MPD: JaxKOMP-EAP genotype: Masp1<sup>tm1.1(KOMP)Vlcg</sup> -/-

JaxKOMP-EAP effect sizes: Masp1^{tm1.1(KOMP)Vlcg} -/- Gene Masp1

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	11.075	2.7725	1.9360	0.0591	0.000850
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	16.591	2.2433	1.9922	0.000434	7.36e-7
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.2198	3.5511	0.10315	0.904	0.735
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	0.99336	4.3670	0.031672	0.932	0.823
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	0.76043	5.2777	0.087029	0.967	0.887
body composition	body length	-0.23370	0.060481	-1.7137	0.00747	0.000242
body composition	body weight (at time of DXA)	-5.4929	0.85101	-2.6684	9.19e-7	1.05e-8
body composition	bone area, whole body scan, head excluded	-0.25501	0.18663	-0.81888	0.438	0.176
body composition	bone mineral content of whole body scan, head excluded	-0.016767	0.012420	-0.77205	0.455	0.181
body composition	bone mineral content to body weight ratio	-0.00084546	0.00058987	-0.87357	0.405	0.156
body composition	bone mineral density of whole body scan, head excluded	-0.00096325	0.00065485	-0.99133	0.417	0.146
body composition	fat tissue mass of whole body scan, head excluded	0.61861	0.33829	0.90191	0.249	0.0716
body composition	fat tissue mass to body weight ratio	0.026169	0.013492	1.1128	0.201	0.0563
body composition	lean tissue mass of whole body scan, head excluded	-0.44372	0.34390	-1.0444	0.503	0.201
body composition	lean tissue mass to body weight ratio	-0.026277	0.012867	-1.3721	0.197	0.0448
body composition	percent fat, whole body scan, head excluded	2.5806	1.2896	1.1896	0.186	0.0491
body composition	ratio of soft-tissue attenuation coefficients	-0.0025951	0.0014394	-1.0914	0.245	0.0756
body composition	tissue area	-0.43040	0.26020	-1.1698	0.354	0.102
body composition	total tissue mass, whole body scan, head excluded	0.18893	0.27325	0.21462	0.711	0.492
clinical blood chemistry	alanine transaminase (plasma ALT)	16.730	15.312	1.0544	0.649	0.281
clinical blood chemistry	albumin (plasma Alb)	-0.10943	0.59204	-0.10571	0.949	0.854
clinical blood chemistry	alkaline phosphatase (plasma ALP)	25.484	6.8802	2.3638	0.0123	0.000672
clinical blood chemistry	chloride (plasma Cl)	0.27731	1.0252	0.18279	0.881	0.788
clinical blood chemistry	HDL cholesterol (plasma HDL)	-7.6649	4.5164	-1.7557	0.340	0.0979
clinical blood chemistry	potassium (plasma K)	0.32016	0.19796	0.27808	0.248	0.114
clinical blood chemistry	sodium (plasma Na)	2.6142	0.73232	1.5961	0.00453	0.000967
EKG	duration of PQ interval	-0.070505	0.71778	0.064524	0.982	0.922
EKG	duration of PR interval	0.27109	0.86109	0.35382	0.938	0.754
EKG	duration of QRS interval	1.1132	0.46361	2.4454	0.695	0.0194
EKG	duration of QT interval	2.8212	1.0263	2.3098	0.266	0.00786
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.4927	0.88913	1.5728	0.687	0.0983
EKG	duration of RR interval	5.8473	1.6337	2.4072	0.0531	0.000683
EKG	duration of ST interval	1.7439	0.87726	1.8613	0.510	0.0513
EKG	heart rate coefficient of variation (signal intensity)	3.7726	1.1268	2.5883	0.498	0.00140
EKG	heart rate variability, mean of differences between sequential beats; beats per min	25.226	8.0974	2.4454	0.533	0.00280
EKG	heart rate, beats per min	-43.395	13.409	-2.3719	0.0936	0.00196
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.044957	0.088201	-0.47843	0.872	0.612
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.16912	0.11207	-1.0484	0.491	0.136
EKG	number of signals	1.9788	4.5065	0.36242	0.920	0.662
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	21.021	5.3383	2.5849	0.263	0.000214
EKG	QT dispersion, measured as inter-lead variability of QT intervals	12.075	3.3948	2.4454	0.405	0.000740
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	11.515	3.9600	2.1629	0.654	0.00510
EKG	root mean square of successive differences of neighboring RR intervals	4.1485	2.2277	1.7673	0.843	0.0674
glucose tolerance test	amount glucose injected	2.5225	2.8516	1.0541	0.738	0.381
glucose tolerance test	plasma glucose, 0min	-24.774	6.6382	-2.1078	0.00699	0.000494
glucose tolerance test	plasma glucose, 15min	-36.196	23.715	-0.87375	0.427	0.133
glucose tolerance test	plasma glucose, 30min	-34.128	26.593	-0.93576	0.550	0.205
glucose tolerance test	plasma glucose, 60min	-44.045	19.616	-1.6359	0.214	0.0293
glucose tolerance test	plasma glucose, 120min	3.7416	8.6477	0.12801	0.866	0.667
grip strength	body weight (at time of grip strength test)	-3.6597	1.1272	-2.2343	0.0237	0.00404
grip strength	forelimb and hindlimb grip strength (mean of trials), average	18.053	8.4540	1.4881	0.151	0.0460
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	1.2513	0.35112	1.8705	0.0191	0.00195
grip strength	forelimb and hindlimb grip strength by trial, trial1	-0.87952	12.375	0.16780	0.977	0.944
grip strength	forelimb and hindlimb grip strength by trial, trial2	22.096	10.471	1.5824	0.201	0.0483
grip strength	forelimb and hindlimb grip strength by trial, trial3	31.478	13.785	2.1248	0.173	0.0341
grip strength	forelimb grip strength (mean of trials), average	12.480	8.8195	1.8075	0.414	0.173
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.70755	0.38308	1.8381	0.276	0.0796
grip strength	forelimb grip strength by trial, trial1	14.519	7.6664	1.7928	0.331	0.0736
grip strength	forelimb grip strength by trial, trial2	21.234	11.356	2.3785	0.328	0.0770
grip strength	forelimb grip strength by trial, trial3	3.3374	13.687	0.60237	0.927	0.810
heart weight	heart weight, normalized to body weight	0.0057908	0.18392	-0.43567	0.985	0.975
heart weight	heart weight, weight	-0.91314	4.6863	-0.48830	0.917	0.846
hematology	basophil differential (percent of total WBC)	0.0023888	0.073395	0.064564	0.997	0.974
hematology	calculated hemoglobin (cHGB)	0.084394	0.18889	-0.029555	0.838	0.658
hematology	eosinophil differential (percent of total WBC)	-0.35876	0.39321	-0.88854	0.751	0.369
hematology	hematocrit (HCT)	-0.00066106	0.49895	-0.37489	0.999	0.999
hematology	hemoglobin concentration distribution width (HDW)	0.0067599	0.020040	0.18355	0.882	0.738
hematology	large unstained cells (percent of total WBC)	0.037260	0.14049	0.25550	0.908	0.793
hematology	lymphocyte differential (percent of total WBC)	-2.6330	1.7638	-1.1071	0.394	0.147
hematology	mean corpuscular hemoglobin (CHr)	0.10302	0.064957	0.82324	0.323	0.124
hematology	mean platelet volume (MPV)	-0.068978	0.064957	-0.65354	0.525	0.297
hematology	mean RBC corpuscular hemoglobin (MCH)	0.20565	0.15112	0.78299	0.526	0.184
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.25672	0.35443	0.57216	0.786	0.475
hematology	mean RBC corpuscular volume (MCV)	0.26543	0.34933	0.49978	0.674	0.453
hematology	measured hemoglobin (mHGB)	0.13522	0.24958	0.096559	0.805	0.592
hematology	monocyte differential (percent of total WBC)	-0.067099	0.19329	-0.0095674	0.903	0.731
hematology	neutrophil differential (percent of total WBC)	2.9246	1.5931	1.3243	0.268	0.0770
hematology	platelet count (PLT; units per volume x 10³)	197.17	74.984	2.1356	0.168	0.0135
hematology	RBC corpuscular distribution width (RDW)	0.034607	0.097300	0.12573	0.860	0.725
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.030904	0.22566	0.060963	0.950	0.892
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.043206	0.14197	-0.52534	0.892	0.763
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-35.183	19.680	-1.3150	0.428	0.0846
hematology	reticulocyte differential (percent of total RBC)	-0.46376	0.16710	-1.5726	0.190	0.00955
hematology	white blood cell count (WBC; units per volume x 10³)	-0.44143	0.84894	-0.12745	0.766	0.607
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.51862	0.82943	0.57845	0.844	0.534
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-1.2187	0.54655	-1.7013	0.459	0.0300
holeboard	number of hole pokes by individual hole number, 20 min test, 3	1.2811	0.71059	1.8205	0.602	0.0772
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.78797	0.98982	-0.72023	0.813	0.430
holeboard	number of hole pokes by individual hole number, 20 min test, 5	1.0339	0.62677	1.5497	0.619	0.105
holeboard	number of hole pokes by individual hole number, 20 min test, 6	0.20405	0.37295	0.59303	0.930	0.587
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.041070	0.39420	-0.13990	0.996	0.917
holeboard	number of hole pokes by individual hole number, 20 min test, 8	2.0181	0.68232	2.4369	0.238	0.00465
holeboard	number of hole pokes by individual hole number, 20 min test, 9	1.4391	0.54389	2.0357	0.267	0.0108
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.021968	0.32297	0.13402	0.989	0.946
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.39255	0.34038	0.91825	0.807	0.254
holeboard	number of hole pokes by individual hole number, 20 min test, 12	1.3008	0.57963	1.7948	0.349	0.0291
holeboard	number of hole pokes by individual hole number, 20 min test, 13	2.5616	0.92850	2.0783	0.319	0.00794
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.64183	0.45160	1.0304	0.594	0.161
holeboard	number of hole pokes by individual hole number, 20 min test, 15	0.94238	0.79346	1.4091	0.689	0.240
holeboard	number of hole pokes by individual hole number, 20 min test, 16	1.5960	1.0301	1.3607	0.552	0.127
holeboard	total number of hole pokes, 20 min test	16.515	5.8647	1.9617	0.0841	0.00686
light / dark	fecal boli count, 20 min test	-0.78841	0.97892	-0.84509	0.780	0.424
light / dark	latency to enter dark zone, 20 min test	231.65	84.569	2.7228	0.186	0.00824
light / dark	number of transitions between light and dark zones, 20 min test	0.25020	10.475	0.13562	0.990	0.981
light / dark	percentage of total time in dark zone, 20 min test	-8.2139	7.1485	-1.3537	0.620	0.255
light / dark	percentage of total time in light zone, 20 min test	8.2139	7.1485	1.3503	0.621	0.255
light / dark	time mobile in dark zone, 20 min test	-31.114	18.124	-1.7152	0.332	0.0916
light / dark	time mobile in light zone, 20 min test	26.782	14.111	1.1817	0.246	0.0629
light / dark	time spent in dark zone, 20 min test	-223.87	84.523	-2.5161	0.180	0.0105
light / dark	time spent in light zone, 20 min test	223.87	84.523	2.5161	0.180	0.0105
open field	average speed in center of arena, 20 min test	0.69990	0.42233	1.0836	0.408	0.102
open field	average speed in periphery of arena, 20 min test	0.74716	0.16159	1.7938	0.000548	0.0000188
open field	distance traveled habituation ratio, 20 min test	-6.9178	11.150	-0.57452	0.781	0.537
open field	distance traveled in center of arena, 20 min test	151.35	78.155	0.59684	0.213	0.0572
open field	distance traveled in periphery of arena, 20 min test	769.36	172.35	1.8356	0.000988	0.0000334
open field	distance traveled slope, 20 min test	-5.6344	10.923	-0.46686	0.836	0.608
open field	distance traveled, 20 min test, 1st 5min	264.02	105.45	1.5459	0.0848	0.0149
open field	distance traveled, 20 min test, 2nd 5min	213.19	55.174	1.5685	0.00524	0.000263
open field	distance traveled, 20 min test, 3rd 5min	329.78	57.577	2.0804	0.0000196	2.94e-7
open field	distance traveled, 20 min test, 4th 5min	223.34	67.799	1.6467	0.0184	0.00162
open field	number of clockwise revolution episodes, 20 min test	1.4697	1.5816	0.44997	0.708	0.356
open field	number of counter-clockwise revolution episodes, 20 min test	4.2476	1.4116	1.6363	0.0624	0.00375
open field	number of fecal boli, 20 min test	-1.3850	0.98722	-0.87172	0.494	0.165
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.3486	2.7264	0.16735	0.817	0.623
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.9868	2.9220	0.42239	0.597	0.311
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	11.147	3.2121	1.9391	0.0221	0.000943
open field	number of rears in 5 min bins, 20 min test, 4th 5min	14.815	3.7423	2.3613	0.00863	0.000194
open field	percentage of total time in center of arena, 20 min test	0.94984	2.8427	0.023498	0.898	0.739
open field	percentage of total time in center of arena, slope, 20 min test	-0.23913	1.2870	-0.0046991	0.958	0.853
open field	percentage of total time in center, habituation ratio, 20 min test	-0.88632	1.3599	-0.32872	0.859	0.517
open field	percentage of total time in corners of arena, 20 min test	-4.1705	4.3108	-0.45492	0.638	0.337
open field	percentage of total time in corners, habituation ratio, 20 min test	1.0872	2.0658	0.21031	0.912	0.601
open field	percentage of total time in corners, slope, 20 min test	-0.032958	2.0787	-0.28929	1.00	0.987
open field	permanence time in center of arena, 20 min test	11.393	34.109	0.024841	0.899	0.739
open field	permanence time in corners of arena, 20 min test	-50.062	51.728	-0.45492	0.638	0.337
open field	permanence time in periphery of arena, 20 min test	-11.387	34.107	-0.024841	0.898	0.740
open field	total distance traveled, 20 min test	933.19	202.41	1.7425	0.000512	0.0000197
open field	total number of rears, 20 min test	36.475	11.577	1.8503	0.0304	0.00249
open field	whole arena average speed, 20 min test	0.77600	0.16878	1.7425	0.000536	0.0000207
open field	whole arena resting time, 20 min test	-74.185	20.618	-1.2960	0.00678	0.000625
open field	whole arena time spent mobile, 20 min test	74.248	20.596	1.4785	0.00704	0.000611
open field	whole arena time spent vertical, 20 min test	25.816	11.369	1.6843	0.190	0.0266
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	15.139	17.896	1.4128	0.846	0.402
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	6.1378	5.7412	1.6975	0.813	0.290
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	4.4291	14.803	0.66046	0.940	0.766
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	8.9703	23.085	0.85191	0.893	0.699
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	3.2643	2.9566	1.4805	0.597	0.283
startle / PPI	average baseline movement during background noise	-2.3156	0.98171	-1.5154	0.428	0.0227
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	-0.18216	0.10912	-1.6583	0.421	0.102
startle / PPI	average of each corrected percent pre-pulse inhibition value	-0.094064	0.079462	-1.0152	0.589	0.243
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.37224	10.670	0.014712	0.995	0.972
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-17.189	7.2486	-1.6925	0.263	0.0221
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-24.544	6.4183	-2.0870	0.0205	0.000401
startle / PPI	average startle response to full pulse (120 dB)	83.588	37.386	1.4936	0.138	0.0305
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	79.860	34.655	1.4169	0.114	0.0260
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	102.00	33.714	1.7288	0.0326	0.00414
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	91.522	24.817	1.7675	0.0108	0.000618
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.35181	1.2452	-0.21389	0.967	0.779
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-2.4432	1.0505	-1.5333	0.443	0.0246
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.6301	1.4511	-1.0542	0.696	0.267
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.062718	0.12453	0.62474	0.922	0.617
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.15974	0.079485	-1.4012	0.311	0.0505
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.20792	0.071064	-1.7412	0.0592	0.00537
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	85.857	37.586	1.5110	0.126	0.0272
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	81.121	34.857	1.4363	0.111	0.0246
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	104.91	33.738	1.7609	0.0278	0.00328
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	94.140	25.056	1.8541	0.00881	0.000502
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.074965	0.19467	-0.65050	0.950	0.702
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-0.23565	0.096124	-1.7740	0.199	0.0182
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-0.30843	0.079731	-2.0867	0.0123	0.000350
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	297.36	136.77	1.4482	0.147	0.0351
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	303.25	127.10	1.4851	0.0980	0.0214
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	358.66	125.42	1.6638	0.0436	0.00646
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	336.42	94.407	1.7811	0.0132	0.000895
startle / PPI	maximum baseline movement during background noise	-5.4571	1.9631	-1.4246	0.309	0.00791
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-9.3839	14.118	-0.89014	0.920	0.510
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-22.599	8.2491	-1.9767	0.175	0.00879
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-29.934	7.2378	-2.2842	0.00909	0.000152
startle / PPI	maximum startle response to full pulse (120 dB)	291.43	136.29	1.4324	0.155	0.0381
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	299.90	126.53	1.4726	0.0996	0.0222
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	352.07	124.89	1.6528	0.0478	0.00719
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	329.68	93.526	1.7743	0.0143	0.00100
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.6848	2.4390	-0.43586	0.853	0.493
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-6.5330	2.7096	-1.6751	0.384	0.0200
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-5.3214	3.1702	-1.2941	0.478	0.100
urinalysis	albumin-creatinine ratio (urine ACR)	8.2532	3.4402	1.5631	0.101	0.0200
urinalysis	creatinine (urine CREA)	-8.1833	6.3306	-0.90846	0.430	0.200
urinalysis	glucose (urine GLU)	-0.73935	4.1461	-0.29730	0.956	0.859
urinalysis	magnesium level (urine Mg)	-0.12692	0.033413	-1.6544	0.0128	0.000377
urinalysis	microalbumin (urine MA), calculated	0.57517	0.25842	1.6529	0.184	0.0303

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
eye morphology	anterior chamber depth	9.0 %	0.0418
eye morphology	bulging eye	9.0 %	0.0277
eye morphology	cornea	9.0 %	0.0678
eye morphology	cornea opacity	9.0 %	0.0556
eye morphology	cornea vascularization	9.0 %	0.0446
eye morphology	corneal deposits	9.0 %	0.0723
eye morphology	corneal mineralization	9.0 %	0.0399
eye morphology	corneal scleralization	25.0 %	0.0000475
eye morphology	corneal ulcer	9.0 %	0.0506
eye morphology	eye closure	9.0 %	0.0276
eye morphology	eye hemorrhage or blood presence	9.0 %	0.0610
eye morphology	eyelid morphology	9.0 %	0.0336
eye morphology	eyes (present, absent)	9.0 %	0.0342
eye morphology	fusion between cornea and lens	8.0 %	0.121
eye morphology	iris pigmentation	9.0 %	0.0992
eye morphology	iris transillumination	9.0 %	0.0804
eye morphology	irispupil	9.0 %	0.108
eye morphology	lacrimation	9.0 %	0.162
eye morphology	lens	8.0 %	0.228
eye morphology	lens opacity	8.0 %	0.261
eye morphology	narrow eye opening	9.0 %	0.0354
eye morphology	optic disc	8.0 %	0.167
eye morphology	persistence of hyaloid vascular system	8.0 %	0.228
eye morphology	pupil dilation	17.0 %	0.00109
eye morphology	pupil light response	9.0 %	0.169
eye morphology	pupil position	23.0 %	0.000737
eye morphology	pupil shape	25.0 %	0.0000100
eye morphology	retina	8.0 %	0.251
eye morphology	retinal blood vessels	8.0 %	0.134
eye morphology	retinal blood vessels pattern	8.0 %	0.196
eye morphology	retinal blood vessels structure	8.0 %	0.148
eye morphology	retinal pigmentation	24.0 %	0.0310
eye morphology	retinal structure	8.0 %	0.153
eye morphology	synechia	8.0 %	0.137
eye morphology	vitreous	8.0 %	0.128
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	9.0 %	0.0161
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	9.0 %	0.0555
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.0
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.0
SHIRPA	coat hair distribution back	0.0 %	1.00
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	13.0 %	0.120
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.0
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.0
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.00
SHIRPA	hindlimb digit size	0.0 %	1.0
SHIRPA	hindlimb nail length	0.0 %	1.0
SHIRPA	hindlimb nail number	0.0 %	1.0
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	2.0 %	0.565
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.0
SHIRPA	tail curvature	0.0 %	1.00
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	16.0 %	0.0185

GENOTYPE CORRELATION PLOT

Correlate Masp1^{tm1.1(KOMP)Vlcg} -/- with genotype: