MPD: JaxKOMP-EAP genotype: Meis1<sup>tm1b(EUCOMM)Hmgu</sup> +/-

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
body composition	body length	-0.29626	0.054196	-1.9565	0.000428	0.00000564
body composition	body weight (at time of DXA)	-3.8385	1.2147	-2.1102	0.0264	0.00344
body composition	bone area, whole body scan, head excluded	-0.052190	0.14768	-0.036871	0.878	0.726
body composition	bone mineral content of whole body scan, head excluded	-0.00092778	0.011213	0.068316	0.976	0.935
body composition	bone mineral content to body weight ratio	0.00051448	0.00048357	0.87557	0.575	0.296
body composition	bone mineral density of whole body scan, head excluded	-0.000071896	0.00059895	-0.052616	0.973	0.905
body composition	fat tissue mass of whole body scan, head excluded	0.11902	0.34330	0.21322	0.866	0.731
body composition	fat tissue mass to body weight ratio	-0.0071137	0.012579	-0.28364	0.771	0.576
body composition	lean tissue mass of whole body scan, head excluded	0.22901	0.46468	0.32079	0.841	0.626
body composition	lean tissue mass to body weight ratio	0.011795	0.012331	0.58090	0.602	0.346
body composition	percent fat, whole body scan, head excluded	-0.80866	1.2505	-0.35258	0.734	0.523
body composition	ratio of soft-tissue attenuation coefficients	0.0010193	0.0013984	0.40485	0.697	0.472
body composition	tissue area	-0.33263	0.21952	-0.94085	0.410	0.140
body composition	total tissue mass, whole body scan, head excluded	0.39901	0.33798	0.63224	0.493	0.247
clinical blood chemistry	alanine transaminase (plasma ALT)	-6.6786	5.5281	-0.61560	0.619	0.247
clinical blood chemistry	alkaline phosphatase (plasma ALP)	1.0872	5.9606	-0.33564	0.934	0.858
clinical blood chemistry	aspartate transaminase (plasma AST)	-37.480	18.641	-1.5552	0.332	0.0656
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	-0.41235	0.43342	-1.2094	0.753	0.359
clinical blood chemistry	blood urea nitrogen (BUN)	0.25000	2.1626	0.056641	0.952	0.910
clinical blood chemistry	calcium (plasma Ca)	-0.0053305	0.077202	0.32032	0.972	0.946
clinical blood chemistry	creatinine (plasma)	-0.051233	0.035811	-1.0090	0.407	0.176
clinical blood chemistry	glucose (plasma GLU, no fast)	-18.464	18.727	-0.41978	0.550	0.341
clinical blood chemistry	HDL cholesterol (plasma HDL)	5.9598	5.5531	1.0252	0.607	0.303
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.0080000	0.015224	-0.59823	0.855	0.607
clinical blood chemistry	phosphorus (plasma phosphate)	0.18681	0.55243	0.26012	0.879	0.740
clinical blood chemistry	total bilirubin (plasma TBIL)	-0.011465	0.014993	-0.85832	0.764	0.458
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	9.5143	7.4243	1.2415	0.535	0.222
clinical blood chemistry	total protein (plasma TP)	-1.1543	1.1055	-0.98737	0.592	0.315
clinical blood chemistry	triglyceride (plasma TG, no fast)	25.453	17.619	1.4371	0.449	0.172
EKG	duration of PQ interval	-0.19322	1.0636	-0.040310	0.971	0.862
EKG	duration of PR interval	0.21719	1.1001	0.29856	0.968	0.850
EKG	duration of QRS interval	0.29057	0.42993	0.70001	0.934	0.524
EKG	duration of QT interval	-0.84829	1.0843	-0.63455	0.886	0.464
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.34313	1.0402	0.43663	0.975	0.753
EKG	duration of RR interval	-3.8392	2.6198	-1.6234	0.605	0.193
EKG	duration of ST interval	-1.1193	0.95966	-0.84680	0.759	0.288
EKG	heart rate coefficient of variation (signal intensity)	0.89652	1.5094	0.82395	0.914	0.574
EKG	heart rate variability, mean of differences between sequential beats; beats per min	8.4834	10.153	1.0420	0.883	0.435
EKG	heart rate, beats per min	37.443	20.493	1.8842	0.496	0.117
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.097205	0.11775	-0.91151	0.759	0.441
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.10786	0.18218	-0.70972	0.825	0.575
EKG	number of signals	-2.0937	6.5228	-0.47463	0.948	0.759
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	0.20925	8.9571	0.11828	0.997	0.982
EKG	QT dispersion, measured as inter-lead variability of QT intervals	6.6102	4.6105	1.6310	0.866	0.202
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	9.3336	5.3511	1.9345	0.856	0.132
EKG	root mean square of successive differences of neighboring RR intervals	4.4054	2.5991	1.8500	0.843	0.141
glucose tolerance test	amount glucose injected	-3.8290	4.2256	-0.73937	0.733	0.375
glucose tolerance test	plasma glucose, 0min	13.871	4.8191	1.1222	0.0519	0.00873
glucose tolerance test	plasma glucose, 15min	-35.066	30.127	-0.84593	0.591	0.258
glucose tolerance test	plasma glucose, 30min	-15.495	23.386	-0.36778	0.778	0.515
glucose tolerance test	plasma glucose, 60min	6.7537	11.774	0.41372	0.827	0.572
glucose tolerance test	plasma glucose, 120min	7.6844	7.5361	0.37661	0.617	0.319
grip strength	body weight (at time of grip strength test)	-2.6249	0.64656	-1.7448	0.00322	0.000244
grip strength	forelimb and hindlimb grip strength (mean of trials), average	1.9655	10.050	0.38704	0.919	0.846
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.021369	0.62503	0.17811	0.984	0.973
grip strength	forelimb and hindlimb grip strength by trial, trial1	6.7571	11.625	0.70489	0.800	0.565
grip strength	forelimb and hindlimb grip strength by trial, trial2	-23.918	13.543	-1.2639	0.276	0.0859
grip strength	forelimb and hindlimb grip strength by trial, trial3	19.509	14.042	1.4212	0.429	0.173
grip strength	forelimb grip strength (mean of trials), average	-8.1983	5.6339	-0.75609	0.388	0.154
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.13748	0.35456	-0.12961	0.866	0.700
grip strength	forelimb grip strength by trial, trial1	-8.4889	7.5099	-0.72174	0.626	0.266
grip strength	forelimb grip strength by trial, trial2	-12.841	7.5391	-1.1302	0.372	0.0969
grip strength	forelimb grip strength by trial, trial3	-2.2027	8.0099	0.033409	0.920	0.785
heart weight	heart weight, normalized to body weight	0.031546	0.21137	-0.33378	0.941	0.883
heart weight	heart weight, weight	-5.9695	5.5127	-1.1930	0.501	0.292
hematology	basophil differential (percent of total WBC)	0.075000	0.074682	1.0600	0.741	0.332
hematology	calculated hemoglobin (cHGB)	-0.25982	0.22806	-1.0138	0.556	0.275
hematology	eosinophil differential (percent of total WBC)	3.9123	2.3983	3.2659	0.513	0.125
hematology	hematocrit (HCT)	-0.81652	0.77416	-1.0603	0.599	0.311
hematology	hemoglobin concentration distribution width (HDW)	0.033571	0.034910	0.89328	0.655	0.353
hematology	large unstained cells (percent of total WBC)	0.066316	0.078938	0.44028	0.736	0.416
hematology	lymphocyte differential (percent of total WBC)	-2.8929	4.0550	-1.2114	0.700	0.487
hematology	mean corpuscular hemoglobin (CHr)	0.28282	0.10267	1.8010	0.0790	0.0155
hematology	mean platelet volume (MPV)	-0.67861	0.22720	-2.3319	0.0546	0.00980
hematology	mean RBC corpuscular hemoglobin (MCH)	0.46009	0.17174	1.4490	0.175	0.0180
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.18519	0.25832	0.42772	0.793	0.485
hematology	mean RBC corpuscular volume (MCV)	1.0964	0.39863	1.6927	0.0802	0.0156
hematology	measured hemoglobin (mHGB)	-0.18817	0.24298	-0.69046	0.707	0.453
hematology	monocyte differential (percent of total WBC)	-0.30000	0.34282	-0.75296	0.723	0.396
hematology	neutrophil differential (percent of total WBC)	-1.2708	2.7737	-0.57721	0.815	0.654
hematology	platelet count (PLT; units per volume x 10³)	-348.43	94.471	-2.5123	0.0637	0.00243
hematology	RBC corpuscular distribution width (RDW)	0.29286	0.37333	1.0072	0.677	0.446
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.12731	0.24605	-0.38345	0.812	0.613
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.38524	0.22123	-1.6480	0.346	0.105
hematology	reticulocyte count (Retic; units per volume x 10⁹)	53.701	24.786	1.8788	0.349	0.0480
hematology	reticulocyte differential (percent of total RBC)	0.74036	0.27667	1.9902	0.233	0.0181
hematology	white blood cell count (WBC; units per volume x 10³)	0.86671	0.68185	0.76390	0.435	0.226
holeboard	number of hole pokes by individual hole number, 20 min test, 1	-2.0953	0.91614	-1.9614	0.398	0.0278
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.023447	0.61983	0.092124	0.990	0.970
holeboard	number of hole pokes by individual hole number, 20 min test, 3	0.26149	0.83790	0.52343	0.948	0.757
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-1.4042	1.1279	-1.3270	0.680	0.221
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-1.8113	0.52621	-2.4711	0.190	0.00142
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.37356	0.40623	-1.0507	0.870	0.364
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.61398	0.38691	-1.7226	0.731	0.121
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.058429	0.58118	0.019413	0.986	0.920
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.42067	0.60086	-0.65553	0.878	0.488
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.61782	0.33920	1.4547	0.664	0.0764
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.50479	0.32417	-1.3226	0.700	0.128
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-1.7502	0.72953	-2.5964	0.314	0.0216
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-1.8566	0.83327	-1.7701	0.381	0.0319
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.87549	0.65212	-1.3233	0.624	0.187
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-1.3185	0.64974	-1.9976	0.462	0.0495
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-2.5648	1.1314	-2.2327	0.336	0.0292
holeboard	total number of hole pokes, 20 min test	-14.360	5.8468	-1.8866	0.150	0.0187
light / dark	fecal boli count, 20 min test	1.9845	0.81433	1.9586	0.313	0.0206
light / dark	latency to enter dark zone, 20 min test	43.407	41.329	0.65677	0.701	0.300
light / dark	number of transitions between light and dark zones, 20 min test	11.183	9.4448	1.1316	0.566	0.243
light / dark	percentage of total time in dark zone, 20 min test	-7.8842	3.3988	-1.2921	0.262	0.0253
light / dark	percentage of total time in light zone, 20 min test	7.8842	3.3988	1.2890	0.259	0.0253
light / dark	time mobile in dark zone, 20 min test	12.934	12.603	0.65845	0.608	0.311
light / dark	time mobile in light zone, 20 min test	35.389	13.679	1.5206	0.0965	0.0132
light / dark	time spent in dark zone, 20 min test	-126.27	46.864	-1.5292	0.180	0.0101
light / dark	time spent in light zone, 20 min test	126.27	46.864	1.5292	0.180	0.0101
open field	average speed in center of arena, 20 min test	-0.28594	0.49843	-0.61134	0.818	0.569
open field	average speed in periphery of arena, 20 min test	0.53816	0.21256	1.3712	0.0753	0.0152
open field	distance traveled habituation ratio, 20 min test	13.760	9.1185	1.1106	0.446	0.139
open field	distance traveled in center of arena, 20 min test	108.84	107.97	0.36867	0.579	0.319
open field	distance traveled in periphery of arena, 20 min test	488.85	207.28	1.3575	0.112	0.0231
open field	distance traveled slope, 20 min test	14.951	8.7519	1.2991	0.367	0.0951
open field	distance traveled, 20 min test, 1st 5min	14.388	90.750	-0.22268	0.944	0.875
open field	distance traveled, 20 min test, 2nd 5min	179.04	63.740	1.3117	0.0574	0.00751
open field	distance traveled, 20 min test, 3rd 5min	262.25	70.953	1.8578	0.0110	0.000628
open field	distance traveled, 20 min test, 4th 5min	139.98	81.607	1.0412	0.277	0.0937
open field	number of clockwise revolution episodes, 20 min test	1.8025	1.4240	0.65023	0.570	0.213
open field	number of counter-clockwise revolution episodes, 20 min test	0.29289	1.6626	-0.27253	0.942	0.861
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-1.6855	2.3424	-0.65855	0.719	0.476
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-1.7355	3.1891	-0.79545	0.798	0.589
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-56.898	46.540	-3.2711	0.504	0.228
open field	number of rears in 5 min bins, 20 min test, 4th 5min	4.9049	3.5406	0.75198	0.442	0.173
open field	percentage of total time in center of arena, 20 min test	3.0369	2.6636	0.46088	0.580	0.261
open field	percentage of total time in center of arena, slope, 20 min test	3.1161	1.3064	1.7938	0.353	0.0218
open field	percentage of total time in center, habituation ratio, 20 min test	3.2166	1.2862	1.8356	0.308	0.0165
open field	percentage of total time in corners of arena, 20 min test	-2.6524	4.8315	-0.17203	0.822	0.586
open field	percentage of total time in corners, habituation ratio, 20 min test	-1.1431	1.7283	-0.82528	0.877	0.512
open field	percentage of total time in corners, slope, 20 min test	-1.9838	1.9939	-1.2163	0.792	0.326
open field	permanence time in center of arena, 20 min test	31.523	32.834	0.38308	0.659	0.343
open field	permanence time in corners of arena, 20 min test	-31.838	57.974	-0.17066	0.822	0.586
open field	permanence time in periphery of arena, 20 min test	-31.481	32.830	-0.38308	0.659	0.343
open field	total distance traveled, 20 min test	597.68	262.31	1.1181	0.113	0.0278
open field	total number of rears, 20 min test	0.40000	9.7347	-0.30894	0.988	0.967
open field	whole arena average speed, 20 min test	0.49867	0.21864	1.1231	0.112	0.0277
open field	whole arena resting time, 20 min test	-64.432	26.430	-1.1131	0.0832	0.0191
open field	whole arena time spent mobile, 20 min test	67.564	26.090	1.3609	0.0675	0.0132
open field	whole arena time spent vertical, 20 min test	-9.4960	9.4532	-0.85393	0.626	0.321
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	1.8648	1.8117	0.97569	0.614	0.310
startle / PPI	average baseline movement during background noise	-0.83465	1.1462	-0.58105	0.877	0.471
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.17374	0.074754	-1.6002	0.236	0.0250
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.17633	0.071708	-1.7805	0.204	0.0181
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-3.4136	8.8070	-0.31551	0.957	0.700
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-17.115	9.0851	-1.6809	0.384	0.0665
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-31.150	8.1821	-2.3917	0.0223	0.000462
startle / PPI	average startle response to full pulse (120 dB)	190.30	52.771	2.2842	0.0107	0.000835
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	173.97	47.673	2.1392	0.00970	0.000722
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	236.16	51.019	2.7110	0.00115	0.0000367
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	230.53	42.674	2.5370	0.000218	0.00000305
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-3.3671	1.6443	-2.0628	0.517	0.0469
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.8572	1.7125	-1.2749	0.803	0.284
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-4.2193	3.1827	-2.0399	0.640	0.192
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.043713	0.091986	-0.36151	0.922	0.637
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.19960	0.096620	-1.7038	0.296	0.0451
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.36336	0.099565	-2.4723	0.0183	0.000736
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	190.29	52.605	2.2656	0.0107	0.000809
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	176.94	47.634	2.1677	0.00837	0.000594
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	236.37	50.790	2.6595	0.00105	0.0000339
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	235.15	43.210	2.7709	0.000200	0.00000268
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.049954	0.098928	-0.41591	0.930	0.616
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.20440	0.10212	-1.6362	0.301	0.0518
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.34079	0.098486	-2.2138	0.0271	0.00127
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	588.60	167.45	2.1124	0.0134	0.00107
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	806.32	185.74	2.4169	0.00222	0.0000905
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	831.62	179.78	2.6595	0.00116	0.0000371
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	773.71	149.32	2.6595	0.000414	0.00000625
startle / PPI	maximum baseline movement during background noise	-0.86678	2.8626	-0.16823	0.958	0.764
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-4.0976	9.7094	-0.37200	0.950	0.675
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-18.444	9.7819	-1.6925	0.373	0.0663
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-30.210	8.8099	-2.3037	0.0372	0.00139
startle / PPI	maximum startle response to full pulse (120 dB)	588.34	167.72	2.1124	0.0133	0.00109
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	800.76	185.67	2.3917	0.00239	0.0000989
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	832.73	180.62	2.6595	0.00118	0.0000389
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	762.39	148.34	2.5737	0.000427	0.00000716
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-8.1618	3.6964	-1.9969	0.480	0.0328
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-4.1580	4.0075	-1.1226	0.770	0.305
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-10.312	8.0892	-2.0747	0.592	0.209

body composition

body length

-0.29626

0.054196

-1.9565

0.000428

0.00000564

body composition

body weight (at time of DXA)

-3.8385

1.2147

-2.1102

0.0264

0.00344

body composition

bone area, whole body scan, head excluded

-0.052190

0.14768

-0.036871

0.878

0.726

body composition

bone mineral content of whole body scan, head excluded

-0.00092778

0.011213

0.068316

0.976

0.935

body composition

bone mineral content to body weight ratio

0.00051448

0.00048357

0.87557

0.575

0.296

body composition

bone mineral density of whole body scan, head excluded

-0.000071896

0.00059895

-0.052616

0.973

0.905

body composition

fat tissue mass of whole body scan, head excluded

0.11902

0.34330

0.21322

0.866

0.731

body composition

fat tissue mass to body weight ratio

-0.0071137

0.012579

-0.28364

0.771

0.576

body composition

lean tissue mass of whole body scan, head excluded

0.22901

0.46468

0.32079

0.841

0.626

body composition

lean tissue mass to body weight ratio

0.011795

0.012331

0.58090

0.602

0.346

body composition

percent fat, whole body scan, head excluded

-0.80866

1.2505

-0.35258

0.734

0.523

body composition

ratio of soft-tissue attenuation coefficients

0.0010193

0.0013984

0.40485

0.697

0.472

body composition

tissue area

-0.33263

0.21952

-0.94085

0.410

0.140

body composition

total tissue mass, whole body scan, head excluded

0.39901

0.33798

0.63224

0.493

0.247

clinical blood chemistry

alanine transaminase (plasma ALT)

-6.6786

5.5281

-0.61560

0.619

0.247

clinical blood chemistry

alkaline phosphatase (plasma ALP)

1.0872

5.9606

-0.33564

0.934

0.858

clinical blood chemistry

aspartate transaminase (plasma AST)

-37.480

18.641

-1.5552

0.332

0.0656

clinical blood chemistry

aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)

-0.41235

0.43342

-1.2094

0.753

0.359

clinical blood chemistry

blood urea nitrogen (BUN)

0.25000

2.1626

0.056641

0.952

0.910

clinical blood chemistry

calcium (plasma Ca)

-0.0053305

0.077202

0.32032

0.972

0.946

clinical blood chemistry

creatinine (plasma)

-0.051233

0.035811

-1.0090

0.407

0.176

clinical blood chemistry

glucose (plasma GLU, no fast)

-18.464

18.727

-0.41978

0.550

0.341

clinical blood chemistry

HDL cholesterol (plasma HDL)

5.9598

5.5531

1.0252

0.607

0.303

clinical blood chemistry

HDL cholesterol to total cholesterol ratio

-0.0080000

0.015224

-0.59823

0.855

0.607

clinical blood chemistry

phosphorus (plasma phosphate)

0.18681

0.55243

0.26012

0.879

0.740

clinical blood chemistry

total bilirubin (plasma TBIL)

-0.011465

0.014993

-0.85832

0.764

0.458

clinical blood chemistry

total cholesterol (plasma CHOL, no fast)

9.5143

7.4243

1.2415

0.535

0.222

clinical blood chemistry

total protein (plasma TP)

-1.1543

1.1055

-0.98737

0.592

0.315

clinical blood chemistry

triglyceride (plasma TG, no fast)

25.453

17.619

1.4371

0.449

0.172

EKG

duration of PQ interval

-0.19322

1.0636

-0.040310

0.971

0.862

EKG

duration of PR interval

0.21719

1.1001

0.29856

0.968

0.850

EKG

duration of QRS interval

0.29057

0.42993

0.70001

0.934

0.524

EKG

duration of QT interval

-0.84829

1.0843

-0.63455

0.886

0.464

EKG

duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval

0.34313

1.0402

0.43663

0.975

0.753

EKG

duration of RR interval

-3.8392

2.6198

-1.6234

0.605

0.193

EKG

duration of ST interval

-1.1193

0.95966

-0.84680

0.759

0.288

EKG

heart rate coefficient of variation (signal intensity)

0.89652

1.5094

0.82395

0.914

0.574

EKG

heart rate variability, mean of differences between sequential beats; beats per min

8.4834

10.153

1.0420

0.883

0.435

EKG

heart rate, beats per min

37.443

20.493

1.8842

0.496

0.117

EKG

mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS

-0.097205

0.11775

-0.91151

0.759

0.441

EKG

mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS

-0.10786

0.18218

-0.70972

0.825

0.575

EKG

number of signals

-2.0937

6.5228

-0.47463

0.948

0.759

EKG

proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms

0.20925

8.9571

0.11828

0.997

0.982

EKG

QT dispersion, measured as inter-lead variability of QT intervals

6.6102

4.6105

1.6310

0.866

0.202

EKG

QTc dispersion, calculated as rate-corrected QT dispersion

9.3336

5.3511

1.9345

0.856

0.132

EKG

root mean square of successive differences of neighboring RR intervals

4.4054

2.5991

1.8500

0.843

0.141

glucose tolerance test

amount glucose injected

-3.8290

4.2256

-0.73937

0.733

0.375

glucose tolerance test

plasma glucose, 0min

13.871

4.8191

1.1222

0.0519

0.00873

glucose tolerance test

plasma glucose, 15min

-35.066

30.127

-0.84593

0.591

0.258

glucose tolerance test

plasma glucose, 30min

-15.495

23.386

-0.36778

0.778

0.515

glucose tolerance test

plasma glucose, 60min

6.7537

11.774

0.41372

0.827

0.572

glucose tolerance test

plasma glucose, 120min

7.6844

7.5361

0.37661

0.617

0.319

grip strength

body weight (at time of grip strength test)

-2.6249

0.64656

-1.7448

0.00322

0.000244

grip strength

forelimb and hindlimb grip strength (mean of trials), average

1.9655

10.050

0.38704

0.919

0.846

grip strength

forelimb and hindlimb grip strength (mean of trials), average normalized to bw

-0.021369

0.62503

0.17811

0.984

0.973

grip strength

forelimb and hindlimb grip strength by trial, trial1

6.7571

11.625

0.70489

0.800

0.565

grip strength

forelimb and hindlimb grip strength by trial, trial2

-23.918

13.543

-1.2639

0.276

0.0859

grip strength

forelimb and hindlimb grip strength by trial, trial3

19.509

14.042

1.4212

0.429

0.173

grip strength

forelimb grip strength (mean of trials), average

-8.1983

5.6339

-0.75609

0.388

0.154

grip strength

forelimb grip strength (mean of trials), average normalized to bw

-0.13748

0.35456

-0.12961

0.866

0.700

grip strength

forelimb grip strength by trial, trial1

-8.4889

7.5099

-0.72174

0.626

0.266

grip strength

forelimb grip strength by trial, trial2

-12.841

7.5391

-1.1302

0.372

0.0969

grip strength

forelimb grip strength by trial, trial3

-2.2027

8.0099

0.033409

0.920

0.785

heart weight

heart weight, normalized to body weight

0.031546

0.21137

-0.33378

0.941

0.883

heart weight

heart weight, weight

-5.9695

5.5127

-1.1930

0.501

0.292

hematology

basophil differential (percent of total WBC)

0.075000

0.074682

1.0600

0.741

0.332

hematology

calculated hemoglobin (cHGB)

-0.25982

0.22806

-1.0138

0.556

0.275

hematology

eosinophil differential (percent of total WBC)

3.9123

2.3983

3.2659

0.513

0.125

hematology

hematocrit (HCT)

-0.81652

0.77416

-1.0603

0.599

0.311

hematology

hemoglobin concentration distribution width (HDW)

0.033571

0.034910

0.89328

0.655

0.353

hematology

large unstained cells (percent of total WBC)

0.066316

0.078938

0.44028

0.736

0.416

hematology

lymphocyte differential (percent of total WBC)

-2.8929

4.0550

-1.2114

0.700

0.487

hematology

mean corpuscular hemoglobin (CHr)

0.28282

0.10267

1.8010

0.0790

0.0155

hematology

mean platelet volume (MPV)

-0.67861

0.22720

-2.3319

0.0546

0.00980

hematology

mean RBC corpuscular hemoglobin (MCH)

0.46009

0.17174

1.4490

0.175

0.0180

hematology

mean RBC corpuscular hemoglobin concentration (MCHC)

0.18519

0.25832

0.42772

0.793

0.485

hematology

mean RBC corpuscular volume (MCV)

1.0964

0.39863

1.6927

0.0802

0.0156

hematology

measured hemoglobin (mHGB)

-0.18817

0.24298

-0.69046

0.707

0.453

hematology

monocyte differential (percent of total WBC)

-0.30000

0.34282

-0.75296

0.723

0.396

hematology

neutrophil differential (percent of total WBC)

-1.2708

2.7737

-0.57721

0.815

0.654

hematology

platelet count (PLT; units per volume x 10³)

-348.43

94.471

-2.5123

0.0637

0.00243

hematology

RBC corpuscular distribution width (RDW)

0.29286

0.37333

1.0072

0.677

0.446

hematology

RBC corpuscular hemoglobin concentration mean (CHCM)

-0.12731

0.24605

-0.38345

0.812

0.613

hematology

red blood cell count (RBC; per volume x 10⁶)

-0.38524

0.22123

-1.6480

0.346

0.105

hematology

reticulocyte count (Retic; units per volume x 10⁹)

53.701

24.786

1.8788

0.349

0.0480

hematology

reticulocyte differential (percent of total RBC)

0.74036

0.27667

1.9902

0.233

0.0181

hematology

white blood cell count (WBC; units per volume x 10³)

0.86671

0.68185

0.76390

0.435

0.226

holeboard

number of hole pokes by individual hole number, 20 min test, 1

-2.0953

0.91614

-1.9614

0.398

0.0278

holeboard

number of hole pokes by individual hole number, 20 min test, 2

-0.023447

0.61983

0.092124

0.990

0.970

holeboard

number of hole pokes by individual hole number, 20 min test, 3

0.26149

0.83790

0.52343

0.948

0.757

holeboard

number of hole pokes by individual hole number, 20 min test, 4

-1.4042

1.1279

-1.3270

0.680

0.221

holeboard

number of hole pokes by individual hole number, 20 min test, 5

-1.8113

0.52621

-2.4711

0.190

0.00142

holeboard

number of hole pokes by individual hole number, 20 min test, 6

-0.37356

0.40623

-1.0507

0.870

0.364

holeboard

number of hole pokes by individual hole number, 20 min test, 7

-0.61398

0.38691

-1.7226

0.731

0.121

holeboard

number of hole pokes by individual hole number, 20 min test, 8

-0.058429

0.58118

0.019413

0.986

0.920

holeboard

number of hole pokes by individual hole number, 20 min test, 9

-0.42067

0.60086

-0.65553

0.878

0.488

holeboard

number of hole pokes by individual hole number, 20 min test, 10

0.61782

0.33920

1.4547

0.664

0.0764

holeboard

number of hole pokes by individual hole number, 20 min test, 11

-0.50479

0.32417

-1.3226

0.700

0.128

holeboard

number of hole pokes by individual hole number, 20 min test, 12

-1.7502

0.72953

-2.5964

0.314

0.0216

holeboard

number of hole pokes by individual hole number, 20 min test, 13

-1.8566

0.83327

-1.7701

0.381

0.0319

holeboard

number of hole pokes by individual hole number, 20 min test, 14

-0.87549

0.65212

-1.3233

0.624

0.187

holeboard

number of hole pokes by individual hole number, 20 min test, 15

-1.3185

0.64974

-1.9976

0.462

0.0495

holeboard

number of hole pokes by individual hole number, 20 min test, 16

-2.5648

1.1314

-2.2327

0.336

0.0292

holeboard

total number of hole pokes, 20 min test

-14.360

5.8468

-1.8866

0.150

0.0187

light / dark

fecal boli count, 20 min test

1.9845

0.81433

1.9586

0.313

0.0206

light / dark

latency to enter dark zone, 20 min test

43.407

41.329

0.65677

0.701

0.300

light / dark

number of transitions between light and dark zones, 20 min test

11.183

9.4448

1.1316

0.566

0.243

light / dark

percentage of total time in dark zone, 20 min test

-7.8842

3.3988

-1.2921

0.262

0.0253

light / dark

percentage of total time in light zone, 20 min test

7.8842

3.3988

1.2890

0.259

0.0253

light / dark

time mobile in dark zone, 20 min test

12.934

12.603

0.65845

0.608

0.311

light / dark

time mobile in light zone, 20 min test

35.389

13.679

1.5206

0.0965

0.0132

light / dark

time spent in dark zone, 20 min test

-126.27

46.864

-1.5292

0.180

0.0101

light / dark

time spent in light zone, 20 min test

126.27

46.864

1.5292

0.180

0.0101

open field

average speed in center of arena, 20 min test

-0.28594

0.49843

-0.61134

0.818

0.569

open field

average speed in periphery of arena, 20 min test

0.53816

0.21256

1.3712

0.0753

0.0152

open field

distance traveled habituation ratio, 20 min test

13.760

9.1185

1.1106

0.446

0.139

open field

distance traveled in center of arena, 20 min test

108.84

107.97

0.36867

0.579

0.319

open field

distance traveled in periphery of arena, 20 min test

488.85

207.28

1.3575

0.112

0.0231

open field

distance traveled slope, 20 min test

14.951

8.7519

1.2991

0.367

0.0951

open field

distance traveled, 20 min test, 1st 5min

14.388

90.750

-0.22268

0.944

0.875

open field

distance traveled, 20 min test, 2nd 5min

179.04

63.740

1.3117

0.0574

0.00751

open field

distance traveled, 20 min test, 3rd 5min

262.25

70.953

1.8578

0.0110

0.000628

open field

distance traveled, 20 min test, 4th 5min

139.98

81.607

1.0412

0.277

0.0937

open field

number of clockwise revolution episodes, 20 min test

1.8025

1.4240

0.65023

0.570

0.213

open field

number of counter-clockwise revolution episodes, 20 min test

0.29289

1.6626

-0.27253

0.942

0.861

open field

number of rears in 5 min bins, 20 min test, 1st 5min

-1.6855

2.3424

-0.65855

0.719

0.476

open field

number of rears in 5 min bins, 20 min test, 2nd 5min

-1.7355

3.1891

-0.79545

0.798

0.589

open field

number of rears in 5 min bins, 20 min test, 3rd 5min

-56.898

46.540

-3.2711

0.504

0.228

open field

number of rears in 5 min bins, 20 min test, 4th 5min

4.9049

3.5406

0.75198

0.442

0.173

open field

percentage of total time in center of arena, 20 min test

3.0369

2.6636

0.46088

0.580

0.261

open field

percentage of total time in center of arena, slope, 20 min test

3.1161

1.3064

1.7938

0.353

0.0218

open field

percentage of total time in center, habituation ratio, 20 min test

3.2166

1.2862

1.8356

0.308

0.0165

open field

percentage of total time in corners of arena, 20 min test

-2.6524

4.8315

-0.17203

0.822

0.586

open field

percentage of total time in corners, habituation ratio, 20 min test

-1.1431

1.7283

-0.82528

0.877

0.512

open field

percentage of total time in corners, slope, 20 min test

-1.9838

1.9939

-1.2163

0.792

0.326

open field

permanence time in center of arena, 20 min test

31.523

32.834

0.38308

0.659

0.343

open field

permanence time in corners of arena, 20 min test

-31.838

57.974

-0.17066

0.822

0.586

open field

permanence time in periphery of arena, 20 min test

-31.481

32.830

-0.38308

0.659

0.343

open field

total distance traveled, 20 min test

597.68

262.31

1.1181

0.113

0.0278

open field

total number of rears, 20 min test

0.40000

9.7347

-0.30894

0.988

0.967

open field

whole arena average speed, 20 min test

0.49867

0.21864

1.1231

0.112

0.0277

open field

whole arena resting time, 20 min test

-64.432

26.430

-1.1131

0.0832

0.0191

open field

whole arena time spent mobile, 20 min test

67.564

26.090

1.3609

0.0675

0.0132

open field

whole arena time spent vertical, 20 min test

-9.4960

9.4532

-0.85393

0.626

0.321

SHIRPA

locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)

1.8648

1.8117

0.97569

0.614

0.310

startle / PPI

average baseline movement during background noise

-0.83465

1.1462

-0.58105

0.877

0.471

startle / PPI

average of each corrected maximum percent pre-pulse inhibition value

-0.17374

0.074754

-1.6002

0.236

0.0250

startle / PPI

average of each corrected percent pre-pulse inhibition value

-0.17633

0.071708

-1.7805

0.204

0.0181

startle / PPI

average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

-3.4136

8.8070

-0.31551

0.957

0.700

startle / PPI

average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

-17.115

9.0851

-1.6809

0.384

0.0665

startle / PPI

average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

-31.150

8.1821

-2.3917

0.0223

0.000462

startle / PPI

average startle response to full pulse (120 dB)

190.30

52.771

2.2842

0.0107

0.000835

startle / PPI

average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

173.97

47.673

2.1392

0.00970

0.000722

startle / PPI

average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

236.16

51.019

2.7110

0.00115

0.0000367

startle / PPI

average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

230.53

42.674

2.5370

0.000218

0.00000305

startle / PPI

average startle response to pre-pulse, 74dB sound pressure level

-3.3671

1.6443

-2.0628

0.517

0.0469

startle / PPI

average startle response to pre-pulse, 78dB sound pressure level

-1.8572

1.7125

-1.2749

0.803

0.284

startle / PPI

average startle response to pre-pulse, 82dB sound pressure level

-4.2193

3.1827

-2.0399

0.640

0.192

startle / PPI

corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

-0.043713

0.091986

-0.36151

0.922

0.637

startle / PPI

corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

-0.19960

0.096620

-1.7038

0.296

0.0451

startle / PPI

corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

-0.36336

0.099565

-2.4723

0.0183

0.000736

startle / PPI

corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise

190.29

52.605

2.2656

0.0107

0.000809

startle / PPI

corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level

176.94

47.634

2.1677

0.00837

0.000594

startle / PPI

corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level

236.37

50.790

2.6595

0.00105

0.0000339

startle / PPI

corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level

235.15

43.210

2.7709

0.000200

0.00000268

startle / PPI

corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

-0.049954

0.098928

-0.41591

0.930

0.616

startle / PPI

corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

-0.20440

0.10212

-1.6362

0.301

0.0518

startle / PPI

corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

-0.34079

0.098486

-2.2138

0.0271

0.00127

startle / PPI

corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise

588.60

167.45

2.1124

0.0134

0.00107

startle / PPI

corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level

806.32

185.74

2.4169

0.00222

0.0000905

startle / PPI

corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level

831.62

179.78

2.6595

0.00116

0.0000371

startle / PPI

corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level

773.71

149.32

2.6595

0.000414

0.00000625

startle / PPI

maximum baseline movement during background noise

-0.86678

2.8626

-0.16823

0.958

0.764

startle / PPI

maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

-4.0976

9.7094

-0.37200

0.950

0.675

startle / PPI

maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

-18.444

9.7819

-1.6925

0.373

0.0663

startle / PPI

maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

-30.210

8.8099

-2.3037

0.0372

0.00139

startle / PPI

maximum startle response to full pulse (120 dB)

588.34

167.72

2.1124

0.0133

0.00109

startle / PPI

maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level

800.76

185.67

2.3917

0.00239

0.0000989

startle / PPI

maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level

832.73

180.62

2.6595

0.00118

0.0000389

startle / PPI

maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level

762.39

148.34

2.5737

0.000427

0.00000716

startle / PPI

maximum startle response to pre-pulse, 74dB sound pressure level

-8.1618

3.6964

-1.9969

0.480

0.0328

startle / PPI

maximum startle response to pre-pulse, 78dB sound pressure level

-4.1580

4.0075

-1.1226

0.770

0.305

startle / PPI

maximum startle response to pre-pulse, 82dB sound pressure level

-10.312

8.0892

-2.0747

0.592

0.209

There is currently no JaxKOMP-EAP categorical effect size data in MPD for this genotype