ITP phenotypes:   body weight     17-a-estradiol

Trial code: 17aE2 Dose: 14.4 ppm   initiated at age: 16 or 20 mo Sex: m Cohort: C2016
The plots below show the means with ± SEM error bars





ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 2 6167.9664 3083.9832 82.3464 < 0.0001
time 3 7273.8425 2424.6142 64.7403 < 0.0001
group:time 6 11430.7936 1905.1323 50.8695 < 0.0001
Residuals 2360 88385.2206 37.4514 NA NA


Means

group time mean SE
17aE2_16m time_m12 43.6327 0.5123
17aE2_16m time_m18 36.9942 0.3742
17aE2_16m time_m24 36.0133 0.4073
17aE2_16m time_m6 42.3737 0.3945
17aE2_20m time_m12 43.4603 0.5039
17aE2_20m time_m18 45.0595 0.5004
17aE2_20m time_m24 36.0461 0.4607
17aE2_20m time_m6 42.7797 0.3537
Control time_m12 45.5251 0.3571
Control time_m18 46.4913 0.3832
Control time_m24 43.8836 0.5016
Control time_m6 40.4271 0.3208


Pairwise comparisons (Tukey multiple-test correction)

comparison time estimate SE df t.ratio p.value
17aE2_16m - 17aE2_20m time_m6 -0.406 0.6963 2360 -0.5831 0.8292
17aE2_16m - Control time_m6 1.9467 0.5826 2360 3.3414 0.0024
17aE2_20m - Control time_m6 2.3527 0.5866 2360 4.0106 0.0002
17aE2_16m - 17aE2_20m time_m12 0.1724 0.7214 2360 0.2389 0.969
17aE2_16m - Control time_m12 -1.8924 0.5992 2360 -3.158 0.0046
17aE2_20m - Control time_m12 -2.0648 0.6082 2360 -3.3948 0.002
17aE2_16m - 17aE2_20m time_m18 -8.0654 0.7554 2360 -10.6772 < 0.0001
17aE2_16m - Control time_m18 -9.4971 0.6278 2360 -15.1268 < 0.0001
17aE2_20m - Control time_m18 -1.4318 0.6466 2360 -2.2144 0.069
17aE2_16m - 17aE2_20m time_m24 -0.0327 0.8242 2360 -0.0397 0.9991
17aE2_16m - Control time_m24 -7.8703 0.6823 2360 -11.5343 < 0.0001
17aE2_20m - Control time_m24 -7.8375 0.7216 2360 -10.8618 < 0.0001










See our ITP data portal page for more information on National Institute on Aging's Interventions Testing Program (ITP) including bibliography, data set downloads, and links to all available hosted data.