ITP phenotypes:   body weight     candesartan cilexetil

Trial code: CC Dose: 30 ppm   initiated at age: 7 mo Sex: f Cohort: C2016
Trial code: CC Dose: 30 ppm   initiated at age: 7 mo Sex: m Cohort: C2016
The plots below show the means with ± SEM error bars





ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 908.772 908.772 12.8135 0.0004
time 3 22243.9629 7414.6543 104.5448 < 0.0001
group:time 3 876.3215 292.1072 4.1186 0.0064
Residuals 1127 79930.4644 70.9232 NA NA


Means

group time mean SE
CC time_m12 39.2761 0.9134
CC time_m18 42.0155 1.0245
CC time_m24 41.4151 1.0814
CC time_m6 34.3227 0.6682
Control time_m12 41.4571 0.5573
Control time_m18 45.6604 0.6419
Control time_m24 44.8555 0.7746
Control time_m6 33.1995 0.4124


Pairwise comparisons (Tukey multiple-test correction)

comparison time estimate SE df t.ratio p.value
CC - Control time_m6 1.1232 1.0679 1127 1.0517 0.2931
CC - Control time_m12 -2.181 1.0694 1127 -2.0394 0.0416
CC - Control time_m18 -3.6449 1.0895 1127 -3.3456 0.0008
CC - Control time_m24 -3.4404 1.1754 1127 -2.9271 0.0035










ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 629.064 629.064 12.2134 0.0005
time 3 11253.4177 3751.1392 72.8293 < 0.0001
group:time 3 91.9832 30.6611 0.5953 0.6181
Residuals 1968 101363.5941 51.5059 NA NA


Means

group time mean SE
CC time_m12 43.894 0.5927
CC time_m18 45.6864 0.6133
CC time_m24 42.0492 0.7281
CC time_m6 39.602 0.4888
Control time_m12 45.5251 0.3571
Control time_m18 46.4913 0.3832
Control time_m24 43.8836 0.5016
Control time_m6 40.4271 0.3208


Pairwise comparisons (Tukey multiple-test correction)

comparison time estimate SE df t.ratio p.value
CC - Control time_m6 -0.825 0.6309 1968 -1.3076 0.1911
CC - Control time_m12 -1.6311 0.6519 1968 -2.5022 0.0124
CC - Control time_m18 -0.8049 0.6773 1968 -1.1884 0.2348
CC - Control time_m24 -1.8344 0.7793 1968 -2.3539 0.0187










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