MPD: JaxKOMP-LAP genotype: Igsf11<sup>tm1b(KOMP)Wtsi</sup> -/-

JaxKOMP-LAP effect sizes: Igsf11^{tm1b(KOMP)Wtsi} -/- Gene Igsf11

MULTIPLE (NUMERIC) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

Procedure	JaxKOMP-LAP Trait	Trait Effect	Trait Effect SE	Trait Effect RankZ	Adjusted p-value	Unadjusted p-value
body composition	body length	-0.071402	0.057919	-0.23090	0.531	0.231
body composition	body weight (at time of DXA)	-5.2066	3.4597	-0.94467	0.295	0.146
body composition	bone area, whole body scan, head excluded	-0.76792	0.30216	-1.4835	0.175	0.0182
body composition	bone mineral content of whole body scan, head excluded	-0.056039	0.021914	-1.2156	0.127	0.0176
body composition	bone mineral content to body weight ratio	-0.0019751	0.00066497	-1.7158	0.108	0.00706
body composition	bone mineral density of whole body scan, head excluded	-0.0019629	0.00084881	-0.94467	0.146	0.0305
body composition	fat tissue mass of whole body scan, head excluded	1.2534	0.85120	0.70187	0.447	0.155
body composition	fat tissue mass to body weight ratio	0.048821	0.022129	1.4215	0.209	0.0381
body composition	lean tissue mass of whole body scan, head excluded	-1.2566	0.66199	-0.97899	0.291	0.0709
body composition	lean tissue mass to body weight ratio	-0.031586	0.017863	-0.97899	0.337	0.0909
body composition	percent fat, whole body scan, head excluded	4.2229	2.0541	1.3645	0.256	0.0519
body composition	ratio of soft-tissue attenuation coefficients	-0.0046912	0.0022830	-1.3067	0.252	0.0520
body composition	tissue area	0.36944	0.34509	0.62118	0.670	0.296
body composition	total tissue mass, whole body scan, head excluded	0.16249	0.63318	0.064872	0.964	0.800
clinical blood chemistry	alanine transaminase (plasma ALT)	-5.5011	12.449	-0.49585	0.891	0.664
clinical blood chemistry	albumin (plasma Alb)	-0.95984	0.83832	-1.1628	0.732	0.267
clinical blood chemistry	alkaline phosphatase (plasma ALP)	22.170	17.426	1.4861	0.846	0.219
clinical blood chemistry	aspartate transaminase (plasma AST)	-0.77611	10.249	-0.21254	0.990	0.940
clinical blood chemistry	aspartate transaminase to alanine transaminase ratio (plasma AST:ALT)	0.069510	0.14762	0.36800	0.890	0.643
clinical blood chemistry	blood urea nitrogen (BUN)	-0.87258	1.6930	-0.28940	0.843	0.613
clinical blood chemistry	calcium (plasma Ca)	-0.090839	0.094143	-0.87790	0.762	0.347
clinical blood chemistry	creatinine (plasma)	-0.029912	0.010173	-0.68230	0.0972	0.00875
clinical blood chemistry	glucose (plasma GLU, no fast)	20.171	11.725	0.59110	0.391	0.102
clinical blood chemistry	HDL cholesterol (plasma HDL)	4.3104	4.0776	0.43073	0.683	0.304
clinical blood chemistry	HDL cholesterol to total cholesterol ratio	0.0062674	0.020138	0.31538	0.937	0.759
clinical blood chemistry	phosphorus (plasma phosphate)	-0.80503	0.31289	-1.0428	0.231	0.0186
clinical blood chemistry	total bilirubin (plasma TBIL)	0.00040659	0.0083039	-0.088734	0.988	0.961
clinical blood chemistry	total cholesterol (plasma CHOL, no fast)	8.5647	6.0607	0.59110	0.546	0.175
clinical blood chemistry	total protein (plasma TP)	-2.3674	1.6371	-1.4861	0.618	0.164
clinical blood chemistry	triglyceride (plasma TG, no fast)	6.8515	10.825	0.39469	0.891	0.535
glucose tolerance test	amount glucose injected	2.5169	3.7112	0.041104	0.782	0.504
glucose tolerance test	plasma glucose, 0min	2.5369	6.0011	-0.061677	0.880	0.676
glucose tolerance test	plasma glucose, 15min	35.750	24.943	0.66165	0.472	0.164
glucose tolerance test	plasma glucose, 30min	53.559	22.246	1.3397	0.221	0.0238
glucose tolerance test	plasma glucose, 60min	84.817	19.992	1.7394	0.0160	0.000265
glucose tolerance test	plasma glucose, 120min	45.925	16.589	1.1210	0.141	0.0105
grip strength	body weight (at time of grip strength test)	-5.5951	2.7005	-1.0729	0.163	0.0480
grip strength	forelimb and hindlimb grip strength (mean of trials), average	19.307	5.5624	1.2816	0.0550	0.00183
grip strength	forelimb and hindlimb grip strength (mean of trials), average normalized to bw	0.42063	0.17274	1.1108	0.174	0.0221
grip strength	forelimb and hindlimb grip strength by trial, trial1	18.542	7.8925	0.96742	0.228	0.0267
grip strength	forelimb and hindlimb grip strength by trial, trial2	18.130	5.5377	1.1108	0.0892	0.00300
grip strength	forelimb and hindlimb grip strength by trial, trial3	18.342	7.5467	1.0729	0.189	0.0223
grip strength	forelimb grip strength (mean of trials), average	7.9296	3.0065	1.0013	0.203	0.0139
grip strength	forelimb grip strength (mean of trials), average normalized to bw	0.14825	0.099042	0.81222	0.498	0.146
grip strength	forelimb grip strength by trial, trial1	6.1825	5.3395	0.81222	0.701	0.257
grip strength	forelimb grip strength by trial, trial2	5.4648	4.4124	0.64849	0.726	0.227
grip strength	forelimb grip strength by trial, trial3	10.753	4.8859	1.2816	0.398	0.0368
heart weight	heart weight, normalized to body weight	-0.12060	0.16085	-0.62814	0.722	0.461
heart weight	heart weight, weight	-4.4297	5.5242	-0.72979	0.723	0.431
hematology	basophil differential (percent of total WBC)	-0.021367	0.044642	0.025069	0.865	0.638
hematology	calculated hemoglobin (cHGB)	0.0010870	0.26770	0.099634	0.997	0.997
hematology	eosinophil differential (percent of total WBC)	0.25805	0.34955	0.098458	0.753	0.470
hematology	hematocrit (HCT)	-0.17391	0.85107	-0.17637	0.946	0.840
hematology	hemoglobin concentration distribution width (HDW)	0.042835	0.029789	0.50593	0.482	0.167
hematology	large unstained cells (percent of total WBC)	0.12457	0.19838	0.18001	0.803	0.538
hematology	lymphocyte differential (percent of total WBC)	-0.72848	2.8320	-0.086973	0.909	0.800
hematology	mean corpuscular hemoglobin (CHr)	-0.34135	0.10932	-1.4051	0.0793	0.00561
hematology	mean platelet volume (MPV)	0.094196	0.13879	0.44895	0.760	0.506
hematology	mean RBC corpuscular hemoglobin (MCH)	-0.010916	0.14383	-0.080947	0.940	0.940
hematology	mean RBC corpuscular hemoglobin concentration (MCHC)	0.58200	0.28836	1.2872	0.567	0.0587
hematology	mean RBC corpuscular volume (MCV)	-1.0177	0.59353	-1.1809	0.380	0.103
hematology	measured hemoglobin (mHGB)	0.14630	0.30123	0.19105	0.863	0.633
hematology	monocyte differential (percent of total WBC)	0.076892	0.33861	0.13425	0.974	0.823
hematology	neutrophil differential (percent of total WBC)	0.96826	2.4761	0.34157	0.912	0.700
hematology	platelet count (PLT; units per volume x 10³)	-224.08	121.79	-1.1809	0.465	0.0815
hematology	RBC corpuscular distribution width (RDW)	0.44413	0.27331	0.91537	0.584	0.121
hematology	RBC corpuscular hemoglobin concentration mean (CHCM)	0.015625	0.23311	0.25335	0.947	0.947
hematology	red blood cell count (RBC; per volume x 10⁶)	0.20572	0.24301	0.34157	0.715	0.408
hematology	reticulocyte count (Retic; units per volume x 10⁹)	64.224	51.676	1.1809	0.941	0.230
hematology	reticulocyte differential (percent of total RBC)	0.73219	0.71934	1.1926	0.852	0.322
hematology	white blood cell count (WBC; units per volume x 10³)	-0.87270	0.91713	-0.71397	0.694	0.354
holeboard	number of hole pokes by individual hole number, 20 min test, 1	0.69747	1.0331	0.36611	0.864	0.511
holeboard	number of hole pokes by individual hole number, 20 min test, 3	-0.38710	0.76699	-0.52737	0.905	0.622
holeboard	number of hole pokes by individual hole number, 20 min test, 4	0.34041	1.2214	0.20607	0.909	0.785
holeboard	number of hole pokes by individual hole number, 20 min test, 5	-0.30068	0.47437	-0.49790	0.986	0.537
holeboard	number of hole pokes by individual hole number, 20 min test, 7	-0.49079	0.37388	-1.1772	0.701	0.212
holeboard	number of hole pokes by individual hole number, 20 min test, 8	-0.97558	0.61015	-1.2147	0.763	0.134
holeboard	number of hole pokes by individual hole number, 20 min test, 9	-0.3125	0.43951	-0.42139	0.849	0.489
holeboard	number of hole pokes by individual hole number, 20 min test, 10	-0.19761	0.40461	-0.37410	0.957	0.633
holeboard	number of hole pokes by individual hole number, 20 min test, 11	-0.29397	0.26942	-0.68262	0.731	0.295
holeboard	number of hole pokes by individual hole number, 20 min test, 12	0.26820	0.41478	0.44951	0.941	0.529
holeboard	number of hole pokes by individual hole number, 20 min test, 13	-0.77045	0.99479	-0.82713	0.785	0.453
holeboard	number of hole pokes by individual hole number, 20 min test, 14	-0.37753	0.60395	-0.42139	0.892	0.543
holeboard	number of hole pokes by individual hole number, 20 min test, 15	-0.95144	0.69479	-1.0611	0.665	0.194
holeboard	number of hole pokes by individual hole number, 20 min test, 16	-2.0337	1.5467	-1.7413	0.709	0.211
holeboard	total number of hole pokes, 20 min test	-5.7918	6.6067	-0.86370	0.759	0.397
light / dark	latency to enter dark zone, 20 min test	80.061	41.048	0.84162	0.552	0.0701
light / dark	number of transitions between light and dark zones, 20 min test	-34.679	12.338	-2.1444	0.164	0.0139
light / dark	percentage of total time in dark zone, 20 min test	22.124	3.9628	1.9774	0.00837	0.0000675
light / dark	percentage of total time in light zone, 20 min test	-22.124	3.9628	-1.9774	0.00837	0.0000675
light / dark	time mobile in dark zone, 20 min test	-2.1857	28.597	-0.49019	0.983	0.940
light / dark	time mobile in light zone, 20 min test	-57.477	18.057	-2.4089	0.103	0.00664
light / dark	time spent in dark zone, 20 min test	181.92	55.464	1.4051	0.105	0.00506
light / dark	time spent in light zone, 20 min test	-181.92	55.464	-1.4051	0.105	0.00506
open field	average speed in center of arena, 20 min test	1.6245	0.92231	1.5647	0.410	0.104
open field	average speed in periphery of arena, 20 min test	-0.098857	0.35322	-0.56595	0.903	0.784
open field	distance traveled habituation ratio, 20 min test	-22.169	17.197	-1.6408	0.626	0.222
open field	distance traveled in center of arena, 20 min test	-186.16	286.51	-1.3784	0.799	0.528
open field	distance traveled in periphery of arena, 20 min test	327.85	340.64	0.80613	0.742	0.352
open field	distance traveled slope, 20 min test	-21.826	17.942	-1.5647	0.672	0.247
open field	distance traveled, 20 min test, 1st 5min	69.962	180.25	0.33252	0.914	0.705
open field	distance traveled, 20 min test, 2nd 5min	98.812	146.30	0.64179	0.748	0.512
open field	distance traveled, 20 min test, 3rd 5min	56.687	149.81	0.22301	0.881	0.711
open field	distance traveled, 20 min test, 4th 5min	-120.83	153.45	-1.4351	0.760	0.444
open field	number of clockwise revolution episodes, 20 min test	0.39181	3.5039	0.010532	0.968	0.913
open field	number of counter-clockwise revolution episodes, 20 min test	1.7749	2.4921	0.59085	0.835	0.488
open field	number of rears in 5 min bins, 20 min test, 1st 5min	1.6691	4.5840	0.37739	0.936	0.722
open field	number of rears in 5 min bins, 20 min test, 2nd 5min	2.5078	3.9156	0.18001	0.724	0.534
open field	number of rears in 5 min bins, 20 min test, 3rd 5min	9.0322	4.6675	1.2306	0.345	0.0734
open field	number of rears in 5 min bins, 20 min test, 4th 5min	5.1550	5.3209	0.54140	0.664	0.349
open field	percentage of total time in center of arena, 20 min test	-25.933	7.0034	-2.1247	0.0664	0.00302
open field	percentage of total time in center of arena, slope, 20 min test	0.69754	2.2075	0.40011	0.891	0.757
open field	percentage of total time in center, habituation ratio, 20 min test	1.1856	2.4867	0.44619	0.879	0.642
open field	percentage of total time in corners of arena, 20 min test	21.400	6.4086	1.9564	0.0976	0.00590
open field	percentage of total time in corners, habituation ratio, 20 min test	-8.7328	3.7008	-2.3909	0.400	0.0333
open field	percentage of total time in corners, slope, 20 min test	-8.0894	4.0205	-2.3909	0.462	0.0639
open field	permanence time in center of arena, 20 min test	-311.16	84.036	-2.1247	0.0665	0.00302
open field	permanence time in corners of arena, 20 min test	256.80	76.904	1.9564	0.0977	0.00590
open field	permanence time in periphery of arena, 20 min test	311.28	84.063	2.1247	0.0662	0.00302
open field	total distance traveled, 20 min test	243.54	542.45	0.35487	0.875	0.660
open field	total number of rears, 20 min test	14.581	17.645	0.59085	0.684	0.425
open field	whole arena average speed, 20 min test	0.20149	0.45229	0.35487	0.876	0.663
open field	whole arena resting time, 20 min test	-17.507	46.622	-0.073791	0.825	0.713
open field	whole arena time spent mobile, 20 min test	17.561	46.655	0.46958	0.857	0.712
open field	whole arena time spent vertical, 20 min test	-17.594	14.955	-0.72152	0.673	0.262
SHIRPA	locomotor activity (number of squares in the arena the mouse moves into with all four paws in first 30 s of test)	0.36159	1.6809	0.12159	0.905	0.831

MULTIPLE (CATEGORICAL) TRAIT PROFILE PLOT — Late Adult Phenotyping study (LAP)

Procedure	JaxKOMP-LAP Trait	Trait Effect	P-value
eye morphology	anterior chamber depth	2.0 %	1.0
eye morphology	bulging eye	2.0 %	1.0
eye morphology	cornea	5.0 %	1.0
eye morphology	cornea opacity	5.0 %	1.0
eye morphology	cornea vascularization	2.0 %	1.0
eye morphology	corneal deposits	1.0 %	1.0
eye morphology	corneal mineralization	33.0 %	0.00312
eye morphology	corneal scleralization	2.0 %	1.0
eye morphology	corneal ulcer	2.0 %	1.0
eye morphology	eye closure	1.0 %	1.0
eye morphology	eye hemorrhage or blood presence	2.0 %	1.0
eye morphology	eyelid morphology	1.0 %	1.0
eye morphology	eyes (present, absent)	0.0 %	1.00
eye morphology	fusion between cornea and lens	16.0 %	0.0410
eye morphology	iris pigmentation	2.0 %	1.00
eye morphology	iris transillumination	2.0 %	1.00
eye morphology	irispupil	4.0 %	1.00
eye morphology	lacrimation	19.0 %	0.00936
eye morphology	lens	21.0 %	0.398
eye morphology	lens opacity	16.0 %	0.128
eye morphology	narrow eye opening	2.0 %	1.0
eye morphology	optic disc	16.0 %	0.0916
eye morphology	persistence of hyaloid vascular system	18.0 %	0.0427
eye morphology	pupil dilation	3.0 %	1.00
eye morphology	pupil light response	2.0 %	1.00
eye morphology	pupil position	4.0 %	1.0
eye morphology	pupil shape	3.0 %	1.00
eye morphology	retina	16.0 %	0.0666
eye morphology	retinal blood vessels	16.0 %	0.0410
eye morphology	retinal blood vessels pattern	16.0 %	0.0410
eye morphology	retinal blood vessels structure	16.0 %	0.0916
eye morphology	retinal pigmentation	16.0 %	0.0914
eye morphology	retinal structure	16.0 %	0.0500
eye morphology	synechia	17.0 %	0.0274
eye morphology	vitreous	16.0 %	0.0410
SHIRPA	activity body position	6.0 %	0.121
SHIRPA	aggression	10.0 %	0.00588
SHIRPA	body length	0.0 %	1.0
SHIRPA	body position	2.0 %	0.534
SHIRPA	body thickness	1.0 %	0.534
SHIRPA	coat color abdomen	17.0 %	0.0871
SHIRPA	coat color back	16.0 %	0.0569
SHIRPA	coat color head	4.0 %	1.0
SHIRPA	coat color pattern abdomen	4.0 %	1.00
SHIRPA	coat color pattern back	12.0 %	0.0859
SHIRPA	coat color pattern head	4.0 %	1.0
SHIRPA	coat hair abdomen texture appearance	0.0 %	1.0
SHIRPA	coat hair back texture appearance	1.0 %	1.0
SHIRPA	coat hair distribution abdomen	5.0 %	1.0
SHIRPA	coat hair distribution back	3.0 %	1.0
SHIRPA	coat hair distribution head	10.0 %	0.473
SHIRPA	coat hair head texture appearance	2.0 %	1.0
SHIRPA	contact righting	78.0 %	1.03e-12
SHIRPA	ear morphology	0.0 %	1.0
SHIRPA	eye morphology	2.0 %	1.00
SHIRPA	fat distribution	8.0 %	0.371
SHIRPA	forelimb digit number	0.0 %	1.0
SHIRPA	forelimb digit position	0.0 %	1.0
SHIRPA	forelimb digit shape	0.0 %	1.0
SHIRPA	forelimb digit size	0.0 %	1.0
SHIRPA	forelimb footpads	0.0 %	1.0
SHIRPA	forelimb nail length	0.0 %	1.00
SHIRPA	forelimb nail number	0.0 %	1.0
SHIRPA	forelimb nail position	0.0 %	1.0
SHIRPA	forelimb nail shape	0.0 %	1.0
SHIRPA	forelimbs position	0.0 %	1.0
SHIRPA	forelimbs shape	0.0 %	1.0
SHIRPA	forelimbs size	0.0 %	1.0
SHIRPA	forepaw position	0.0 %	1.0
SHIRPA	forepaw shape	0.0 %	1.0
SHIRPA	forepaw size	0.0 %	1.0
SHIRPA	gait (fluidity)	2.0 %	1.00
SHIRPA	genitalia morphology	0.0 %	1.0
SHIRPA	genitalia presence	0.0 %	1.0
SHIRPA	genitalia size	0.0 %	1.0
SHIRPA	head bobbing	0.0 %	1.0
SHIRPA	head morphology	0.0 %	1.0
SHIRPA	head size	0.0 %	1.0
SHIRPA	hindlimb digit number	0.0 %	1.00
SHIRPA	hindlimb digit position	0.0 %	1.00
SHIRPA	hindlimb digit shape	1.0 %	1.0
SHIRPA	hindlimb digit size	0.0 %	1.00
SHIRPA	hindlimb nail length	10.0 %	0.115
SHIRPA	hindlimb nail number	0.0 %	1.00
SHIRPA	hindlimb nail position	0.0 %	1.00
SHIRPA	hindlimb nail shape	0.0 %	1.0
SHIRPA	hindlimbs footpads	1.0 %	1.00
SHIRPA	hindlimbs position	1.0 %	1.00
SHIRPA	hindlimbs shape	3.0 %	1.00
SHIRPA	hindlimbs size	10.0 %	0.00868
SHIRPA	hindpaw position	0.0 %	1.00
SHIRPA	hindpaw shape	0.0 %	1.0
SHIRPA	hindpaw size	1.0 %	1.00
SHIRPA	limb grasp	81.0 %	6.36e-14
SHIRPA	lower lip morphology	0.0 %	1.0
SHIRPA	lower teeth appearance	0.0 %	1.0
SHIRPA	mouth morphology	0.0 %	1.00
SHIRPA	salivation	0.0 %	1.0
SHIRPA	skin color back paws	0.0 %	1.0
SHIRPA	skin color ear	0.0 %	1.0
SHIRPA	skin color front paws	0.0 %	1.0
SHIRPA	skin color snout	0.0 %	1.0
SHIRPA	skin color tail	0.0 %	1.0
SHIRPA	skin color whole body	0.0 %	1.0
SHIRPA	skin texture back paw	0.0 %	1.0
SHIRPA	skin texture ear	0.0 %	1.00
SHIRPA	skin texture front paws	0.0 %	1.0
SHIRPA	skin texture snout	0.0 %	1.0
SHIRPA	skin texture tail	0.0 %	1.0
SHIRPA	skin texture whole body	0.0 %	1.0
SHIRPA	snout size	5.0 %	0.144
SHIRPA	startle response	26.0 %	0.00587
SHIRPA	tail curvature	1.0 %	1.0
SHIRPA	tail elevation	2.0 %	1.0
SHIRPA	tail length	0.0 %	1.0
SHIRPA	tail morphology	2.0 %	1.0
SHIRPA	tail presence	0.0 %	1.0
SHIRPA	tail shape	0.0 %	1.0
SHIRPA	tail thickness	1.0 %	1.00
SHIRPA	teeth presence	0.0 %	1.0
SHIRPA	transfer arousal	30.0 %	0.000296
SHIRPA	tremor	2.0 %	1.0
SHIRPA	trunk curl	0.0 %	1.0
SHIRPA	unexpected behaviors (circling, head bobbing, jumping, retropulsion)	0.0 %	1.0
SHIRPA	upper lip morphology	0.0 %	1.0
SHIRPA	upper teeth appearance	0.0 %	1.0
SHIRPA	vibrissae appearance	4.0 %	1.00
SHIRPA	vibrissae presence	8.0 %	0.472
SHIRPA	vocalization	7.0 %	1.0

GENOTYPE CORRELATION PLOT

Correlate Igsf11^{tm1b(KOMP)Wtsi} -/- with genotype:

This genotype correlation visualization can include both EAP and LAP measures.