MPD: JaxKOMP-LAP genotype: Catsperz<sup>tm1.1(KOMP)Vlcg</sup> -/-

JaxKOMP-LAP effect sizes: Catsperz^{tm1.1(KOMP)Vlcg} -/- Gene Catsperz

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-LAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-LAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

body composition	body length	-0.13457	0.059585	-0.69516	0.175	0.0322
body composition	body weight (at time of DXA)	-4.7287	2.1038	-0.78742	0.107	0.0327
body composition	bone area, whole body scan, head excluded	-1.1619	0.34380	-2.1144	0.0825	0.00215
body composition	bone mineral content of whole body scan, head excluded	-0.081588	0.020403	-2.1144	0.0162	0.000421
body composition	bone mineral content to body weight ratio	-0.0013946	0.00054501	-1.2621	0.145	0.0164
body composition	bone mineral density of whole body scan, head excluded	-0.0017314	0.00084651	-0.81724	0.212	0.0507
body composition	fat tissue mass of whole body scan, head excluded	0.32242	0.64360	0.10826	0.849	0.620
body composition	fat tissue mass to body weight ratio	0.016716	0.014120	0.39932	0.531	0.247
body composition	lean tissue mass of whole body scan, head excluded	-0.82776	0.51717	-0.56958	0.398	0.121
body composition	lean tissue mass to body weight ratio	-0.00086678	0.012221	0.10826	0.987	0.944
body composition	percent fat, whole body scan, head excluded	1.0887	1.2961	0.30729	0.737	0.408
body composition	ratio of soft-tissue attenuation coefficients	-0.0012051	0.0014437	-0.32151	0.742	0.411
body composition	tissue area	-0.19242	0.36482	-0.21780	0.845	0.602
body composition	total tissue mass, whole body scan, head excluded	-0.50533	0.38507	-0.81724	0.658	0.200
clinical blood chemistry	alanine transaminase (plasma ALT)	8.2739	9.0179	0.41246	0.770	0.369
clinical blood chemistry	albumin (plasma Alb)	-0.10364	0.41121	-0.025581	0.924	0.803
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-4.0236	13.977	-0.24828	0.912	0.776
clinical blood chemistry	aspartate transaminase (plasma AST)	7.0528	7.4148	0.23800	0.735	0.352
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.072474	0.13361	-0.21254	0.847	0.593
clinical blood chemistry	blood urea nitrogen (BUN)	3.5346	1.5658	1.2323	0.294	0.0353
clinical blood chemistry	calcium (plasma Ca)	0.023040	0.073434	-0.050154	0.988	0.757
clinical blood chemistry	creatinine (plasma)	-0.016090	0.017633	-0.26361	0.775	0.372
clinical blood chemistry	glucose (plasma GLU, no fast)	9.4870	14.819	0.11191	0.821	0.529
clinical blood chemistry	HDL cholesterol (plasma HDL)	-2.4110	3.7067	-0.72152	0.915	0.522
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0098976	0.017684	0.39469	0.855	0.581
clinical blood chemistry	phosphorus (plasma phosphate)	-0.26504	0.43058	-0.36800	0.707	0.545
clinical blood chemistry	total bilirubin (plasma TBIL)	0.014467	0.0078353	1.0740	0.556	0.0790
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-5.3289	5.0975	-0.81366	0.716	0.308
clinical blood chemistry	total protein (plasma TP)	-2.0567	4.1071	-1.2381	0.878	0.622
clinical blood chemistry	triglyceride (plasma TG, no fast)	0.16781	9.6660	0.037236	0.986	0.986
glucose tolerance test	amount glucose injected	13.371	3.3486	1.0470	0.0248	0.000614
glucose tolerance test	plasma glucose, 0min	-8.8144	9.7774	-0.91412	0.702	0.377
glucose tolerance test	plasma glucose, 15min	-39.725	56.995	-0.88335	0.846	0.493
glucose tolerance test	plasma glucose, 30min	-63.159	46.012	-1.1604	0.599	0.183
glucose tolerance test	plasma glucose, 60min	-80.124	41.691	-1.6529	0.330	0.0671
glucose tolerance test	plasma glucose, 120min	-71.613	29.589	-1.6529	0.229	0.0238
grip strength	body weight (at time of grip strength test)	-3.9911	2.1831	-0.72791	0.205	0.0778
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-6.1815	8.8188	-0.40792	0.646	0.489
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.27891	0.20881	-0.67449	0.458	0.192
grip strength	forelimb and hindlimb grip strength by trial, trial1	-7.5415	10.655	-0.64849	0.779	0.485
grip strength	forelimb and hindlimb grip strength by trial, trial2	-2.7055	11.669	-0.25335	0.953	0.818
grip strength	forelimb and hindlimb grip strength by trial, trial3	-8.2975	9.5276	-0.47704	0.646	0.391
grip strength	forelimb grip strength (mean of trials), average	-2.6127	4.5605	-0.45376	0.848	0.571
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.14579	0.10519	-0.75542	0.513	0.177
grip strength	forelimb grip strength by trial, trial1	-0.48924	6.3660	-0.25335	0.972	0.939
grip strength	forelimb grip strength by trial, trial2	-1.9528	4.4188	-0.43073	0.955	0.662
grip strength	forelimb grip strength by trial, trial3	-5.2262	5.7872	-0.57297	0.742	0.374
heart weight	heart weight, normalized to body weight	-0.027368	0.090189	-0.31582	0.914	0.764
heart weight	heart weight, weight	-9.2157	2.9466	-1.3645	0.0939	0.00490
hematology	basophil differential (percent of total WBC)	0.032192	0.074116	0.41246	0.868	0.668
hematology	calculated hemoglobin (cHGB)	0.43630	0.71878	0.81915	0.793	0.550
hematology	eosinophil differential (percent of total WBC)	0.0032160	0.20291	-0.27370	0.988	0.988
hematology	hematocrit (HCT)	0.48470	2.4107	0.27932	0.946	0.843
hematology	hemoglobin concentration distribution width (HDW)	0.10393	0.073846	1.4007	0.482	0.174
hematology	large unstained cells (percent of total WBC)	1.0252	0.58415	1.6684	0.525	0.0932
hematology	lymphocyte differential (percent of total WBC)	0.78828	2.8173	0.26361	0.909	0.782
hematology	mean corpuscular hemoglobin (CHr)	0.15937	0.25992	0.67449	0.819	0.546
hematology	mean platelet volume (MPV)	0.53756	0.12888	1.8852	0.0432	0.000432
hematology	mean RBC corpuscular hemoglobin (MCH)	0.024422	0.27293	0.040441	0.940	0.930
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.23086	0.26346	0.65130	0.711	0.391
hematology	mean RBC corpuscular volume (MCV)	-0.39117	0.90905	-0.31538	0.858	0.671
hematology	measured hemoglobin (mHGB)	0.28144	0.76781	0.40311	0.863	0.718
hematology	monocyte differential (percent of total WBC)	-0.40620	0.15420	-0.52161	0.105	0.0155
hematology	neutrophil differential (percent of total WBC)	-1.3366	2.5885	-0.42167	0.912	0.611
hematology	platelet count (PLT; units per volume x 10³)	-533.04	123.06	-2.3301	0.0294	0.000294
hematology	RBC corpuscular distribution width (RDW)	-0.098350	0.54034	-0.27932	0.971	0.857
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.50867	0.20558	0.95721	0.197	0.0215
hematology	red blood cell count (RBC; per volume x 10⁶)	0.31857	0.85393	0.62092	0.910	0.713
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-18.025	73.699	-0.56179	0.979	0.809
hematology	reticulocyte differential (percent of total RBC)	-0.62796	0.88203	-0.97392	0.852	0.484
hematology	white blood cell count (WBC; units per volume x 10³)	0.22606	1.1104	0.086973	0.944	0.841
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.31532	0.72519	0.12824	0.899	0.667
holeboard	number of hole pokes by individual hole number, 20 min test, 2	0.29129	0.42990	0.29129	0.949	0.504
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.0039004	0.33674	0.090569	1.0	0.991
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.38511	0.54944	0.23227	0.886	0.489
holeboard	number of hole pokes by individual hole number, 20 min test, 5	0.14565	0.72671	0.35626	0.986	0.843
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.0091303	0.31839	-0.039589	0.986	0.977
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.072072	0.35058	-0.21972	0.966	0.839
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.34384	0.34338	-0.39360	0.799	0.326
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.31682	0.42691	0.59623	0.836	0.465
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.0060060	0.26917	0.052245	0.982	0.982
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.46547	0.27485	1.0167	0.575	0.102
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.23874	0.40586	0.36611	0.941	0.561
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.29129	0.95981	0.076809	0.912	0.764
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.0018151	0.59522	0.051178	0.998	0.998
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.18911	0.51922	-0.24801	0.862	0.719
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.68619	0.62910	0.44951	0.709	0.285
holeboard	total number of hole pokes, 20 min test	3.0225	4.2825	0.23227	0.759	0.486
light / dark	latency to enter dark zone, 20 min test	-36.208	97.530	0.030084	0.905	0.713
light / dark	number of transitions between light and dark zones, 20 min test	-4.6415	7.3551	-0.42340	0.882	0.534
light / dark	percentage of total time in dark zone, 20 min test	4.4924	6.0528	0.58284	0.805	0.464
light / dark	percentage of total time in light zone, 20 min test	-4.4924	6.0528	-0.58284	0.805	0.464
light / dark	time mobile in dark zone, 20 min test	12.325	18.752	0.37993	0.832	0.517
light / dark	time mobile in light zone, 20 min test	-12.838	11.890	-0.87055	0.621	0.290
light / dark	time spent in dark zone, 20 min test	101.14	90.694	0.46770	0.631	0.275
light / dark	time spent in light zone, 20 min test	-101.14	90.694	-0.46770	0.631	0.275
open field	average speed in center of arena, 20 min test	-0.047085	0.20990	-0.35487	0.913	0.824
open field	average speed in periphery of arena, 20 min test	0.15281	0.19530	0.28831	0.729	0.440
open field	distance traveled habituation ratio, 20 min test	10.077	6.2095	1.0676	0.454	0.115
open field	distance traveled in center of arena, 20 min test	28.633	123.59	-0.052685	0.908	0.818
open field	distance traveled in periphery of arena, 20 min test	90.661	162.13	0.11611	0.890	0.580
open field	distance traveled slope, 20 min test	6.7535	5.1918	0.80613	0.586	0.204
open field	distance traveled, 20 min test, 1st 5min	-41.453	72.087	-0.69446	0.887	0.570
open field	distance traveled, 20 min test, 2nd 5min	92.190	65.407	0.51716	0.425	0.169
open field	distance traveled, 20 min test, 3rd 5min	25.303	65.070	-0.094931	0.881	0.700
open field	distance traveled, 20 min test, 4th 5min	45.575	62.633	0.18001	0.775	0.473
open field	number of clockwise revolution episodes, 20 min test	0.38427	1.4872	-0.031601	0.961	0.798
open field	number of counter-clockwise revolution episodes, 20 min test	-0.32712	1.0223	-0.54140	0.920	0.751
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.9685	2.5295	0.42304	0.794	0.443
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	7.3467	3.4383	1.0676	0.286	0.0412
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	7.4017	4.4904	0.92890	0.395	0.110
open field	number of rears in 5 min bins, 20 min test, 4th 5min	10.488	4.2833	1.4968	0.187	0.0206
open field	percentage of total time in center of arena, 20 min test	2.7022	5.1858	0.31034	0.842	0.606
open field	percentage of total time in center of arena, slope, 20 min test	-4.7732	2.6577	-1.3784	0.721	0.0829
open field	percentage of total time in center, habituation ratio, 20 min test	-4.7581	2.9939	-1.3784	0.691	0.123
open field	percentage of total time in corners of arena, 20 min test	-8.9140	5.0624	-1.1453	0.403	0.0888
open field	percentage of total time in corners, habituation ratio, 20 min test	4.4284	2.3896	1.1453	0.440	0.0740
open field	percentage of total time in corners, slope, 20 min test	5.3042	2.2657	1.5647	0.382	0.0263
open field	permanence time in center of arena, 20 min test	32.406	62.230	0.31034	0.842	0.607
open field	permanence time in corners of arena, 20 min test	-106.98	60.753	-1.1453	0.403	0.0888
open field	permanence time in periphery of arena, 20 min test	-32.415	62.239	-0.31034	0.842	0.607
open field	total distance traveled, 20 min test	119.29	240.74	0.010532	0.875	0.624
open field	total number of rears, 20 min test	25.878	13.465	1.0676	0.302	0.0645
open field	whole arena average speed, 20 min test	0.099627	0.20042	0.031601	0.876	0.623
open field	whole arena resting time, 20 min test	-8.6120	23.915	0.094931	0.825	0.721
open field	whole arena time spent mobile, 20 min test	8.5556	23.909	0.15864	0.857	0.723
open field	whole arena time spent vertical, 20 min test	19.976	14.191	1.0310	0.647	0.170
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-1.2803	1.0544	-0.60018	0.559	0.234

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-LAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-LAP Trait	Trait Effect	P-value

eye morphology	anterior chamber depth	2.0 %	1.0
eye morphology	bulging eye	2.0 %	1.0
eye morphology	cornea	5.0 %	1.0
eye morphology	cornea opacity	6.0 %	0.505
eye morphology	cornea vascularization	7.0 %	0.115
eye morphology	corneal deposits	1.0 %	1.0
eye morphology	corneal mineralization	32.0 %	0.0147
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	7.0 %	0.115
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	2.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	5.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	2.0 %	1.0
eye morphology	irispupil	4.0 %	1.0
eye morphology	lacrimation	4.0 %	1.0
eye morphology	lens	7.0 %	0.859
eye morphology	lens opacity	6.0 %	0.519
eye morphology	narrow eye opening	8.0 %	0.0640
eye morphology	optic disc	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	9.0 %	1.0
eye morphology	pupil dilation	28.0 %	0.0000571
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	11.0 %	1.0
eye morphology	retinal blood vessels	5.0 %	1.0
eye morphology	retinal blood vessels pattern	5.0 %	1.0
eye morphology	retinal blood vessels structure	5.0 %	1.0
eye morphology	retinal pigmentation	7.0 %	1.0
eye morphology	retinal structure	6.0 %	1.0
eye morphology	synechia	5.0 %	1.0
eye morphology	vitreous	5.0 %	1.0
SHIRPA	activity body position	1.0 %	0.643
SHIRPA	aggression	0.0 %	1.0
SHIRPA	body length	5.0 %	0.0783
SHIRPA	body position	1.0 %	0.552
SHIRPA	body thickness	1.0 %	0.552
SHIRPA	coat color abdomen	0.0 %	1.0
SHIRPA	coat color back	16.0 %	0.0570
SHIRPA	coat color head	4.0 %	1.0
SHIRPA	coat color pattern abdomen	4.0 %	1.0
SHIRPA	coat color pattern back	16.0 %	0.0301
SHIRPA	coat color pattern head	4.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	0.0 %	1.0
SHIRPA	coat hair back texture appearance	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	5.0 %	1.0
SHIRPA	coat hair distribution back	9.0 %	0.401
SHIRPA	coat hair distribution head	33.0 %	0.00168
SHIRPA	coat hair head texture appearance	2.0 %	1.00
SHIRPA	contact righting	78.0 %	2.54e-13
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	eye morphology	2.0 %	1.00
SHIRPA	fat distribution	22.0 %	0.0360
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.00
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	3.0 %	0.337
SHIRPA	genitalia morphology	5.0 %	0.0783
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.00
SHIRPA	hindlimb digit shape	1.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	9.0 %	0.0663
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.00
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	1.0 %	1.0
SHIRPA	hindlimbs position	5.0 %	0.0843
SHIRPA	hindlimbs shape	3.0 %	1.00
SHIRPA	hindlimbs size	1.0 %	1.00
SHIRPA	hindpaw position	0.0 %	1.00
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	1.0 %	1.00
SHIRPA	limb grasp	81.0 %	1.35e-14
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.00
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	1.0 %	1.0
SHIRPA	startle response	21.0 %	0.0354
SHIRPA	tail curvature	1.0 %	1.0
SHIRPA	tail elevation	2.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	2.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	1.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	13.0 %	0.122
SHIRPA	tremor	2.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	4.0 %	1.00
SHIRPA	vibrissae presence	29.0 %	0.00633
SHIRPA	vocalization	7.0 %	0.615

GENOTYPE CORRELATION PLOT

Correlate Catsperz^{tm1.1(KOMP)Vlcg} -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.