ITP phenotypes:   body weight     17-a-estradiol

Trial code: 17aE2_hi Dose: 14 ppm   initiated at age: 10 mo Sex: f Cohort: C2011
Trial code: 17aE2_hi Dose: 14 ppm   initiated at age: 10 mo Sex: m Cohort: C2011
The plots below show the means with ± SEM error bars





ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 4872.1651 4872.1651 33.7909 < 0.0001
time 3 23269.1553 7756.3851 53.7943 < 0.0001
group:time 3 1475.2878 491.7626 3.4106 0.0169
Residuals 1566 225795.0988 144.1859 NA NA


Means

group time mean SE
17aE2_hi time_m12 34.3059 0.6257
17aE2_hi time_m18 37.2209 0.7689
17aE2_hi time_m24 36.7712 0.8004
17aE2_hi time_m6 31.0655 0.5689
Control time_m12 39.0436 0.5318
Control time_m18 42.8495 0.609
Control time_m24 41.7939 0.6595
Control time_m6 31.3862 1.2574


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
17aE2_hi - Control time_m6 -0.3207 1.3287 1566 -0.2414 0.8093
17aE2_hi - Control time_m12 -4.7377 1.25 1566 -3.79 0.0002
17aE2_hi - Control time_m18 -5.6286 1.2592 1566 -4.4701 < 0.0001
17aE2_hi - Control time_m24 -5.0228 1.3868 1566 -3.6219 0.0003










ANOVA

Factor Df Sum Sq Mean Sq F value Pr(>F)
group 1 5867.0971 5867.0971 155.1831 < 0.0001
time 3 5078.0575 1692.6858 44.7711 < 0.0001
group:time 3 2617.3046 872.4349 23.0757 < 0.0001
Residuals 1455 55010.0363 37.8076 NA NA


Means

group time mean SE
17aE2_hi time_m12 38.3928 0.4863
17aE2_hi time_m18 39.48 0.5384
17aE2_hi time_m24 35.6009 0.4735
17aE2_hi time_m6 39.6279 0.5527
Control time_m12 45.1358 0.3568
Control time_m18 44.6654 0.401
Control time_m24 40.5988 0.5568
Control time_m6 39.2211 0.3751


Pairwise comparisons (Tukey multiple-test correction)

contrast time estimate SE df t.ratio p.value
17aE2_hi - Control time_m6 0.4069 0.6503 1455 0.6257 0.5316
17aE2_hi - Control time_m12 -6.743 0.6384 1455 -10.563 < 0.0001
17aE2_hi - Control time_m18 -5.1854 0.6711 1455 -7.7269 < 0.0001
17aE2_hi - Control time_m24 -4.9979 0.7492 1455 -6.6711 < 0.0001










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