ITP phenotypes:   body weight     canagliflozin

Trial code: Cana Dose: 180 ppm   initiated at age: 7 mo Sex: f Cohort: C2016
Trial code: Cana Dose: 180 ppm   initiated at age: 7 mo Sex: m Cohort: C2016
The plots below show the means with ± SEM error bars





ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 6913.4384 6913.4384 114.009 < 0.0001
time 3 17309.7883 5769.9294 95.1515 < 0.0001
group:time 3 3572.6266 1190.8755 19.6386 < 0.0001
Residuals 1139 69068.2767 60.6394 NA NA


Means

group time mean SE
Cana time_m12 34.437 0.572
Cana time_m18 36.8844 0.6133
Cana time_m24 38.0296 0.768
Cana time_m6 34.1522 0.667
Control time_m12 41.4571 0.5573
Control time_m18 45.6604 0.6419
Control time_m24 44.8555 0.7746
Control time_m6 33.1995 0.4124


Pairwise comparisons (Tukey multiple-test correction)

comparison time estimate SE df t.ratio p.value
Cana - Control time_m6 0.9526 0.9722 1139 0.9799 0.3273
Cana - Control time_m12 -7.0202 0.9736 1139 -7.2106 < 0.0001
Cana - Control time_m18 -8.7759 0.9832 1139 -8.9257 < 0.0001
Cana - Control time_m24 -6.8259 1.0975 1139 -6.2193 < 0.0001










ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 3064.6542 3064.6542 61.2574 < 0.0001
time 3 7308.7864 2436.2621 48.6969 < 0.0001
group:time 3 1065.9962 355.3321 7.1025 0.0001
Residuals 1994 99758.0659 50.0291 NA NA


Means

group time mean SE
Cana time_m12 41.2389 0.5723
Cana time_m18 42.9278 0.5895
Cana time_m24 41.4421 0.5876
Cana time_m6 40.0087 0.5018
Control time_m12 45.5251 0.3571
Control time_m18 46.4913 0.3832
Control time_m24 43.8836 0.5016
Control time_m6 40.4271 0.3208


Pairwise comparisons (Tukey multiple-test correction)

comparison time estimate SE df t.ratio p.value
Cana - Control time_m6 -0.4183 0.6239 1994 -0.6705 0.5026
Cana - Control time_m12 -4.2862 0.6401 1994 -6.6956 < 0.0001
Cana - Control time_m18 -3.5635 0.6628 1994 -5.3763 < 0.0001
Cana - Control time_m24 -2.4415 0.7309 1994 -3.3405 0.0009










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