MPD: JaxKOMP-EAP genotype: Vegfb<sup>tm1b(EUCOMM)Hmgu</sup> -/-

JaxKOMP-EAP effect sizes: Vegfb^{tm1b(EUCOMM)Hmgu} -/- Gene Vegfb

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	1.9326	3.8572	0.35293	0.886	0.626
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	3.6730	3.1510	0.78597	0.720	0.271
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-7.0895	2.7785	-1.5310	0.237	0.0269
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-3.9163	4.1659	-0.70710	0.720	0.367
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-1.4702	3.2055	-0.26814	0.864	0.656
body composition	body length	0.018212	0.034216	0.45395	0.807	0.597
body composition	body weight (at time of DXA)	0.56452	0.52429	0.55455	0.507	0.286
body composition	bone area, whole body scan, head excluded	0.15635	0.088285	0.85178	0.291	0.0817
body composition	bone mineral content of whole body scan, head excluded	0.0097078	0.0067054	0.71094	0.411	0.153
body composition	bone mineral content to body weight ratio	0.00043476	0.00032084	0.77389	0.433	0.180
body composition	bone mineral density of whole body scan, head excluded	0.00031441	0.00041808	0.35642	0.728	0.455
body composition	fat tissue mass of whole body scan, head excluded	-0.0069539	0.19406	-0.015018	0.984	0.972
body composition	fat tissue mass to body weight ratio	-0.000063832	0.0080483	0.064212	0.996	0.994
body composition	lean tissue mass of whole body scan, head excluded	-0.26405	0.20407	-0.72329	0.503	0.201
body composition	lean tissue mass to body weight ratio	-0.016123	0.0075821	-0.89949	0.177	0.0376
body composition	percent fat, whole body scan, head excluded	0.17952	0.77322	0.16180	0.916	0.817
body composition	ratio of soft-tissue attenuation coefficients	-0.00016730	0.00086612	-0.15108	0.937	0.847
body composition	tissue area	0.17968	0.11639	0.75115	0.397	0.128
body composition	total tissue mass, whole body scan, head excluded	-0.25090	0.17041	-0.82271	0.373	0.146
clinical blood chemistry	alanine transaminase (plasma ALT)	1.4575	13.611	0.13288	0.974	0.915
clinical blood chemistry	albumin (plasma Alb)	0.23839	0.38336	0.38118	0.806	0.536
clinical blood chemistry	alkaline phosphatase (plasma ALP)	-2.3908	2.5629	-0.95133	0.603	0.355
clinical blood chemistry	aspartate transaminase (plasma AST)	21.450	25.254	0.82477	0.705	0.399
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.33033	0.23305	0.97045	0.542	0.162
clinical blood chemistry	blood urea nitrogen (BUN)	-2.6330	1.0019	-1.0647	0.0955	0.0122
clinical blood chemistry	calcium (plasma Ca)	0.0044879	0.065265	0.38081	0.972	0.945
clinical blood chemistry	carbon dioxide (plasma CO₂)	-0.037848	0.42555	-0.32432	0.966	0.929
clinical blood chemistry	chloride (plasma Cl)	1.0210	0.38820	0.78047	0.0480	0.0108
clinical blood chemistry	glucose (plasma GLU, no fast)	-39.715	18.491	-1.0273	0.131	0.0385
clinical blood chemistry	HDL cholesterol (plasma HDL)	2.6107	2.1476	0.29987	0.534	0.229
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0025713	0.013678	0.0064054	0.962	0.852
clinical blood chemistry	iron (plasma Fe)	0.0044299	0.0062299	0.38195	0.712	0.480
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	0.028216	0.060808	0.27638	0.819	0.645
clinical blood chemistry	phosphorus (plasma phosphate)	-0.25816	0.47807	-0.46910	0.807	0.591
clinical blood chemistry	potassium (plasma K)	0.53296	0.18218	0.97892	0.0320	0.00485
clinical blood chemistry	sodium (plasma Na)	1.6854	0.51095	0.61714	0.00698	0.00165
clinical blood chemistry	total bilirubin (plasma TBIL)	0.013848	0.011131	0.89163	0.562	0.219
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	3.9261	2.3492	0.44900	0.351	0.100
clinical blood chemistry	total protein (plasma TP)	1.9211	0.89441	1.3270	0.211	0.0364
clinical blood chemistry	triglyceride (plasma TG, no fast)	-13.456	7.7625	-0.51066	0.320	0.0893
ECT	applied stimulus (current), by day, day 2	-0.37536	0.18319	-1.2762	0.273	0.0466
ECT	applied stimulus (current), by day, day 3	-0.35130	0.17945	-1.2828	0.260	0.0568
ECT	applied stimulus (current), by day, day 4	-1.7459	0.77339	-1.5108	0.336	0.0539
ECT	behavior following applied stimulus (current), by day, day 1	0.42152	0.23311	1.2193	0.319	0.0776
ECT	behavior following applied stimulus (current), by day, day 3	0.22571	0.30402	0.42294	0.871	0.462
ECT	behavior following applied stimulus (current), by day, day 4	-0.96774	0.66537	-1.5535	0.506	0.184
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	-0.41404	0.18445	-1.4696	0.173	0.0300
EKG	duration of PQ interval	0.025203	0.61958	0.17212	0.990	0.968
EKG	duration of PR interval	0.31500	0.73102	0.40362	0.938	0.668
EKG	duration of QRS interval	0.21372	0.25987	0.43220	0.901	0.414
EKG	duration of QT interval	-0.024980	0.83533	0.12729	0.998	0.976
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-0.29361	0.70155	-0.26293	0.946	0.677
EKG	duration of RR interval	0.58689	1.3007	0.56696	0.878	0.654
EKG	duration of ST interval	-0.49435	0.73448	-0.27128	0.868	0.504
EKG	heart rate coefficient of variation (signal intensity)	0.40086	1.0988	0.41677	0.951	0.717
EKG	heart rate variability, mean of differences between sequential beats; beats per min	2.9262	8.1383	0.41677	0.950	0.721
EKG	heart rate, beats per min	-5.2156	10.255	-0.59975	0.850	0.613
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.093973	0.086496	0.62652	0.661	0.282
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.16179	0.12527	0.88137	0.568	0.202
EKG	number of signals	8.7840	2.6991	1.4945	0.158	0.00193
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	-0.80836	4.2839	-0.10191	0.983	0.851
EKG	QT dispersion, measured as inter-lead variability of QT intervals	-0.55845	2.7048	-0.13542	0.982	0.837
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	-0.69041	3.2328	-0.16394	0.975	0.832
EKG	root mean square of successive differences of neighboring RR intervals	0.15636	1.8985	0.19055	0.985	0.935
electroretinography	a-wave amplitude of rod photoreceptors, left	22.327	12.326	0.65044	0.531	0.130
electroretinography	a-wave amplitude of rod photoreceptors, right	4.9067	4.6510	-0.32597	0.744	0.332
electroretinography	b-wave amplitude of cone photoreceptors, left	-7.5525	15.271	-0.57913	0.995	0.638
electroretinography	b-wave amplitude of cone photoreceptors, right	-2.1275	9.4591	-0.049308	0.981	0.830
electroretinography	b-wave amplitude of rod photoreceptors, left	-11.242	28.302	0.13343	0.883	0.705
electroretinography	b-wave amplitude of rod photoreceptors, right	-0.42500	28.917	0.41033	0.992	0.989
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	0.73785	0.99019	0.56471	0.827	0.490
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	0.60473	1.0341	0.48516	0.839	0.584
electroretinography	rod b wave implicit time, left	0.86516	0.50722	0.15594	0.607	0.149
electroretinography	rod b wave implicit time, right	-0.72979	0.82286	-0.66320	0.852	0.409
glucose tolerance test	amount glucose injected	-4.2558	1.6655	-0.84084	0.172	0.0139
glucose tolerance test	plasma glucose, 0min	-16.242	4.8963	-1.5954	0.0175	0.00174
glucose tolerance test	plasma glucose, 15min	-59.766	26.196	-1.4833	0.199	0.0270
glucose tolerance test	plasma glucose, 30min	-42.061	25.378	-1.1326	0.405	0.104
glucose tolerance test	plasma glucose, 60min	17.756	24.726	0.82646	0.766	0.476
glucose tolerance test	plasma glucose, 120min	21.703	20.064	1.3285	0.595	0.285
grip strength	body weight (at time of grip strength test)	1.7699	0.47749	1.7062	0.00744	0.000849
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-10.337	8.3336	-0.48448	0.429	0.225
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-0.52972	0.42373	-0.60063	0.422	0.221
grip strength	forelimb and hindlimb grip strength by trial, trial1	-26.560	8.1883	-1.4414	0.0397	0.00297
grip strength	forelimb and hindlimb grip strength by trial, trial2	-8.3690	10.276	-0.27500	0.664	0.422
grip strength	forelimb and hindlimb grip strength by trial, trial3	0.18462	10.532	0.21365	0.994	0.986
grip strength	forelimb grip strength (mean of trials), average	-7.0503	6.0181	-0.63401	0.514	0.251
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.47551	0.29183	-0.96433	0.339	0.114
grip strength	forelimb grip strength by trial, trial1	-8.5214	6.8094	-0.72552	0.573	0.221
grip strength	forelimb grip strength by trial, trial2	-8.8728	6.4392	-0.73500	0.500	0.179
grip strength	forelimb grip strength by trial, trial3	-9.9072	7.0646	-0.79933	0.475	0.171
heart weight	heart weight, normalized to body weight	0.14839	0.17539	0.091338	0.613	0.401
heart weight	heart weight, weight	2.5195	4.0362	-0.047989	0.716	0.535
hematology	basophil differential (percent of total WBC)	0.040973	0.048319	0.64971	0.773	0.401
hematology	calculated hemoglobin (cHGB)	0.17100	0.24959	0.24223	0.747	0.497
hematology	eosinophil differential (percent of total WBC)	-0.27585	0.28671	-0.66124	0.725	0.341
hematology	hematocrit (HCT)	0.93569	0.81744	0.69610	0.561	0.258
hematology	hemoglobin concentration distribution width (HDW)	-0.0032955	0.017418	-0.078303	0.935	0.851
hematology	large unstained cells (percent of total WBC)	-0.017769	0.14003	-0.087836	0.951	0.900
hematology	lymphocyte differential (percent of total WBC)	-0.025322	1.2136	-0.057435	0.990	0.983
hematology	mean corpuscular hemoglobin (CHr)	-0.031095	0.054397	-0.24223	0.773	0.570
hematology	mean platelet volume (MPV)	0.079169	0.099106	0.34783	0.654	0.428
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.15638	0.38159	-0.60136	0.863	0.684
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.45535	0.83353	-0.83772	0.832	0.587
hematology	mean RBC corpuscular volume (MCV)	-0.16996	0.32336	-0.30823	0.785	0.602
hematology	measured hemoglobin (mHGB)	0.13969	0.48973	0.10618	0.897	0.777
hematology	monocyte differential (percent of total WBC)	-0.015074	0.14941	0.15921	0.970	0.920
hematology	neutrophil differential (percent of total WBC)	0.26426	0.99869	0.15368	0.891	0.792
hematology	platelet count (PLT; units per volume x 10³)	28.355	54.944	0.44024	0.842	0.608
hematology	RBC corpuscular distribution width (RDW)	-0.0013252	0.10680	-0.015761	0.994	0.990
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.045924	0.24648	0.11339	0.940	0.853
hematology	red blood cell count (RBC; per volume x 10⁶)	0.18815	0.18948	0.47265	0.597	0.326
hematology	reticulocyte count (Retic; units per volume x 10⁹)	6.3316	12.279	0.36873	0.868	0.609
hematology	reticulocyte differential (percent of total RBC)	0.030118	0.11846	0.33620	0.922	0.800
hematology	white blood cell count (WBC; units per volume x 10³)	0.21308	0.65142	0.33125	0.860	0.745
insulin blood level	insulin (plasma)	-18.558	164.93	0.44415	0.988	0.911
light / dark	fecal boli count, 20 min test	0.30973	0.81920	0.37355	0.922	0.707
light / dark	latency to enter dark zone, 20 min test	31.710	39.742	0.49392	0.793	0.429
light / dark	number of transitions between light and dark zones, 20 min test	-19.097	6.1724	-1.7455	0.0655	0.00339
light / dark	percentage of total time in dark zone, 20 min test	-7.6600	5.2623	-1.2264	0.521	0.152
light / dark	percentage of total time in light zone, 20 min test	7.6600	5.2623	1.2235	0.521	0.152
light / dark	time mobile in dark zone, 20 min test	-60.490	14.531	-2.7228	0.00469	0.000144
light / dark	time mobile in light zone, 20 min test	0.63628	12.194	-0.20007	0.979	0.959
light / dark	time spent in dark zone, 20 min test	-105.03	57.543	-1.2467	0.434	0.0746
light / dark	time spent in light zone, 20 min test	105.03	57.543	1.2467	0.434	0.0746
open field	average speed in center of arena, 20 min test	-0.076700	0.30633	-0.24199	0.937	0.803
open field	average speed in periphery of arena, 20 min test	-0.35750	0.15667	-1.7549	0.109	0.0261
open field	distance traveled habituation ratio, 20 min test	8.6095	8.2919	0.70300	0.623	0.303
open field	distance traveled in center of arena, 20 min test	-190.10	75.834	-1.5156	0.0966	0.0149
open field	distance traveled in periphery of arena, 20 min test	-277.40	143.20	-1.5549	0.201	0.0574
open field	distance traveled slope, 20 min test	8.0031	7.9402	0.71682	0.641	0.318
open field	distance traveled, 20 min test, 1st 5min	-145.07	83.763	-1.4666	0.271	0.0884
open field	distance traveled, 20 min test, 2nd 5min	-127.82	48.640	-1.8356	0.0708	0.0109
open field	distance traveled, 20 min test, 3rd 5min	-120.48	49.345	-1.6572	0.0963	0.0176
open field	distance traveled, 20 min test, 4th 5min	-67.580	49.097	-1.2247	0.393	0.174
open field	number of clockwise revolution episodes, 20 min test	-2.4725	1.0893	-1.8500	0.195	0.0268
open field	number of counter-clockwise revolution episodes, 20 min test	-1.9719	1.1821	-1.5199	0.353	0.101
open field	number of fecal boli, 20 min test	0.79781	0.81067	0.83929	0.647	0.329
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-0.96750	2.2158	-0.47238	0.835	0.664
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-0.55750	1.9298	-0.50311	0.897	0.774
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-3.1778	1.7511	-1.0435	0.273	0.0746
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-0.98000	1.9280	-0.56662	0.809	0.613
open field	percentage of total time in center of arena, 20 min test	-4.1920	2.5121	-1.2449	0.385	0.100
open field	percentage of total time in center of arena, slope, 20 min test	-1.7929	1.4937	-0.83856	0.693	0.235
open field	percentage of total time in center, habituation ratio, 20 min test	-2.2814	1.4958	-1.0206	0.585	0.132
open field	percentage of total time in corners of arena, 20 min test	7.5567	3.7627	1.6162	0.270	0.0491
open field	percentage of total time in corners, habituation ratio, 20 min test	-0.23616	1.9212	-0.40484	0.988	0.903
open field	percentage of total time in corners, slope, 20 min test	-0.59592	1.8521	-0.55719	0.943	0.749
open field	permanence time in center of arena, 20 min test	-50.292	30.147	-1.2449	0.387	0.100
open field	permanence time in corners of arena, 20 min test	90.697	45.154	1.6162	0.270	0.0491
open field	permanence time in periphery of arena, 20 min test	50.290	30.143	1.2449	0.387	0.100
open field	total distance traveled, 20 min test	-461.61	194.82	-1.6679	0.0922	0.0211
open field	total number of rears, 20 min test	-5.6525	6.2989	-0.73077	0.621	0.373
open field	whole arena average speed, 20 min test	-0.38428	0.16236	-1.6679	0.0926	0.0212
open field	whole arena resting time, 20 min test	31.052	21.858	1.4359	0.339	0.161
open field	whole arena time spent mobile, 20 min test	-31.076	21.863	-1.6679	0.343	0.160
open field	whole arena time spent vertical, 20 min test	0.85025	6.0276	-0.043648	0.958	0.888
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-0.30875	8.3688	0.22192	0.979	0.971
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	0.47025	2.9327	0.35310	0.962	0.873
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-20.757	8.1119	-1.4128	0.140	0.0130
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-14.868	14.971	-0.61639	0.804	0.325
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-3.5546	1.4592	-1.2988	0.174	0.0217
tail suspension	duration of immobility, 5 min test	29.377	8.9049	1.4067	0.0238	0.00183
tail suspension	latency to immobility, 5 min test	-24.542	7.7148	-2.3574	0.182	0.00260

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
electroretinography	blind eyes, left	females	0.0 %	1.0
electroretinography	blind eyes, left	males	0.0 %	1.0
electroretinography	blind eyes, left	both	0.0 %	1.0
electroretinography	blind eyes, right	females	0.0 %	1.0
electroretinography	blind eyes, right	males	0.0 %	1.0
electroretinography	blind eyes, right	both	0.0 %	1.0
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	2.0 %	1.0
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	1.0 %	1.00
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	4.0 %	1.00
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	3.0 %	1.00
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	10.0 %	1.00
eye morphology	lens	males	9.0 %	0.496
eye morphology	lens	both	3.0 %	0.783
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	14.0 %	1.0
eye morphology	persistence of hyaloid vascular system	males	5.0 %	1.0
eye morphology	persistence of hyaloid vascular system	both	9.0 %	1.00
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	4.0 %	1.00
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	4.0 %	1.00
eye morphology	pupil shape	females	3.0 %	1.00
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	3.0 %	1.00
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	7.0 %	0.610
eye morphology	retina	both	7.0 %	0.801
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	12.0 %	0.0256
eye morphology	retinal blood vessels	both	6.0 %	0.0329
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	9.0 %	0.529
eye morphology	retinal pigmentation	both	7.0 %	0.794
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	females	0.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	males	0.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	both	0.0 %	1.0
rotarod	trial number	females	0.0 %	1.0
rotarod	trial number	males	0.0 %	1.0
rotarod	trial number	both	0.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.0
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	37.0 %	0.00506
SHIRPA	contact righting	males	95.0 %	1.75e-9
SHIRPA	contact righting	both	66.0 %	3.31e-10
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.0
SHIRPA	gait (fluidity)	both	0.0 %	1.0
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.0
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.618
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.0
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.0
SHIRPA	tail curvature	females	0.0 %	1.00
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	0.0 %	1.0
SHIRPA	tail elevation	females	1.0 %	1.0
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	touch escape	females	14.0 %	1.0
SHIRPA	touch escape	both	14.0 %	1.0
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.0
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.0
SHIRPA	trunk curl	females	0.0 %	1.0
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.0
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00
tail suspension	climbing, 5 min test (yes, no)	females	78.0 %	0.00000603
tail suspension	climbing, 5 min test (yes, no)	males	78.0 %	0.00000664
tail suspension	climbing, 5 min test (yes, no)	both	78.0 %	3.92e-11

GENOTYPE CORRELATION PLOT

Correlate Vegfb^{tm1b(EUCOMM)Hmgu} -/- with genotype: