ITP phenotypes: grip duration nordihydroguaiaretic acid
Trial code: NDGA_hi
Dose: 5000 ppm
initiated at age: 6 mo
Sex: f
Cohort: C2010
Trial code: NDGA_mid
Dose: 2500 ppm
initiated at age: 6 mo
Sex: m
Cohort: C2010
The plots below show the means with ± SEM error bars
Analysis details -- Female
ANOVA
Factor Df Sum Sq Mean Sq F value Pr(>F)
group 2 30292.4721 15146.2361 3.3225 0.0376
Residuals 267 1217170.4946 4558.691 NA NA
Means
group mean SE
Old_Control 96.31 7.5487
Old_NDGA_hi 88.5789 6.0852
Young_Control 115.0267 7.6212
Pairwise comparisons (Tukey multiple-test correction)
contrast estimate SE df t.ratio p.value
Old_Control - Old_NDGA_hi 7.7311 9.6733 267 0.7992 0.7038
Old_Control - Young_Control -18.7167 10.3136 267 -1.8148 0.1667
Old_NDGA_hi - Young_Control -26.4477 10.4292 267 -2.5359 0.0315
Analysis details -- Male
ANOVA
Factor Df Sum Sq Mean Sq F value Pr(>F)
group 2 176021.7117 88010.8559 18.3556 < 0.0001
Residuals 222 1064436.0483 4794.757 NA NA
Means
group mean SE
Old_Control 109.1905 5.7962
Old_NDGA_mid 180.4444 12.8603
Young_Control 148.5067 8.1661
Pairwise comparisons (Tukey multiple-test correction)
contrast estimate SE df t.ratio p.value
Old_Control - Old_NDGA_mid -71.254 12.3375 222 -5.7754 < 0.0001
Old_Control - Young_Control -39.3162 10.4687 222 -3.7556 0.0006
Old_NDGA_mid - Young_Control 31.9378 13.0568 222 2.4461 0.0402
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ITP data portal page for more information on
National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.