners of arena, 20 min test	78.033	57.206	1.4588	0.489	0.180
open field	permanence time in periphery of arena, 20 min test	65.987	37.274	1.5371	0.364	0.0841
open field	total distance traveled, 20 min test	-114.83	271.55	-0.84430	0.826	0.675
open field	total number of rears, 20 min test	-12.966	9.3161	-1.2391	0.407	0.171
open field	whole arena average speed, 20 min test	-0.095006	0.22586	-0.84239	0.826	0.676
open field	whole arena resting time, 20 min test	2.4009	22.910	0.63744	0.954	0.917
open field	whole arena time spent mobile, 20 min test	-2.2805	22.903	-0.63580	0.959	0.921
open field	whole arena time spent vertical, 20 min test	-11.018	9.1654	-0.95711	0.545	0.236
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	17.412	16.550	1.5620	0.816	0.299
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	5.8863	5.1497	1.6788	0.787	0.260
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-10.979	10.610	-0.62729	0.691	0.307
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-0.71416	18.623	0.29627	0.996	0.970
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-0.20992	1.8394	0.084835	0.974	0.910
startle / PPI	average baseline movement during background noise	-0.031579	1.3631	0.059583	0.997	0.982
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.11084	0.099265	-1.1096	0.637	0.273
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.10296	0.089356	-1.0960	0.609	0.258
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-7.9287	11.368	-0.81751	0.895	0.491
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-12.174	8.8544	-1.2470	0.543	0.179
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-7.3935	6.5769	-0.79232	0.571	0.270
startle / PPI	average startle response to full pulse (120 dB)	9.6011	25.758	0.44357	0.874	0.712
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	32.389	26.158	0.81751	0.459	0.225
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	32.555	29.326	0.85326	0.495	0.276
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	8.5965	26.615	0.41286	0.858	0.749
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.0811	1.3261	-0.73236	0.835	0.421
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.78965	1.2909	-0.53359	0.903	0.545
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-3.3245	2.8790	-1.7104	0.691	0.257
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.10961	0.11559	-0.99731	0.869	0.351
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.17932	0.096761	-1.5749	0.366	0.0737
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.064837	0.093158	-0.67625	0.733	0.492
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	9.0441	26.314	0.42203	0.880	0.734
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	33.554	26.425	0.83923	0.443	0.214
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	32.942	29.532	0.86950	0.488	0.273
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	11.895	26.836	0.49045	0.797	0.661
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.11608	0.12593	-0.98358	0.860	0.364
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.20720	0.10687	-1.6470	0.330	0.0620
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.046371	0.10293	-0.51702	0.840	0.656
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	86.757	102.32	0.68552	0.636	0.403
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	171.28	98.621	1.0325	0.268	0.0927
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	156.48	115.35	0.99731	0.396	0.185
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	50.284	104.53	0.50951	0.776	0.634
startle / PPI	maximum baseline movement during background noise	0.71807	2.7723	0.32288	0.960	0.797
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-11.733	11.976	-1.1096	0.890	0.335
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-18.997	10.556	-1.7226	0.399	0.0820
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-1.7528	9.6082	-0.30228	0.939	0.856
startle / PPI	maximum startle response to full pulse (120 dB)	88.350	101.65	0.68730	0.627	0.392
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	167.72	98.143	1.0253	0.279	0.0978
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	155.34	115.05	0.97679	0.399	0.187
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	40.638	103.98	0.45287	0.820	0.699
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.8186	2.9939	-1.0277	0.717	0.212
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-1.8774	3.3285	-0.51430	0.899	0.577
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-10.302	8.2054	-2.0628	0.603	0.219
urinalysis	albumin-creatinine ratio (urine ACR)	1.3309	1.6048	-0.27889	0.605	0.412
urinalysis	creatinine (urine CREA)	-1.3956	3.9319	0.39234	0.852	0.725
urinalysis	glucose (urine GLU)	0.049793	2.7435	0.0	0.989	0.986
urinalysis	magnesium level (urine Mg)	0.030816	0.026254	0.61895	0.596	0.248
urinalysis	microalbumin (urine MA), calculated	0.073329	0.12874	0.012328	0.814	0.572

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Include Sexes Data Both Females Males

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value

electroretinography	blind eyes, left	males	0.0 %	1.0
electroretinography	blind eyes, left	both	0.0 %	1.0
electroretinography	blind eyes, right	males	0.0 %	1.0
electroretinography	blind eyes, right	both	0.0 %	1.0
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.00
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	50.0 %	0.0249
eye morphology	lacrimation	males	87.0 %	5.24e-17
eye morphology	lacrimation	both	80.0 %	2.95e-16
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	17.0 %	0.177
eye morphology	lens	both	11.0 %	0.298
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	12.0 %	0.134
eye morphology	persistence of hyaloid vascular system	both	8.0 %	0.370
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.00
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.00
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	12.0 %	0.00631
eye morphology	retinal blood vessels	both	10.0 %	0.0192
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	46.0 %	0.230
eye morphology	retinal pigmentation	males	61.0 %	0.000114
eye morphology	retinal pigmentation	both	57.0 %	0.0000370
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	females	0.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	males	0.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	both	0.0 %	1.0
rotarod	trial number	females	0.0 %	1.0
rotarod	trial number	males	0.0 %	1.0
rotarod	trial number	both	0.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.00
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.00
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.00
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.00
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.0
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.00
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.00
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.00
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.00
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.00
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.0
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	12.0 %	0.00592
SHIRPA	forelimb digit shape	both	10.0 %	0.00369
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.00
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.00
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	19.0 %	0.0730
SHIRPA	limb grasp	both	13.0 %	0.162
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.00
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.00
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.00
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.00
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.00
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.00
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.0
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Sp5^{tm1b(KOMP)Wtsi} -/+ with genotype: