MPD: JaxKOMP-EAP genotype: Isca1<sup>tm1b(KOMP)Wtsi</sup>/2J -/+

JaxKOMP-EAP effect sizes: Isca1^{tm1b(KOMP)Wtsi}/2J -/+ Gene Isca1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	3.7500	1.2500	0.84573	0.162	0.00769
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	4.3750	2.0321	0.92059	0.398	0.0451
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-2.5000	1.3842	-0.71288	0.423	0.0876
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	6.5024	2.2717	0.90807	0.139	0.0108
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	1.8750	2.3544	0.26959	0.755	0.436
body composition	body length	-0.013157	0.043770	0.036406	0.900	0.765
body composition	body weight (at time of DXA)	-0.43108	0.55160	-0.24181	0.650	0.437
body composition	bone area, whole body scan, head excluded	0.25011	0.11511	1.2741	0.171	0.0334
body composition	bone mineral content of whole body scan, head excluded	0.013314	0.0088738	0.91844	0.389	0.138
body composition	bone mineral content to body weight ratio	0.00049480	0.00037962	0.85768	0.451	0.197
body composition	bone mineral density of whole body scan, head excluded	0.000091831	0.00046988	0.13358	0.939	0.846
body composition	fat tissue mass of whole body scan, head excluded	-0.49621	0.21482	-0.96307	0.140	0.0241
body composition	fat tissue mass to body weight ratio	-0.017739	0.0085139	-0.79806	0.166	0.0411
body composition	lean tissue mass of whole body scan, head excluded	0.25649	0.24428	0.38915	0.599	0.298
body composition	lean tissue mass to body weight ratio	0.013577	0.0082271	0.68266	0.315	0.104
body composition	percent fat, whole body scan, head excluded	-1.6980	0.82026	-0.79057	0.169	0.0424
body composition	ratio of soft-tissue attenuation coefficients	0.0018854	0.00091152	0.80022	0.171	0.0425
body composition	tissue area	-0.24114	0.13155	-0.62636	0.293	0.0714
body composition	total tissue mass, whole body scan, head excluded	-0.25591	0.17411	-0.83812	0.373	0.146
ECT	applied stimulus (current), by day, day 3	0.42128	0.25761	0.81965	0.364	0.110
ECT	behavior following applied stimulus (current), by day, day 1	-0.60672	0.26666	-1.1303	0.212	0.0265
ECT	behavior following applied stimulus (current), by day, day 3	-0.073245	0.38449	-0.35391	0.971	0.850
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.29252	0.14411	0.53642	0.216	0.0470
EKG	duration of PQ interval	0.94893	0.64727	1.1801	0.719	0.147
EKG	duration of PR interval	1.3413	0.74226	1.4412	0.620	0.0754
EKG	duration of QRS interval	0.18006	0.27761	0.34312	0.931	0.519
EKG	duration of QT interval	0.039530	0.66190	0.20906	0.995	0.953
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.19306	0.58766	0.27756	0.970	0.744
EKG	duration of RR interval	-0.44182	1.3713	0.036277	0.917	0.748
EKG	duration of ST interval	-0.19177	0.56730	0.022167	0.953	0.736
EKG	heart rate coefficient of variation (signal intensity)	1.2825	1.0067	1.1291	0.841	0.207
EKG	heart rate variability, mean of differences between sequential beats; beats per min	9.6328	7.4759	1.1602	0.853	0.202
EKG	heart rate, beats per min	3.3131	10.609	-0.069629	0.907	0.756
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.046474	0.077808	-0.48977	0.831	0.552
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.090492	0.10019	-0.61186	0.701	0.370
EKG	number of signals	11.932	4.2728	1.7302	0.219	0.00686
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	1.9075	4.0914	0.43222	0.920	0.643
EKG	QT dispersion, measured as inter-lead variability of QT intervals	3.5545	2.9658	1.0012	0.881	0.235
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	4.1432	3.3042	1.0666	0.860	0.214
EKG	root mean square of successive differences of neighboring RR intervals	0.91630	1.7901	0.61983	0.919	0.610
electroretinography	a-wave amplitude of rod photoreceptors, left	13.592	7.9315	0.21582	0.531	0.117
electroretinography	a-wave amplitude of rod photoreceptors, right	5.4702	6.0993	-0.27498	0.758	0.393
electroretinography	b-wave amplitude of cone photoreceptors, left	-8.4900	10.925	-0.65672	0.863	0.455
electroretinography	b-wave amplitude of cone photoreceptors, right	-4.8057	4.8231	-0.34468	0.756	0.345
electroretinography	b-wave amplitude of rod photoreceptors, left	-56.026	24.673	-0.75123	0.392	0.0465
electroretinography	b-wave amplitude of rod photoreceptors, right	-36.512	26.141	-0.29845	0.542	0.193
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	1.8000	1.0162	1.6155	0.501	0.107
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	1.1500	0.96189	1.0901	0.683	0.259
electroretinography	rod a wave implicit time, left	1.1185	0.71373	0.98163	0.540	0.148
electroretinography	rod a wave implicit time, right	1.1037	0.62382	0.92890	0.439	0.107
electroretinography	rod b wave implicit time, left	1.1311	1.0121	0.35015	0.771	0.293
electroretinography	rod b wave implicit time, right	0.90000	0.98119	0.24441	0.846	0.381
glucose tolerance test	amount glucose injected	-1.6302	1.9407	-0.13031	0.742	0.405
glucose tolerance test	plasma glucose, 0min	-14.293	3.6138	-1.4203	0.00430	0.000251
glucose tolerance test	plasma glucose, 15min	-8.3639	16.090	-0.13355	0.850	0.606
glucose tolerance test	plasma glucose, 30min	6.6218	17.227	0.32840	0.880	0.702
glucose tolerance test	plasma glucose, 60min	27.628	12.834	1.2117	0.231	0.0365
glucose tolerance test	plasma glucose, 120min	27.283	8.8088	1.6204	0.0667	0.00329
grip strength	body weight (at time of grip strength test)	1.3328	0.54580	1.3792	0.0785	0.0205
grip strength	forelimb and hindlimb grip strength (mean of trials), average	3.0495	6.9849	0.46175	0.816	0.666
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.18103	0.38277	0.44404	0.794	0.640
grip strength	forelimb and hindlimb grip strength by trial, trial1	-2.9134	8.6713	0.023239	0.891	0.739
grip strength	forelimb and hindlimb grip strength by trial, trial2	11.748	11.624	0.97596	0.577	0.320
grip strength	forelimb and hindlimb grip strength by trial, trial3	-4.4327	10.161	-0.084332	0.841	0.666
grip strength	forelimb grip strength (mean of trials), average	4.1575	4.5654	0.81138	0.625	0.370
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.18888	0.28299	0.74454	0.755	0.510
grip strength	forelimb grip strength by trial, trial1	-1.6946	6.9213	0.082874	0.926	0.808
grip strength	forelimb grip strength by trial, trial2	4.4351	7.6867	0.73310	0.829	0.568
grip strength	forelimb grip strength by trial, trial3	2.8629	6.1077	0.56109	0.854	0.643
heart weight	heart weight, normalized to body weight	0.37893	0.19354	0.78519	0.184	0.0545
heart weight	heart weight, weight	8.4670	4.7344	0.72410	0.235	0.0784
hematology	basophil differential (percent of total WBC)	0.010642	0.036048	0.19758	0.938	0.769
hematology	calculated hemoglobin (cHGB)	-0.11322	0.16158	-0.63040	0.738	0.486
hematology	eosinophil differential (percent of total WBC)	-0.15805	0.18463	-0.37437	0.766	0.395
hematology	hematocrit (HCT)	-0.062204	0.53422	-0.43273	0.958	0.908
hematology	hemoglobin concentration distribution width (HDW)	-0.015312	0.018669	-0.39790	0.705	0.415
hematology	large unstained cells (percent of total WBC)	-0.049908	0.068252	-0.32619	0.769	0.467
hematology	lymphocyte differential (percent of total WBC)	1.9283	0.92244	0.69436	0.197	0.0404
hematology	mean corpuscular hemoglobin (CHr)	-0.12147	0.050619	-0.96558	0.0907	0.0192
hematology	mean platelet volume (MPV)	0.15724	0.052169	0.77950	0.0265	0.00367
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.14965	0.067415	-0.57649	0.223	0.0299
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.17317	0.12765	-0.38901	0.537	0.180
hematology	mean RBC corpuscular volume (MCV)	-0.14640	0.23004	-0.26975	0.733	0.527
hematology	measured hemoglobin (mHGB)	-0.10179	0.18101	-0.50085	0.792	0.576
hematology	monocyte differential (percent of total WBC)	-0.056765	0.15413	0.027339	0.895	0.714
hematology	neutrophil differential (percent of total WBC)	-1.6283	0.83527	-0.72424	0.224	0.0555
hematology	platelet count (PLT; units per volume x 10³)	29.112	31.896	0.45535	0.702	0.365
hematology	RBC corpuscular distribution width (RDW)	0.044413	0.15304	0.16312	0.884	0.773
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.19403	0.11156	-0.56274	0.270	0.0867
hematology	red blood cell count (RBC; per volume x 10⁶)	0.024941	0.12964	-0.24883	0.928	0.848
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-4.0506	15.871	-0.096983	0.943	0.799
hematology	reticulocyte differential (percent of total RBC)	-0.027322	0.16725	0.11473	0.947	0.871
hematology	white blood cell count (WBC; units per volume x 10³)	-0.10456	0.61638	0.12332	0.927	0.866
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-0.63544	0.58487	-0.57048	0.731	0.281
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.79463	0.43748	-1.1266	0.572	0.0739
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.78950	0.52022	-1.2533	0.661	0.134
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.80994	0.60197	-0.74451	0.653	0.183
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.65384	0.36277	-0.97962	0.570	0.0761
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.17410	0.21798	-0.46116	0.884	0.427
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.48041	0.29445	-1.3596	0.731	0.108
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-1.2441	0.33990	-1.9614	0.149	0.000502
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-1.0901	0.49821	-1.7010	0.380	0.0323
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.56546	0.31829	-1.5774	0.664	0.0802
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.12802	0.27725	-0.31065	0.921	0.646
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-1.2173	0.50946	-1.8574	0.305	0.0197
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.3553	0.64404	-1.2611	0.394	0.0392
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-1.1311	0.34708	-1.7541	0.173	0.00177
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-1.1741	0.47762	-1.8208	0.329	0.0166
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-2.7125	0.79089	-2.2985	0.101	0.00105
holeboard	total number of hole pokes, 20 min test	-15.069	4.1423	-1.9734	0.0288	0.000540
light / dark	fecal boli count, 20 min test	0.45699	0.63387	0.55679	0.810	0.474
light / dark	latency to enter dark zone, 20 min test	47.385	34.074	0.72018	0.605	0.169
light / dark	number of transitions between light and dark zones, 20 min test	-30.903	7.4006	-2.4299	0.00606	0.0000916
light / dark	percentage of total time in dark zone, 20 min test	9.7895	3.0803	1.8623	0.0798	0.00228
light / dark	percentage of total time in light zone, 20 min test	-9.7895	3.0803	-1.8623	0.0798	0.00228
light / dark	time mobile in dark zone, 20 min test	-37.757	9.8054	-1.9450	0.00749	0.000275
light / dark	time mobile in light zone, 20 min test	-46.191	10.417	-2.5860	0.00181	0.0000371
light / dark	time spent in dark zone, 20 min test	77.824	45.375	1.3708	0.460	0.0912
light / dark	time spent in light zone, 20 min test	-77.824	45.375	-1.3708	0.460	0.0912
open field	average speed in center of arena, 20 min test	0.18483	0.34767	0.23647	0.829	0.597
open field	average speed in periphery of arena, 20 min test	-0.43528	0.13937	-1.9756	0.0238	0.00266
open field	distance traveled habituation ratio, 20 min test	15.816	8.5819	1.2929	0.328	0.0699
open field	distance traveled in center of arena, 20 min test	-283.50	71.005	-2.0148	0.00389	0.000169
open field	distance traveled in periphery of arena, 20 min test	-290.38	135.14	-1.6064	0.150	0.0353
open field	distance traveled slope, 20 min test	14.525	8.3865	1.2596	0.363	0.0880
open field	distance traveled, 20 min test, 1st 5min	-247.21	74.355	-2.0148	0.0193	0.00146
open field	distance traveled, 20 min test, 2nd 5min	-106.76	51.353	-1.6625	0.171	0.0415
open field	distance traveled, 20 min test, 3rd 5min	-106.58	43.963	-1.5594	0.0970	0.0181
open field	distance traveled, 20 min test, 4th 5min	-104.80	48.521	-1.6467	0.160	0.0344
open field	number of clockwise revolution episodes, 20 min test	-1.2967	1.2572	-1.2159	0.665	0.306
open field	number of counter-clockwise revolution episodes, 20 min test	-1.7898	0.96131	-1.3956	0.285	0.0671
open field	number of fecal boli, 20 min test	-0.15169	0.82089	0.16223	0.939	0.854
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-8.9708	2.1341	-2.3611	0.00486	0.0000807
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-9.6790	1.9906	-2.4074	0.000552	0.00000769
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-8.3432	1.9463	-1.9851	0.00343	0.0000613
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-8.2379	2.2166	-2.0804	0.0155	0.000423
open field	percentage of total time in center of arena, 20 min test	-6.4430	3.0106	-1.7740	0.241	0.0361
open field	percentage of total time in center of arena, slope, 20 min test	-4.0181	1.2576	-1.8578	0.137	0.00216
open field	percentage of total time in center, habituation ratio, 20 min test	-4.4587	1.2943	-1.9218	0.109	0.000998
open field	percentage of total time in corners of arena, 20 min test	13.006	4.0792	2.2819	0.0493	0.00220
open field	percentage of total time in corners, habituation ratio, 20 min test	4.5324	1.6694	1.6162	0.213	0.00845
open field	percentage of total time in corners, slope, 20 min test	4.2521	1.6064	1.5824	0.235	0.0101
open field	permanence time in center of arena, 20 min test	-77.329	36.128	-1.7740	0.240	0.0361
open field	permanence time in corners of arena, 20 min test	156.07	48.951	2.2819	0.0493	0.00220
open field	permanence time in periphery of arena, 20 min test	77.324	36.134	1.7740	0.241	0.0361
open field	total distance traveled, 20 min test	-574.09	173.01	-1.9391	0.0155	0.00148
open field	total number of rears, 20 min test	-35.516	6.5197	-2.3198	0.0000980	8.40e-7
open field	whole arena average speed, 20 min test	-0.47736	0.14424	-1.9304	0.0156	0.00152
open field	whole arena resting time, 20 min test	54.425	17.836	1.9570	0.0238	0.00328
open field	whole arena time spent mobile, 20 min test	-54.398	17.817	-2.2470	0.0248	0.00326
open field	whole arena time spent vertical, 20 min test	-30.940	6.7301	-2.1702	0.00147	0.0000203
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	4.8385	9.9477	0.65488	0.918	0.628
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	1.4391	3.3247	0.62729	0.914	0.667
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-11.152	7.5572	-0.64379	0.501	0.145
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-15.520	12.813	-0.68866	0.788	0.230
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.9877	1.4255	-0.66389	0.489	0.173
startle / PPI	average baseline movement during background noise	-0.80392	0.97986	-0.54656	0.867	0.417
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.059290	0.064440	-0.65050	0.700	0.363
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.059043	0.067171	-0.67405	0.716	0.385
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-10.029	9.4941	-1.0373	0.877	0.298
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-9.5597	6.7245	-0.97679	0.523	0.164
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.24799	5.1539	-0.077841	0.987	0.962
startle / PPI	average startle response to full pulse (120 dB)	-59.157	16.296	-0.84722	0.0111	0.000873
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-42.140	16.562	-0.59939	0.0819	0.0153
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-21.973	14.323	-0.27453	0.332	0.134
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-29.430	12.396	-0.52071	0.110	0.0230
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.13388	1.0645	0.18530	0.981	0.901
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.69638	1.0348	-0.47001	0.891	0.505
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-4.4169	2.0600	-2.0870	0.346	0.0387
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.084684	0.10664	-0.76575	0.897	0.432
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.087468	0.077542	-0.79920	0.608	0.267
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.0047398	0.064874	-0.21760	0.978	0.942
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-58.466	16.783	-0.82536	0.0157	0.00132
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-42.430	16.775	-0.59270	0.0834	0.0158
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-21.341	14.665	-0.26146	0.357	0.154
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-25.102	12.589	-0.39462	0.188	0.0536
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.085282	0.11489	-0.73236	0.909	0.463
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.086297	0.072544	-0.75225	0.592	0.242
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.0043447	0.060183	-0.22622	0.979	0.943
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-207.52	65.180	-0.83525	0.0270	0.00295
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-166.48	67.252	-0.67669	0.0885	0.0180
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-82.935	57.469	-0.28327	0.360	0.157
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-93.370	49.715	-0.39159	0.213	0.0683
startle / PPI	maximum baseline movement during background noise	-0.86851	1.8194	-0.17107	0.917	0.636
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-9.7676	10.604	-0.92611	0.890	0.363
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-9.1453	6.6506	-0.88391	0.534	0.177
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.089950	5.2821	-0.15970	0.993	0.987
startle / PPI	maximum startle response to full pulse (120 dB)	-212.86	64.002	-0.85326	0.0200	0.00204
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-166.26	67.104	-0.68552	0.0884	0.0179
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-84.826	57.156	-0.29496	0.346	0.146
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-104.07	49.232	-0.46689	0.158	0.0413
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	0.082108	2.1966	0.14553	0.995	0.970
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-1.5909	1.7768	-0.41439	0.800	0.377
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-10.273	5.9553	-2.0512	0.461	0.0929
urinalysis	albumin-creatinine ratio (urine ACR)	3.0415	2.0040	0.37428	0.334	0.134
urinalysis	creatinine (urine CREA)	-9.3142	3.1058	-1.0821	0.0765	0.00387
urinalysis	glucose (urine GLU)	-2.6954	2.0385	-0.87217	0.554	0.191
urinalysis	magnesium level (urine Mg)	-0.00057958	0.020608	-0.057373	0.987	0.978
urinalysis	microalbumin (urine MA), calculated	0.068619	0.13227	0.0041092	0.826	0.606

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.00
eye morphology	lacrimation	3.0 %	1.00
eye morphology	lens	16.0 %	0.0267
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	3.0 %	0.790
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.00
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	13.0 %	1.0
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	13.0 %	1.0
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	7.0 %	0.624
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.00
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Isca1^{tm1b(KOMP)Wtsi}/2J -/+ with genotype: