MPD: JaxKOMP-EAP genotype: Nrap<sup>em1(IMPC)J</sup> -/-

JaxKOMP-EAP effect sizes: Nrap^em1(IMPC)J -/- Gene Nrap

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-4.3396	2.0582	-1.3536	0.439	0.0795
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-5.6930	2.1484	-1.1398	0.375	0.0380
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-2.2035	1.8447	-0.67137	0.634	0.277
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-1.0288	4.6335	-0.27872	0.936	0.832
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-6.6723	4.4852	-0.99694	0.572	0.187
body composition	body length	-0.086950	0.049804	-0.78802	0.307	0.0889
body composition	body weight (at time of DXA)	0.18821	0.69180	0.25588	0.893	0.787
body composition	bone area, whole body scan, head excluded	-0.18809	0.14877	-0.59434	0.480	0.214
body composition	bone mineral content of whole body scan, head excluded	-0.014629	0.011306	-0.65575	0.480	0.204
body composition	bone mineral content to body weight ratio	-0.00058942	0.00044482	-0.57651	0.447	0.193
body composition	bone mineral density of whole body scan, head excluded	-0.00045947	0.00058537	-0.47564	0.714	0.437
body composition	fat tissue mass of whole body scan, head excluded	0.93904	0.39871	1.3184	0.139	0.0238
body composition	fat tissue mass to body weight ratio	0.030415	0.013471	1.2619	0.135	0.0298
body composition	lean tissue mass of whole body scan, head excluded	-0.39092	0.33204	-0.97398	0.544	0.246
body composition	lean tissue mass to body weight ratio	-0.022565	0.010900	-1.2174	0.197	0.0451
body composition	percent fat, whole body scan, head excluded	2.8337	1.2539	1.2897	0.141	0.0296
body composition	ratio of soft-tissue attenuation coefficients	-0.0031217	0.0013919	-1.2791	0.143	0.0308
body composition	tissue area	0.18609	0.19907	0.77492	0.653	0.356
body composition	total tissue mass, whole body scan, head excluded	0.54180	0.22909	0.88765	0.124	0.0232
clinical blood chemistry	alanine transaminase (plasma ALT)	-4.2278	4.0413	-0.41163	0.740	0.405
clinical blood chemistry	albumin (plasma Alb)	0.41485	0.95775	0.62778	0.889	0.707
clinical blood chemistry	alkaline phosphatase (plasma ALP)	2.0524	8.0484	-0.17302	0.918	0.823
clinical blood chemistry	aspartate transaminase (plasma AST)	-7.2835	10.432	-0.37131	0.817	0.557
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.099347	0.32047	-0.31304	0.932	0.786
clinical blood chemistry	blood urea nitrogen (BUN)	3.2427	6.3615	1.2462	0.836	0.661
clinical blood chemistry	calcium (plasma Ca)	-0.26105	0.34587	-1.4904	0.727	0.529
clinical blood chemistry	creatinine (plasma)	0.0056032	0.048668	0.23399	0.956	0.919
clinical blood chemistry	glucose (plasma GLU, no fast)	7.1188	10.330	0.56667	0.740	0.562
clinical blood chemistry	HDL cholesterol (plasma HDL)	2.0315	3.5807	0.16153	0.849	0.628
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.026169	0.0088521	1.2627	0.394	0.0979
clinical blood chemistry	phosphorus (plasma phosphate)	-1.2433	0.55818	-1.7209	0.418	0.156
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0049487	0.022377	0.33248	0.946	0.846
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	0.11691	3.7462	-0.22146	0.995	0.978
clinical blood chemistry	total protein (plasma TP)	-0.17470	1.7624	-0.19828	0.970	0.930
clinical blood chemistry	triglyceride (plasma TG, no fast)	21.814	12.713	1.2822	0.518	0.228
EKG	duration of PQ interval	-0.016376	0.73458	0.13135	0.995	0.982
EKG	duration of PR interval	0.080153	0.71243	0.16599	0.982	0.911
EKG	duration of QRS interval	0.10947	0.35823	0.17416	0.976	0.762
EKG	duration of QT interval	0.27938	0.74124	0.41897	0.937	0.709
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.093876	0.74411	-0.062505	0.998	0.900
EKG	duration of RR interval	2.0018	1.2699	1.2697	0.533	0.126
EKG	duration of ST interval	0.18023	0.84789	0.38402	0.960	0.833
EKG	heart rate coefficient of variation (signal intensity)	1.1940	1.1584	1.0630	0.863	0.311
EKG	heart rate variability, mean of differences between sequential beats; beats per min	8.3974	8.2252	1.0351	0.853	0.316
EKG	heart rate, beats per min	-15.896	10.515	-1.2738	0.534	0.142
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.084710	0.11912	-0.81772	0.786	0.483
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.068191	0.15158	-0.50117	0.868	0.656
EKG	number of signals	-0.48473	4.4307	-0.15782	0.982	0.914
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	6.6618	3.5536	1.3108	0.758	0.0709
EKG	QT dispersion, measured as inter-lead variability of QT intervals	2.2634	2.5602	0.70517	0.924	0.384
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	1.7518	2.7001	0.45443	0.931	0.522
EKG	root mean square of successive differences of neighboring RR intervals	0.90719	1.3622	0.61252	0.899	0.511
glucose tolerance test	amount glucose injected	8.8826	3.3729	2.0706	0.187	0.0169
glucose tolerance test	plasma glucose, 0min	4.8353	5.2090	0.25817	0.593	0.365
glucose tolerance test	plasma glucose, 15min	1.6560	44.194	0.14464	0.987	0.971
glucose tolerance test	plasma glucose, 30min	-7.5200	30.553	-0.092104	0.926	0.808
glucose tolerance test	plasma glucose, 60min	12.250	20.401	0.61285	0.818	0.556
glucose tolerance test	plasma glucose, 120min	34.879	18.468	1.9295	0.342	0.0743
grip strength	body weight (at time of grip strength test)	-0.23795	0.53344	-0.018859	0.799	0.660
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-6.6711	6.7799	-0.24645	0.550	0.335
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.36908	0.32824	-0.31749	0.480	0.272
grip strength	forelimb and hindlimb grip strength by trial, trial1	-8.3648	10.490	-0.33127	0.709	0.433
grip strength	forelimb and hindlimb grip strength by trial, trial2	-6.8402	9.1254	-0.20029	0.703	0.461
grip strength	forelimb and hindlimb grip strength by trial, trial3	-3.4338	8.6383	-0.023239	0.865	0.695
grip strength	forelimb grip strength (mean of trials), average	-0.050894	4.3441	0.26596	0.996	0.991
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.0051483	0.26990	0.22406	0.997	0.985
grip strength	forelimb grip strength by trial, trial1	4.0055	5.7451	0.72930	0.793	0.492
grip strength	forelimb grip strength by trial, trial2	1.7271	5.9145	0.41063	0.921	0.773
grip strength	forelimb grip strength by trial, trial3	-5.8704	6.6560	-0.40117	0.703	0.387
heart weight	heart weight, normalized to body weight	-0.12683	0.11829	-0.94009	0.518	0.298
heart weight	heart weight, weight	-3.5726	3.1644	-0.84935	0.483	0.275
hematology	basophil differential (percent of total WBC)	0.032626	0.042286	0.52094	0.802	0.451
hematology	calculated hemoglobin (cHGB)	-0.29535	0.28127	-1.0957	0.584	0.308
hematology	eosinophil differential (percent of total WBC)	-0.011799	0.20175	0.048565	0.984	0.954
hematology	hematocrit (HCT)	-0.91012	1.0027	-1.1510	0.640	0.376
hematology	hemoglobin concentration distribution width (HDW)	-0.0034361	0.044849	-0.090515	0.969	0.940
hematology	large unstained cells (percent of total WBC)	-0.23139	0.13645	-1.4118	0.443	0.107
hematology	lymphocyte differential (percent of total WBC)	3.5474	3.2834	1.1590	0.551	0.295
hematology	mean corpuscular hemoglobin (CHr)	0.011705	0.055983	0.11292	0.920	0.837
hematology	mean platelet volume (MPV)	-0.014356	0.13191	-0.30154	0.962	0.915
hematology	mean RBC corpuscular hemoglobin (MCH)	0.13970	0.15392	0.51782	0.724	0.376
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.0062201	0.46313	0.0027395	0.994	0.989
hematology	mean RBC corpuscular volume (MCV)	0.25782	0.21801	0.48743	0.481	0.253
hematology	measured hemoglobin (mHGB)	-0.38155	0.36740	-1.0270	0.615	0.313
hematology	monocyte differential (percent of total WBC)	0.064234	0.18333	0.43874	0.903	0.730
hematology	neutrophil differential (percent of total WBC)	-3.9152	2.7565	-1.4612	0.412	0.173
hematology	platelet count (PLT; units per volume x 10³)	-92.097	93.184	-1.0921	0.683	0.336
hematology	RBC corpuscular distribution width (RDW)	-0.042550	0.25659	-0.13679	0.941	0.870
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.094827	0.19208	-0.28041	0.821	0.628
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.33494	0.22040	-1.5188	0.399	0.146
hematology	reticulocyte count (Retic; units per volume x 10⁹)	11.846	30.557	0.61074	0.907	0.703
hematology	reticulocyte differential (percent of total RBC)	0.24000	0.30688	1.1543	0.757	0.444
hematology	white blood cell count (WBC; units per volume x 10³)	-0.60629	0.76237	-0.26126	0.630	0.437
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.026958	0.66343	0.080264	0.990	0.968
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.60275	0.40973	-0.78983	0.678	0.149
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.025881	0.37993	0.12439	0.978	0.946
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.64293	0.66625	-0.59046	0.765	0.340
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.081312	0.47040	-0.019413	0.970	0.864
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.15864	0.24077	0.47811	0.908	0.514
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.44548	0.37817	-1.2525	0.819	0.245
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.83944	0.50563	-1.2682	0.630	0.104
holeboard	number of hole pokes by individual hole number, 20 min test, 9	0.042043	0.38440	0.18173	0.990	0.913
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.14903	0.33961	-0.34680	0.946	0.663
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.35334	0.35784	-0.93642	0.816	0.329
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.25037	0.33208	-0.34224	0.831	0.455
holeboard	number of hole pokes by individual hole number, 20 min test, 13	0.15164	0.83565	0.23840	0.968	0.857
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.33401	0.51536	0.62347	0.848	0.520
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.33185	0.37052	0.59504	0.792	0.376
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.2394	0.64921	1.0774	0.438	0.0631
holeboard	total number of hole pokes, 20 min test	-0.87656	3.8275	-0.030368	0.923	0.820
light / dark	fecal boli count, 20 min test	2.9809	0.75888	2.6483	0.0539	0.000305
light / dark	latency to enter dark zone, 20 min test	53.856	46.656	0.83931	0.671	0.255
light / dark	number of transitions between light and dark zones, 20 min test	4.8851	7.0916	0.54342	0.757	0.495
light / dark	percentage of total time in dark zone, 20 min test	-0.69619	4.0418	0.0040560	0.961	0.864
light / dark	percentage of total time in light zone, 20 min test	0.69619	4.0418	-0.0081122	0.961	0.864
light / dark	time mobile in dark zone, 20 min test	5.3043	13.558	0.26257	0.874	0.698
light / dark	time mobile in light zone, 20 min test	11.527	12.105	0.47416	0.613	0.346
light / dark	time spent in dark zone, 20 min test	-41.224	54.036	-0.40124	0.802	0.450
light / dark	time spent in light zone, 20 min test	41.224	54.036	0.40124	0.802	0.450
open field	average speed in center of arena, 20 min test	0.32934	0.43891	0.50616	0.762	0.457
open field	average speed in periphery of arena, 20 min test	0.42693	0.17974	1.0504	0.0954	0.0219
open field	distance traveled habituation ratio, 20 min test	17.356	5.6191	1.4064	0.0579	0.00348
open field	distance traveled in center of arena, 20 min test	165.64	72.466	0.68082	0.134	0.0270
open field	distance traveled in periphery of arena, 20 min test	391.92	192.22	1.0435	0.186	0.0474
open field	distance traveled slope, 20 min test	17.265	4.9822	1.4627	0.0314	0.00119
open field	distance traveled, 20 min test, 1st 5min	45.078	63.755	0.028870	0.714	0.483
open field	distance traveled, 20 min test, 2nd 5min	131.15	70.899	0.94236	0.238	0.0709
open field	distance traveled, 20 min test, 3rd 5min	170.72	68.054	1.3023	0.0898	0.0158
open field	distance traveled, 20 min test, 4th 5min	207.41	61.523	1.5459	0.0179	0.00155
open field	number of clockwise revolution episodes, 20 min test	0.85867	1.1040	0.088775	0.761	0.441
open field	number of counter-clockwise revolution episodes, 20 min test	3.1558	1.3624	1.2051	0.179	0.0252
open field	number of fecal boli, 20 min test	0.89415	0.88136	0.92060	0.635	0.316
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.4869	2.0475	0.21112	0.715	0.472
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.74894	2.6673	-0.16250	0.898	0.780
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	2.2350	2.9544	0.21443	0.709	0.453
open field	number of rears in 5 min bins, 20 min test, 4th 5min	6.1483	3.4269	1.0094	0.304	0.0795
open field	percentage of total time in center of arena, 20 min test	2.5442	2.0391	0.37155	0.536	0.219
open field	percentage of total time in center of arena, slope, 20 min test	2.7952	1.4879	1.6625	0.478	0.0668
open field	percentage of total time in center, habituation ratio, 20 min test	2.8038	1.5638	1.6415	0.513	0.0797
open field	percentage of total time in corners of arena, 20 min test	-5.8235	2.5646	-0.80099	0.205	0.0280
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.8046	1.9270	-1.1181	0.814	0.354
open field	percentage of total time in corners, slope, 20 min test	-2.0735	1.7589	-1.2626	0.735	0.245
open field	permanence time in center of arena, 20 min test	30.531	24.470	0.37155	0.536	0.219
open field	permanence time in corners of arena, 20 min test	-69.865	30.773	-0.80099	0.205	0.0280
open field	permanence time in periphery of arena, 20 min test	-30.600	24.475	-0.37155	0.533	0.218
open field	total distance traveled, 20 min test	559.13	237.24	1.0343	0.0973	0.0228
open field	total number of rears, 20 min test	12.376	9.7618	0.49247	0.454	0.212
open field	whole arena average speed, 20 min test	0.46478	0.19779	1.0274	0.0987	0.0232
open field	whole arena resting time, 20 min test	-58.306	21.167	-0.98508	0.0472	0.00845
open field	whole arena time spent mobile, 20 min test	58.346	21.181	1.1968	0.0491	0.00845
open field	whole arena time spent vertical, 20 min test	4.5668	9.0286	0.25584	0.842	0.616
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.85381	2.1654	0.54874	0.880	0.697
startle / PPI	average baseline movement during background noise	-4.8294	2.4990	-3.2590	0.565	0.0657
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.030214	0.068058	-0.36450	0.855	0.661
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.026899	0.066958	-0.33065	0.878	0.692
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-7.1033	7.9328	-0.73053	0.879	0.380
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-2.8361	6.7985	-0.33916	0.891	0.680
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-2.1552	6.5700	-0.33471	0.905	0.746
startle / PPI	average startle response to full pulse (120 dB)	2.2517	41.030	0.26291	0.983	0.957
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	41.297	45.392	0.94784	0.608	0.372
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	20.853	37.072	0.62474	0.744	0.579
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	15.801	33.675	0.57608	0.791	0.643
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	0.61218	1.4880	0.48414	0.941	0.685
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	0.94757	1.1757	0.61964	0.863	0.429
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-3.1228	2.0827	-1.6365	0.588	0.147
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.050304	0.084635	-0.44048	0.922	0.558
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.0079789	0.073112	-0.16557	0.976	0.914
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.019461	0.070683	-0.34307	0.908	0.786
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	7.0811	41.563	0.35702	0.947	0.866
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	40.684	45.817	0.93259	0.620	0.384
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	19.905	37.400	0.60443	0.761	0.600
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	25.641	33.041	0.80970	0.648	0.446
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.057380	0.081728	-0.48888	0.916	0.490
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.0061155	0.076312	-0.13641	0.974	0.937
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.023124	0.078596	-0.36846	0.905	0.771
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-7.6690	143.18	0.15545	0.982	0.958
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	115.62	153.88	0.77707	0.675	0.460
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	54.514	136.65	0.49520	0.816	0.694
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	54.886	123.94	0.54656	0.795	0.662
startle / PPI	maximum baseline movement during background noise	-10.389	5.7481	-2.5737	0.541	0.0838
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-6.7492	7.8433	-0.63499	0.890	0.398
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-2.0908	7.2950	-0.25132	0.915	0.777
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-2.6108	7.5159	-0.38253	0.890	0.731
startle / PPI	maximum startle response to full pulse (120 dB)	-18.058	142.29	0.076436	0.961	0.900
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	116.96	152.88	0.78468	0.670	0.452
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	58.825	135.62	0.51910	0.803	0.669
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	49.759	124.57	0.51590	0.817	0.693
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	1.3364	3.1951	0.52392	0.930	0.680
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	4.3111	2.4537	1.0325	0.582	0.0922
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-5.1813	4.2475	-1.2844	0.619	0.235

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.0
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.0
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.0
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.0
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.0
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.0
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.0
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.0
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.00
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.0
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	8.0 %	1.00
eye morphology	lens	both	9.0 %	1.0
eye morphology	lens opacity	females	41.0 %	0.00340
eye morphology	lens opacity	males	14.0 %	0.0818
eye morphology	lens opacity	both	26.0 %	0.00247
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.00
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.00
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	10.0 %	0.499
eye morphology	persistence of hyaloid vascular system	males	12.0 %	0.299
eye morphology	persistence of hyaloid vascular system	both	5.0 %	0.372
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.00
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.0
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.0
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.0
eye morphology	retina	females	10.0 %	0.560
eye morphology	retina	males	13.0 %	0.229
eye morphology	retina	both	9.0 %	0.277
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.00
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.0
eye morphology	retinal pigmentation	females	9.0 %	0.648
eye morphology	retinal pigmentation	males	72.0 %	0.0000341
eye morphology	retinal pigmentation	both	35.0 %	0.00119
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.00
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.00
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.00
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.0
SHIRPA	body length	both	0.0 %	1.0
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.00
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.00
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.00
SHIRPA	coat color abdomen	both	4.0 %	1.00
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.0
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.0
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.00
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.0
SHIRPA	coat color pattern back	both	0.0 %	1.00
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.00
SHIRPA	coat color pattern head	both	0.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.0
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.00
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.0
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.0
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.00
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.00
SHIRPA	genitalia size	both	0.0 %	1.00
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.0
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.00
SHIRPA	head size	both	0.0 %	1.0
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.0
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.00
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.00
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.00
SHIRPA	hindlimb nail length	both	0.0 %	1.0
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.00
SHIRPA	hindlimb nail number	both	0.0 %	1.0
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.620
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	12.0 %	0.00294
SHIRPA	lower teeth appearance	males	0.0 %	1.0
SHIRPA	lower teeth appearance	both	7.0 %	0.0138
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.0
SHIRPA	mouth morphology	both	0.0 %	1.0
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.0
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.00
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.00
SHIRPA	tail length	both	0.0 %	1.0
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.00
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.0
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	12.0 %	0.00879
SHIRPA	teeth presence	males	0.0 %	1.0
SHIRPA	teeth presence	both	7.0 %	0.0138
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.00
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.0
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	12.0 %	0.00587
SHIRPA	upper teeth appearance	males	0.0 %	1.00
SHIRPA	upper teeth appearance	both	7.0 %	0.0138
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Nrap^em1(IMPC)J -/- with genotype: