MPD: JaxKOMP-EAP genotype: Rab40c<sup>tm1b(KOMP)Wtsi</sup> -/+

JaxKOMP-EAP effect sizes: Rab40c^{tm1b(KOMP)Wtsi} -/+ Gene Rab40c

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	0.27105	1.6999	-0.20748	0.966	0.875
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-3.0808	1.9298	-0.67850	0.597	0.130
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	1.5264	1.8297	0.17198	0.755	0.417
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	-0.20833	3.3801	-0.15330	0.984	0.952
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	-1.6667	3.1732	-0.30319	0.847	0.607
body composition	body length	-0.046654	0.041767	-0.34094	0.579	0.276
body composition	body weight (at time of DXA)	0.90388	0.52614	0.81928	0.264	0.0992
body composition	bone area, whole body scan, head excluded	-0.097976	0.11529	-0.20624	0.662	0.405
body composition	bone mineral content of whole body scan, head excluded	-0.00082596	0.0074276	0.083378	0.966	0.912
body composition	bone mineral content to body weight ratio	-0.0000048516	0.00035662	0.14661	0.997	0.989
body composition	bone mineral density of whole body scan, head excluded	0.00043145	0.00048985	0.49253	0.676	0.388
body composition	fat tissue mass of whole body scan, head excluded	0.15496	0.27127	0.27087	0.781	0.574
body composition	fat tissue mass to body weight ratio	0.012364	0.011495	0.60742	0.539	0.293
body composition	lean tissue mass of whole body scan, head excluded	-0.59610	0.22213	-1.2680	0.129	0.0136
body composition	lean tissue mass to body weight ratio	-0.027196	0.010578	-1.4043	0.120	0.0171
body composition	percent fat, whole body scan, head excluded	1.4804	1.0886	0.76106	0.418	0.187
body composition	ratio of soft-tissue attenuation coefficients	-0.0016452	0.0012103	-0.77411	0.419	0.187
body composition	tissue area	-0.19177	0.14059	-0.44477	0.470	0.186
body composition	total tissue mass, whole body scan, head excluded	-0.44114	0.18814	-1.3055	0.144	0.0285
clinical blood chemistry	alanine transaminase (plasma ALT)	-7.2589	14.295	-0.65198	0.874	0.617
clinical blood chemistry	albumin (plasma Alb)	1.5218	0.44503	2.1185	0.0539	0.00258
clinical blood chemistry	alkaline phosphatase (plasma ALP)	7.6533	3.2198	0.79761	0.134	0.0270
clinical blood chemistry	aspartate transaminase (plasma AST)	18.996	26.950	0.73818	0.773	0.488
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.51529	0.35920	1.3618	0.547	0.166
clinical blood chemistry	blood urea nitrogen (BUN)	1.5012	1.1246	0.57052	0.451	0.196
clinical blood chemistry	calcium (plasma Ca)	-0.12143	0.084596	-0.50638	0.383	0.165
clinical blood chemistry	carbon dioxide (plasma CO₂)	-2.0179	0.71799	-2.0329	0.110	0.0102
clinical blood chemistry	chloride (plasma Cl)	1.9272	0.64188	1.5150	0.0346	0.00656
clinical blood chemistry	glucose (plasma GLU, no fast)	-59.038	17.844	-1.5856	0.0281	0.00415
clinical blood chemistry	HDL cholesterol (plasma HDL)	2.4638	3.0397	0.26008	0.709	0.426
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.010009	0.020037	0.40587	0.865	0.622
clinical blood chemistry	iron (plasma Fe)	-0.013080	0.0062524	-0.82258	0.233	0.0482
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.21744	0.11628	-1.6410	0.292	0.0770
clinical blood chemistry	phosphorus (plasma phosphate)	0.62634	0.27200	0.88886	0.172	0.0311
clinical blood chemistry	potassium (plasma K)	0.17790	0.25087	-0.26322	0.641	0.486
clinical blood chemistry	sodium (plasma Na)	3.8147	0.69402	2.3446	0.000204	0.0000160
clinical blood chemistry	total bilirubin (plasma TBIL)	0.020357	0.032412	1.2243	0.800	0.536
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	0.85279	2.8184	-0.086125	0.906	0.765
clinical blood chemistry	total protein (plasma TP)	2.3080	0.87795	1.5014	0.130	0.0153
clinical blood chemistry	triglyceride (plasma TG, no fast)	-7.5883	7.1258	-0.19728	0.590	0.299
ECT	behavior following applied stimulus (current), by day, day 3	0.19862	0.42218	0.34824	0.927	0.643
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.092378	0.10798	-0.062707	0.688	0.402
EKG	duration of PQ interval	-0.27649	1.4765	-0.14559	0.968	0.853
EKG	duration of PR interval	0.76125	1.0053	0.89690	0.888	0.457
EKG	duration of QRS interval	0.22125	0.40477	0.47013	0.949	0.590
EKG	duration of QT interval	0.90750	1.1154	1.0180	0.862	0.424
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	1.3050	1.0550	1.3760	0.789	0.229
EKG	duration of RR interval	-0.87625	2.7746	-0.19671	0.920	0.755
EKG	duration of ST interval	0.71250	0.97946	0.93677	0.862	0.474
EKG	heart rate coefficient of variation (signal intensity)	0.35225	1.4161	0.37320	0.968	0.806
EKG	heart rate variability, mean of differences between sequential beats; beats per min	1.905	9.1723	0.29856	0.972	0.837
EKG	heart rate, beats per min	12.512	19.461	0.49889	0.809	0.527
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.16662	0.11749	1.1716	0.541	0.170
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.1375	0.12829	0.70454	0.654	0.295
EKG	number of signals	-0.32024	2.8899	-0.13338	0.982	0.913
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	14.209	8.2590	2.1805	0.791	0.0994
EKG	QT dispersion, measured as inter-lead variability of QT intervals	3.8437	3.9523	1.0737	0.907	0.341
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	3.2562	3.8133	0.86716	0.914	0.402
EKG	root mean square of successive differences of neighboring RR intervals	1.9348	2.4907	1.0595	0.884	0.445
electroretinography	a-wave amplitude of rod photoreceptors, left	11.213	13.153	0.059717	0.783	0.416
electroretinography	a-wave amplitude of rod photoreceptors, right	2.6098	20.602	-0.46149	0.970	0.902
electroretinography	b-wave amplitude of cone photoreceptors, left	-6.5979	10.681	-0.52114	0.946	0.552
electroretinography	b-wave amplitude of cone photoreceptors, right	-26.292	17.538	-1.6130	0.609	0.168
electroretinography	b-wave amplitude of rod photoreceptors, left	-25.962	27.613	-0.11931	0.699	0.372
electroretinography	b-wave amplitude of rod photoreceptors, right	-95.442	72.526	-1.3983	0.549	0.221
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	-0.88043	0.81256	-1.0931	0.710	0.307
electroretinography	rod a wave implicit time, right	0.30435	0.45773	-0.073791	0.779	0.523
electroretinography	rod b wave implicit time, left	1.6739	3.5932	0.69964	0.948	0.652
FACS	spleen weight	-0.00090947	0.0060659	-0.10384	0.952	0.895
glucose tolerance test	amount glucose injected	-2.9148	2.7914	-0.48365	0.679	0.308
glucose tolerance test	plasma glucose, 0min	5.8174	9.2292	0.35899	0.734	0.535
glucose tolerance test	plasma glucose, 15min	-29.371	29.291	-0.69270	0.651	0.327
glucose tolerance test	plasma glucose, 30min	13.487	25.828	0.50372	0.829	0.607
glucose tolerance test	plasma glucose, 60min	23.877	21.442	1.0552	0.605	0.278
glucose tolerance test	plasma glucose, 120min	11.387	10.643	0.66162	0.603	0.296
grip strength	body weight (at time of grip strength test)	3.1521	0.53635	2.5617	0.252	0.107
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-26.522	15.838	-1.5673	0.556	0.343
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	-1.6184	0.39911	-1.9516	0.334	0.154
grip strength	forelimb and hindlimb grip strength by trial, trial1	-24.266	21.586	-1.3420	0.730	0.463
grip strength	forelimb and hindlimb grip strength by trial, trial2	15.848	21.255	1.1899	0.797	0.592
grip strength	forelimb and hindlimb grip strength by trial, trial3	-33.991	24.075	-1.8001	0.660	0.392
grip strength	forelimb grip strength (mean of trials), average	-4.4083	6.3662	-0.29315	0.823	0.614
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.37143	0.23250	-0.70117	0.629	0.356
grip strength	forelimb grip strength by trial, trial1	-5.7015	9.9278	-0.40117	0.864	0.668
grip strength	forelimb grip strength by trial, trial2	2.3324	11.403	0.48939	0.951	0.872
grip strength	forelimb grip strength by trial, trial3	-9.8559	9.7688	-0.79334	0.765	0.497
heart weight	heart weight, normalized to body weight	0.24375	0.27251	0.39443	0.594	0.381
heart weight	heart weight, weight	4.3645	6.1698	0.19790	0.682	0.487
hematology	basophil differential (percent of total WBC)	-0.0625	0.066536	-0.89403	0.754	0.358
hematology	calculated hemoglobin (cHGB)	0.11250	0.14508	0.043471	0.711	0.447
hematology	eosinophil differential (percent of total WBC)	0.55	0.28278	1.4811	0.375	0.0653
hematology	hematocrit (HCT)	0.93750	0.48739	0.70483	0.305	0.0681
hematology	hemoglobin concentration distribution width (HDW)	-0.015625	0.017548	-0.41489	0.688	0.383
hematology	large unstained cells (percent of total WBC)	-0.1375	0.13663	-0.88860	0.664	0.326
hematology	lymphocyte differential (percent of total WBC)	-1.7062	1.0695	-0.78047	0.364	0.126
hematology	mean corpuscular hemoglobin (CHr)	-0.31103	0.068919	-1.8679	0.00356	0.000212
hematology	mean platelet volume (MPV)	0.012500	0.069597	-0.10515	0.934	0.859
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.47106	0.11128	-1.1201	0.0150	0.000408
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	-0.58125	0.26392	-0.97621	0.276	0.0390
hematology	mean RBC corpuscular volume (MCV)	-0.53750	0.29128	-0.95585	0.225	0.0791
hematology	measured hemoglobin (mHGB)	-2.0267e-15	0.15708	-0.24940	1.00	1.00
hematology	monocyte differential (percent of total WBC)	0.043750	0.20548	0.36611	0.938	0.833
hematology	neutrophil differential (percent of total WBC)	1.3	0.84476	0.68396	0.370	0.139
hematology	platelet count (PLT; units per volume x 10³)	26.854	42.747	0.41479	0.812	0.537
hematology	RBC corpuscular distribution width (RDW)	0.19375	0.14490	0.69049	0.455	0.195
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.31250	0.20740	-0.86669	0.370	0.147
hematology	red blood cell count (RBC; per volume x 10⁶)	0.345	0.10081	1.1610	0.0442	0.00256
hematology	reticulocyte count (Retic; units per volume x 10⁹)	4.5563	11.818	0.30189	0.907	0.704
hematology	reticulocyte differential (percent of total RBC)	-0.060625	0.098211	-0.038170	0.809	0.544
hematology	white blood cell count (WBC; units per volume x 10³)	-3.1131	0.81858	-1.7924	0.0126	0.00104
insulin blood level	insulin (plasma)	91.665	270.82	0.84336	0.895	0.736
light / dark	fecal boli count, 20 min test	0.025000	0.66018	0.038542	0.986	0.970
light / dark	latency to enter dark zone, 20 min test	118.36	39.015	1.7839	0.154	0.00591
light / dark	number of transitions between light and dark zones, 20 min test	-4.4500	6.4869	-0.34758	0.759	0.500
light / dark	percentage of total time in dark zone, 20 min test	1.7539	5.3560	0.44561	0.915	0.746
light / dark	percentage of total time in light zone, 20 min test	-1.7539	5.3560	-0.44860	0.917	0.746
light / dark	time mobile in dark zone, 20 min test	-33.975	11.678	-1.8042	0.0800	0.00790
light / dark	time mobile in light zone, 20 min test	-17.886	8.5474	-1.4709	0.206	0.0476
light / dark	time spent in dark zone, 20 min test	-85.044	92.987	-1.0003	0.739	0.370
light / dark	time spent in light zone, 20 min test	85.044	92.987	1.0003	0.739	0.370
open field	average speed in center of arena, 20 min test	-0.77300	0.51121	-1.5549	0.465	0.144
open field	average speed in periphery of arena, 20 min test	-0.50815	0.19211	-2.1296	0.0732	0.0145
open field	distance traveled habituation ratio, 20 min test	25.361	10.549	1.8578	0.193	0.0247
open field	distance traveled in center of arena, 20 min test	38.868	170.62	-0.14483	0.904	0.822
open field	distance traveled in periphery of arena, 20 min test	-536.70	203.88	-2.4878	0.0890	0.0149
open field	distance traveled slope, 20 min test	21.371	10.013	1.7364	0.256	0.0437
open field	distance traveled, 20 min test, 1st 5min	-327.61	105.20	-2.4878	0.0394	0.00488
open field	distance traveled, 20 min test, 2nd 5min	-108.94	61.788	-1.6733	0.272	0.0912
open field	distance traveled, 20 min test, 3rd 5min	-152.58	62.366	-1.9662	0.113	0.0225
open field	distance traveled, 20 min test, 4th 5min	104.90	99.335	0.65565	0.552	0.302
open field	number of clockwise revolution episodes, 20 min test	-3.975	1.1850	-2.4590	0.0497	0.00275
open field	number of counter-clockwise revolution episodes, 20 min test	-0.96250	1.9128	-0.94027	0.809	0.620
open field	number of fecal boli, 20 min test	0.7875	0.97646	0.81911	0.722	0.428
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-4.9375	3.5352	-1.5153	0.429	0.176
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	0.73750	2.6293	-0.16386	0.899	0.782
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-3.1750	3.2139	-1.0412	0.604	0.333
open field	number of rears in 5 min bins, 20 min test, 4th 5min	2.0125	3.0581	0.11099	0.741	0.517
open field	percentage of total time in center of arena, 20 min test	0.33775	4.1983	-0.10964	0.984	0.937
open field	percentage of total time in center of arena, slope, 20 min test	-3.3241	2.8642	-1.5594	0.716	0.258
open field	percentage of total time in center, habituation ratio, 20 min test	-3.7186	2.9114	-1.6519	0.693	0.214
open field	percentage of total time in corners of arena, 20 min test	-1.2026	5.1813	0.075930	0.935	0.819
open field	percentage of total time in corners, habituation ratio, 20 min test	0.17875	2.8727	-0.20209	0.995	0.951
open field	percentage of total time in corners, slope, 20 min test	-0.0026250	2.7819	-0.26974	1.00	0.999
open field	permanence time in center of arena, 20 min test	4.0338	50.383	-0.10964	0.983	0.937
open field	permanence time in corners of arena, 20 min test	-14.417	62.178	0.075930	0.935	0.819
open field	permanence time in periphery of arena, 20 min test	-4.0762	50.391	0.10694	0.983	0.936
open field	total distance traveled, 20 min test	-688.56	241.49	-2.1994	0.0509	0.00904
open field	total number of rears, 20 min test	-5.3625	9.6522	-0.71682	0.776	0.584
open field	whole arena average speed, 20 min test	-0.57312	0.20142	-2.1994	0.0516	0.00916
open field	whole arena resting time, 20 min test	64.121	23.478	2.1994	0.0605	0.0119
open field	whole arena time spent mobile, 20 min test	-63.980	23.492	-2.4878	0.0633	0.0121
open field	whole arena time spent vertical, 20 min test	12.83	14.175	0.88528	0.674	0.375
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	27.162	21.413	2.2990	0.755	0.217
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	9.1300	6.5584	2.1879	0.757	0.177
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-1.9025	11.087	0.094476	0.961	0.865
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	20.638	25.795	1.6094	0.838	0.432
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	2.5625	1.8937	1.2523	0.688	0.405
tail suspension	duration of immobility, 5 min test	15.683	15.464	0.54035	0.556	0.322
tail suspension	latency to immobility, 5 min test	2.4250	2.4274	1.2746	0.739	0.328

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Sex	Trait Effect	P-value
electroretinography	blind eyes, left	females	0.0 %	1.0
electroretinography	blind eyes, left	males	0.0 %	1.0
electroretinography	blind eyes, left	both	0.0 %	1.0
electroretinography	blind eyes, right	females	0.0 %	1.0
electroretinography	blind eyes, right	males	0.0 %	1.0
electroretinography	blind eyes, right	both	0.0 %	1.0
eye morphology	anterior chamber depth	females	1.0 %	1.0
eye morphology	anterior chamber depth	males	0.0 %	1.0
eye morphology	anterior chamber depth	both	1.0 %	1.0
eye morphology	bulging eye	females	1.0 %	1.0
eye morphology	bulging eye	males	0.0 %	1.0
eye morphology	bulging eye	both	1.0 %	1.00
eye morphology	cornea	females	4.0 %	1.0
eye morphology	cornea	males	2.0 %	1.0
eye morphology	cornea	both	3.0 %	1.00
eye morphology	cornea opacity	females	5.0 %	1.00
eye morphology	cornea opacity	males	1.0 %	1.0
eye morphology	cornea opacity	both	3.0 %	1.00
eye morphology	cornea vascularization	females	3.0 %	1.0
eye morphology	cornea vascularization	males	1.0 %	1.0
eye morphology	cornea vascularization	both	2.0 %	1.00
eye morphology	corneal deposits	females	12.0 %	0.0944
eye morphology	corneal deposits	males	1.0 %	1.0
eye morphology	corneal deposits	both	6.0 %	0.136
eye morphology	corneal mineralization	females	2.0 %	1.0
eye morphology	corneal mineralization	males	1.0 %	1.0
eye morphology	corneal mineralization	both	1.0 %	1.00
eye morphology	corneal scleralization	females	3.0 %	1.00
eye morphology	corneal scleralization	males	1.0 %	1.0
eye morphology	corneal scleralization	both	2.0 %	1.00
eye morphology	corneal ulcer	females	1.0 %	1.0
eye morphology	corneal ulcer	males	1.0 %	1.0
eye morphology	corneal ulcer	both	1.0 %	1.00
eye morphology	eye closure	females	1.0 %	1.00
eye morphology	eye closure	males	0.0 %	1.0
eye morphology	eye closure	both	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	females	2.0 %	1.00
eye morphology	eye hemorrhage or blood presence	males	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	both	1.0 %	1.00
eye morphology	eyelid morphology	females	1.0 %	1.0
eye morphology	eyelid morphology	males	0.0 %	1.0
eye morphology	eyelid morphology	both	1.0 %	1.0
eye morphology	eyes (present, absent)	females	1.0 %	1.0
eye morphology	eyes (present, absent)	males	0.0 %	1.0
eye morphology	eyes (present, absent)	both	0.0 %	1.0
eye morphology	fusion between cornea and lens	females	4.0 %	1.00
eye morphology	fusion between cornea and lens	males	2.0 %	1.0
eye morphology	fusion between cornea and lens	both	3.0 %	1.00
eye morphology	iris pigmentation	females	2.0 %	1.0
eye morphology	iris pigmentation	males	1.0 %	1.0
eye morphology	iris pigmentation	both	2.0 %	1.00
eye morphology	iris transillumination	females	2.0 %	1.00
eye morphology	iris transillumination	males	1.0 %	1.0
eye morphology	iris transillumination	both	1.0 %	1.00
eye morphology	irispupil	females	11.0 %	0.275
eye morphology	irispupil	males	3.0 %	1.0
eye morphology	irispupil	both	5.0 %	0.435
eye morphology	lacrimation	females	3.0 %	1.0
eye morphology	lacrimation	males	2.0 %	1.0
eye morphology	lacrimation	both	3.0 %	1.0
eye morphology	lens	females	34.0 %	0.0394
eye morphology	lens	males	9.0 %	0.496
eye morphology	lens	both	21.0 %	0.0500
eye morphology	lens opacity	females	9.0 %	1.0
eye morphology	lens opacity	males	6.0 %	1.0
eye morphology	lens opacity	both	7.0 %	1.00
eye morphology	narrow eye opening	females	2.0 %	1.0
eye morphology	narrow eye opening	males	1.0 %	1.0
eye morphology	narrow eye opening	both	1.0 %	1.0
eye morphology	optic disc	females	4.0 %	1.00
eye morphology	optic disc	males	2.0 %	1.0
eye morphology	optic disc	both	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	females	12.0 %	0.218
eye morphology	persistence of hyaloid vascular system	males	20.0 %	0.0205
eye morphology	persistence of hyaloid vascular system	both	12.0 %	0.0374
eye morphology	pupil dilation	females	2.0 %	1.0
eye morphology	pupil dilation	males	1.0 %	1.0
eye morphology	pupil dilation	both	2.0 %	1.0
eye morphology	pupil light response	females	2.0 %	1.00
eye morphology	pupil light response	males	1.0 %	1.0
eye morphology	pupil light response	both	2.0 %	1.00
eye morphology	pupil position	females	11.0 %	0.301
eye morphology	pupil position	males	3.0 %	1.0
eye morphology	pupil position	both	5.0 %	0.461
eye morphology	pupil shape	females	12.0 %	0.236
eye morphology	pupil shape	males	2.0 %	1.0
eye morphology	pupil shape	both	5.0 %	0.342
eye morphology	retina	females	10.0 %	1.0
eye morphology	retina	males	16.0 %	1.0
eye morphology	retina	both	13.0 %	1.0
eye morphology	retinal blood vessels	females	4.0 %	1.0
eye morphology	retinal blood vessels	males	2.0 %	1.0
eye morphology	retinal blood vessels	both	3.0 %	1.0
eye morphology	retinal blood vessels pattern	females	5.0 %	1.0
eye morphology	retinal blood vessels pattern	males	2.0 %	1.0
eye morphology	retinal blood vessels pattern	both	4.0 %	1.00
eye morphology	retinal blood vessels structure	females	4.0 %	1.00
eye morphology	retinal blood vessels structure	males	2.0 %	1.0
eye morphology	retinal blood vessels structure	both	3.0 %	1.00
eye morphology	retinal pigmentation	females	12.0 %	1.0
eye morphology	retinal pigmentation	males	14.0 %	1.0
eye morphology	retinal pigmentation	both	13.0 %	1.0
eye morphology	retinal structure	females	4.0 %	1.00
eye morphology	retinal structure	males	2.0 %	1.0
eye morphology	retinal structure	both	3.0 %	1.00
eye morphology	synechia	females	4.0 %	1.0
eye morphology	synechia	males	2.0 %	1.0
eye morphology	synechia	both	3.0 %	1.00
eye morphology	vitreous	females	4.0 %	1.00
eye morphology	vitreous	males	2.0 %	1.0
eye morphology	vitreous	both	3.0 %	1.00
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	females	0.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	males	0.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	both	0.0 %	1.0
rotarod	trial number	females	0.0 %	1.0
rotarod	trial number	males	0.0 %	1.0
rotarod	trial number	both	0.0 %	1.0
SHIRPA	activity body position	females	1.0 %	1.0
SHIRPA	activity body position	males	2.0 %	1.0
SHIRPA	activity body position	both	1.0 %	1.00
SHIRPA	aggression	females	0.0 %	1.00
SHIRPA	aggression	males	1.0 %	1.0
SHIRPA	aggression	both	1.0 %	1.0
SHIRPA	body length	females	0.0 %	1.0
SHIRPA	body length	males	0.0 %	1.00
SHIRPA	body length	both	0.0 %	1.00
SHIRPA	body position	females	0.0 %	1.0
SHIRPA	body position	males	1.0 %	1.0
SHIRPA	body position	both	0.0 %	1.0
SHIRPA	body thickness	females	1.0 %	1.0
SHIRPA	body thickness	males	0.0 %	1.0
SHIRPA	body thickness	both	0.0 %	1.0
SHIRPA	coat color abdomen	females	3.0 %	1.00
SHIRPA	coat color abdomen	males	4.0 %	1.0
SHIRPA	coat color abdomen	both	4.0 %	1.0
SHIRPA	coat color back	females	0.0 %	1.0
SHIRPA	coat color back	males	0.0 %	1.00
SHIRPA	coat color back	both	0.0 %	1.00
SHIRPA	coat color head	females	0.0 %	1.0
SHIRPA	coat color head	males	0.0 %	1.00
SHIRPA	coat color head	both	0.0 %	1.0
SHIRPA	coat color pattern abdomen	females	1.0 %	1.0
SHIRPA	coat color pattern abdomen	males	1.0 %	1.0
SHIRPA	coat color pattern abdomen	both	1.0 %	1.0
SHIRPA	coat color pattern back	females	0.0 %	1.0
SHIRPA	coat color pattern back	males	0.0 %	1.00
SHIRPA	coat color pattern back	both	0.0 %	1.0
SHIRPA	coat color pattern head	females	0.0 %	1.0
SHIRPA	coat color pattern head	males	0.0 %	1.0
SHIRPA	coat color pattern head	both	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	females	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	males	2.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	both	2.0 %	1.0
SHIRPA	coat hair back texture appearance	females	0.0 %	1.0
SHIRPA	coat hair back texture appearance	males	0.0 %	1.0
SHIRPA	coat hair back texture appearance	both	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	females	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	males	1.0 %	1.00
SHIRPA	coat hair distribution abdomen	both	1.0 %	1.00
SHIRPA	coat hair distribution back	females	0.0 %	1.0
SHIRPA	coat hair distribution back	males	0.0 %	1.0
SHIRPA	coat hair distribution back	both	0.0 %	1.0
SHIRPA	coat hair distribution head	females	1.0 %	1.00
SHIRPA	coat hair distribution head	males	1.0 %	1.0
SHIRPA	coat hair distribution head	both	1.0 %	1.0
SHIRPA	coat hair head texture appearance	females	0.0 %	1.00
SHIRPA	coat hair head texture appearance	males	0.0 %	1.0
SHIRPA	coat hair head texture appearance	both	0.0 %	1.0
SHIRPA	contact righting	females	5.0 %	1.0
SHIRPA	contact righting	males	5.0 %	1.00
SHIRPA	contact righting	both	5.0 %	1.00
SHIRPA	ear morphology	females	0.0 %	1.0
SHIRPA	ear morphology	males	0.0 %	1.0
SHIRPA	ear morphology	both	0.0 %	1.0
SHIRPA	fat distribution	females	0.0 %	1.0
SHIRPA	fat distribution	males	0.0 %	1.0
SHIRPA	fat distribution	both	0.0 %	1.00
SHIRPA	forelimb digit number	females	0.0 %	1.00
SHIRPA	forelimb digit number	males	0.0 %	1.0
SHIRPA	forelimb digit number	both	0.0 %	1.00
SHIRPA	forelimb digit position	females	0.0 %	1.0
SHIRPA	forelimb digit position	males	0.0 %	1.0
SHIRPA	forelimb digit position	both	0.0 %	1.0
SHIRPA	forelimb digit shape	females	0.0 %	1.0
SHIRPA	forelimb digit shape	males	0.0 %	1.0
SHIRPA	forelimb digit shape	both	0.0 %	1.0
SHIRPA	forelimb digit size	females	0.0 %	1.0
SHIRPA	forelimb digit size	males	0.0 %	1.0
SHIRPA	forelimb digit size	both	0.0 %	1.0
SHIRPA	forelimb footpads	females	0.0 %	1.0
SHIRPA	forelimb footpads	males	0.0 %	1.0
SHIRPA	forelimb footpads	both	0.0 %	1.0
SHIRPA	forelimb nail length	females	0.0 %	1.0
SHIRPA	forelimb nail length	males	0.0 %	1.0
SHIRPA	forelimb nail length	both	0.0 %	1.0
SHIRPA	forelimb nail number	females	0.0 %	1.0
SHIRPA	forelimb nail number	males	0.0 %	1.0
SHIRPA	forelimb nail number	both	0.0 %	1.0
SHIRPA	forelimb nail position	females	0.0 %	1.0
SHIRPA	forelimb nail position	males	0.0 %	1.0
SHIRPA	forelimb nail position	both	0.0 %	1.0
SHIRPA	forelimb nail shape	females	0.0 %	1.0
SHIRPA	forelimb nail shape	males	0.0 %	1.0
SHIRPA	forelimb nail shape	both	0.0 %	1.0
SHIRPA	forelimbs position	females	0.0 %	1.0
SHIRPA	forelimbs position	males	0.0 %	1.0
SHIRPA	forelimbs position	both	0.0 %	1.0
SHIRPA	forelimbs shape	females	0.0 %	1.0
SHIRPA	forelimbs shape	males	0.0 %	1.0
SHIRPA	forelimbs shape	both	0.0 %	1.0
SHIRPA	forelimbs size	females	0.0 %	1.0
SHIRPA	forelimbs size	males	0.0 %	1.0
SHIRPA	forelimbs size	both	0.0 %	1.0
SHIRPA	forepaw position	females	0.0 %	1.0
SHIRPA	forepaw position	males	0.0 %	1.0
SHIRPA	forepaw position	both	0.0 %	1.0
SHIRPA	forepaw shape	females	0.0 %	1.0
SHIRPA	forepaw shape	males	0.0 %	1.0
SHIRPA	forepaw shape	both	0.0 %	1.0
SHIRPA	forepaw size	females	0.0 %	1.0
SHIRPA	forepaw size	males	0.0 %	1.0
SHIRPA	forepaw size	both	0.0 %	1.0
SHIRPA	gait (fluidity)	females	0.0 %	1.0
SHIRPA	gait (fluidity)	males	0.0 %	1.00
SHIRPA	gait (fluidity)	both	0.0 %	1.00
SHIRPA	genitalia morphology	females	0.0 %	1.00
SHIRPA	genitalia morphology	males	0.0 %	1.0
SHIRPA	genitalia morphology	both	0.0 %	1.00
SHIRPA	genitalia presence	females	0.0 %	1.0
SHIRPA	genitalia presence	males	0.0 %	1.0
SHIRPA	genitalia presence	both	0.0 %	1.0
SHIRPA	genitalia size	females	0.0 %	1.0
SHIRPA	genitalia size	males	0.0 %	1.0
SHIRPA	genitalia size	both	0.0 %	1.0
SHIRPA	head bobbing	females	0.0 %	1.0
SHIRPA	head bobbing	males	0.0 %	1.0
SHIRPA	head bobbing	both	0.0 %	1.0
SHIRPA	head morphology	females	0.0 %	1.0
SHIRPA	head morphology	males	0.0 %	1.00
SHIRPA	head morphology	both	0.0 %	1.0
SHIRPA	head size	females	0.0 %	1.0
SHIRPA	head size	males	0.0 %	1.0
SHIRPA	head size	both	0.0 %	1.00
SHIRPA	hindlimb digit number	females	1.0 %	1.00
SHIRPA	hindlimb digit number	males	0.0 %	1.0
SHIRPA	hindlimb digit number	both	0.0 %	1.00
SHIRPA	hindlimb digit position	females	0.0 %	1.0
SHIRPA	hindlimb digit position	males	0.0 %	1.0
SHIRPA	hindlimb digit position	both	0.0 %	1.0
SHIRPA	hindlimb digit shape	females	0.0 %	1.0
SHIRPA	hindlimb digit shape	males	0.0 %	1.0
SHIRPA	hindlimb digit shape	both	0.0 %	1.0
SHIRPA	hindlimb digit size	females	0.0 %	1.00
SHIRPA	hindlimb digit size	males	0.0 %	1.0
SHIRPA	hindlimb digit size	both	0.0 %	1.00
SHIRPA	hindlimb nail length	females	0.0 %	1.0
SHIRPA	hindlimb nail length	males	0.0 %	1.0
SHIRPA	hindlimb nail length	both	0.0 %	1.00
SHIRPA	hindlimb nail number	females	0.0 %	1.0
SHIRPA	hindlimb nail number	males	1.0 %	1.0
SHIRPA	hindlimb nail number	both	0.0 %	1.00
SHIRPA	hindlimb nail position	females	0.0 %	1.0
SHIRPA	hindlimb nail position	males	0.0 %	1.0
SHIRPA	hindlimb nail position	both	0.0 %	1.0
SHIRPA	hindlimb nail shape	females	0.0 %	1.0
SHIRPA	hindlimb nail shape	males	0.0 %	1.0
SHIRPA	hindlimb nail shape	both	0.0 %	1.0
SHIRPA	hindlimbs footpads	females	0.0 %	1.0
SHIRPA	hindlimbs footpads	males	0.0 %	1.0
SHIRPA	hindlimbs footpads	both	0.0 %	1.0
SHIRPA	hindlimbs position	females	0.0 %	1.0
SHIRPA	hindlimbs position	males	0.0 %	1.0
SHIRPA	hindlimbs position	both	0.0 %	1.0
SHIRPA	hindlimbs shape	females	0.0 %	1.0
SHIRPA	hindlimbs shape	males	0.0 %	1.0
SHIRPA	hindlimbs shape	both	0.0 %	1.0
SHIRPA	hindlimbs size	females	0.0 %	1.0
SHIRPA	hindlimbs size	males	0.0 %	1.0
SHIRPA	hindlimbs size	both	0.0 %	1.0
SHIRPA	hindpaw position	females	0.0 %	1.0
SHIRPA	hindpaw position	males	0.0 %	1.0
SHIRPA	hindpaw position	both	0.0 %	1.0
SHIRPA	hindpaw shape	females	0.0 %	1.0
SHIRPA	hindpaw shape	males	0.0 %	1.0
SHIRPA	hindpaw shape	both	0.0 %	1.0
SHIRPA	hindpaw size	females	0.0 %	1.0
SHIRPA	hindpaw size	males	0.0 %	1.0
SHIRPA	hindpaw size	both	0.0 %	1.0
SHIRPA	limb grasp	females	9.0 %	1.00
SHIRPA	limb grasp	males	6.0 %	1.0
SHIRPA	limb grasp	both	7.0 %	0.624
SHIRPA	lower lip morphology	females	0.0 %	1.0
SHIRPA	lower lip morphology	males	0.0 %	1.0
SHIRPA	lower lip morphology	both	0.0 %	1.0
SHIRPA	lower teeth appearance	females	0.0 %	1.0
SHIRPA	lower teeth appearance	males	0.0 %	1.00
SHIRPA	lower teeth appearance	both	0.0 %	1.00
SHIRPA	mouth morphology	females	0.0 %	1.0
SHIRPA	mouth morphology	males	0.0 %	1.00
SHIRPA	mouth morphology	both	0.0 %	1.00
SHIRPA	salivation	females	0.0 %	1.0
SHIRPA	salivation	males	0.0 %	1.0
SHIRPA	salivation	both	0.0 %	1.0
SHIRPA	skin color back paws	females	0.0 %	1.0
SHIRPA	skin color back paws	males	0.0 %	1.0
SHIRPA	skin color back paws	both	0.0 %	1.0
SHIRPA	skin color ear	females	0.0 %	1.0
SHIRPA	skin color ear	males	0.0 %	1.0
SHIRPA	skin color ear	both	0.0 %	1.0
SHIRPA	skin color front paws	females	0.0 %	1.0
SHIRPA	skin color front paws	males	0.0 %	1.0
SHIRPA	skin color front paws	both	0.0 %	1.0
SHIRPA	skin color snout	females	0.0 %	1.0
SHIRPA	skin color snout	males	0.0 %	1.0
SHIRPA	skin color snout	both	0.0 %	1.0
SHIRPA	skin color tail	females	0.0 %	1.0
SHIRPA	skin color tail	males	0.0 %	1.0
SHIRPA	skin color tail	both	0.0 %	1.0
SHIRPA	skin color whole body	females	0.0 %	1.0
SHIRPA	skin color whole body	males	0.0 %	1.0
SHIRPA	skin color whole body	both	0.0 %	1.0
SHIRPA	skin texture back paw	females	0.0 %	1.0
SHIRPA	skin texture back paw	males	0.0 %	1.0
SHIRPA	skin texture back paw	both	0.0 %	1.0
SHIRPA	skin texture ear	females	0.0 %	1.0
SHIRPA	skin texture ear	males	0.0 %	1.0
SHIRPA	skin texture ear	both	0.0 %	1.0
SHIRPA	skin texture front paws	females	0.0 %	1.0
SHIRPA	skin texture front paws	males	0.0 %	1.0
SHIRPA	skin texture front paws	both	0.0 %	1.0
SHIRPA	skin texture snout	females	0.0 %	1.0
SHIRPA	skin texture snout	males	0.0 %	1.0
SHIRPA	skin texture snout	both	0.0 %	1.0
SHIRPA	skin texture tail	females	0.0 %	1.0
SHIRPA	skin texture tail	males	0.0 %	1.0
SHIRPA	skin texture tail	both	0.0 %	1.0
SHIRPA	skin texture whole body	females	0.0 %	1.0
SHIRPA	skin texture whole body	males	0.0 %	1.00
SHIRPA	skin texture whole body	both	0.0 %	1.00
SHIRPA	snout size	females	0.0 %	1.0
SHIRPA	snout size	males	1.0 %	1.0
SHIRPA	snout size	both	0.0 %	1.0
SHIRPA	startle response	females	0.0 %	1.00
SHIRPA	startle response	males	0.0 %	1.00
SHIRPA	startle response	both	0.0 %	1.00
SHIRPA	tail curvature	females	12.0 %	0.00587
SHIRPA	tail curvature	males	0.0 %	1.0
SHIRPA	tail curvature	both	6.0 %	0.00883
SHIRPA	tail elevation	females	1.0 %	1.00
SHIRPA	tail elevation	males	2.0 %	1.0
SHIRPA	tail elevation	both	1.0 %	1.0
SHIRPA	tail length	females	0.0 %	1.0
SHIRPA	tail length	males	0.0 %	1.0
SHIRPA	tail length	both	0.0 %	1.00
SHIRPA	tail morphology	females	0.0 %	1.00
SHIRPA	tail morphology	males	0.0 %	1.0
SHIRPA	tail morphology	both	0.0 %	1.00
SHIRPA	tail presence	females	0.0 %	1.0
SHIRPA	tail presence	males	0.0 %	1.0
SHIRPA	tail presence	both	0.0 %	1.0
SHIRPA	tail shape	females	0.0 %	1.0
SHIRPA	tail shape	males	0.0 %	1.0
SHIRPA	tail shape	both	0.0 %	1.00
SHIRPA	tail thickness	females	0.0 %	1.0
SHIRPA	tail thickness	males	0.0 %	1.0
SHIRPA	tail thickness	both	0.0 %	1.0
SHIRPA	teeth presence	females	0.0 %	1.0
SHIRPA	teeth presence	males	0.0 %	1.00
SHIRPA	teeth presence	both	0.0 %	1.00
SHIRPA	touch escape	females	14.0 %	0.606
SHIRPA	touch escape	males	14.0 %	0.611
SHIRPA	touch escape	both	14.0 %	0.161
SHIRPA	transfer arousal	females	1.0 %	1.0
SHIRPA	transfer arousal	males	2.0 %	1.00
SHIRPA	transfer arousal	both	1.0 %	1.0
SHIRPA	tremor	females	0.0 %	1.0
SHIRPA	tremor	males	0.0 %	1.0
SHIRPA	tremor	both	0.0 %	1.00
SHIRPA	trunk curl	females	0.0 %	1.00
SHIRPA	trunk curl	males	0.0 %	1.0
SHIRPA	trunk curl	both	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	females	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	males	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	both	0.0 %	1.00
SHIRPA	upper lip morphology	females	0.0 %	1.0
SHIRPA	upper lip morphology	males	0.0 %	1.0
SHIRPA	upper lip morphology	both	0.0 %	1.0
SHIRPA	upper teeth appearance	females	0.0 %	1.0
SHIRPA	upper teeth appearance	males	0.0 %	1.0
SHIRPA	upper teeth appearance	both	0.0 %	1.00
SHIRPA	vibrissae appearance	females	2.0 %	1.0
SHIRPA	vibrissae appearance	males	1.0 %	1.0
SHIRPA	vibrissae appearance	both	1.0 %	1.0
SHIRPA	vibrissae presence	females	2.0 %	1.00
SHIRPA	vibrissae presence	males	1.0 %	1.0
SHIRPA	vibrissae presence	both	2.0 %	1.0
SHIRPA	vocalization	females	2.0 %	1.00
SHIRPA	vocalization	males	2.0 %	1.0
SHIRPA	vocalization	both	2.0 %	1.00
tail suspension	climbing, 5 min test (yes, no)	females	22.0 %	0.213
tail suspension	climbing, 5 min test (yes, no)	males	22.0 %	0.212
tail suspension	climbing, 5 min test (yes, no)	both	22.0 %	0.0307

GENOTYPE CORRELATION PLOT

Correlate Rab40c^{tm1b(KOMP)Wtsi} -/+ with genotype: