MPD: JaxKOMP-EAP genotype: Dnajc7<sup>tm1b(KOMP)Wtsi</sup> -/-

JaxKOMP-EAP effect sizes: Dnajc7^{tm1b(KOMP)Wtsi} -/- Gene Dnajc7

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect size vs. C57BL/6NJ controls, for all measured numeric phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure Standard Error Show Effect Sizes RankZ

Significance Threshold p-Value Threshold Adjusted Unadjusted

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Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value

body composition	body length	-0.0090231	0.037347	0.081814	0.921	0.809
body composition	body weight (at time of DXA)	-1.1003	0.52486	-0.69215	0.141	0.0381
body composition	bone area, whole body scan, head excluded	0.27636	0.11109	1.3830	0.0987	0.0142
body composition	bone mineral content of whole body scan, head excluded	0.018095	0.0083684	1.1597	0.170	0.0325
body composition	bone mineral content to body weight ratio	0.00078101	0.00035386	1.2235	0.145	0.0291
body composition	bone mineral density of whole body scan, head excluded	0.00069562	0.00044491	0.79204	0.378	0.121
body composition	fat tissue mass of whole body scan, head excluded	-0.58611	0.24266	-1.1103	0.114	0.0172
body composition	fat tissue mass to body weight ratio	-0.027400	0.0090208	-1.2206	0.0335	0.00291
body composition	lean tissue mass of whole body scan, head excluded	0.53678	0.22136	0.91636	0.139	0.0168
body composition	lean tissue mass to body weight ratio	0.016677	0.0087396	0.82615	0.229	0.0587
body composition	percent fat, whole body scan, head excluded	-2.5680	0.87226	-1.2322	0.0413	0.00387
body composition	ratio of soft-tissue attenuation coefficients	0.0031344	0.00094906	1.3471	0.0218	0.00125
body composition	tissue area	-0.25081	0.12970	-0.65828	0.255	0.0554
body composition	total tissue mass, whole body scan, head excluded	-0.042187	0.15360	-0.31362	0.890	0.784
clinical blood chemistry	alanine transaminase (plasma ALT)	-11.280	13.679	-0.94467	0.743	0.412
clinical blood chemistry	albumin (plasma Alb)	-0.13500	0.39386	-0.15605	0.901	0.733
clinical blood chemistry	alkaline phosphatase (plasma ALP)	4.7766	2.7184	0.35369	0.261	0.0821
clinical blood chemistry	aspartate transaminase (plasma AST)	-5.3418	25.441	-0.26243	0.950	0.834
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.16103	0.24943	0.54207	0.828	0.520
clinical blood chemistry	blood urea nitrogen (BUN)	0.88054	1.1505	0.31393	0.699	0.447
clinical blood chemistry	calcium (plasma Ca)	0.053567	0.059841	0.73045	0.616	0.373
clinical blood chemistry	carbon dioxide (plasma CO₂)	0.67579	0.56721	0.36501	0.516	0.236
clinical blood chemistry	chloride (plasma Cl)	0.66210	0.41794	0.50366	0.260	0.116
clinical blood chemistry	glucose (plasma GLU, no fast)	-30.096	14.357	-0.76280	0.133	0.0393
clinical blood chemistry	HDL cholesterol (plasma HDL)	-0.58196	2.4674	-0.47257	0.935	0.814
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.017020	0.030269	-1.0368	0.831	0.575
clinical blood chemistry	iron (plasma Fe)	-0.016275	0.010613	-0.95091	0.379	0.128
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.11663	0.046156	-0.94086	0.113	0.0137
clinical blood chemistry	phosphorus (plasma phosphate)	-1.2432	0.37295	-1.7146	0.0304	0.00126
clinical blood chemistry	potassium (plasma K)	0.39191	0.14440	0.48374	0.0430	0.00788
clinical blood chemistry	sodium (plasma Na)	-0.027572	0.40268	-0.90453	0.962	0.946
clinical blood chemistry	total bilirubin (plasma TBIL)	0.0056249	0.0079008	0.37479	0.776	0.478
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	0.69287	3.3018	-0.11757	0.937	0.834
clinical blood chemistry	total protein (plasma TP)	-2.5545	1.9646	-1.7794	0.478	0.197
clinical blood chemistry	triglyceride (plasma TG, no fast)	-15.970	7.4786	-0.64779	0.191	0.0360
ECT	applied stimulus (current), by day, day 2	0.33803	0.25098	0.62722	0.505	0.182
ECT	applied stimulus (current), by day, day 3	0.39626	0.18564	0.77384	0.204	0.0359
ECT	behavior following applied stimulus (current), by day, day 1	-0.029726	0.24124	0.11470	0.979	0.902
ECT	behavior following applied stimulus (current), by day, day 3	0.035265	0.32029	-0.085436	0.983	0.913
ECT	stimulus level (current) required for minimal clonic forebrain seizure (score of 3 or higher)	0.52899	0.17443	1.2698	0.0477	0.00329
EKG	duration of PQ interval	-0.66620	0.56106	-0.56460	0.786	0.238
EKG	duration of PR interval	-0.29276	0.57221	-0.20288	0.938	0.610
EKG	duration of QRS interval	0.10043	0.26003	0.14355	0.967	0.700
EKG	duration of QT interval	-1.0082	0.69429	-0.80152	0.665	0.150
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	-1.0971	0.67438	-1.0524	0.687	0.107
EKG	duration of RR interval	0.094961	1.2951	0.28595	0.973	0.942
EKG	duration of ST interval	-1.2078	0.63835	-0.93990	0.513	0.0613
EKG	heart rate coefficient of variation (signal intensity)	0.96367	0.94814	0.87010	0.863	0.312
EKG	heart rate variability, mean of differences between sequential beats; beats per min	6.9265	6.8409	0.88193	0.853	0.314
EKG	heart rate, beats per min	0.13446	10.523	-0.24129	0.994	0.990
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	-0.13002	0.082641	-1.1402	0.456	0.119
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	-0.17428	0.10690	-1.0768	0.438	0.106
EKG	number of signals	6.8010	3.2204	1.2216	0.460	0.0371
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	1.8191	4.4465	0.40777	0.943	0.683
EKG	QT dispersion, measured as inter-lead variability of QT intervals	1.5795	2.5169	0.48367	0.955	0.532
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	0.54478	2.8385	0.15782	0.975	0.848
EKG	root mean square of successive differences of neighboring RR intervals	0.38109	1.5950	0.31758	0.956	0.812
electroretinography	a-wave amplitude of rod photoreceptors, right	20.470	21.960	0.70988	0.758	0.404
electroretinography	b-wave amplitude of cone photoreceptors, left	-0.97639	10.609	-0.10702	0.995	0.931
electroretinography	b-wave amplitude of cone photoreceptors, right	-0.95000	5.1551	0.056359	0.981	0.863
electroretinography	b-wave amplitude of rod photoreceptors, left	-32.275	18.589	-0.20447	0.593	0.158
electroretinography	b-wave amplitude of rod photoreceptors, right	-72.100	47.800	-0.99768	0.546	0.206
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), left	1.5000	0.80623	1.2968	0.507	0.136
electroretinography	b-wave implicit time of rod photoreceptors (interval from onset of stimulus to peak of the wave), right	1.1626	0.54890	1.1310	0.499	0.124
electroretinography	rod a wave implicit time, left	1.0000	0.54772	0.88785	0.540	0.142
electroretinography	rod b wave implicit time, left	1.9385	0.70915	0.83546	0.468	0.0717
glucose tolerance test	amount glucose injected	-1.2758	1.5007	-0.019939	0.741	0.399
glucose tolerance test	plasma glucose, 0min	5.5807	3.3164	0.33275	0.254	0.0975
glucose tolerance test	plasma glucose, 15min	17.337	20.656	0.61119	0.717	0.405
glucose tolerance test	plasma glucose, 30min	12.050	17.827	0.46819	0.771	0.502
glucose tolerance test	plasma glucose, 60min	29.280	11.519	1.2558	0.145	0.0135
glucose tolerance test	plasma glucose, 120min	21.418	9.3052	1.2992	0.205	0.0247
grip strength	body weight (at time of grip strength test)	0.26394	0.38963	0.47249	0.684	0.501
grip strength	forelimb and hindlimb grip strength (mean of trials), average	1.8710	5.8572	0.37611	0.870	0.751
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.027876	0.34012	0.23748	0.961	0.935
grip strength	forelimb and hindlimb grip strength by trial, trial1	15.393	8.6339	1.2802	0.292	0.0801
grip strength	forelimb and hindlimb grip strength by trial, trial2	-4.5567	7.4644	-0.053760	0.769	0.544
grip strength	forelimb and hindlimb grip strength by trial, trial3	-2.3146	8.2121	0.061033	0.909	0.779
grip strength	forelimb grip strength (mean of trials), average	-8.6574	4.3825	-0.79334	0.215	0.0532
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.50824	0.25002	-1.0312	0.205	0.0469
grip strength	forelimb grip strength by trial, trial1	-5.4282	5.8641	-0.36677	0.689	0.359
grip strength	forelimb grip strength by trial, trial2	-7.5763	6.3902	-0.60935	0.562	0.241
grip strength	forelimb grip strength by trial, trial3	-10.844	6.1928	-0.88849	0.345	0.0855
heart weight	heart weight, normalized to body weight	0.43973	0.13450	0.96133	0.0166	0.00142
heart weight	heart weight, weight	8.8774	3.3238	0.78519	0.0610	0.00865
hematology	basophil differential (percent of total WBC)	-0.081693	0.043237	-1.1120	0.429	0.0638
hematology	calculated hemoglobin (cHGB)	-0.029906	0.19084	-0.37915	0.951	0.876
hematology	eosinophil differential (percent of total WBC)	0.080866	0.29710	0.31630	0.932	0.786
hematology	hematocrit (HCT)	0.22238	0.55281	-0.13986	0.852	0.689
hematology	hemoglobin concentration distribution width (HDW)	0.022884	0.020478	0.63252	0.576	0.268
hematology	large unstained cells (percent of total WBC)	0.089187	0.080007	0.57471	0.608	0.270
hematology	lymphocyte differential (percent of total WBC)	-1.6772	1.1926	-0.76390	0.416	0.165
hematology	mean corpuscular hemoglobin (CHr)	-0.16382	0.069883	-1.2762	0.101	0.0225
hematology	mean platelet volume (MPV)	-0.062821	0.058424	-0.61164	0.512	0.287
hematology	mean RBC corpuscular hemoglobin (MCH)	0.15859	0.34396	0.58888	0.855	0.646
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.66786	0.77378	1.2332	0.735	0.392
hematology	mean RBC corpuscular volume (MCV)	-0.12443	0.34436	-0.22185	0.866	0.719
hematology	measured hemoglobin (mHGB)	0.082575	0.42655	-0.034878	0.934	0.847
hematology	monocyte differential (percent of total WBC)	-0.084025	0.17199	-0.062912	0.859	0.627
hematology	neutrophil differential (percent of total WBC)	1.7321	1.0120	0.88083	0.294	0.0923
hematology	platelet count (PLT; units per volume x 10³)	10.421	33.314	0.18835	0.912	0.756
hematology	RBC corpuscular distribution width (RDW)	0.32791	0.17547	1.0829	0.257	0.0667
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	-0.31603	0.19809	-0.87687	0.324	0.116
hematology	red blood cell count (RBC; per volume x 10⁶)	0.11625	0.15266	0.16910	0.692	0.449
hematology	reticulocyte count (Retic; units per volume x 10⁹)	11.017	14.455	0.57310	0.783	0.449
hematology	reticulocyte differential (percent of total RBC)	0.12598	0.15666	0.72759	0.747	0.425
hematology	white blood cell count (WBC; units per volume x 10³)	-1.2877	0.74073	-0.70658	0.235	0.0874
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.34160	0.74623	0.39032	0.897	0.648
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.88285	0.52004	-1.2607	0.612	0.0934
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.40664	0.60774	-0.61679	0.878	0.505
holeboard	number of hole pokes by individual hole number, 20 min test, 4	-0.90809	0.85677	-0.85858	0.739	0.292
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.80872	0.59926	-1.2065	0.683	0.181
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.46873	0.38033	-1.3233	0.834	0.221
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.19941	0.35205	0.54370	0.936	0.573
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.19532	0.50109	-0.20827	0.943	0.698
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.75843	0.42839	-1.2061	0.506	0.0804
holeboard	number of hole pokes by individual hole number, 20 min test, 10	0.016228	0.38160	0.12038	0.993	0.966
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.30006	0.34625	-0.79395	0.839	0.389
holeboard	number of hole pokes by individual hole number, 20 min test, 12	-0.65478	0.47861	-1.0218	0.620	0.175
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.83681	1.0603	-0.73615	0.773	0.432
holeboard	number of hole pokes by individual hole number, 20 min test, 14	0.32536	0.49136	0.61530	0.845	0.510
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.35872	0.49578	-0.46492	0.847	0.471
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-0.69558	0.99111	-0.56708	0.816	0.485
holeboard	total number of hole pokes, 20 min test	-7.9883	4.4316	-1.0654	0.301	0.0751
insulin blood level	insulin (plasma)	-167.84	226.75	-0.23074	0.741	0.460
light / dark	fecal boli count, 20 min test	1.6715	0.59924	1.6512	0.182	0.00618
light / dark	latency to enter dark zone, 20 min test	60.469	30.637	0.95242	0.426	0.0510
light / dark	number of transitions between light and dark zones, 20 min test	-29.211	6.4302	-2.3374	0.00232	0.0000138
light / dark	percentage of total time in dark zone, 20 min test	-4.6600	4.4803	-0.71843	0.659	0.301
light / dark	percentage of total time in light zone, 20 min test	4.6600	4.4803	0.71668	0.659	0.301
light / dark	time mobile in dark zone, 20 min test	-46.293	10.427	-2.3171	0.000957	0.0000207
light / dark	time mobile in light zone, 20 min test	-15.965	9.7957	-1.3571	0.318	0.106
light / dark	time spent in dark zone, 20 min test	-138.79	52.411	-1.6485	0.171	0.00922
light / dark	time spent in light zone, 20 min test	138.79	52.411	1.6485	0.171	0.00922
open field	average speed in center of arena, 20 min test	-0.20389	0.33805	-0.44304	0.811	0.548
open field	average speed in periphery of arena, 20 min test	-0.21913	0.13672	-1.3310	0.281	0.112
open field	distance traveled habituation ratio, 20 min test	10.594	8.2831	0.86950	0.524	0.204
open field	distance traveled in center of arena, 20 min test	-210.22	72.247	-1.6415	0.0432	0.00450
open field	distance traveled in periphery of arena, 20 min test	-117.08	129.92	-0.91141	0.616	0.370
open field	distance traveled slope, 20 min test	8.6687	7.6927	0.78080	0.593	0.263
open field	distance traveled, 20 min test, 1st 5min	-137.35	77.512	-1.3815	0.252	0.0796
open field	distance traveled, 20 min test, 2nd 5min	-56.810	46.860	-1.1410	0.464	0.228
open field	distance traveled, 20 min test, 3rd 5min	-87.677	48.059	-1.3609	0.240	0.0712
open field	distance traveled, 20 min test, 4th 5min	-28.899	44.413	-0.78993	0.740	0.517
open field	number of clockwise revolution episodes, 20 min test	-0.69482	0.95938	-0.84009	0.771	0.471
open field	number of counter-clockwise revolution episodes, 20 min test	-2.0333	1.1255	-1.5549	0.298	0.0739
open field	number of fecal boli, 20 min test	-1.5323	0.85281	-0.97178	0.324	0.0755
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-4.5540	2.1695	-1.4356	0.191	0.0385
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-6.1681	2.1844	-1.7740	0.0641	0.00577
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-4.4653	2.0797	-1.3278	0.181	0.0343
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-1.1917	2.3711	-0.60327	0.810	0.616
open field	percentage of total time in center of arena, 20 min test	-3.8933	2.2646	-1.1968	0.367	0.0888
open field	percentage of total time in center of arena, slope, 20 min test	-2.9974	1.2823	-1.3921	0.353	0.0215
open field	percentage of total time in center, habituation ratio, 20 min test	-3.3195	1.3020	-1.4866	0.295	0.0124
open field	percentage of total time in corners of arena, 20 min test	6.6913	3.5335	1.4989	0.308	0.0613
open field	percentage of total time in corners, habituation ratio, 20 min test	3.0427	1.5179	1.0365	0.448	0.0479
open field	percentage of total time in corners, slope, 20 min test	2.7923	1.5049	1.0005	0.499	0.0666
open field	permanence time in center of arena, 20 min test	-46.724	27.176	-1.1968	0.367	0.0888
open field	permanence time in corners of arena, 20 min test	80.302	42.402	1.4989	0.308	0.0613
open field	permanence time in periphery of arena, 20 min test	46.730	27.175	1.1940	0.367	0.0887
open field	total distance traveled, 20 min test	-327.30	172.22	-1.3956	0.187	0.0604
open field	total number of rears, 20 min test	-15.586	7.4292	-1.3885	0.176	0.0386
open field	whole arena average speed, 20 min test	-0.27261	0.14358	-1.3921	0.188	0.0606
open field	whole arena resting time, 20 min test	30.879	15.337	1.4247	0.156	0.0469
open field	whole arena time spent mobile, 20 min test	-30.967	15.337	-1.6572	0.156	0.0463
open field	whole arena time spent vertical, 20 min test	-14.236	7.2892	-1.1805	0.273	0.0538
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	6.1185	9.8011	0.79516	0.901	0.534
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	2.8638	3.0464	1.0418	0.840	0.349
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-0.25590	9.0188	0.27754	0.997	0.977
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	11.212	13.448	1.0653	0.838	0.406
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-2.6712	1.4445	-0.93385	0.307	0.0698
sleep	differential wake percentages during light and dark phase	-1.1366	0.60007	-1.4825	0.446	0.0638
sleep	mean breath rate during-sleep	-0.22129	0.071838	-1.6179	0.0337	0.00330
sleep	mean of sleep bout lengths	-102.42	22.636	-1.9040	0.00434	0.0000354
sleep	mean of sleep bout lengths with lights off	-71.400	18.782	-1.7918	0.0232	0.000379
sleep	mean of sleep bout lengths with lights on	-101.15	33.079	-1.7432	0.144	0.00352
sleep	mean percentage of time sleeping over 24 h periods	-1.2747	1.1574	-1.0701	0.827	0.276
sleep	mean percentage of time sleeping with lights on	-1.9902	1.4384	-0.80163	0.528	0.172
sleep	mean percentage of time spent sleeping with lights off	-0.61504	1.7839	-0.61798	0.951	0.732
sleep	peak wake with respect to dark onset median	0.13719	0.60377	0.25756	0.963	0.821
sleep	percentage of time awake one hour before and after light onset	-6.6842	4.2767	-0.70683	0.454	0.124
sleep	sleep data confidence level (<0.6=questionable; 1=good quality)	-0.0049878	0.0092134	-0.36072	0.938	0.591
startle / PPI	average baseline movement during background noise	-3.2098	1.2285	-2.0747	0.372	0.0125
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.025653	0.083569	0.11867	0.900	0.760
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.026142	0.082680	0.18694	0.904	0.753
startle / PPI	average of maximum percent pre-pulse inhibition for each pre-pulse tested	2.8263	9.7256	0.29285	0.919	0.773
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-2.9216	9.0315	-0.26436	0.964	0.748
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	4.9892	9.4630	0.44977	0.845	0.601
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.4183	7.3446	0.26001	0.859	0.644
startle / PPI	average startle response to full pulse (120 dB)	41.615	22.239	1.0089	0.219	0.0683
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	44.714	21.290	1.0042	0.157	0.0418
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	25.940	22.775	0.73971	0.480	0.261
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	17.688	19.417	0.61456	0.586	0.368
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-0.50500	1.2537	-0.31256	0.946	0.689
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-1.1346	0.99256	-0.78658	0.777	0.259
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	-1.0876	1.2607	-0.73971	0.767	0.393
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.012766	0.097414	-0.090496	0.990	0.896
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.055321	0.10333	0.38147	0.838	0.595
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.035872	0.082071	0.13499	0.851	0.664
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	44.921	22.541	1.0567	0.185	0.0528
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	45.330	21.359	1.0042	0.153	0.0398
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	27.252	23.144	0.76763	0.463	0.246
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	18.761	19.805	0.64014	0.565	0.349
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-0.023575	0.095843	-0.18103	0.971	0.807
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.059090	0.10966	0.37598	0.812	0.593
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.041445	0.082094	0.13075	0.816	0.616
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	144.89	88.306	0.96779	0.294	0.108
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	144.15	80.713	0.91541	0.249	0.0813
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	84.243	90.054	0.65050	0.574	0.355
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	63.468	74.793	0.58936	0.606	0.401
startle / PPI	maximum baseline movement during background noise	-7.5331	2.5406	-1.8947	0.270	0.00497
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-3.7239	9.1525	-0.33323	0.951	0.686
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	5.5996	10.290	0.42663	0.831	0.589
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	3.3477	7.4574	0.17534	0.847	0.656
startle / PPI	maximum startle response to full pulse (120 dB)	137.02	87.727	0.93042	0.323	0.126
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	142.84	80.533	0.91541	0.251	0.0834
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	80.528	89.418	0.63157	0.594	0.373
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	62.367	73.755	0.58105	0.608	0.403
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-1.0344	2.7969	-0.22969	0.942	0.713
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-3.4802	2.6077	-0.96779	0.696	0.189
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	-0.68729	3.1917	-0.30962	0.940	0.831
tail suspension	duration of immobility, 5 min test	7.0280	12.726	-0.16218	0.776	0.585
tail suspension	latency to immobility, 5 min test	0.41308	7.9501	0.47905	0.999	0.959
urinalysis	albumin-creatinine ratio (urine ACR)	0.72450	1.9626	-0.46403	0.818	0.713
urinalysis	creatinine (urine CREA)	0.66451	4.9510	0.72650	0.957	0.894
urinalysis	glucose (urine GLU)	-1.3062	3.3686	-0.48191	0.905	0.699
urinalysis	magnesium level (urine Mg)	0.10040	0.13212	1.8428	0.770	0.449
urinalysis	microalbumin (urine MA), calculated	0.10043	0.15799	0.094653	0.809	0.527

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

In this plot, data points are the computed genotype effect % vs. C57BL/6NJ controls, for all measured categorical phenotypes in JaxKOMP-EAP

Dimensions Width: × Height: px

Plot Options Group by Procedure

Significance Threshold p-Value Threshold

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Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value

electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	5.0 %	0.344
eye morphology	cornea opacity	3.0 %	1.00
eye morphology	cornea vascularization	2.0 %	1.00
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	2.0 %	1.00
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	1.0 %	1.00
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.0
eye morphology	fusion between cornea and lens	3.0 %	1.00
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.00
eye morphology	lacrimation	3.0 %	1.0
eye morphology	lens	16.0 %	0.0267
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.0
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	5.0 %	0.564
eye morphology	pupil dilation	2.0 %	1.0
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.00
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	7.0 %	0.663
eye morphology	retinal blood vessels	3.0 %	1.0
eye morphology	retinal blood vessels pattern	6.0 %	0.207
eye morphology	retinal blood vessels structure	3.0 %	1.00
eye morphology	retinal pigmentation	7.0 %	0.889
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	6.0 %	0.0139
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	5.0 %	0.110
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.00
SHIRPA	coat color abdomen	4.0 %	1.0
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.00
SHIRPA	coat color pattern abdomen	5.0 %	0.102
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.0
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	48.0 %	2.10e-7
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.0
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.00
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.0
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.00
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.0
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	6.0 %	0.00323
SHIRPA	hindlimb nail length	0.0 %	1.0
SHIRPA	hindlimb nail number	0.0 %	1.0
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	10.0 %	0.123
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.0
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	0.0 %	1.0
SHIRPA	startle response	0.0 %	1.0
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	touch escape	14.0 %	1.0
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	6.0 %	0.0279
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.0
tail suspension	climbing, 5 min test (yes, no)	78.0 %	0.00000579

GENOTYPE CORRELATION PLOT

Correlate Dnajc7^{tm1b(KOMP)Wtsi} -/- with genotype: