ITP phenotypes:   body weight     ursodeoxycholic acid

Trial code: UDCA Dose: 5000 ppm   initiated at age: 5 mo Sex: f Cohort: C2011
Trial code: UDCA Dose: 5000 ppm   initiated at age: 5 mo Sex: m Cohort: C2011
The plots below show the means with ± SEM error bars





ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 5085.2581 5085.2581 34.0202 < 0.0001
time 3 25542.562 8514.1873 56.9597 < 0.0001
group:time 3 978.704 326.2347 2.1825 0.0883
Residuals 1562 233483.7209 149.4774 NA NA


Means

group time mean SE
Control time_m12 39.0436 0.5318
Control time_m18 42.8495 0.609
Control time_m24 41.7939 0.6595
Control time_m6 31.3862 1.2574
UDCA time_m12 36.2286 0.7683
UDCA time_m18 37.2656 0.9594
UDCA time_m24 36.486 0.947
UDCA time_m6 29.837 0.4728


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
Control - UDCA time_m6 1.5492 1.2841 1562 1.2065 0.2278
Control - UDCA time_m12 2.815 1.2825 1562 2.195 0.0283
Control - UDCA time_m18 5.5839 1.313 1562 4.2527 < 0.0001
Control - UDCA time_m24 5.3079 1.4635 1562 3.6269 0.0003










ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 1401.0043 1401.0043 33.6479 < 0.0001
time 3 7118.055 2372.685 56.9847 < 0.0001
group:time 3 493.0772 164.3591 3.9474 0.0081
Residuals 1446 60207.3815 41.6372 NA NA


Means

group time mean SE
Control time_m12 45.1358 0.3568
Control time_m18 44.6654 0.401
Control time_m24 40.5988 0.5568
Control time_m6 39.2211 0.3751
UDCA time_m12 42.2852 0.5587
UDCA time_m18 41.6298 0.7148
UDCA time_m24 38.8469 0.7472
UDCA time_m6 39.1053 0.4329


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
Control - UDCA time_m6 0.1158 0.6598 1446 0.1755 0.8607
Control - UDCA time_m12 2.8507 0.6765 1446 4.2138 < 0.0001
Control - UDCA time_m18 3.0356 0.7152 1446 4.2445 < 0.0001
Control - UDCA time_m24 1.7519 0.8193 1446 2.1383 0.0327










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