MPD: JaxKOMP-EAP genotype: Sp5<sup>tm1b(KOMP)Wtsi</sup> -/-

JaxKOMP-EAP effect sizes: Sp5^{tm1b(KOMP)Wtsi} -/- Gene Sp5

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	5.8024	3.5312	1.2783	0.629	0.199
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	8.5681	4.3759	1.5008	0.630	0.145
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	0.23532	3.7326	-0.12173	0.988	0.954
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-1.6196	4.1097	-0.36020	0.896	0.720
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-3.9801	6.1273	-0.64314	0.827	0.562
body composition	body length	-0.0022594	0.042720	0.17045	0.991	0.958
body composition	body weight (at time of DXA)	-0.33086	0.55406	-0.17625	0.748	0.553
body composition	bone area, whole body scan, head excluded	0.099811	0.15053	0.59923	0.746	0.510
body composition	bone mineral content of whole body scan, head excluded	0.00014227	0.010852	0.14661	0.998	0.990
body composition	bone mineral content to body weight ratio	0.00010333	0.00046634	0.29931	0.929	0.826
body composition	bone mineral density of whole body scan, head excluded	-0.00044108	0.00049870	-0.45736	0.673	0.381
body composition	fat tissue mass of whole body scan, head excluded	-0.19698	0.30212	-0.35258	0.743	0.517
body composition	fat tissue mass to body weight ratio	-0.012653	0.010675	-0.55249	0.475	0.242
body composition	lean tissue mass of whole body scan, head excluded	0.64494	0.23795	1.0829	0.107	0.00924
body composition	lean tissue mass to body weight ratio	0.018412	0.0091037	0.91599	0.203	0.0486
body composition	percent fat, whole body scan, head excluded	-1.3787	1.0248	-0.63390	0.417	0.185
body composition	ratio of soft-tissue attenuation coefficients	0.0015209	0.0011483	0.63716	0.424	0.192
body composition	tissue area	0.013091	0.18903	0.24714	0.984	0.945
body composition	total tissue mass, whole body scan, head excluded	0.43253	0.20722	0.69000	0.178	0.0421
clinical blood chemistry	alanine transaminase (plasma ALT)	-32.379	11.848	-2.0132	0.183	0.0103
clinical blood chemistry	albumin (plasma Alb)	-0.35992	0.53627	-0.45590	0.786	0.507
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-5.5301	4.3172	-1.4264	0.466	0.210
clinical blood chemistry	aspartate transaminase (plasma AST)	-46.747	21.842	-1.7359	0.261	0.0406
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.19389	0.19887	0.64014	0.738	0.337
clinical blood chemistry	blood urea nitrogen (BUN)	-4.2989	1.2364	-1.5497	0.0293	0.00152
clinical blood chemistry	calcium (plasma Ca)	0.14471	0.079561	1.3055	0.246	0.0786
clinical blood chemistry	carbon dioxide (plasma CO₂)	1.2241	0.77266	0.90912	0.378	0.129
clinical blood chemistry	chloride (plasma Cl)	0.40055	0.63445	0.29108	0.705	0.535
clinical blood chemistry	glucose (plasma GLU, no fast)	-2.9887	11.510	0.18022	0.893	0.797
clinical blood chemistry	HDL cholesterol (plasma HDL)	-6.1896	2.6520	-1.5096	0.178	0.0263
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0071883	0.011165	-0.56619	0.799	0.524
clinical blood chemistry	iron (plasma Fe)	0.014746	0.0093264	1.3277	0.379	0.130
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.094618	0.063704	-0.78671	0.423	0.154
clinical blood chemistry	phosphorus (plasma phosphate)	-0.38457	0.39972	-0.67583	0.634	0.343
clinical blood chemistry	potassium (plasma K)	0.23678	0.17811	-0.011937	0.369	0.199
clinical blood chemistry	sodium (plasma Na)	0.10096	0.58519	-0.78188	0.912	0.865
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.0036147	0.0092222	-0.27894	0.885	0.698
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-7.4740	3.5805	-1.3572	0.224	0.0452
clinical blood chemistry	total protein (plasma TP)	-0.031672	0.66703	-0.081455	0.987	0.962
clinical blood chemistry	triglyceride (plasma TG, no fast)	-32.021	9.5678	-1.3431	0.0431	0.00221
EKG	duration of PQ interval	-0.12816	1.0240	0.012090	0.978	0.901
EKG	duration of PR interval	-0.43660	1.2169	-0.34312	0.938	0.722
EKG	duration of QRS interval	-0.12869	0.39322	-0.49731	0.969	0.746
EKG	duration of QT interval	-0.13020	0.98691	0.032245	0.985	0.896
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.017994	0.97013	0.086753	0.999	0.985
EKG	duration of RR interval	-0.73087	0.91751	-0.10700	0.796	0.432
EKG	duration of ST interval	-0.60181	0.87300	-0.38619	0.867	0.496
EKG	heart rate coefficient of variation (signal intensity)	0.050405	1.1403	0.14152	0.986	0.965
EKG	heart rate variability, mean of differences between sequential beats; beats per min	0.16371	8.1886	0.12322	0.997	0.984
EKG	heart rate, beats per min	7.3117	7.6237	0.17943	0.737	0.345
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.20263	0.10294	-1.6008	0.335	0.0586
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.21074	0.13842	-1.2603	0.491	0.139
EKG	number of signals	-9.0676	3.6647	-1.5325	0.372	0.0194
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	5.4081	3.3013	1.0568	0.791	0.112
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-3.0136	2.4704	-0.86423	0.881	0.232
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-2.8657	2.7999	-0.76591	0.892	0.315
EKG	root mean square of successive differences of neighboring RR intervals	-0.44961	1.8058	-0.12322	0.956	0.805
glucose tolerance test	amount glucose injected	-3.0027	6.4187	-0.50072	0.880	0.642
glucose tolerance test	plasma glucose, 0min	-18.152	6.7918	-1.7509	0.0581	0.0104
glucose tolerance test	plasma glucose, 15min	33.194	32.822	1.0409	0.643	0.317
glucose tolerance test	plasma glucose, 30min	26.208	31.847	0.89403	0.722	0.415
glucose tolerance test	plasma glucose, 60min	13.298	17.871	0.64632	0.757	0.461
glucose tolerance test	plasma glucose, 120min	2.3673	9.4974	0.032952	0.929	0.804
grip strength	body weight (at time of grip strength test)	-0.10939	0.49685	0.10463	0.904	0.827
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-3.4847	7.1539	-0.0087138	0.790	0.629
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.12386	0.34363	0.020333	0.841	0.721
grip strength	forelimb and hindlimb grip strength by trial, trial1	-10.628	10.442	-0.48939	0.618	0.316
grip strength	forelimb and hindlimb grip strength by trial, trial2	5.2625	12.656	0.56961	0.846	0.680
grip strength	forelimb and hindlimb grip strength by trial, trial3	-10.701	10.537	-0.48285	0.586	0.317
grip strength	forelimb grip strength (mean of trials), average	-11.742	4.7675	-1.1412	0.114	0.0190
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.63184	0.21394	-1.2543	0.0594	0.00576
grip strength	forelimb grip strength by trial, trial1	-8.2302	6.7363	-0.69007	0.587	0.230
grip strength	forelimb grip strength by trial, trial2	-16.469	6.0268	-1.4455	0.105	0.00989
grip strength	forelimb grip strength by trial, trial3	-9.7789	7.2799	-0.78343	0.497	0.188
heart weight	heart weight, normalized to body weight	0.26132	0.18652	0.45058	0.369	0.168
heart weight	heart weight, weight	5.5046	4.9317	0.34237	0.479	0.270
hematology	basophil differential (percent of total WBC)	0.0080282	0.064446	0.15714	0.982	0.902
hematology	calculated hemoglobin (cHGB)	-0.46014	0.30630	-1.3527	0.406	0.143
hematology	eosinophil differential (percent of total WBC)	0.20208	0.27825	0.64769	0.811	0.473
hematology	hematocrit (HCT)	-2.5528	0.86747	-2.0391	0.0814	0.00622
hematology	hemoglobin concentration distribution width (HDW)	0.12733	0.053275	2.1818	0.184	0.0233
hematology	large unstained cells (percent of total WBC)	0.17464	0.088564	1.1283	0.326	0.0582
hematology	lymphocyte differential (percent of total WBC)	-5.2308	1.6583	-1.7467	0.0527	0.00364
hematology	mean corpuscular hemoglobin (CHr)	0.13675	0.086375	1.0387	0.323	0.124
hematology	mean platelet volume (MPV)	0.11749	0.060403	0.57564	0.191	0.0612
hematology	mean RBC corpuscular hemoglobin (MCH)	0.59500	0.17005	1.6312	0.0386	0.00153
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	1.6614	0.37239	1.9576	0.0137	0.000106
hematology	mean RBC corpuscular volume (MCV)	-0.66174	0.33104	-1.0970	0.182	0.0551
hematology	measured hemoglobin (mHGB)	-0.16642	0.25723	-0.64432	0.748	0.523
hematology	monocyte differential (percent of total WBC)	0.44088	0.15846	1.4533	0.160	0.00940
hematology	neutrophil differential (percent of total WBC)	4.2979	1.5189	1.6927	0.0825	0.00823
hematology	platelet count (PLT; units per volume x 10³)	-10.066	53.317	-0.083469	0.953	0.852
hematology	RBC corpuscular distribution width (RDW)	0.37005	0.14087	1.1681	0.111	0.0134
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.76748	0.26710	1.6867	0.0584	0.00739
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.53699	0.20195	-1.9136	0.107	0.0124
hematology	reticulocyte count (Retic; units per volume x 10⁹)	68.374	38.098	2.0829	0.423	0.0828
hematology	reticulocyte differential (percent of total RBC)	1.0965	0.56627	2.2787	0.366	0.0623
hematology	white blood cell count (WBC; units per volume x 10³)	0.28105	0.51880	0.36903	0.754	0.592
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.0041667	0.51339	0.044746	0.999	0.994
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.20500	0.43372	-0.17560	0.908	0.639
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.36667	0.44086	-0.54485	0.841	0.411
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.48418	0.58060	-0.42333	0.797	0.409
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.46338	0.45109	-0.66025	0.778	0.310
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.019578	0.28324	0.11156	0.997	0.945
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.30195	0.31034	-0.82869	0.852	0.336
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.45360	0.42352	0.91101	0.790	0.291
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.45000	0.31057	-0.70882	0.620	0.155
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.41250	0.31976	1.0608	0.752	0.204
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.11252	0.30197	-0.27539	0.939	0.711
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.65701	0.47325	-1.0275	0.619	0.173
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.36714	0.54883	-0.27150	0.828	0.507
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.62288	0.40965	-0.89373	0.572	0.136
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.39660	0.47267	-0.53177	0.815	0.407
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.20006	0.63236	-0.16607	0.933	0.753
holeboard	total number of hole pokes, 20 min test	-3.7788	3.4714	-0.44807	0.570	0.283
light / dark	fecal boli count, 20 min test	-1.8500	1.0342	-1.9870	0.450	0.0812
light / dark	latency to enter dark zone, 20 min test	59.664	41.446	0.94183	0.592	0.158
light / dark	number of transitions between light and dark zones, 20 min test	-4.8724	7.3077	-0.38809	0.766	0.509
light / dark	percentage of total time in dark zone, 20 min test	2.7121	3.7165	0.60400	0.768	0.470
light / dark	percentage of total time in light zone, 20 min test	-2.7121	3.7165	-0.60724	0.766	0.470
light / dark	time mobile in dark zone, 20 min test	0.99971	11.721	-0.020282	0.976	0.932
light / dark	time mobile in light zone, 20 min test	4.7621	11.361	0.071718	0.838	0.677
light / dark	time spent in dark zone, 20 min test	-16.319	43.315	-0.032454	0.910	0.708
light / dark	time spent in light zone, 20 min test	16.319	43.315	0.032454	0.910	0.708
open field	average speed in center of arena, 20 min test	0.42712	0.36474	0.67238	0.598	0.249
open field	average speed in periphery of arena, 20 min test	0.26162	0.18220	0.48641	0.356	0.159
open field	distance traveled habituation ratio, 20 min test	-18.326	9.0299	-1.4706	0.270	0.0493
open field	distance traveled in center of arena, 20 min test	-36.662	97.206	-0.61458	0.843	0.708
open field	distance traveled in periphery of arena, 20 min test	368.63	168.05	0.95287	0.147	0.0345
open field	distance traveled slope, 20 min test	-18.305	8.1343	-1.5639	0.216	0.0301
open field	distance traveled, 20 min test, 1st 5min	196.41	93.771	1.1333	0.175	0.0429
open field	distance traveled, 20 min test, 2nd 5min	78.904	53.486	0.39321	0.361	0.148
open field	distance traveled, 20 min test, 3rd 5min	21.198	57.872	-0.18567	0.871	0.716
open field	distance traveled, 20 min test, 4th 5min	37.674	63.003	-0.022155	0.760	0.553
open field	number of clockwise revolution episodes, 20 min test	1.3829	1.2191	0.40289	0.619	0.264
open field	number of counter-clockwise revolution episodes, 20 min test	1.5562	1.6813	0.40922	0.648	0.360
open field	number of fecal boli, 20 min test	-3.1212	0.99167	-1.9691	0.0670	0.00315
open field	number of rears in 5 min bins, 20 min test, 1st 5min	0.62173	2.8498	-0.048378	0.934	0.828
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	3.1222	2.4870	0.45790	0.510	0.217
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	1.5605	2.4363	0.054402	0.751	0.526
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-0.75458	2.5927	-0.51227	0.892	0.773
open field	percentage of total time in center of arena, 20 min test	-3.1235	2.3233	-0.98726	0.499	0.187
open field	percentage of total time in center of arena, slope, 20 min test	-3.1094	1.1596	-1.4434	0.277	0.0108
open field	percentage of total time in center, habituation ratio, 20 min test	-3.0588	1.1928	-1.3885	0.303	0.0144
open field	percentage of total time in corners of arena, 20 min test	-1.3207	4.0468	0.050369	0.898	0.746
open field	percentage of total time in corners, habituation ratio, 20 min test	3.6160	1.7198	1.2806	0.425	0.0422
open field	percentage of total time in corners, slope, 20 min test	3.6650	1.7675	1.3442	0.456	0.0450
open field	permanence time in center of arena, 20 min test	-37.484	27.875	-0.98726	0.499	0.187
open field	permanence time in corners of arena, 20 min test	-15.842	48.561	0.050369	0.898	0.746
open field	permanence time in periphery of arena, 20 min test	37.469	27.877	0.98508	0.499	0.187
open field	total distance traveled, 20 min test	315.12	235.70	0.41800	0.391	0.189
open field	total number of rears, 20 min test	4.5860	8.6865	-0.026184	0.786	0.601
open field	whole arena average speed, 20 min test	0.26258	0.19633	0.42093	0.391	0.189
open field	whole arena resting time, 20 min test	-21.240	21.845	-0.066508	0.540	0.337
open field	whole arena time spent mobile, 20 min test	21.239	21.835	0.31458	0.549	0.337
open field	whole arena time spent vertical, 20 min test	6.9031	9.5143	0.42827	0.748	0.472
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.9950	1.6208	1.0368	0.547	0.230
sleep	differential wake percentages during light and dark phase	-0.066161	0.27006	0.28929	0.937	0.808
sleep	mean breath rate during-sleep	-0.060959	0.059729	-0.43073	0.598	0.315
sleep	mean of sleep bout lengths	-3.1947	19.779	0.31061	0.967	0.873
sleep	mean of sleep bout lengths with lights off	-20.004	18.685	-0.46452	0.658	0.292
sleep	mean of sleep bout lengths with lights on	41.671	34.127	1.0701	0.607	0.230
sleep	mean percentage of time sleeping over 24 h periods	1.5493	0.98365	0.90427	0.724	0.125
sleep	mean percentage of time sleeping with lights on	2.9568	1.0890	1.4526	0.179	0.0103
sleep	mean percentage of time spent sleeping with lights off	0.14675	1.8392	-0.23655	0.987	0.937
sleep	peak wake with respect to dark onset median	0.66650	0.64043	0.93538	0.860	0.305
sleep	percentage of time awake one hour before and after light onset	-10.512	4.6489	-1.1856	0.263	0.0303
sleep	sleep data confidence level (<0.6=questionable; 1=good quality)	-0.0076832	0.0065336	-0.62007	0.830	0.248
startle / PPI	average baseline movement during background noise	-0.97499	1.2631	-0.68375	0.874	0.445
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.25998	1.0636	-2.1124	0.929	0.808
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.083292	0.052166	-0.89353	0.439	0.118
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-10.029	6.5454	-1.0397	0.843	0.133
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-6.5489	5.7671	-0.67141	0.636	0.263
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-7.5730	4.8763	-0.81165	0.391	0.128
startle / PPI	average startle response to full pulse (120 dB)	10.067	27.794	0.45753	0.879	0.719
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	25.788	25.236	0.70875	0.551	0.313
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	25.410	26.675	0.73420	0.562	0.347
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	18.652	20.166	0.63499	0.580	0.361
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.56745	0.97768	0.45598	0.910	0.565
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.93958	1.7308	-0.65223	0.913	0.590
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.4600	1.4438	-0.95666	0.728	0.318
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.098870	0.073178	-0.87977	0.831	0.184
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.069548	0.065135	-0.65134	0.630	0.292
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.095124	0.058049	-0.89392	0.321	0.109
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	10.895	28.070	0.48257	0.863	0.700
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	25.370	25.305	0.70336	0.558	0.322
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	16.241	27.160	0.53682	0.735	0.553
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	20.792	20.132	0.68907	0.522	0.308
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.10637	0.079633	-0.90904	0.821	0.189
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.081833	0.069466	-0.71193	0.597	0.246
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.60838	3.1291	-2.5033	0.946	0.847
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	46.516	100.02	0.47158	0.834	0.644
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	86.928	94.097	0.62645	0.589	0.361
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	65.051	102.03	0.55471	0.709	0.527
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	72.056	79.238	0.64186	0.578	0.369
startle / PPI	maximum baseline movement during background noise	-1.8471	2.6552	-0.50632	0.853	0.491
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-10.575	7.4143	-1.0183	0.878	0.162
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-7.6911	6.5201	-0.73787	0.612	0.245
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-7.9615	5.4993	-0.81751	0.428	0.155
startle / PPI	maximum startle response to full pulse (120 dB)	45.089	99.461	0.46376	0.836	0.653
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	88.280	93.836	0.63499	0.581	0.352
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	63.249	102.46	0.53844	0.722	0.541
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	68.974	79.569	0.61794	0.599	0.391
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.6968	2.0311	0.59437	0.800	0.409
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-1.8326	3.9234	-0.50314	0.923	0.643
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-1.2677	3.2662	-0.44357	0.891	0.700
urinalysis	albumin-creatinine ratio (urine ACR)	1.0898	2.2575	-0.36548	0.767	0.634
urinalysis	creatinine (urine CREA)	-0.097062	3.8397	0.59484	0.989	0.980
urinalysis	glucose (urine GLU)	3.0184	2.8313	0.79164	0.647	0.297
urinalysis	magnesium level (urine Mg)	-0.012605	0.024264	-0.36861	0.867	0.608
urinalysis	microalbumin (urine MA), calculated	0.079603	0.16709	0.036991	0.834	0.638

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value

electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.00
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	22.0 %	0.00293
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	6.0 %	0.138
eye morphology	persistence of hyaloid vascular system	8.0 %	0.504
eye morphology	pupil dilation	6.0 %	0.0954
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.00
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	7.0 %	0.801
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	8.0 %	0.435
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.00
SHIRPA	coat color back	0.0 %	1.0
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.0
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.0
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.0
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.00
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.00
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.618
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.0
SHIRPA	tail curvature	0.0 %	1.00
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	0.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Sp5^{tm1b(KOMP)Wtsi} -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.