ITP phenotypes:   body weight     acarbose

Trial code: ACA Dose: 400, 1000, 2500 ppm   initiated at age: 8 mo Sex: f Cohort: C2013
Trial code: ACA Dose: 400, 1000, 2500 ppm   initiated at age: 8 mo Sex: m Cohort: C2013
The plots below show the means with ± SEM error bars





ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 3 20857.2305 6952.4102 153.5387 < 0.0001
time 3 13498.5554 4499.5185 99.3685 < 0.0001
group:time 9 8312.2954 923.5884 20.3968 < 0.0001
Residuals 2691 121851.5781 45.2812 NA NA


Means

group time mean SE
ACA_hi time_m12 31.7536 0.3866
ACA_hi time_m18 32.3617 0.3685
ACA_hi time_m24 31.6906 0.395
ACA_hi time_m6 32.4397 0.4978
ACA_lo time_m12 36.1784 0.6175
ACA_lo time_m18 38.341 0.7188
ACA_lo time_m24 36.4991 0.6873
ACA_lo time_m6 32.1345 0.4971
ACA_mid time_m12 32.5289 0.3773
ACA_mid time_m18 32.9439 0.35
ACA_mid time_m24 32.4529 0.4364
ACA_mid time_m6 30.7148 0.4212
Control time_m12 39.7416 0.4829
Control time_m18 42.1924 0.5418
Control time_m24 40.1077 0.6201
Control time_m6 31.5131 0.3396


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_hi - ACA_lo time_m6 0.3052 0.791 2691 0.3859 0.9805
ACA_hi - ACA_mid time_m6 1.7249 0.7866 2691 2.1929 0.1254
ACA_hi - Control time_m6 0.9267 0.6781 2691 1.3665 0.5206
ACA_lo - ACA_mid time_m6 1.4197 0.8029 2691 1.7683 0.2889
ACA_lo - Control time_m6 0.6215 0.697 2691 0.8917 0.8092
ACA_mid - Control time_m6 -0.7983 0.692 2691 -1.1536 0.6562
ACA_hi - ACA_lo time_m12 -4.4248 0.791 2691 -5.5941 < 0.0001
ACA_hi - ACA_mid time_m12 -0.7752 0.7866 2691 -0.9855 0.7577
ACA_hi - Control time_m12 -7.988 0.6769 2691 -11.8007 < 0.0001
ACA_lo - ACA_mid time_m12 3.6495 0.8029 2691 4.5455 < 0.0001
ACA_lo - Control time_m12 -3.5632 0.6958 2691 -5.1213 < 0.0001
ACA_mid - Control time_m12 -7.2127 0.6908 2691 -10.4411 < 0.0001
ACA_hi - ACA_lo time_m18 -5.9793 0.8011 2691 -7.4635 < 0.0001
ACA_hi - ACA_mid time_m18 -0.5821 0.7935 2691 -0.7336 0.8836
ACA_hi - Control time_m18 -9.8306 0.6841 2691 -14.3707 < 0.0001
ACA_lo - ACA_mid time_m18 5.3972 0.8147 2691 6.625 < 0.0001
ACA_lo - Control time_m18 -3.8513 0.7085 2691 -5.4359 < 0.0001
ACA_mid - Control time_m18 -9.2485 0.6999 2691 -13.2145 < 0.0001
ACA_hi - ACA_lo time_m24 -4.8085 0.8765 2691 -5.4863 < 0.0001
ACA_hi - ACA_mid time_m24 -0.7624 0.8585 2691 -0.888 0.8111
ACA_hi - Control time_m24 -8.4172 0.7499 2691 -11.2242 < 0.0001
ACA_lo - ACA_mid time_m24 4.0461 0.89 2691 4.5461 < 0.0001
ACA_lo - Control time_m24 -3.6086 0.7858 2691 -4.5924 < 0.0001
ACA_mid - Control time_m24 -7.6548 0.7657 2691 -9.9968 < 0.0001










ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 3 9667.0784 3222.3595 92.1205 < 0.0001
time 3 3660.7655 1220.2552 34.8846 < 0.0001
group:time 9 4417.9324 490.8814 14.0333 < 0.0001
Residuals 2795 97768.5856 34.9798 NA NA


Means

group time mean SE
ACA_hi time_m12 38.3571 0.4512
ACA_hi time_m18 38.0585 0.435
ACA_hi time_m24 35.9829 0.3227
ACA_hi time_m6 41.7109 0.4081
ACA_lo time_m12 42.5771 0.5414
ACA_lo time_m18 43.6911 0.5961
ACA_lo time_m24 39.5849 0.6526
ACA_lo time_m6 40.7617 0.4169
ACA_mid time_m12 40.3652 0.4927
ACA_mid time_m18 40.1159 0.5229
ACA_mid time_m24 37.6905 0.4674
ACA_mid time_m6 40.6635 0.4164
Control time_m12 44.9844 0.3602
Control time_m18 44.8886 0.4035
Control time_m24 41.7494 0.5086
Control time_m6 41.1043 0.304


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
ACA_hi - ACA_lo time_m6 0.9492 0.6542 2795 1.451 0.4676
ACA_hi - ACA_mid time_m6 1.0474 0.6573 2795 1.5936 0.3824
ACA_hi - Control time_m6 0.6066 0.5722 2795 1.0601 0.7139
ACA_lo - ACA_mid time_m6 0.0982 0.6602 2795 0.1487 0.9988
ACA_lo - Control time_m6 -0.3426 0.5756 2795 -0.5951 0.9336
ACA_mid - Control time_m6 -0.4408 0.5792 2795 -0.761 0.8719
ACA_hi - ACA_lo time_m12 -4.2199 0.6634 2795 -6.3613 < 0.0001
ACA_hi - ACA_mid time_m12 -2.008 0.6623 2795 -3.0319 0.0131
ACA_hi - Control time_m12 -6.6273 0.5842 2795 -11.3439 < 0.0001
ACA_lo - ACA_mid time_m12 2.2119 0.6665 2795 3.3188 0.0051
ACA_lo - Control time_m12 -2.4073 0.5889 2795 -4.0876 0.0003
ACA_mid - Control time_m12 -4.6192 0.5877 2795 -7.8593 < 0.0001
ACA_hi - ACA_lo time_m18 -5.6326 0.6779 2795 -8.3086 < 0.0001
ACA_hi - ACA_mid time_m18 -2.0574 0.6721 2795 -3.0614 0.0119
ACA_hi - Control time_m18 -6.8301 0.6068 2795 -11.2557 < 0.0001
ACA_lo - ACA_mid time_m18 3.5752 0.6865 2795 5.2081 < 0.0001
ACA_lo - Control time_m18 -1.1975 0.6227 2795 -1.9229 0.2186
ACA_mid - Control time_m18 -4.7727 0.6163 2795 -7.7436 < 0.0001
ACA_hi - ACA_lo time_m24 -3.602 0.7304 2795 -4.9313 < 0.0001
ACA_hi - ACA_mid time_m24 -1.7076 0.7035 2795 -2.4273 0.0722
ACA_hi - Control time_m24 -5.7665 0.6673 2795 -8.641 < 0.0001
ACA_lo - ACA_mid time_m24 1.8944 0.7411 2795 2.556 0.052
ACA_lo - Control time_m24 -2.1645 0.7069 2795 -3.062 0.0119
ACA_mid - Control time_m24 -4.0589 0.679 2795 -5.9774 < 0.0001










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