MPD: JaxKOMP-EAP genotype: Cdk19<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Cdk19^em1(IMPC)J -/- Gene Cdk19

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
body composition	body length	-0.12971	0.046124	-1.1454	0.0680	0.00701
body composition	body weight (at time of DXA)	-0.97017	0.59645	-0.61444	0.284	0.110
body composition	bone area, whole body scan, head excluded	-0.040789	0.12236	0.0068264	0.882	0.740
body composition	bone mineral content of whole body scan, head excluded	0.011816	0.0083807	0.82846	0.426	0.165
body composition	bone mineral content to body weight ratio	0.00068985	0.00045377	1.0853	0.372	0.135
body composition	bone mineral density of whole body scan, head excluded	0.0013799	0.00051825	1.4419	0.0981	0.0104
body composition	fat tissue mass of whole body scan, head excluded	-0.061043	0.16632	-0.10669	0.858	0.715
body composition	fat tissue mass to body weight ratio	0.0024600	0.0075937	0.19232	0.880	0.747
body composition	lean tissue mass of whole body scan, head excluded	-0.077247	0.22698	-0.31792	0.895	0.735
body composition	lean tissue mass to body weight ratio	0.0031564	0.0092109	0.11294	0.868	0.733
body composition	percent fat, whole body scan, head excluded	0.19756	0.71980	0.16734	0.903	0.785
body composition	ratio of soft-tissue attenuation coefficients	-0.00021750	0.00079995	-0.17743	0.908	0.787
body composition	tissue area	-0.23217	0.15924	-0.59997	0.424	0.151
body composition	total tissue mass, whole body scan, head excluded	-0.16634	0.20195	-0.61565	0.659	0.414
clinical blood chemistry	alanine transaminase (plasma ALT)	-2.2114	8.0799	-0.23816	0.935	0.785
clinical blood chemistry	albumin (plasma Alb)	-0.24308	0.46105	-0.30853	0.842	0.600
clinical blood chemistry	alkaline phosphatase (plasma ALP)	15.656	4.3253	1.6871	0.0124	0.000687
clinical blood chemistry	aspartate transaminase (plasma AST)	28.422	19.645	1.0297	0.468	0.154
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.61384	0.27655	1.5788	0.299	0.0309
clinical blood chemistry	blood urea nitrogen (BUN)	4.2132	1.0188	1.5839	0.00622	0.000157
clinical blood chemistry	calcium (plasma Ca)	-0.22240	0.091810	-1.2508	0.105	0.0191
clinical blood chemistry	carbon dioxide (plasma CO₂)	1.3330	0.72331	1.0238	0.292	0.0711
clinical blood chemistry	chloride (plasma Cl)	-1.2440	0.52671	-1.2433	0.0848	0.0220
clinical blood chemistry	glucose (plasma GLU, no fast)	-73.877	17.725	-1.9212	0.00223	0.000122
clinical blood chemistry	HDL cholesterol (plasma HDL)	-5.3420	2.4210	-1.3699	0.199	0.0320
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0085177	0.010770	0.32970	0.734	0.433
clinical blood chemistry	iron (plasma Fe)	0.019203	0.0074365	1.6647	0.109	0.0128
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	0.030055	0.10502	0.28689	0.881	0.776
clinical blood chemistry	phosphorus (plasma phosphate)	-0.45497	0.50033	-0.78373	0.652	0.368
clinical blood chemistry	potassium (plasma K)	0.15426	0.22229	-0.34323	0.641	0.491
clinical blood chemistry	sodium (plasma Na)	-0.41481	0.60259	-1.2240	0.626	0.494
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0053242	0.0090114	0.35356	0.810	0.557
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-8.1702	2.7268	-1.4404	0.0582	0.00425
clinical blood chemistry	total protein (plasma TP)	1.0232	0.79310	0.74050	0.487	0.203
clinical blood chemistry	triglyceride (plasma TG, no fast)	2.8857	11.650	0.37640	0.914	0.805
ECT	applied stimulus (current), by day, day 1	0.32077	0.12004	1.7317	0.0547	0.0113
ECT	applied stimulus (current), by day, day 2	0.64547	0.23480	1.3907	0.108	0.00929
ECT	applied stimulus (current), by day, day 3	0.73955	0.23225	1.5943	0.0481	0.00299
ECT	behavior following applied stimulus (current), by day, day 1	-0.48947	0.23183	-0.86411	0.271	0.0418
ECT	behavior following applied stimulus (current), by day, day 3	0.61164	0.48560	1.4586	0.724	0.216
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.62979	0.19148	1.4250	0.0385	0.00225
EKG	duration of PQ interval	-0.59718	0.83762	-0.50416	0.889	0.479
EKG	duration of PR interval	0.23536	0.84253	0.31334	0.941	0.781
EKG	duration of QRS interval	0.72433	0.42453	1.8176	0.885	0.0943
EKG	duration of QT interval	-0.063768	1.0278	0.092822	0.994	0.951
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.16390	0.87627	-0.12932	0.986	0.852
EKG	duration of RR interval	-0.59546	1.9353	-0.028213	0.922	0.760
EKG	duration of ST interval	-1.1188	0.97694	-0.84392	0.748	0.258
EKG	heart rate coefficient of variation (signal intensity)	-0.65451	1.6975	-0.43441	0.950	0.701
EKG	heart rate variability, mean of differences between sequential beats; beats per min	-4.0806	11.791	-0.41018	0.952	0.731
EKG	heart rate, beats per min	1.0227	14.998	-0.19585	0.981	0.946
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.092691	0.10969	0.62162	0.748	0.402
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.14981	0.14451	0.78987	0.662	0.305
EKG	number of signals	13.239	6.6453	1.9089	0.516	0.0519
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-9.8337	8.4254	-1.7347	0.814	0.249
EKG	QT dispersion, measured as inter-lead variability of QT intervals	5.4328	6.1634	1.4412	0.923	0.382
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	7.3295	6.4508	1.6234	0.873	0.261
EKG	root mean square of successive differences of neighboring RR intervals	-0.16399	3.5877	0.022167	0.990	0.964
glucose tolerance test	amount glucose injected	1.4477	2.2884	0.78347	0.826	0.533
glucose tolerance test	plasma glucose, 0min	6.7965	5.0508	0.47125	0.397	0.191
glucose tolerance test	plasma glucose, 15min	-15.202	42.378	-0.31107	0.900	0.723
glucose tolerance test	plasma glucose, 30min	-12.219	50.633	-0.25959	0.927	0.811
glucose tolerance test	plasma glucose, 60min	-26.992	28.920	-1.0130	0.688	0.360
glucose tolerance test	plasma glucose, 120min	18.026	12.654	1.0672	0.477	0.167
grip strength	body weight (at time of grip strength test)	-1.5756	0.71609	-1.1475	0.116	0.0354
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-4.6154	7.5315	-0.097457	0.724	0.544
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.066562	0.49958	0.10622	0.948	0.895
grip strength	forelimb and hindlimb grip strength by trial, trial1	6.3669	11.684	0.67358	0.818	0.590
grip strength	forelimb and hindlimb grip strength by trial, trial2	6.0204	7.1845	0.63579	0.649	0.408
grip strength	forelimb and hindlimb grip strength by trial, trial3	-15.204	11.049	-0.78541	0.435	0.179
grip strength	forelimb grip strength (mean of trials), average	-4.4664	4.4361	-0.29770	0.585	0.322
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.29801	0.28054	-0.52074	0.575	0.297
grip strength	forelimb grip strength by trial, trial1	-10.228	6.9113	-0.88849	0.469	0.149
grip strength	forelimb grip strength by trial, trial2	-1.1667	5.9615	0.090163	0.943	0.846
grip strength	forelimb grip strength by trial, trial3	-4.6747	5.6377	-0.26897	0.721	0.413
heart weight	heart weight, normalized to body weight	0.94603	0.20929	2.0225	0.00147	0.0000381
heart weight	heart weight, weight	19.664	4.9942	1.8549	0.00582	0.000255
hematology	basophil differential (percent of total WBC)	0.0034884	0.050330	0.075573	0.993	0.948
hematology	calculated hemoglobin (cHGB)	-0.12965	0.18262	-0.67340	0.760	0.517
hematology	eosinophil differential (percent of total WBC)	0.17788	0.31863	0.58323	0.872	0.606
hematology	hematocrit (HCT)	0.37544	0.77118	0.035543	0.831	0.652
hematology	hemoglobin concentration distribution width (HDW)	0.043645	0.037178	1.1614	0.606	0.306
hematology	large unstained cells (percent of total WBC)	-0.075080	0.20287	-0.51426	0.890	0.730
hematology	lymphocyte differential (percent of total WBC)	-2.8523	1.1558	-1.1973	0.264	0.0691
hematology	mean corpuscular hemoglobin (CHr)	-0.13107	0.12644	-1.0316	0.604	0.358
hematology	mean platelet volume (MPV)	-0.23124	0.078757	-1.3524	0.151	0.0426
hematology	mean RBC corpuscular hemoglobin (MCH)	0.045024	0.23949	0.14949	0.950	0.860
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.059943	0.42831	-0.13464	0.961	0.895
hematology	mean RBC corpuscular volume (MCV)	0.23451	0.59797	0.44628	0.863	0.715
hematology	measured hemoglobin (mHGB)	0.090116	0.26439	-0.015727	0.886	0.750
hematology	monocyte differential (percent of total WBC)	-0.19797	0.21392	-0.45384	0.727	0.407
hematology	neutrophil differential (percent of total WBC)	3.2218	1.0624	1.4455	0.183	0.0387
hematology	platelet count (PLT; units per volume x 10³)	-22.609	50.516	-0.26550	0.875	0.678
hematology	RBC corpuscular distribution width (RDW)	0.31844	0.24561	1.0562	0.531	0.265
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.36435	0.42223	-1.0013	0.687	0.437
hematology	red blood cell count (RBC; per volume x 10⁶)	0.0099873	0.15933	-0.31864	0.975	0.953
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-0.074623	26.696	0.081814	0.999	0.998
hematology	reticulocyte differential (percent of total RBC)	-0.021463	0.22844	0.13736	0.976	0.930
hematology	white blood cell count (WBC; units per volume x 10³)	-3.5832	1.0539	-2.0074	0.112	0.0273
insulin blood level	insulin (plasma)	-378.79	221.87	-1.3258	0.524	0.0923
light / dark	fecal boli count, 20 min test	0.087500	0.67676	0.10158	0.957	0.898
light / dark	latency to enter dark zone, 20 min test	60.598	46.218	0.95668	0.626	0.197
light / dark	number of transitions between light and dark zones, 20 min test	1.1925	8.9978	0.22774	0.957	0.895
light / dark	percentage of total time in dark zone, 20 min test	-0.63794	5.6284	0.014873	0.973	0.910
light / dark	percentage of total time in light zone, 20 min test	0.63794	5.6284	-0.018929	0.972	0.910
light / dark	time mobile in dark zone, 20 min test	-3.2883	15.647	-0.33182	0.934	0.835
light / dark	time mobile in light zone, 20 min test	-2.1978	16.764	-0.38663	0.953	0.896
light / dark	time spent in dark zone, 20 min test	-53.780	74.762	-0.58303	0.813	0.476
light / dark	time spent in light zone, 20 min test	53.780	74.762	0.58303	0.813	0.476
open field	average speed in center of arena, 20 min test	-1.1983	2.0522	-2.1845	0.818	0.562
open field	average speed in periphery of arena, 20 min test	-0.91071	2.3606	-2.7848	0.843	0.702
open field	distance traveled habituation ratio, 20 min test	15.434	53.786	1.2626	0.908	0.776
open field	distance traveled in center of arena, 20 min test	-535.89	2050.5	-2.5186	0.893	0.795
open field	distance traveled in periphery of arena, 20 min test	-477.94	545.93	-2.1845	0.632	0.386
open field	distance traveled slope, 20 min test	5.3625	48.433	0.51380	0.982	0.912
open field	distance traveled, 20 min test, 1st 5min	-284.20	889.89	-2.3198	0.888	0.751
open field	distance traveled, 20 min test, 2nd 5min	-287.57	600.81	-2.7251	0.815	0.635
open field	distance traveled, 20 min test, 3rd 5min	-296.35	672.51	-2.9465	0.835	0.662
open field	distance traveled, 20 min test, 4th 5min	-145.31	414.43	-2.1168	0.873	0.728
open field	number of clockwise revolution episodes, 20 min test	-4.6844	11.588	-2.7846	0.887	0.688
open field	number of counter-clockwise revolution episodes, 20 min test	-2.1209	4.4185	-1.6415	0.816	0.634
open field	number of fecal boli, 20 min test	1.4943	1.1613	1.3374	0.531	0.206
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-3.5498	3.2181	-1.1801	0.543	0.277
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-6.6040	2.8057	-1.8809	0.144	0.0235
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-2.3675	2.4093	-0.84814	0.603	0.332
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-5.1792	2.9302	-1.4746	0.311	0.0846
open field	percentage of total time in center of arena, 20 min test	3.2123	5.5361	0.50921	0.823	0.565
open field	percentage of total time in center of arena, slope, 20 min test	0.99507	2.2021	0.69102	0.920	0.654
open field	percentage of total time in center, habituation ratio, 20 min test	1.3237	2.2171	0.83856	0.869	0.554
open field	percentage of total time in corners of arena, 20 min test	-0.89167	6.9907	0.13941	0.964	0.899
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.5075	1.9835	-0.99604	0.860	0.452
open field	percentage of total time in corners, slope, 20 min test	-1.5008	1.8038	-0.99164	0.838	0.410
open field	permanence time in center of arena, 20 min test	38.559	66.433	0.51227	0.823	0.565
open field	permanence time in corners of arena, 20 min test	-10.700	83.889	0.13941	0.964	0.899
open field	permanence time in periphery of arena, 20 min test	-38.567	66.433	-0.51380	0.823	0.565
open field	total distance traveled, 20 min test	-1013.8	2571.4	-2.6288	0.841	0.695
open field	total number of rears, 20 min test	-15.904	8.9638	-1.4210	0.278	0.0834
open field	whole arena average speed, 20 min test	-0.84253	2.1429	-2.6288	0.839	0.696
open field	whole arena resting time, 20 min test	32.775	35.650	1.4785	0.564	0.363
open field	whole arena time spent mobile, 20 min test	-32.667	35.646	-1.7185	0.577	0.365
open field	whole arena time spent vertical, 20 min test	-30.116	70.448	-2.1043	0.870	0.671
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-18.180	14.593	-1.2594	0.755	0.219
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-6.1708	4.5853	-1.3214	0.757	0.184
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	12.544	12.336	1.3889	0.692	0.314
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-13.478	18.151	-0.53681	0.838	0.461
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-4.1577	2.7206	-1.5356	0.450	0.146
startle / PPI	average baseline movement during background noise	-0.33638	1.5124	-0.16396	0.971	0.826
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.049648	0.10336	-0.56454	0.840	0.636
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.0085337	0.10574	-0.14853	0.970	0.936
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	-4.1853	9.4387	-0.34812	0.852	0.662
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	22.155	17.304	2.5370	0.854	0.215
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-13.436	6.4253	-1.3582	0.344	0.0502
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-22.914	6.6939	-1.9867	0.0615	0.00269
startle / PPI	average startle response to full pulse (120 dB)	99.883	36.810	1.6583	0.0797	0.0134
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	96.992	38.249	1.6002	0.0953	0.0197
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	105.00	29.803	1.7543	0.0207	0.00214
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	89.233	29.552	1.7164	0.0511	0.00677
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.62178	1.5630	-0.41744	0.946	0.695
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.1220	1.3813	-0.77897	0.863	0.426
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.3496	1.6300	-0.91116	0.790	0.417
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.29734	0.27201	2.5035	0.868	0.287
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.16853	0.070695	-1.4846	0.250	0.0277
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.26481	0.085521	-1.9967	0.0602	0.00569
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	100.22	36.975	1.6638	0.0800	0.0135
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	97.615	38.771	1.6312	0.0964	0.0204
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	105.98	29.630	1.7675	0.0186	0.00189
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	89.211	29.463	1.7879	0.0484	0.00665
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.29357	0.26900	2.1256	0.853	0.288
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.24664	0.075890	-1.8385	0.113	0.00421
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.28554	0.092644	-2.0177	0.0600	0.00588
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	328.66	126.56	1.5470	0.0918	0.0172
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	324.82	130.14	1.5378	0.0980	0.0214
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	389.74	103.80	1.7675	0.0140	0.00125
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	327.18	106.57	1.7675	0.0444	0.00604
startle / PPI	maximum baseline movement during background noise	-2.8629	2.5761	-0.79041	0.752	0.280
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	24.560	21.224	2.5370	0.884	0.261
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-21.533	7.0371	-1.8863	0.157	0.00644
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-24.533	8.3832	-2.0073	0.0989	0.00866
startle / PPI	maximum startle response to full pulse (120 dB)	329.41	126.52	1.5658	0.0902	0.0170
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	324.06	129.15	1.5333	0.0969	0.0208
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	389.02	103.94	1.7543	0.0144	0.00128
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	324.25	106.19	1.7543	0.0462	0.00627
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-0.76321	2.2806	-0.12150	0.949	0.741
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.58185	2.7076	-0.14978	0.974	0.832
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-2.3193	3.0154	-0.65396	0.793	0.451
urinalysis	albumin-creatinine ratio (urine ACR)	5.7712	2.6187	1.1849	0.134	0.0321
urinalysis	creatinine (urine CREA)	-5.8222	4.7817	-0.40998	0.462	0.229
urinalysis	glucose (urine GLU)	1.8846	3.7963	0.48191	0.864	0.622
urinalysis	magnesium level (urine Mg)	0.0078455	0.031514	0.13144	0.940	0.804
urinalysis	microalbumin (urine MA), calculated	0.25215	0.20592	0.77330	0.510	0.226

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.0
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.0
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.0
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.0
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.00
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.00
eye morphology	eyes (present, absent)	females	1.0 %	1.00
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.00
eye morphology	fusion between cornea and lens	females	4.0 %	1.0
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.0
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.0
eye morphology	irispupil	females	4.0 %	1.0
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.00
eye morphology	lens	females	16.0 %	0.410
eye morphology	lens	males	46.0 %	0.157
eye morphology	lens	both	25.0 %	0.115
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.00
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.0
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.0
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.00
eye morphology	pupil light response	females	2.0 %	1.0
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.0
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.0
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	1.00
eye morphology	retina	males	45.0 %	0.194
eye morphology	retina	both	10.0 %	0.486
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.00
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.0
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	18.0 %	0.363
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	12.0 %	0.390
eye morphology	retinal structure	females	4.0 %	1.0
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.0
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.0
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	females	0.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	males	0.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	both	0.0 %	1.0
rotarod	trial number	females	0.0 %	1.0
rotarod	trial number	males	0.0 %	1.0
rotarod	trial number	both	0.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.0
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.00
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.00
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.0
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.00
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.00
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.00
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.0
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	45.0 %	0.105
SHIRPA	contact righting	both	9.0 %	0.324
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.0
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.00
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.0
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.0
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.0
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.00
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.0
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.0
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	1.00
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	0.0 %	1.0
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.0
SHIRPA	snout size	females	0.0 %	1.00
SHIRPA	snout size	males	1.0 %	1.00
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.0
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.0
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.0
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	0.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.00
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.0
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.0
SHIRPA	vibrissae presence	males	1.0 %	1.00
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Cdk19^em1(IMPC)J -/- with genotype: