ITP phenotypes:   body weight     nordihydroguaiaretic acid

Trial code: NDGA_hi Dose: 5000 ppm   initiated at age: 6 mo Sex: f Cohort: C2010
Trial code: NDGA Dose: 800, 2500, 5000 ppm   initiated at age: 6 mo Sex: m Cohort: C2010
The plots below show the means with ± SEM error bars





ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 11703.4363 11703.4363 203.4169 < 0.0001
time 3 28698.2964 9566.0988 166.2679 < 0.0001
group:time 3 5828.57 1942.8567 33.7687 < 0.0001
Residuals 1522 87567.1244 57.5342 NA NA


Means

group time mean SE
Control time_m12 39.5611 0.4796
Control time_m18 44.7833 0.6354
Control time_m24 41.9161 0.6264
Control time_m6 29.9664 0.3427
NDGA_hi time_m12 33.8866 0.5331
NDGA_hi time_m18 34.8932 0.5502
NDGA_hi time_m24 32.4352 0.4645
NDGA_hi time_m6 30.273 0.4966


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
Control - NDGA_hi time_m6 -0.3066 0.7923 1522 -0.387 0.6988
Control - NDGA_hi time_m12 5.6745 0.7991 1522 7.1011 < 0.0001
Control - NDGA_hi time_m18 9.8901 0.813 1522 12.1656 < 0.0001
Control - NDGA_hi time_m24 9.4809 0.9017 1522 10.5144 < 0.0001










ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 3 1215.7751 405.2584 10.2808 < 0.0001
time 3 17181.7962 5727.2654 145.2923 < 0.0001
group:time 9 438.2829 48.6981 1.2354 0.2683
Residuals 2490 98153.1342 39.4189 NA NA


Means

group time mean SE
Control time_m12 45.8326 0.37
Control time_m18 45.4535 0.4269
Control time_m24 41.8306 0.525
Control time_m6 39.4061 0.3619
NDGA_hi time_m12 42.9757 0.5423
NDGA_hi time_m18 44.21 0.6144
NDGA_hi time_m24 39.2833 0.651
NDGA_hi time_m6 38.7641 0.473
NDGA_lo time_m12 45.3317 0.4934
NDGA_lo time_m18 46.1463 0.5369
NDGA_lo time_m24 41.5753 0.7585
NDGA_lo time_m6 39.1395 0.48
NDGA_mid time_m12 45.2972 0.4715
NDGA_mid time_m18 45.2635 0.583
NDGA_mid time_m24 41.5731 0.6625
NDGA_mid time_m6 40.1913 0.4786


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
Control - NDGA_hi time_m6 0.642 0.6251 2490 1.027 0.7336
Control - NDGA_lo time_m6 0.2666 0.6265 2490 0.4255 0.9741
Control - NDGA_mid time_m6 -0.7852 0.6307 2490 -1.245 0.5982
NDGA_hi - NDGA_lo time_m6 -0.3754 0.719 2490 -0.5221 0.9538
NDGA_hi - NDGA_mid time_m6 -1.4272 0.7226 2490 -1.975 0.1977
NDGA_lo - NDGA_mid time_m6 -1.0518 0.7238 2490 -1.4532 0.4663
Control - NDGA_hi time_m12 2.8569 0.6379 2490 4.4783 < 0.0001
Control - NDGA_lo time_m12 0.5009 0.6567 2490 0.7628 0.8712
Control - NDGA_mid time_m12 0.5354 0.6491 2490 0.8247 0.8428
NDGA_hi - NDGA_lo time_m12 -2.356 0.7368 2490 -3.1975 0.0077
NDGA_hi - NDGA_mid time_m12 -2.3216 0.7301 2490 -3.1797 0.0081
NDGA_lo - NDGA_mid time_m12 0.0344 0.7465 2490 0.0461 1
Control - NDGA_hi time_m18 1.2435 0.6969 2490 1.7843 0.2811
Control - NDGA_lo time_m18 -0.6928 0.7129 2490 -0.9717 0.7656
Control - NDGA_mid time_m18 0.19 0.7038 2490 0.27 0.9931
NDGA_hi - NDGA_lo time_m18 -1.9363 0.7931 2490 -2.4414 0.0698
NDGA_hi - NDGA_mid time_m18 -1.0535 0.7849 2490 -1.3422 0.536
NDGA_lo - NDGA_mid time_m18 0.8828 0.7991 2490 1.1047 0.6867
Control - NDGA_hi time_m24 2.5473 0.7819 2490 3.2578 0.0063
Control - NDGA_lo time_m24 0.2553 0.8302 2490 0.3076 0.9899
Control - NDGA_mid time_m24 0.2575 0.7908 2490 0.3257 0.9881
NDGA_hi - NDGA_lo time_m24 -2.2919 0.8988 2490 -2.5499 0.0528
NDGA_hi - NDGA_mid time_m24 -2.2897 0.8626 2490 -2.6546 0.0399
NDGA_lo - NDGA_mid time_m24 0.0022 0.9066 2490 0.0024 1










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