MPD: JaxKOMP-EAP genotype: Cnbp<sup>tm1b(KOMP)Wtsi</sup> -/+

JaxKOMP-EAP effect sizes: Cnbp^{tm1b(KOMP)Wtsi} -/+ Gene Cnbp

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 6 kHz pip	-0.96809	2.2775	-0.55607	0.903	0.680
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 12 kHz pip	-0.76431	3.2349	-0.16153	0.949	0.818
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 18 kHz pip	-4.5680	3.0940	-1.1169	0.530	0.171
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 24 kHz pip	8.9663	1.8038	1.2536	0.0277	0.000561
ABR test	auditory brainstem response (ABR) threshold, sound pressure level, 30 kHz pip	3.8956	4.1912	0.59893	0.711	0.375
body composition	body length	-0.015603	0.055333	0.010301	0.907	0.779
body composition	body weight (at time of DXA)	-2.2108	0.41333	-1.3352	0.0000952	0.00000270
body composition	bone area, whole body scan, head excluded	0.24211	0.19828	1.2322	0.497	0.228
body composition	bone mineral content of whole body scan, head excluded	0.0059879	0.013953	0.47918	0.852	0.670
body composition	bone mineral content to body weight ratio	0.00051827	0.00047508	0.88160	0.557	0.281
body composition	bone mineral density of whole body scan, head excluded	-0.00059877	0.00070272	-0.65701	0.685	0.399
body composition	fat tissue mass of whole body scan, head excluded	-0.47467	0.34890	-0.90397	0.416	0.180
body composition	fat tissue mass to body weight ratio	-0.021834	0.010363	-1.0007	0.165	0.0406
body composition	lean tissue mass of whole body scan, head excluded	0.18180	0.34567	0.22161	0.825	0.602
body composition	lean tissue mass to body weight ratio	0.012295	0.0099892	0.60862	0.480	0.225
body composition	percent fat, whole body scan, head excluded	-2.0644	1.0197	-1.0007	0.185	0.0487
body composition	ratio of soft-tissue attenuation coefficients	0.0022996	0.0011336	1.0083	0.187	0.0483
body composition	tissue area	0.12995	0.20506	0.62304	0.798	0.529
body composition	total tissue mass, whole body scan, head excluded	-0.22530	0.23645	-0.73756	0.598	0.346
clinical blood chemistry	alanine transaminase (plasma ALT)	13.549	25.361	0.91627	0.864	0.598
clinical blood chemistry	albumin (plasma Alb)	-1.8522	0.45019	-2.1185	0.0193	0.000395
clinical blood chemistry	alkaline phosphatase (plasma ALP)	3.9870	3.4582	0.18454	0.513	0.260
clinical blood chemistry	aspartate transaminase (plasma AST)	34.409	27.441	1.1726	0.542	0.222
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.091559	0.34750	0.31752	0.933	0.795
clinical blood chemistry	blood urea nitrogen (BUN)	-6.1611	4.3687	-1.9771	0.421	0.175
clinical blood chemistry	calcium (plasma Ca)	-0.089762	0.10944	-0.29053	0.653	0.420
clinical blood chemistry	carbon dioxide (plasma CO₂)	-0.78515	0.90536	-1.0238	0.654	0.394
clinical blood chemistry	chloride (plasma Cl)	3.1655	0.65162	2.0730	0.00125	0.0000596
clinical blood chemistry	glucose (plasma GLU, no fast)	-2.0339	16.688	0.22835	0.946	0.904
clinical blood chemistry	HDL cholesterol (plasma HDL)	-3.1175	3.8560	-0.99223	0.710	0.427
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	-0.020050	0.013681	-1.1931	0.483	0.156
clinical blood chemistry	iron (plasma Fe)	0.0055534	0.010606	0.47695	0.805	0.606
clinical blood chemistry	non-esterified fatty acids (plasma NEFA)	-0.10518	0.12783	-0.86489	0.664	0.421
clinical blood chemistry	phosphorus (plasma phosphate)	0.35612	0.36166	0.47866	0.627	0.336
clinical blood chemistry	potassium (plasma K)	0.77575	0.16102	1.8738	0.00314	0.0000660
clinical blood chemistry	sodium (plasma Na)	1.3882	0.79051	0.39434	0.176	0.0918
clinical blood chemistry	total bilirubin (plasma TBIL)	0.039957	0.010980	2.0234	0.0339	0.00130
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	-7.3526	5.7852	-1.3292	0.528	0.216
clinical blood chemistry	total protein (plasma TP)	-3.1360	0.99851	-1.9788	0.0659	0.00494
clinical blood chemistry	triglyceride (plasma TG, no fast)	-22.928	16.529	-0.99521	0.462	0.181
EKG	duration of PQ interval	-0.019791	0.92229	0.12932	0.995	0.983
EKG	duration of PR interval	-0.21928	1.1027	-0.11308	0.968	0.844
EKG	duration of QRS interval	0.12942	0.37270	0.22349	0.967	0.732
EKG	duration of QT interval	1.0962	1.2585	1.1924	0.858	0.394
EKG	duration of QTC interval, calculated by dividing QT interval by square root of preceding RR interval	0.50250	1.1630	0.62227	0.946	0.670
EKG	duration of RR interval	2.2731	1.9061	1.3356	0.672	0.247
EKG	duration of ST interval	1.0037	1.1398	1.2519	0.810	0.388
EKG	heart rate coefficient of variation (signal intensity)	1.9574	1.3893	1.6310	0.841	0.173
EKG	heart rate variability, mean of differences between sequential beats; beats per min	12.926	10.282	1.5390	0.853	0.223
EKG	heart rate, beats per min	-13.861	14.355	-1.1597	0.737	0.346
EKG	mean R amplitude, mean amplitude of signal measured from isoelectric line to peak of QRS	0.13871	0.11357	0.93000	0.607	0.236
EKG	mean SR amplitude, mean amplitude of signal measured from signal minimum line to peak of QRS	0.13950	0.14998	0.71492	0.698	0.363
EKG	number of signals	1.6976	4.1934	0.30911	0.934	0.690
EKG	proportion of number pairs of successive beat-to-beat intervals that exceed 50 ms	10.303	6.2267	1.8027	0.791	0.113
EKG	QT dispersion, measured as inter-lead variability of QT intervals	3.8047	2.8953	1.0630	0.867	0.204
EKG	QTc dispersion, calculated as rate-corrected QT dispersion	5.2546	3.7784	1.2475	0.856	0.179
EKG	root mean square of successive differences of neighboring RR intervals	0.51143	2.4276	0.41018	0.962	0.835
glucose tolerance test	amount glucose injected	-0.38767	4.5216	0.25647	0.976	0.932
glucose tolerance test	plasma glucose, 0min	1.7193	5.8609	-0.056312	0.885	0.772
glucose tolerance test	plasma glucose, 15min	-45.902	28.178	-1.1457	0.400	0.115
glucose tolerance test	plasma glucose, 30min	-28.776	20.365	-0.76983	0.507	0.169
glucose tolerance test	plasma glucose, 60min	-36.291	16.807	-1.4017	0.238	0.0402
glucose tolerance test	plasma glucose, 120min	23.416	7.0127	1.4091	0.0609	0.00246
grip strength	body weight (at time of grip strength test)	-2.0010	0.48710	-1.4544	0.00558	0.000502
grip strength	forelimb and hindlimb grip strength (mean of trials), average	-2.5083	11.059	0.053760	0.906	0.823
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.86014	0.56246	1.4496	0.319	0.141
grip strength	forelimb and hindlimb grip strength by trial, trial1	4.5306	17.681	0.56279	0.927	0.800
grip strength	forelimb and hindlimb grip strength by trial, trial2	-8.2000	14.960	-0.25995	0.796	0.589
grip strength	forelimb and hindlimb grip strength by trial, trial3	-1.4750	11.924	0.11206	0.958	0.903
grip strength	forelimb grip strength (mean of trials), average	-4.0833	4.5476	-0.25995	0.634	0.379
grip strength	forelimb grip strength (mean of trials), average normalized to bw	-0.20013	0.30736	-0.28255	0.763	0.522
grip strength	forelimb grip strength by trial, trial1	-13.890	7.4367	-1.2511	0.334	0.0758
grip strength	forelimb grip strength by trial, trial2	-0.073492	9.4897	0.19881	0.996	0.994
grip strength	forelimb grip strength by trial, trial3	-9.0427	10.274	-0.72552	0.706	0.389
heart weight	heart weight, normalized to body weight	0.053632	0.20479	-0.25754	0.890	0.794
heart weight	heart weight, weight	-11.587	4.9367	-1.8255	0.111	0.0225
hematology	basophil differential (percent of total WBC)	0.0027996	0.13465	0.068691	0.997	0.984
hematology	calculated hemoglobin (cHGB)	-1.0496	1.2028	-2.2210	0.662	0.396
hematology	eosinophil differential (percent of total WBC)	-0.19795	0.31570	-0.48387	0.853	0.539
hematology	hematocrit (HCT)	-4.4307	4.2703	-2.5123	0.603	0.315
hematology	hemoglobin concentration distribution width (HDW)	-0.016428	0.024967	-0.43582	0.757	0.520
hematology	large unstained cells (percent of total WBC)	-0.027483	0.14248	-0.17547	0.934	0.849
hematology	lymphocyte differential (percent of total WBC)	-1.0758	2.2680	-0.50288	0.812	0.642
hematology	mean corpuscular hemoglobin (CHr)	-0.31850	0.078397	-1.8922	0.00991	0.000905
hematology	mean platelet volume (MPV)	-0.36283	0.15105	-1.7324	0.121	0.0297
hematology	mean RBC corpuscular hemoglobin (MCH)	1.4913	1.3232	2.5389	0.628	0.276
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	4.8070	2.8570	3.0638	0.439	0.112
hematology	mean RBC corpuscular volume (MCV)	-1.7969	0.45713	-2.1356	0.0137	0.00133
hematology	measured hemoglobin (mHGB)	0.29429	1.8191	0.54475	0.947	0.874
hematology	monocyte differential (percent of total WBC)	-0.026087	0.24138	0.12194	0.969	0.915
hematology	neutrophil differential (percent of total WBC)	1.2575	2.2062	0.65319	0.764	0.577
hematology	platelet count (PLT; units per volume x 10³)	-100.51	118.68	-1.1807	0.733	0.410
hematology	RBC corpuscular distribution width (RDW)	0.010591	0.22944	0.026728	0.986	0.964
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.58386	0.32158	1.3222	0.276	0.0895
hematology	red blood cell count (RBC; per volume x 10⁶)	-0.65429	0.95503	-2.1351	0.730	0.503
hematology	reticulocyte count (Retic; units per volume x 10⁹)	-37.025	37.588	-1.3656	0.715	0.339
hematology	reticulocyte differential (percent of total RBC)	-0.23260	0.24944	-0.79149	0.712	0.366
hematology	white blood cell count (WBC; units per volume x 10³)	3.1066	0.96689	2.0391	0.0394	0.00581
holeboard	number of hole pokes by individual hole number, 20 min test, 1	1.7515	0.91658	1.5331	0.485	0.0656
holeboard	number of hole pokes by individual hole number, 20 min test, 2	-0.033886	0.58363	0.066724	0.990	0.954
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.11918	0.34967	-0.083652	0.941	0.736
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.20105	0.62391	0.27783	0.926	0.750
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.90512	0.66764	-1.3476	0.689	0.185
holeboard	number of hole pokes by individual hole number, 20 min test, 6	-0.19264	0.34870	-0.52983	0.930	0.585
holeboard	number of hole pokes by individual hole number, 20 min test, 7	0.19646	0.40639	0.53393	0.958	0.632
holeboard	number of hole pokes by individual hole number, 20 min test, 8	0.085617	0.54364	0.27257	0.985	0.876
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.67846	0.58108	-1.0887	0.732	0.252
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.62274	0.47448	-1.6792	0.748	0.199
holeboard	number of hole pokes by individual hole number, 20 min test, 11	0.31024	0.51343	0.75071	0.899	0.550
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.46018	0.57724	0.83730	0.823	0.432
holeboard	number of hole pokes by individual hole number, 20 min test, 13	1.0949	1.0629	1.1238	0.722	0.311
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.71009	0.48376	-1.0595	0.581	0.153
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.022668	0.47194	0.065834	0.985	0.962
holeboard	number of hole pokes by individual hole number, 20 min test, 16	0.98569	1.0183	0.87626	0.730	0.341
holeboard	total number of hole pokes, 20 min test	0.82530	5.4437	0.20038	0.946	0.881
light / dark	fecal boli count, 20 min test	-1.1585	0.83246	-1.2843	0.581	0.172
light / dark	latency to enter dark zone, 20 min test	-2.4534	26.085	-0.15885	0.975	0.926
light / dark	number of transitions between light and dark zones, 20 min test	-12.445	6.8375	-1.1576	0.340	0.0762
light / dark	percentage of total time in dark zone, 20 min test	5.3979	3.8721	1.1264	0.550	0.171
light / dark	percentage of total time in light zone, 20 min test	-5.3979	3.8721	-1.1290	0.551	0.171
light / dark	time mobile in dark zone, 20 min test	14.100	15.935	0.71668	0.674	0.382
light / dark	time mobile in light zone, 20 min test	-18.582	9.6313	-1.5206	0.244	0.0608
light / dark	time spent in dark zone, 20 min test	64.471	42.674	1.1982	0.557	0.139
light / dark	time spent in light zone, 20 min test	-64.471	42.674	-1.1982	0.557	0.139
open field	average speed in center of arena, 20 min test	0.097375	0.34911	0.082664	0.925	0.781
open field	average speed in periphery of arena, 20 min test	-0.17100	0.13074	-1.1778	0.406	0.197
open field	distance traveled habituation ratio, 20 min test	2.9518	8.7849	0.29209	0.893	0.738
open field	distance traveled in center of arena, 20 min test	-131.71	92.212	-1.2134	0.398	0.159
open field	distance traveled in periphery of arena, 20 min test	-49.254	128.39	-0.62597	0.844	0.703
open field	distance traveled slope, 20 min test	1.9870	8.5553	0.25723	0.940	0.817
open field	distance traveled, 20 min test, 1st 5min	-72.280	82.742	-0.89928	0.633	0.387
open field	distance traveled, 20 min test, 2nd 5min	-14.895	55.242	-0.67913	0.901	0.789
open field	distance traveled, 20 min test, 3rd 5min	-38.706	42.309	-0.88528	0.621	0.365
open field	distance traveled, 20 min test, 4th 5min	-81.636	48.952	-1.3677	0.287	0.102
open field	number of clockwise revolution episodes, 20 min test	0.46798	1.2061	-0.13067	0.890	0.700
open field	number of counter-clockwise revolution episodes, 20 min test	-2.0802	1.0427	-1.5967	0.245	0.0514
open field	number of fecal boli, 20 min test	-0.70032	0.96716	-0.27749	0.747	0.472
open field	number of rears in 5 min bins, 20 min test, 1st 5min	-4.9482	2.3167	-1.5196	0.189	0.0376
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	-6.3901	2.2751	-1.8006	0.0729	0.00703
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	-8.3953	2.7481	-1.9948	0.0477	0.00360
open field	number of rears in 5 min bins, 20 min test, 4th 5min	-9.1970	2.8892	-2.2306	0.0433	0.00248
open field	percentage of total time in center of arena, 20 min test	-3.8215	2.7637	-1.1698	0.486	0.173
open field	percentage of total time in center of arena, slope, 20 min test	-2.0526	1.2944	-0.95287	0.574	0.119
open field	percentage of total time in center, habituation ratio, 20 min test	-2.7251	1.2462	-1.2362	0.405	0.0335
open field	percentage of total time in corners of arena, 20 min test	7.5152	4.2409	1.6015	0.360	0.0825
open field	percentage of total time in corners, habituation ratio, 20 min test	4.4476	1.6412	1.5871	0.222	0.00914
open field	percentage of total time in corners, slope, 20 min test	3.9541	1.6073	1.4826	0.303	0.0173
open field	permanence time in center of arena, 20 min test	-45.855	33.164	-1.1698	0.487	0.173
open field	permanence time in corners of arena, 20 min test	90.207	50.888	1.6015	0.360	0.0824
open field	permanence time in periphery of arena, 20 min test	45.876	33.170	1.1671	0.486	0.173
open field	total distance traveled, 20 min test	-244.97	176.79	-1.1618	0.367	0.172
open field	total number of rears, 20 min test	-27.156	8.5592	-2.0357	0.0311	0.00258
open field	whole arena average speed, 20 min test	-0.20453	0.14715	-1.1644	0.365	0.171
open field	whole arena resting time, 20 min test	16.632	17.004	1.0388	0.536	0.333
open field	whole arena time spent mobile, 20 min test	-16.533	17.003	-1.2219	0.548	0.335
open field	whole arena time spent vertical, 20 min test	-36.961	7.6254	-2.4592	0.00108	0.0000121
rotarod	learning difference on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-14.163	11.779	-0.94612	0.779	0.237
rotarod	learning slope on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-6.0121	3.8688	-1.2898	0.738	0.128
rotarod	mean duration on accelerating rotarod (4-40 rpm/5 min) over 5 trials	-1.9054	9.1212	0.089965	0.953	0.836
rotarod	mean latency to fall off accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	-18.503	15.773	-0.84547	0.788	0.248
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	-4.6152	2.0398	-1.6864	0.212	0.0344
sleep	differential wake percentages during light and dark phase	-0.34102	0.50000	-0.22608	0.810	0.504
sleep	mean breath rate during-sleep	-0.0080431	0.080465	0.091835	0.969	0.922
sleep	mean of sleep bout lengths	-57.092	48.271	-1.1260	0.573	0.254
sleep	mean of sleep bout lengths with lights off	-28.807	37.456	-0.78766	0.760	0.453
sleep	mean of sleep bout lengths with lights on	-60.016	41.807	-0.91971	0.562	0.169
sleep	mean percentage of time sleeping over 24 h periods	1.7398	1.5532	1.0174	0.827	0.278
sleep	mean percentage of time sleeping with lights on	1.9088	2.4958	0.90427	0.853	0.455
sleep	mean percentage of time spent sleeping with lights off	1.5743	1.7322	0.40847	0.794	0.376
sleep	peak wake with respect to dark onset median	1.1430	0.40642	1.4526	0.420	0.0120
sleep	percentage of time awake one hour before and after light onset	6.1768	7.6482	1.3699	0.746	0.431
sleep	sleep data confidence level (<0.6=questionable; 1=good quality)	-0.0088063	0.0044528	-0.77791	0.700	0.0644
startle / PPI	average baseline movement during background noise	-2.1569	1.4127	-1.4644	0.674	0.134
startle / PPI	average of each corrected maximum percent pre-pulse inhibition value	0.15310	0.065966	1.2289	0.236	0.0253
startle / PPI	average of each corrected percent pre-pulse inhibition value	0.14415	0.067329	1.2934	0.279	0.0383
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	7.0827	7.5837	0.81165	0.879	0.356
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	12.173	7.1216	1.1882	0.428	0.0950
startle / PPI	average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	9.8536	6.7579	0.89014	0.429	0.152
startle / PPI	average startle response to full pulse (120 dB)	-63.384	26.696	-0.90270	0.113	0.0223
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-41.367	34.351	-0.58437	0.475	0.236
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-58.082	24.525	-0.90060	0.105	0.0227
startle / PPI	average startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-44.719	20.994	-0.82339	0.159	0.0392
startle / PPI	average startle response to pre-pulse, 74dB sound pressure level	-1.0542	0.99429	-0.71778	0.785	0.295
startle / PPI	average startle response to pre-pulse, 78dB sound pressure level	-0.83783	1.1188	-0.57112	0.866	0.458
startle / PPI	average startle response to pre-pulse, 82dB sound pressure level	0.54945	1.0892	0.089090	0.895	0.617
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.10103	0.082995	0.98814	0.852	0.230
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.15751	0.079117	1.2463	0.318	0.0532
startle / PPI	corrected average percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.19183	0.081505	1.2777	0.138	0.0235
startle / PPI	corrected average startle response to full pulse (120 dB) minus average baseline movement during background noise	-61.266	26.720	-0.87360	0.125	0.0271
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 74dB sound pressure level	-40.120	34.187	-0.55962	0.486	0.248
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 78dB sound pressure level	-57.178	24.286	-0.88806	0.106	0.0234
startle / PPI	corrected average startle response to pre-pulse and full pulse (120 dB) minus average startle response to same pre-pulse, 82dB sound pressure level	-45.124	21.033	-0.80582	0.152	0.0379
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	0.11960	0.083055	1.0616	0.804	0.157
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	0.18316	0.078560	1.3614	0.229	0.0247
startle / PPI	corrected maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	0.19054	0.080799	1.1822	0.137	0.0232
startle / PPI	corrected maximum startle response to full pulse (120 dB) minus maximum baseline movement during background noise	-202.73	93.891	-0.80388	0.150	0.0367
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 74dB sound pressure level	-157.43	123.55	-0.62645	0.444	0.210
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 78dB sound pressure level	-195.11	84.937	-0.82931	0.115	0.0268
startle / PPI	corrected maximum startle response to pre-pulse and full pulse (120 dB) minus maximum startle response to same pre-pulse, 82dB sound pressure level	-157.91	75.979	-0.77897	0.162	0.0440
startle / PPI	maximum baseline movement during background noise	-5.1014	3.3340	-1.3442	0.624	0.134
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	10.364	7.9981	1.0665	0.884	0.202
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	15.039	7.1381	1.3204	0.309	0.0413
startle / PPI	maximum percent pre-pulse inhibition to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	12.085	7.0507	0.96779	0.336	0.0941
startle / PPI	maximum startle response to full pulse (120 dB)	-208.02	93.860	-0.83326	0.141	0.0323
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 74dB sound pressure level	-161.47	123.69	-0.64877	0.429	0.199
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 78dB sound pressure level	-195.82	85.449	-0.82931	0.115	0.0271
startle / PPI	maximum startle response to full pulse (120 dB) preceded by pre-pulse, 82dB sound pressure level	-157.15	75.857	-0.78658	0.167	0.0446
startle / PPI	maximum startle response to pre-pulse, 74dB sound pressure level	-3.8705	2.2339	-1.0421	0.561	0.0907
startle / PPI	maximum startle response to pre-pulse, 78dB sound pressure level	-0.49924	2.3471	-0.13138	0.974	0.833
startle / PPI	maximum startle response to pre-pulse, 82dB sound pressure level	0.94303	2.6409	0.0077063	0.901	0.723
urinalysis	albumin-creatinine ratio (urine ACR)	3.4606	2.7985	0.48242	0.435	0.225
urinalysis	creatinine (urine CREA)	5.7537	3.7134	1.7256	0.337	0.131
urinalysis	glucose (urine GLU)	4.7468	2.0530	1.2597	0.230	0.0270
urinalysis	magnesium level (urine Mg)	-0.012661	0.057158	-0.37739	0.941	0.826
urinalysis	microalbumin (urine MA), calculated	0.47523	0.17968	1.4366	0.113	0.0123

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Early Adult Phenotyping study (EAP)

Procedure	JaxKOMP-EAP Trait	Trait Effect	P-value
electroretinography	blind eyes, left	0.0 %	1.0
electroretinography	blind eyes, right	0.0 %	1.0
eye morphology	anterior chamber depth	1.0 %	1.0
eye morphology	bulging eye	1.0 %	1.00
eye morphology	cornea	3.0 %	1.00
eye morphology	cornea opacity	3.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.00
eye morphology	corneal mineralization	1.0 %	1.00
eye morphology	corneal scleralization	14.0 %	0.00191
eye morphology	corneal ulcer	1.0 %	1.00
eye morphology	eye closure	1.0 %	1.00
eye morphology	eye hemorrhage or blood presence	1.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.00
eye morphology	eyes (present, absent)	0.0 %	1.00
eye morphology	fusion between cornea and lens	3.0 %	1.0
eye morphology	iris pigmentation	2.0 %	1.0
eye morphology	iris transillumination	1.0 %	1.00
eye morphology	irispupil	3.0 %	1.0
eye morphology	lacrimation	3.0 %	1.00
eye morphology	lens	12.0 %	0.209
eye morphology	lens opacity	7.0 %	1.00
eye morphology	narrow eye opening	1.0 %	1.00
eye morphology	optic disc	3.0 %	1.00
eye morphology	persistence of hyaloid vascular system	9.0 %	1.00
eye morphology	pupil dilation	2.0 %	1.00
eye morphology	pupil light response	2.0 %	1.0
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.0
eye morphology	retina	13.0 %	1.00
eye morphology	retinal blood vessels	3.0 %	1.00
eye morphology	retinal blood vessels pattern	4.0 %	1.00
eye morphology	retinal blood vessels structure	3.0 %	1.0
eye morphology	retinal pigmentation	10.0 %	0.334
eye morphology	retinal structure	3.0 %	1.00
eye morphology	synechia	3.0 %	1.00
eye morphology	vitreous	3.0 %	1.0
rotarod	outcome of accelerating rotarod (4-40 rpm/ 5 min) over 5 trials	0.0 %	1.0
rotarod	trial number	0.0 %	1.0
SHIRPA	activity body position	1.0 %	1.00
SHIRPA	aggression	1.0 %	1.0
SHIRPA	body length	0.0 %	1.00
SHIRPA	body position	0.0 %	1.0
SHIRPA	body thickness	0.0 %	1.0
SHIRPA	coat color abdomen	3.0 %	0.440
SHIRPA	coat color back	0.0 %	1.00
SHIRPA	coat color head	0.0 %	1.0
SHIRPA	coat color pattern abdomen	1.0 %	1.0
SHIRPA	coat color pattern back	0.0 %	1.0
SHIRPA	coat color pattern head	0.0 %	1.00
SHIRPA	coat hair abdomen texture appearance	2.0 %	1.0
SHIRPA	coat hair back texture appearance	0.0 %	1.0
SHIRPA	coat hair distribution abdomen	1.0 %	1.00
SHIRPA	coat hair distribution back	0.0 %	1.0
SHIRPA	coat hair distribution head	1.0 %	1.0
SHIRPA	coat hair head texture appearance	0.0 %	1.0
SHIRPA	contact righting	5.0 %	1.00
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	fat distribution	0.0 %	1.00
SHIRPA	forelimb digit number	0.0 %	1.00
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.0
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	0.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.00
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.00
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.0
SHIRPA	hindlimb digit shape	0.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	0.0 %	1.00
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.0
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	0.0 %	1.0
SHIRPA	hindlimbs position	0.0 %	1.0
SHIRPA	hindlimbs shape	0.0 %	1.0
SHIRPA	hindlimbs size	0.0 %	1.0
SHIRPA	hindpaw position	0.0 %	1.0
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	0.0 %	1.0
SHIRPA	limb grasp	5.0 %	0.327
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.00
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.0
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.00
SHIRPA	snout size	6.0 %	0.0575
SHIRPA	startle response	6.0 %	0.0349
SHIRPA	tail curvature	0.0 %	1.0
SHIRPA	tail elevation	1.0 %	1.0
SHIRPA	tail length	0.0 %	1.00
SHIRPA	tail morphology	0.0 %	1.00
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.00
SHIRPA	tail thickness	0.0 %	1.0
SHIRPA	teeth presence	0.0 %	1.00
SHIRPA	transfer arousal	1.0 %	1.0
SHIRPA	tremor	0.0 %	1.00
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.00
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.00
SHIRPA	vibrissae appearance	1.0 %	1.0
SHIRPA	vibrissae presence	2.0 %	1.0
SHIRPA	vocalization	2.0 %	1.00

GENOTYPE CORRELATION PLOT

Correlate Cnbp^{tm1b(KOMP)Wtsi} -/+ with genotype: